Browsing by Author "Bayram, Feyza"

Now showing 1 - 5 of 5

Perinatal asphyxia is associated with the umbilical cord nucleated red blood cell count in pre-eclamptic pregnancies
(Taylor & Francis, 2010-05) Bayram, Feyza; Özerkan, Kemal; Cengiz, Candan; Develioğlu, Osman Haldun; Çetinkaya, Merih; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; AAH-9791-2021; 23479310200; 6603345841; 6701513182; 6701315440; 23994946300
Nucleated red blood cells are commonly present in the blood of newborns. Our objective was to investigate the value of umbilical cord nucleated red blood cell (NRBC) count in predicting fetal asphyxia in pre-eclamptic women. NRBCs were counted in umbilical cord blood samples of neonates born to 43 pre-eclamptic and 25 healthy pregnant women. Pre-eclamptic women were further subgrouped based on the presence or absence of intrauterine growth restriction. The NRBC count differed significantly between pre-eclamptic women with and without intrauterine growth restriction, and controls (26.3 +/- 7.5; 17.1 +/- 6.8; and 9.9 +/- 2.7; p < 0.001). A NRBC count of 18.5 or above could predict fetal asphyxia with a sensitivity of 94.4% and a specificity of 80.0%. The umbilical cord NRBC count is effective in predicting fetal asphyxia in pre-eclamptic women.
Preeklamptik gebelerde umbilikal kord kanındaki eritroblast düzeyinin fetal asfiksi ve perinatal sonuçlarla ilişkisi
(Uludağ Üniversitesi, 2008) Bayram, Feyza; Cengiz, Candan; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
Amaç: Preeklamptik gebelerde doğum esnasında umbilikal kord kanında bakılan eritroblast (NRBC) sayısının fetal asfiksiyi saptamada prediktif etkinliğini ve güvenilirliğini belirlemek ve bunun perinatal sonuçlar ile ilişkisini araştırmakGereç ve Yöntem: Ocak 2007 ile Ocak 2008 tarihleri arasında Uludağ Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum kliniğine başvuran 28-41 gebelik haftaları arası 21 preeklamptik (Grup I), 22 preeklamptik ve fetal gelişme geriliği olan (Grup II) ve 25 herhangi bir obstetrik problemi olmayan sağlıklı (Grup III) olmak üzere 68 gebe çalışma kapsamına alınmıştır. Doğumda umbilikal kord kanından alınan örneklerde periferik yaymada NRBC sayısı, hemogram ve kan gazı çalışıldı. İstatistiksel değerlendirmede; Ki-kare, Mann-Whitney U ve ANOVA testi, çoklu ve lojistik regresyon analizi kullanıldı.Bulgular: Gruplar arasında demografik özellikler açısından istatistiksel anlamlı fark yoktu (p>0.05). Ortalama NRBC sayısı, preeklamptik grupta (17.1+ 6.8 NRBC / 100 wbc) kontrol grubundan ( 9.9 + 2.7 NRBC / 100 wbc) anlamlı olarak yüksek bulundu. Preeklampsiye ek olarak fetal gelişme geriliği olan grubun (Grup II) NRBC sayısı ise diğer iki gruptan belirgin olarak yüksekti (26.3 + 7.5 NRBC / 100 wbc). ROC analizinde, fetal asidoz için NRBC'nin eşik değeri 18.5 NRBC / 100 wbc olarak hesaplandı (sensitivite %94.4, spesifite %80 ).Sonuç: NRBC sayısı, preeklamptik gebelerde perinatal asfiksiyi öngörmede etkin bulunmuştur ve erken neonatal sonuçları değerlendirirken güvenilir bir parametre olarak kullanılabilir. Ayrıca NRBC değerinin, fetal asfiksinin süresini ve derecesini belirlerken yararlı bir parametre olabileceği kanısına varılmıştır.
