Browsing by Author "Şahin, İbrahim"

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Corpus callosum in schizophrenia with deficit and non-deficit syndrome: A statistical shape analysis
(Bmj Publishing Group, 2021-10-27) Türk, Yaşar; Ercan, İlker; Şahin, İbrahim; Gürsel, Başak Erdemli; Uzunoğlu, Arda; Oğe, Cem; Beyazyüz, Elmas; Albayrak, Yakup; ERCAN, İLKER; Şahin, İbrahim; ERDEMLİ GÜRSEL, BAŞAK; Uzunoğlu, Arda; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; ABF-2367-2020; HII-7787-2022; AAH-6568-2021; IAK-9330-2023
Background The corpus callosum (CC) is the most targeted region in the cerebrum that integrates cognitive data between homologous areas in the right and left hemispheres.Aims Our study used statistical analysis to determine whether there was a correlation between shape changes in the CC in patients with schizophrenia (SZ) (deficit syndrome (DS) and non-deficit syndrome (NDS)) and healthy control (HC) subjects.Methods This study consisted of 27 HC subjects and 50 schizophrenic patients (20 with DS and 30 with NDS). 3 patients with DS and 4 patients with NDS were excluded. Three-dimensional, sagittal, T1-spoiled, gradient-echo imaging was used. Standard anatomical landmarks were selected and marked on each image using specific software.Results As to comparing the Procrustes mean shapes of the CC, statistically significant differences were observed between HC and SZ (DS+NDS) (p=0.017, James's F-j=73.732), HC and DS (p<0.001, James's F-j=140.843), HC and NDS (p=0.006, James's F-j=89.178) and also DS and NDS (p<0.001, James's F-j=152.967). Shape variability in the form of CC was 0.131, 0.085, 0.082 and 0.086 in the HC, SZ (DS+NDS), DS and NDS groups, respectively.Conclusions This study reveals callosal shape variations in patients with SZ and their DS and NDS subgroups that take into account the CC's topographic distribution.
K-ortalamalar kümeleme yöntemi ile hipotirodizm tanısı konmuş olguların büyük veri kullanılarak incelenmesi
(Bursa Uludağ Üniversitesi, 2019-07-19) Şahin, İbrahim; Ercan, İlker; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Biyoistatistik Anabilim Dalı.
Büyük veriyi açıklanabilir hale getirmek geçmişte güç olmasından dolayı ve yakın geçmişte ise zaman ve maliyet bakımından kısıtlarının olması nedeniyle, büyük veri çalışmaları yaygın değildi. Günümüzde ise büyük veriyi analiz etmek hem donanımsal hem de yazılımsal gelişmeler ve her gün genişleyen veri havuzuna karşın mümkün hale gelmiştir. Tez çalışmasında; konjenital hipotiroidizm, hipotroidizm, akut tiroidit tanısı almış olguların laboratuvar ve sosyo-demografik özelliklerine göre büyük veri kullanımı ile analizi yapılması amaçlanmıştır. Tez çalışmasında, Bursa Uludağ Üniversitesi Sağlık Uygulama ve Araştırma Merkezi Hastanesi'nde, bilgi işlem veri tabanından tarama yapılarak ulaşılabilir olan 2005-2018 yılları arasında belirtilen tanıları olan hastaların, ilk tanıda aldığı değerler dikkate alınarak 21125 hasta analize dahil edilmiştir. Veri setinde bulunan laboratuvar ölçüm ve demografik değişkenlere göre k-ortalamalar kümeleme metodu iki kümede şekillenecek şekilde analizler yapılmıştır. Büyük veri kullanımına ek olarak Cliff's Delta etki büyüklüğü katsayısı ile kümeler analiz edilmiştir. Tanı koymada referans alınan Serbest T3 ve Serbest T4 laboratuvar değerleri çalışmamızdaki büyük veri analiz sonuçlarıyla uyumlu çıkarken, TSH laboratuvar ölçüm değerleri uyumsuz çıkmıştır. Büyük veri analizinin sonrasında ortaya çıkan bu farklılıklar, kontrollü çalışmalar ile planlanarak farklılıkların değerlendirilmesi ve araştırılması gerektiğini düşündürmektedir.
