Browsing by Author "Karakurt, Sait"

Filter results by typing the first few letters
Now showing 1 - 4 of 4
  • Thumbnail Image
    Item
    Comparison of thoracic hrct and self-reported questionnaires in the assessment of pulmonary involvement in rheumatoid arthritis patients: preliminary results
    (BMJ Publishing Group, 2018-06) Topçu, Ahmet; Yalçınkaya, Yasemin; Karakurt, Sait; Mursaloğlu, Hüseyin Hakan; Albayrak, Ece; Demir, M.; İnanç, Nevsun; Coşkun, Nihan; Dalkılıç, Ediz; Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı/Romatoloji Bilim Dalı.
  • No Thumbnail Available
    Publication
    Evaluation of rheumatoid arthritis and connective tissue disease-related interstitial lung disease with pulmonary physiologic test, HRCT, and patient-based measures of dyspnea and functional disability
    (Springer London, 2021-03-11) Topcu, Atakan; Mursaloğlu, H. Hakan; Yalcınkaya, Yasemin; Karakurt, Sait; Yağız, Burcu; Alaca, Zeynep; Demir, Meryem; Coşkun, Belkıs Nihan; Dalkılıç, Ediz; İnanç, Nevsun; YAĞIZ, BURCU; COŞKUN, BELKIS NİHAN; DALKILIÇ, HÜSEYİN EDİZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; 0000-0003-0298-4157; 0000-0002-0624-1986; 0000-0001-8645-2670; JQW-5031-2023; AAG-7155-2021; CMF-4757-2022
    Objectives We aim to investigate the relationship between pulmonary function and imaging parameters with symptom-related patient-reported outcome measures (PROs). Method We included 65 patients of rheumatoid arthritis (RA) and connective tissue disease (CTD) with and without interstitial lung disease (ILD) into this cross-sectional study. We evaluated the relationship between FVC, DLco, and PROs and compared to HRCT findings. PROs included visual analogue scale for breathing, modified Borg scale, medical research council dyspnea scale, St. George's respiratory questionnaire (SGRQ), Leicester cough questionnaire, and Short Form 36 quality of life (SF-36 QoL). Results The mean age was 57.4 +/- 9.7 and 61.9% (39/65) of patients had an established ILD. In RA-ILD group, SGRQ score was higher (p < 0.001) and SF-36 physical functioning score was lower (p = 0.02) than CTD-ILD group. In RA group, there was a significant correlation between FVC and SF-36 role functioning/physical score (r = 0.724, p = 0.012). In CTD group, SF-36 general health score was correlated with both FVC (r = 0.441, p = 0.045) and DLco (r = 0.485, p = 0.035), and also SF-36 physical functioning score was correlated with FVC (r = 0.441, p = 0.040). PROs were found to be similar between ILD and non-ILD patients. SF-36 QoL total and SGRQ outcomes were worse in non-ILD group. Conclusions We concluded that PROs could be used to evaluate health-related quality of life (HRQoL) in RA- or CTD-related ILD. The physical health determinants of HRQoL are measurably worse in RA-ILD patients than in CTD patients. But, PROs may not be very helpful in differentiating patients with cough and/or shortness of breath due to ILD or non-ILD causes in RA/CTD.
  • Thumbnail Image
    Item
    The progression of lung involvement in rheumatoid arthritis patients receiving biological therapies
    (BMJ Publishing Group, 2018-06) Yalçınkaya, Yasemin; Can, Müge; Karakurt, Sait; Albayrak, Ece; Mursaloğlu, Hakan; Topçu, Ahmet; Demir, M.; İnanç, Nevsun; Coşkun, Nihan; Dalkılıç, Ediz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Bilim Dalı.
  • No Thumbnail Available
    Item
    The risk of tuberculosis in patients with psoriasis treated with anti-tumor necrosis factor agents
    (Wiley, 2015-05) Ergün, Tülin; Seçkin, Dilek; Onsun, Nahide; Özgen, Züleyha; Ünalan, Pemra; Alpsoy, Erkan; Karakurt, Sait; Bülbül, Emel Başkan; Uludağ Üniversitesi/Tıp Fakültesi/Deri ve Zührevi Hastalıklar Anabilim Dalı.; 0000-0002-0144-3263; AAH-1388-2021; 43760921800
    BackgroundTumor necrosis factor-alpha (TNF-) antagonist treatment is associated with 1.6 to 27 times higher risk of tuberculosis (TB). ObjectiveTo find TB incidence of psoriasis patients treated with TNF- antagonists and define risk factors related with this condition in a country with moderately high risk of TB. MethodsThree hundred seventy psoriasis patients treated by anti-TNF agents in four referral centers were included. The data on the characteristics of the patients, TB history, tuberculosis skin test results, anti-TNF agent type and exposure time, localization of TB, and isoniazide prophylaxis state were analyzed. ResultsFour patients (1.08%) developed TB, three pulmonary and one gastrointestinal, 2-23months after initiating anti-TNF agents. Other than the patient with gastrointestinal TB, who was using methotrexate and corticosteroid concomitantly, none had contributing risk factors for TB. Two patients developed pulmonary TB in spite of chemoprophylaxis. Three patients with pulmonary TB completely recovered following antiTB treatment whereas patients with gastroinrestinal TB developed renal failure. LimitationsThe major limitation of the study is the lack of a diseased control group, which enables us to compare the risk of psoriatics with that of patients having other inflammatory diseases. ConclusionTuberculosis is a rare but a severe complication of anti-TNF treatment and may develop in spite of chemoprophylaxis. The risk of TB in psoriasis patients in the present study is comparable to literature mostly based on rheumatology patients.