Browsing by Author "Akova, Berna Budak"

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Biofilm forming capacity and antibiotic susceptibility of Staphylococcus spp. with the icaA/icaD/bap genotype isolated from ocular surface of patients with diabetes
(Kamuzu University Health Sciences, 2018-12) Arık, Gizem; Kıvanç, Merih; Kıvanç, Sertaç Argün; Akova, Berna Budak; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; 0000-0002-0932-6977; 0000-0003-0995-5260; AAH-6518-2021; ABE-3033-2020; 47861204900; 55370489800
Introduction Bacterial biofilm is an exopolysaccharide matrix that is produced by bacteria while they adhere on abiotic or biotic surfaces. The bacteria living in this matrix are more resistant to antibiotics than planctonic bacteria. The biofilm formation property of the bacteria is determined by genes; and this is related to virulence of the microorganism. In ophthalmology, biofilms form especially on abiotic surfaces such as silicon tubes, contact lenses, intraocular lenses etc. Aim Our aim was to investigate genotypic and phenotypic structures of biofilms that are produced by Staphylococcus spp., which was obtained from the eyes of diabetic patients and determine the effect on antibiotic susceptibility. Methods The study group was comprised with 83 isolates from diabetic patients and 21 isolates from non-diabetic patients. Presumptive isolates were detected and confirmed by a microbial identification system VITEK II. Automated EcoRI Ribotyping was performed. Biofilm production was detected by Congo Red Agar Plate and Microtiter Plate Assay. Disc diffusion method was used for determination of antibiotic susceptibility of isolates. Results Out of the 83 isolates from diabetic patients, 25 were weakly (30%), 20 were moderately (24%), and 25 were strongly (30%) biofilm positive. Seven isolates of S. aureus, 11 isolates of S. epidermidis, 2 isolates of S. warneri, 3 isolates of S. hominis, and 2 isolates of S. lugdunensis were identified as strong biofilm producers. Out of the 83 Staphylococcus isolates, 37 were cefuroxime, 18 ciprofloxacin, 11 vancomycin, 12 gatifloxacin, and 18 moxifloxacin resistant. In total, 37 strains were resistant to three or more antibiotics. There was a statistically significant relation between biofilm formation and multidrug resistance (against three or more antibiotics,p<0.001). In nondiabetic patients, 15(71%) isolates were non adherent or weakly adherent, and 2(10%) were strongly adherent biofilm positive. Conclusion In conclusion, bacterial conjunctival flora of patients with diabetes is likely to produce biofilm. Biofilm formation is associated with multidrug rsistance in patients with diabetes.
Comparison of retinal nerve fiber layer thickness in terms of birth weight in prematurely born children
(Taylor & Francis, 2015-06-18) Olcaysu, Osman Okan; Olcaysu, Elif; Kıvanç, Sertaç Argün; Akova, Berna Budak; Yıldız, Meral; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; 0000-0002-0932-6977; 0000-0003-0995-5260; AAH-6518-2021; ABE-3033-2020; AAH-1885-2021; 47861204900; 55370489800; 35791194600
Purpose: To study the potential effects of both prematurity and the sub-groups of low birth weight on thickness of RNFL. Methods: Prospective case series of 26 preterm school-aged children with low birth weight whose retinal nerve fiber layer analyses with RTVue-100 Fourier-domain optic coherence tomography were performed in 2013 at the Department of Ophthalmology, Erzurum Region Education and Training Hospital. Results: The mean retinal nerve fiber layer thicknesses were 100.6 +/- 13.3 microns in extremely low birth weight, 103.9 +/- 8.4 microns in very low birth weight, and 104.1 +/- 10.8 microns in low birth weight groups. There was no significant difference in RNFL among the groups. Conclusions: No significant relationship was found between birth weights and retinal nerve fiber layer thickness of preterm children who were appropriate for gestational age.