Morphometric shape analysis of corpus callosum in children with down syndrome
(Sage Publications Inc, 2023-08-31) Gürsel, Başak Erdemli; Ercan, İlker; Şahin, İbrahim; Öngen, Gökhan; ERDEMLİ GÜRSEL, BAŞAK; ERCAN, İLKER; Şahin, İbrahim; ÖNGEN, GÖKHAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyolog Anabilim Dalı.; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Biyoistatistik Anabilim Dalı.; 0000-0002-2382-290X; 0000-0002-0047-1780; AAH-6568-2021; HII-7787-2022; ABF-2367-2020; JJO-9241-2023
Down syndrome (DS) is characterized by varying degrees of mental retardation and delay in neurocognitive functions. Herein, we analyzed the morphometric shape of the corpus callosum (CC) in children with DS. Twenty-three DS cases underwent magnetic resonance imaging and have grossly normal CC, and 23 control group cases were included in this retrospective study (2012-2020). The CC was obtained from T2-weighted mid-sagittal images, and certain anatomical points were marked on the CC. Statistical geometric shapes and deformations of CC were evaluated for both groups. The age range of patients with DS and control group was 6 to 42 months. A statistically significant difference was found in the shape of CC between the groups (P < .001). Deformation was most evident in the splenium in the DS group.
Statistical shape analysis of putamen in early-onset Parkinson's disease
(Elsevier, 2021-10) Sığırlı, Deniz; Özdemir, Senem Turan; Erer, Sevda; Şahin, İbrahim; Ercan, İlker; Özpar, Rifat; Örün, Muhammet Okay; Hakyemez, Bahattin; SIĞIRLI, DENİZ; ERER ÖZBEK, ÇİĞDEM SEVDA; ERCAN, İLKER; ÖZPAR, RİFAT; HAKYEMEZ, BAHATTİN; Özdemir, Senem Turan; Şahin, İbrahim; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0001-9031-3040; 0000-0002-3425-0740; 0000-0001-6649-9287; AAA-7472-2021; FPU-9468-2022; DVY-9744-2022; HII-7787-2022; ABF-2367-2020; AAH-5062-2021; AAI-2318-2021
Objective: To investigate the shape differences in the putamen of early-onset Parkinson's patients compared with healthy controls and to assess and to assess sub-regional brain abnormalities. Methods: This study was conducted using the 3-T MRI scans of 23 early-onset Parkinson's patients and age and gender matched control subjects. Landmark coordinate data obtained and Procrustes analysis was used to compare mean shapes. The relationships between the centroid sizes of the left and right putamen, and the durations of disease examined using growth curve models. Results: While there was a significant difference between the right putamen shape of control and patient groups, there was not found a significant difference in terms of left putamen. Sub-regional analyses showed that for the right putamen, the most prominent deformations were localized in the middle-posterior putamen and minimal deformations were seen in the anterior putamen. Conclusion: Although they were not as pronounced as those in the right putamen, the deformations in the left putamen mimic the deformations in the right putamen which are found mainly in the middle-posterior putamen and at a lesser extend in the anterior putamen.
