Browsing by Author "Aycan, Ahmet Emre"

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    Distribution of Streptococcus pneumoniae serotypes that cause parapneumonic empyema in Turkey
    (American Society for Microbiology, 2013-04-15) Ceyhan, Mehmet; Özsürekçi, Yasemin; Gürler, Nezahat; Özkan, Şengül; Şensoy, Gülnar; Belet, Nurşen; Keser, Melike; Dinleyici, Ener Cağrı; Alhan, Emre; Baki, Ali; Öner, Ahmet Faik; Uzun, Hakan; Kurugöl, Zafer; Aycan, Ahmet Emre; Gürbüz, Venhar; Karadağ Öncel, Eda; Çelik, Melda; Parlakay, Aslınur Özkaya; Hacımustafaoğlu, Mustafa Kemal; Çelebi, Solmaz; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Enfeksiyon Hastalıkları Anabilim Dalı.; CTG-5805-2022; ENK-4130-2022; 6602154166; 7006095295
    Streptococcus pneumoniae is the most common etiological cause of complicated pneumonia, including empyema. In this study, we investigated the serotypes of S. pneumoniae that cause empyema in children. One hundred fifty-six children who were diagnosed with pneumonia complicated with empyema in 13 hospitals in seven geographic regions of Turkey between 2010 and 2012 were included in this study. Pleural fluid samples were collected by thoracentesis and tested for 14 serotypes/serogroups using a Bio-Plex multiplex antigen detection assay. The serotypes of S. pneumoniae were specified in 33 of 156 samples. The mean age ± the standard deviation of the 33 patients was 6.17 ± 3.54 years (range, 0.6 to 15 years). All of the children were unvaccinated according to the vaccination reports. Eighteen of the children were male, and 15 were female. The serotypes of the non-7-valent pneumococcal conjugated vaccine (non-PCV-7), serotype 1, serotype 5, and serotype 3, were detected in eight (14.5%), seven (12.7%), and five (9.1%) of the samples, respectively. Serotypes 1 and 5 were codetected in two samples. The remaining non- PCV-7 serotypes were 8 (n = 3), 18 (n = 1), 19A (n = 1), and 7F/A (n = 1). PCV-7 serotypes 6B, 9V, 14, 19F, and 23F were detected in nine (16.3%) of the samples. The potential serotype coverages of PCV-7, PCV-10, and PCV-13 were 16.3%, 45.4%, and 60%, respectively. Pediatric parapneumonic empyema continues to be an important health problem despite the introduction of conjugated pneumococcal vaccines. Active surveillance studies are needed to monitor the change in S. pneumoniae serotypes that cause empyema in order to have a better selection of pneumococcal vaccines.
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    Meningitis caused by neisseria meningitidis, hemophilus influenzae type b and streptococcus pneumoniae during 2005-2012 in Turkey a multicenter prospective surveillance study
    (Taylor & Francis Inc, 2014-09-01) Ceyhan, Mehmet; Gurler, Nezahat; Özsürekci, Yasemin; Keser, Melike; Aycan, Ahmet Emre; Gürbüz, Venhar; Salman, Nuran; Camcıoğlu, Yildiz; Dinleyici, Ener Cağrı; Özkan, Şengül; Şensoy, Gülnar; Belet, Nursen; Alhan, Emre; Uzun, Hakan; Öner, Ahmet Faik; Kurugol, Zafer; Taş, Mehmet Ali; Aygün, Denizmen; Öncel, Eda Karadağ; Çelik, Melda; Yasa, Olcay; Akın, Fatih; Coşkun, Yavuz; Hacimustafaoglu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Celebi, Solmaz; ÇELEBİ, SOLMAZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi
    Successful vaccination policies for protection from bacterial meningitis are dependent on determination of the etiology of bacterial meningitis. Cerebrospinal fluid (CSF) samples were obtained prospectively from children from 1 month to <= 18 years of age hospitalized with suspected meningitis, in order to determine the etiology of meningitis in Turkey. DNA evidence of Neisseria meningitidis (N. meningitidis), Streptococcus pneumoniae (S. pneumoniae), and Hemophilus influenzae type b (Hib) was detected using multiplex polymerase chain reaction (PCR). In total, 1452 CSF samples were evaluated and bacterial etiology was determined in 645 (44.4%) cases between 2005 and 2012; N. meningitidis was detected in 333 (51.6%), S. pneumoniae in 195 (30.2%), and Hib in 117 (18.1%) of the PCR positive samples. Of the 333 N. meningitidis positive samples 127 (38.1%) were identified as serogroup W-135, 87 (26.1%) serogroup B, 28 (8.4%) serogroup A and 3 (0.9%) serogroup Y; 88 (26.4%) were non-groupable. As vaccines against the most frequent bacterial isolates in this study are available and licensed, these results highlight the need for broad based protection against meningococcal disease in Turkey.