Role of increased plasminogen activator inhibitor-1 and vitronectin in gestational diabetes mellitus
(Assoc Medica Brasileira, 2023-01-01) Özgen, Gülten; Dinçgez, Burcu; Bayram, Feyza; Özgen, Levent; ÖZGEN, LEVENT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; JFT-0660-2023
OBJECTIVE: The aim of this study was to analyze the second-trimester levels of vitronectin and plasminogen activator inhibitor-1 in gestational diabetes mellitus.METHODS: This study was conducted between September 2020 and December 2020 at the University of Health Sciences, Bursa Yuksek Ihtisas Research and Training Hospital, Department of Obstetrics and Gynecology. A total of 30 pregnant women with gestational diabetes mellitus and 60 healthy controls between 24 and 27/6 weeks of gestation were included. The inclusion criteria were as follows: being between 18 and 45 years old and 24-27/6 gestational weeks, having singleton pregnancy, diagnosed with gestational diabetes mellitus by using a two-step challenge test. The exclusion criteria of this study were as follows: chronic inflammatory or infectious disease, fasting blood glucose>126 mg/dL, intolerance to glucose tolerance testing, abnormal liver or kidney function tests, as well as pregnancy with pre-gestational diabetes history of adverse perinatal outcomes. Serum vitronectin and plasminogen activator inhibitor-1 levels were measured using the enzyme-linked immunosorbent assay method.RESULTS: Vitronectin and plasminogen activator inhibitor-1 levels were higher in the gestational diabetes mellitus group compared with controls [91.85 (23.08) vs. 80.10 (39.18) ng/mL, for vitronectin and 6.50 (1.05) vs. 4.35(1.0) ng/mL, for plasminogen activator inhibitor-1 (for both p<0.001)]. vitronectin >84.7 ng/mL was found to predict gestational diabetes mellitus with a sensitivity of 70% and specificity of 63.3%. Moreover, vitronectin had a significant positive correlation with fasting blood glucose (r=0.476, p<0.001), postprandial blood glucose (r=0.489, p<0.001), HbA1c (r=0.713, p<0.001), and plasminogen activator inhibitor-1 (r=0.586, p<0.001).CONCLUSION: This study revealed that second-trimester vitronectin and plasminogen activator inhibitor-1 are increased in gestational diabetes mellitus and vitronectin could be a candidate for the prediction of gestational diabetes mellitus.
The predictive value of halp score and systemic immune inflammation (sii) index in hyperemesis gravidarum
(Wiley, 2023-05-21) Bayram, Feyza; Özgen, Gülten; Karasın, Süleyman Serkan; ÖZGEN, LEVENT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; JFT-0660-2023
Aim: Hyperemesis gravidarum (HG) is one of the most common serious diseases in early pregnancy. This study aimed to investigate the clinical significance of hemoglobin, albumin, lymphocyte, and platelet (HALP) score and systemic immune inflammation (SII) index in the presence and severity of HG.Methods: This retrospective case-control study was conducted in a training and educational university hospital between January 2019 and July 2022. A total of 521 pregnant women, of whom 360 were diagnosed with HG at 6-14 weeks of gestation and 161 were low-risk pregnancies, were included in the study. Patients' demographic characteristics and laboratory parameters were recorded. Patients with HG were divided into three categories: mild (n = 160), moderate (n = 116), and severe (n = 84), according to disease severity. The modified PUQE scoring was used to determine the severity of HG.Results: The mean age of the patients was 27.6 (16-40) years. We divided the pregnant women into the control group and HG group. The HALP score was significantly lower in the HG group (average, 2.8 +/- 1.3), whereas the SII index was found to be significantly higher (average, 895.8 +/- 458.1). A negative correlation was found between the increase in the severity of HG and HALP score. The HALP score was the lower in severe HG (mean, 2.16 +/- 0.81) and was significantly different from other HG categories (p < 0.01). Moreover, a positive correlation was noted between increased HG severity and SII index levels. The SII index was higher in the severe HG group and was significantly different from the others (1001.2 +/- 437.2) (p < 0.01).Conclusions: The HALP score and SII index can be useful, cost-effective, and easily accessible objective biomarkers to predict the presence and severity of HG.
The retrospective analysis of fetal echocardiograpy results at the uludag university hospital
(Galenos Yayincilik, 2007-12-01) Kimya, Yalçın; Bostan, Özlem Mehtap; BOSTAN, ÖZLEM MEHTAP; Alyamaç, Funda Akpınar; Özdil, Murat; Bayram, Feyza; Çelik, Nurhan; Cengiz, Candan; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; 0000-0003-1735-6997
Objective: In this study indications, findings and results of fetal echocardiography performed in our department were evaluated.Materials and Methods: The records of fetal echocardiography findings, pregnancy and postpartum period were retrospectively evaluated in 208 patients and had fetal echocardiography who were in high risk for congenital heart diseases, in our department between May 2003-January 2007.Results: The mean age of 208 patients was 21,8 and mean gestational age 25 weeks and 3 days. The two most common indications for fetal echocardiography were congenital heart: disease in the family and suspicion of cardiac anomaly during routine ultrasonogrraphy; 88/208 (42.3%) and 43/208 (20.7%); respectively. Incidence of abnormal findings in fetal echocardiographic examination was 26.9% (56/208). While congenital heart disease ratio in patients with family history of congenital heart disease was 4.6% (4/88), it was 74.4% (32/43) in patients with suspicion of cardiac. anomaly during routine ultrasonography.Discussion: The most common request for fetal echocardiography was presence of congenital heart disease in the family. Routine prenatal ultrasonography has the most important role in detection of cardiac anomalies.