The risk of developing gestational diabetes mellitus in maternal subclinical hypothyroidism: A systematic review and meta-analysis
(Springer Heidelberg, 2023-07-12) Dinçgez, Burcu; Ertürk, Nergis Kender; ERCAN, İLKER; Şahin, İbrahim; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-2382-290X; 0000-0002-2902-9670; AAH-5248-2020; GRY-0743-2022
PurposeThe purpose of this study was to determine the association between maternal subclinical hypothyroidism (SCH) and gestational diabetes mellitus (GDM) risk.MethodsThis study is a systematic review and meta-analysis. Following PubMed, Medline, Scopus, Web of Science, and Google Scholar database search up to April 1 2021, a total of 4597 studies were identified. Studies published in English, with full text available, related to subclinical hypothyroidism in pregnancy, reporting or mentioning the incidence of GDM were included in the analysis. Following exclusion of studies, a total of 16 clinical trial were analyzed. For the risk of GDM, odds ratios (ORs) were calculated. Subgroup analyzes were performed according to gestational age and thyroid antibodies.ResultsPregnant women with SCH were at increased risk of GDM compared to women with euthyroidism, overall (OR = 1.339, 95% CI 1.041-1.724; p = 0.023). Additionally, SCH without thyroid antibodies has no significant effect on GDM risk (OR = 1.173, 95% CI 0.88-1.56; p = 0.277) and pregnant women with SCH in the first trimester were not found to be at increased risk of GDM compared to women with euthyroidism regardless of thyroid antibodies (OR = 1.088, 95%CI 0.816-1.451; p = 0.564).ConclusionsMaternal SCH in pregnancy is related to an increased risk of GDM.
Turkish nationwide survey of glycemic and other metabolic parameters of patients with Diabetes mellitus (TEMD study)
(Elsevier, 2018-12-01) Sönmez, Alper; Haymana, Cem; Bayram, Fahri; Salman, Serpil; Dizdar, Oğuzhan Sıtkı; Gürkan, Eren; Çarlıoğlu, Ayse Kargili; Barçin, Cem; Sabuncu, Tevfik; Satman, İlhan; Güldiken, Sibel; Aytürk, Semra; Yılmaz, Murat; Aşık, Mehmet; Dinccag, Nevin; Çakmak, Ramazan; Türker, Fulya; İdiz, Cemile; Hacışahinoğullari, Hülya; Bağdemir, Elif; Yıldız, Buşra; Yumuk, Volkan Demirhan; Haliloğlu, Özlem; Sancak, Seda; Özsarı, Levent; Çağıltay, Eylem; Deyneli, Oğuzhan; İmre, Eren; Gönen, Sait; Boysan, S. Nur; Altuntaş, Yüksel; Öztürk, Feyza Yener; Mert, Meral; Pişkinpaşa, Hamide; Aydın, Hasan; İmamoğlu, Sazı; Ersoy, Canan; Özgül, Özen; Küçüksaraç Kıyıcı, Sinem; Çetinarslan, Berrin; Selek, Alev; Doğru, Teoman; Kırık, Ali; Kebapçı, Nur; Efe, Belgin; Kaya, Ahmet; Cordan, İlker; Baldane, Süleyman; Kirac, Cem Onur; Demirci, İbrahim; Capa, Zehra; Cesur, Mustafa; Yetkin, Ilhan; Çorapçıoğlu, Demet; Canlar, Şule; Yıldız, Okan Bulent; Sendur, Süleyman Nahit; Cakir, Bekir; özdemir, Didem; Çorakci, Ahmet; Kutlu, Mustafa; Bascil Tutuncu, Neslihan; Bozkuş, Yusuf; Çakal, Erman; Demirbaş, Berrin; Ertek, Sibel; Altay, Mustafa; Dağdeviren, Murat; Abedi, Amir Hassein; Çetinkalp, Sevki; Özışık, Hatice; Oruk, GÜzide Gonca; Yener, Serkan; Saydam, Başak Özgen; Güney, Engin; Unubol, Mustafa; Yaylalı, Güzin Fidan; Topsakal, Şenay; Hekimsoy, Zeliha; Akbaba, Gülhan; Aslan, İbrahim; Balcı, Mustafa Kemal; Dalkıran, Şefika; Akbay, Esen; Gül, Kamile; Agbaht, Kemal; Yılmaz, Müge Özsan; Bozkırlı, Emre; Tetiker, B. Tamer; Altuntaş, Seher Çetinkaya; Atmaca, Ayşegül; Durmuş, Elif Tutku; Mete, Türkan; Kutlutürk, Faruk; Küçükler, Ferit Kerim; Dikbaş, Oğuz; Akın, Şafak; Nuhoğlu, İrfan; Ersöz, Halil Önder; Bayraktaroğlu, Taner; Şişman, Pınar; Şahin, İbrahim; Çetin, Sedat; Capoğlu, İlyas; Akbaş, Emin Murat; Üçler, Rıfkı; Eren, Mehmet Ali; Tuzcu, Alpaslan Kemal; Pekkolay, Zafer; Özkaya, Mesut; Araz, Mustafa; TEMD Study Grp; ERSOY, CANAN; Özgül, Özen; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı; AAH-8861-2021; DLV-5369-2022
