Browsing by Author "Demir, Nesrin"

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    Evaluation of the potential roles of activin-A, activin-B, and follistatin molecules exhibiting immunomodulatory properties in brucellosis
    (Wiley, 2021-08-01) Kızmaz, Muhammed Ali; Ellergezen, Pınar Hız; Demir, Nesrin; Çağan, Eren; Akalın, Emin Halis; Oral, Haluk Barbaros; Budak, Ferah; Kızmaz, Muhammed Ali; ELLERGEZEN, PINAR; AKALIN, EMİN HALİS; ORAL, HALUK BARBAROS; BUDAK, FERAH; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Klinik Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı.; 0000-0001-5334-7911; 0000-0001-7530-1279; 0000-0003-0463-6818; 0000-0001-7625-9148; AAU-8952-2020; F-4657-2014; K-7285-2012; HKN-2347-2023; IZP-9398-2023
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    Potential effects of sCD40L, CD36, IL-23 and arginase-1 molecules on the pathogenesis of brucellosis
    (Wiley, 2021-08) Demir, Nesrin; Çağan, Eren; Kızmaz, Muhammed Ali; Ellergezen, Pınar Hız; Çolak, Zehranur; Akalın, Emine Halis; Oral, Haluk Barbaros; Budak, Ferah; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Klinik Mikrobioloji ve Enfeksiyon Hastalıkları Anabilim Dalı.; 0000-0001-7625-9148; F-4657-2014; AAU-8952-2020; CZW-5095-2022; CPH-1647-2022; EQV-2978-2022; FQR-1753-2022
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    Roles of novel IL-1 family (IL-36, IL-37, and IL-38) members in chronic brucellosis
    (Academic Press, 2020-11) Demir, Nesrin; Çağan, Eren; Hız, Pınar; Kanbur, Ertan; Akalın, Halis; Pashazadeh, Mehrdat; Bal, Salih Haldun; Oral, Haluk Barbaros; Budak, Ferah; Tezcan, Gülçin; Uludağ Üniversitesi/Tıp Fakültesi/İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Diş Hekimliği Fakültesi/Temel Bilimler Bölümü/Temel Bilimler Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri/İmmünoloji Anabilim Dalı.; 0000-0001-8399-8942; 0000-0003-0463-6818; 0000-0001-7625-9148; 0000-0002-5956-8755; EZA-7505-2022; AAU-8952-2020; DLI-4479-2022; HJY-9001-2023; K-7285-2012; F-4657-2014; AAH-3843-2020; 57189853087; 57218292727; 57207553671; 48461762300; 57191480128; 7004498001; 6701913697; 25650627600
    The secretion of interleukin (IL)-1 family cytokines is one of the most potent and earliest pro-inflammatory responses triggered by brucellosis. However, the roles of the most recently discovered IL-1 family members, IL-36, IL-37, and IL-38, in the transition into the chronic form of brucellos is remain largely unknown. Therefore, in this study, the roles of IL-36, IL-37, and IL-38 in brucella infections and their effects on the transition from the acute to chronic form of the disease were investigated. Using peripheral blood samples from 40 patients with acute brucellosis, 40 patients with chronic brucellosis, and 40 healthy control subjects, we analysed the serum concentrations of secreted IL-36, IL-37, and IL-38 using ELISA. The findings were confirmed by using RT-qPCR to analyse the mRNA levels of the genes encoding IL-36, IL-37, and IL-38 in peripheral blood mononuclear cells (PBMCs) from 10 randomly selected patients from each of the three groups. Our results showed that serum IL-37 (p < 0.001) and IL-38 (p < 0.001) concentrations were lower in patients with brucellosis than in the healthy controls. In addition, serum IL-37 and IL-38 concentrations were higher in the chronic patient group than in the acute patient group. The mRNA expression levels of IL-37 and IL1F10, genes that encode IL-38, did not affect serum cytokine secretion levels. This result suggests that the high secretion levels of IL-37 and IL-38 may be related to the progression into the chronic form of brucellosis. Our findings will aid in clarifying the mechanism of the transition of brucellosis from the acute to the chronic form of the disease.