Correlation of spectral domain optical coherence tomography findings and visual acuity in central serous chorioretinopathy
(Lippincott Williams & Wilkins, 2014-04) Yalçınbayır, Özgür; Gelişken, Öner; Akova, Berna Budak; Özkaya, Güven; Çevik, Sadık Görkem; Yücel, Ahmet Ali; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0003-0297-846X; 0000-0003-0995-5260; A-4421-2016; AAH-6625-2021; ABE-3033-2020; 8702056700; 6602526353; 55370489800; 16316866500; 55871327000; 7005217049
Purpose: To investigate the correlation between spectral domain optical coherence tomography findings and best-corrected visual acuity (BCVA) in patients with central serous chorioretinopathy (CSC) and to determine the visual prognostic factors. Methods: We retrospectively studied 56 eyes of 49 patients who had the diagnosis of CSC. Patients were categorized into subgroups depending on symptoms and clinical findings. Together with the overall foveal integrity of inner segment/outer segment (IS/OS) and external limiting membrane, several features of CSC including hyperreflective dots and hypertrophy of retinal pigment epithelium were investigated with spectral domain optical coherence tomography. Thickness measurements within the retina and choroid were performed. Results: Best-corrected visual acuity was closely associated with IS/OS line integrity (P < 0.001). The length of IS/OS disruption also had significant correlation with BCVA (r = -0.324, P = 0.016). Loss of foveal IS/OS and external limiting membrane line integrity was related to low BCVA (P < 0.001 for both). Presence of hyperreflective dots (P < 0.001) and retinal pigment epithelium hypertrophy (P = 0.011) had significant association with visual status. In cases with sequelae of CSC, BCVA was correlated with parameters of outer retinal damage. Conclusion: Besides the overall integrity of IS/OS line and the length of disruption, loss of foveal IS/OS and external limiting membrane integrity are also noteworthy in cases with CSC. Hyperreflective dots and retinal pigment epithelium hypertrophy are closely associated with BCVA in cases with CSC. Analysis of the subgroups has shown that morphologic changes that persist until the late phases of the disease could potentially affect the visual outcome.
Early results of selective laser trabeculoplasty in patients resistant to deep sclerectomy
(Sage Publications, 2014-05) Baykara, Mehmet; Amuk Hamidi, Nagihan; Akova, Berna Budak; Sabur, Huri; Poroy, Ceren; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; 0000-0003-0995-5260; ABI-7051-2020; ABE-3033-2020; AAI-8604-2020; 7004578592; 56140824200; 55370489800; 55633463900; 56142133900
Purpose: In this study, we aimed to determine the early results of selective laser trabeculoplasty to trabeculo-Descemet membrane in patients resistant to deep sclerectomy (DS) surgery. Methods: Twelve eyes of 12 patients that had undergone DS for primary open-angle glaucoma were enrolled. Preoperative and postoperative intraocular pressures (IOP) were measured by Goldmann applanation tonometer. Time to failure after DS was noted. Failure is described as IOP higher than 20 mm Hg. All patients underwent selective laser trabeculoplasty (SLT) after failure. Eight to 10 applications of SLT were applied over the trabeculo-Descemet membrane. Laser was applied to the surgical site only. The IOPs before SLT, at postoperative first week, first month, and third month were measured. Results: Mean follow-up time was 23.5 +/- 9.5 months, Mean preoperative 10P was 34.2 +/- 6.7 mm Hg; mean postoperative 10P at first week was 12.7 +/- 3.2 mm Hg. Mean time to failure after DS procedure was 21.6 +/- 7.6 months. Mean 10P was 20.6 +/- 1.9 mm Hg just before SLT procedure. Mean 10P measurements after SLT at first week, first month, and third month were 10.5 +/- 2.2 mm Hg, 10.5 +/- 1.9 mm Hg, and 10.9 +/- 2.1 mm Hg, respectively. Conclusions: Selective laser trabeculoplasty after DS is an effective and noninvasive procedure that can be done on an outpatient basis. Our results suggest that SLT applied to the surgical site is an effective intervention in the short term but long-term results are required to assess the efficacy.
How important is the etiology in the treatment of epiphora?