Aims: Turkey has the highest prevalence of diabetes in Europe. It is therefore essential to know the overall cardiovascular risk and reveal the predictors of metabolic control in Turkish adults with diabetes mellitus.Methods: A nationwide, multicenter survey consecutively enrolled patients who were under follow up for at least a year. Optimal control was defined as HbA1c <7%, home arterial blood pressure (ABP) <135/85 mmHg, or LDL-C <100 mg/dL. Achieving all parameters indicated triple metabolic control.Results: HbA1c levels of patients (n = 5211) were 8.6 +/- 1.9% (71 +/- 22 mmol/mol) and 7.7 +/- 1.7% (61 +/- 19 mmol/mol), in Type 1 and Type 2 diabetes, respectively. Glycemic control was achieved in 15.3% and 40.2%, and triple metabolic control was achieved in 5.5% and 10.1%, respectively. Only 1.5% of patients met all the criteria of being non-obese, nonsmoker, exercising, and under triple metabolic control. Low education level was a significant predictor of poor glycemic control in both groups.Conclusions: Few patients with Type 2, and even fewer with Type 1 diabetes have optimal metabolic control in Turkey. TEMD study will provide evidence-based information to policy makers to focus more on the quality and sustainability of diabetes care in order to reduce the national burden of the disease.
Vitamin D receptor gene BsmI, FokI, ApaI, TaqI polymorphisms and bone mineral density in a group of Turkish type 1 diabetic patients
(Springer, 2011-12) Yavuz, Dilek Gogas; Keskin, Lezan; Sert, Murat; Yazıcı, Dilek; Şahin, İbrahim; Yüksel, Meral; Deyneli, Oğuzhan; Aydın, Hasan; Akalın, Sema; Kıyıcı, Sinem; Tuncel, Ercan; Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji Diyabet ve Metabolizma Anabilim Dalı.; 12753880400; 7006929833
Previous studies have suggested an influence of vitamin D receptor alleles on bone metabolism and on susceptibility to type 1 diabetes mellitus in different ethnic populations. We aimed to investigate the distribution of vitamin D receptor (VDR) alleles in relation to biochemical bone turnover parameters and bone densitometry measurements in a group of Turkish type 1 diabetic patients. One hundred and seventeen patients (M/F 57/60, 27.6 +/- A 7.3 y duration of diabetes 8.1 +/- A 6.3 y) and 134 healthy controls (M/F 61/73, 26.2 +/- A 5.3 y) were included in the study. Bone mineral density (BMD) was evaluated by dual-energy X-ray absorptiometry (DEXA). The vitamin D receptor gene (VDR) polymorphisms FokI, Bsm1, Apa1, and Taq1 were examined using a PCR-based restriction analysis. Serum levels of calcium, phosphor osteocalcin, intact parathyroid hormone, and C telopeptide were measured. Vitamin D receptor Bsm1 Fok1, Apa1, and Taq1 genotype distributions were not different between patient with diabetes and control groups. BMD was 0.77 +/- A 0.2 g/cm(2) vs. 0.97 +/- A 0.2 g/cm(2) (P = 0.0001) for the femur, 1.0 +/- A 0.1 g/cm(2) vs. 1.13 +/- A 0.1 g/cm(2) (P = 0.001) for type 1 diabetic patients and controls. Bone turnover markers were significantly lower in type 1 diabetic group. BMD measurements and bone metabolic markers were not different between the genotypes in either the patient with diabetes or the controls. The VDR gene polymorphisms, Bsm1, Fok 1, Apa1, and Taq1 showed no influence on bone metabolism in our group of type 1 diabetic patients.