(Hindawi, 2016-07-17) Ulusoy, Mahmut Oğuz; Atakan, Mehmet; Kıvanç, Sertaç Argün; Akova, Berna Budak; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; 0000-0003-0995-5260; 0000-0002-0932-6977; AAH-6518-2021; ABE-3033-2020; 47861204900; 55370489800
Purpose. There are several etiological factors that cause epiphora, and treatment differs according to the cause. We aimed to evaluate the etiology of epiphora and the treatment modalities of the affected patients. Materials and Methods. Data of patients who were referred to ophthalmology clinics for epiphora were retrospectively analyzed. All patients were evaluated for epiphora etiology, treatment modalities, and duration of complaints, after complete ophthalmologic examination. Results. This study consisted of 163 patients with a mean age of 64.61 +/- 16.52 years (range 1-92 years). Lacrimal system disease (48.4% [79/163]) was the most common cause, followed by ocular surface disease (dry eye/blepharitis) (38.7% [ 63/163]). Among the patients included in this study, 69% (113/163) did not receive any treatment, whereas only 1.8% (3/163) were treated surgically. About 4.3% of the patients (7/163) had a complaint for more than 5 years (p = 0.012) and six of these had chronic dacryocystitis and one had ectropion. Conclusion. Epiphora not only has a negative impact on patients' comfort, but also puts them at risk for probable intraocular operations in the future. Therefore, the wide range of its etiology must be taken into consideration and adequate etiology-specific treatment options must be applied.
An important cause of blindness in children: Open globe injuries
(Hindawi Ltd, 2016-04-19) Çevik, Sadık Görkem; Yıldız, Meral; Kıvanç, Sertaç Argun; Akova, Berna Budak; Özmen, Ahmet Tuncer; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; 0000-0003-0995-5260; 0000-0002-0932-6977; ABE-3033-2020; AAH-1885-2021; AAH-6518-2021; 35791194600; 47861204900; 55370489800; 6701399730
Objective. Our aim was to present and evaluate the predictive factors of visual impairment and blindness according to WHO criteria in pediatric open globe injuries. Methods. The medical records of 94 patients younger than 18 years who underwent primary repair surgery were reviewed retrospectively. The initial and final visual acuity, anterior and posterior segment findings, and zone of injury were noted. The patients were classified as blindness in one eye or visual impairment in one eye. Results. Of 412 patients who presented with open globe injury, 94 (23%) were under 18 years old. Fifty-four (16 females, 38 males) children were included. The mean age of the children was 7.1 +/- 4.1 years. According to WHO criteria, 19 of 54 patients (35%) had unilateral blindness and 8 had unilateral visual impairment (15%). There was no significant relationship between final visual acuity and gender and injured eye. In visually impaired and blind patients, presence of preoperative hyphema, retinal detachment, and zone 2 and zone 3 injuries was significantly higher. Conclusion. Presence of hyphema and zone 2 and zone 3 injuries and retinal detachment may end up with visual impairment and/or blindness in children.
Relationship among corneal biomechanics, anterior segment parameters, and geometric corneal parameters
(Hindawi, 2016-09-14) Çevik, Sadık Görkem; Tok-Çevik, Mediha; Lim, Kin Sheng; Kıvanç, Sertaç Argun; Akova, Berna Budak; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; 0000-0003-0995-5260; 0000-0002-0932-6977; ABE-3033-2020; AAH-6518-2021; 47861204900; 55370489800
Purpose. To investigate the relationship between corneal biomechanical parameters, anterior segment parameters, and geometric corneal parameters in a healthy Caucasian group. Methods. This retrospective study included the healthy eyes with best corrected visual acuity of at least 20/40 of 122 Caucasian subjects. The anterior segment parameters and geometric corneal parameters such as corneal volume, central corneal thickness, horizontal and vertical corneal radii, anterior and posterior steep, and flat keratometric values were measured with a Scheimpflug camera. The biomechanical properties were measured with Ocular Response Analyzer. Results. One hundred and twenty-two healthy Caucasian subjects (67 males, 55 females) with a mean age of 45.32 +/- 20.23 were enrolled. Both corneal hysteresis and corneal resistance factor were positively correlated with CCT (r = 0.529, p < 0.001; p = 0.638, p < 0.001) and CV (r = 0.635, p < 0.001; p = 0.579, p < 0.001) and negatively correlated with age (r =-0.373, p < 0.001; p = -0.249, p < 0.001). Both in age-gender and multivariate models, CH and CRF had statistically significant negative association with the posterior steep K value. Conclusions. CH and CRF are negatively correlated with posterior steep and average posterior K values.