Browsing by Author "Salman, Nuran"

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    Inappropriate antimicrobial use in Turkish pediatric hospitals: A multicenter point prevalence survey
    (Elsevier, 2010-01) Ceyhan, Mehmet; Yıldırım, İnci; Ecevit, Çiğdem Ömür; Aydoğan, Aysel; Örnek, Ahmet Haydar; Salman, Nuran; Somer, Ayper; Hatipoğlu, Nevin; Camcıoğlu, Yıldız; Alhan, Emre; Hacımustafaoğlu, Mustafa Kemal; Çelebi, Solmaz; İnan, Dilara; Kurt, Neşe Çitak; Öner, Ahmet Faik; Gülümser, Özlem; Güneş, Adalet Meral; Coşkun, Yavuz; Çelik, Ümit; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 9843305700
    Objectives: Although well-defined principles of rational antimicrobial use are available, inappropriate prescribing patterns are reported worldwide. Accurate information on the usage of antimicrobials, including factors associated with and influencing their use, is valuable for improving the quality of prescription practices. Methods: In this cross-sectional point prevalence survey, data on patients hospitalized in 12 different children's hospitals were collected on a single day. Appropriateness of prescription was compared between the types of antimicrobials prescribed, indications, wards, and presence of/consultation with an infectious disease physician (IDP). Results: A total 711 of 1302 (54.6%) patients evaluated were receiving one or more antimicrobial drugs. The antimicrobial prescription rate was highest in pediatric intensive care (75.7%) and lowest in the surgery wards (37.0%). Of the 711 patients receiving antimicrobials, 332 patients (46.7%) were found to be receiving at least one inappropriately prescribed drug. Inappropriate use was most frequent in surgery wards (80.2%), while it was less common in oncology wards (31.8%; p < 0.001). Respiratory tract infection was the most common indication for antimicrobial use (29.4%). Inappropriate use was more common in deep-seated infections (54.7%) and respiratory infections (56.5%). Fluoroquinolones were used inappropriately more than any other drugs (81.8%, p = 0.021). Consultation with an IDP appears to increase appropriate antimicrobial use (p = 0.008). Conclusions: Inappropriate antimicrobial use remains a common problem in Turkish pediatric hospitals. Consultation with an IDP and prescribing antimicrobial drugs according to microbiological test results could decrease the inappropriate use of antimicrobials.
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    Meningitis caused by neisseria meningitidis, hemophilus influenzae type b and streptococcus pneumoniae during 2005-2012 in Turkey a multicenter prospective surveillance study
    (Taylor & Francis Inc, 2014-09-01) Ceyhan, Mehmet; Gurler, Nezahat; Özsürekci, Yasemin; Keser, Melike; Aycan, Ahmet Emre; Gürbüz, Venhar; Salman, Nuran; Camcıoğlu, Yildiz; Dinleyici, Ener Cağrı; Özkan, Şengül; Şensoy, Gülnar; Belet, Nursen; Alhan, Emre; Uzun, Hakan; Öner, Ahmet Faik; Kurugol, Zafer; Taş, Mehmet Ali; Aygün, Denizmen; Öncel, Eda Karadağ; Çelik, Melda; Yasa, Olcay; Akın, Fatih; Coşkun, Yavuz; Hacimustafaoglu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Celebi, Solmaz; ÇELEBİ, SOLMAZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi
    Successful vaccination policies for protection from bacterial meningitis are dependent on determination of the etiology of bacterial meningitis. Cerebrospinal fluid (CSF) samples were obtained prospectively from children from 1 month to <= 18 years of age hospitalized with suspected meningitis, in order to determine the etiology of meningitis in Turkey. DNA evidence of Neisseria meningitidis (N. meningitidis), Streptococcus pneumoniae (S. pneumoniae), and Hemophilus influenzae type b (Hib) was detected using multiplex polymerase chain reaction (PCR). In total, 1452 CSF samples were evaluated and bacterial etiology was determined in 645 (44.4%) cases between 2005 and 2012; N. meningitidis was detected in 333 (51.6%), S. pneumoniae in 195 (30.2%), and Hib in 117 (18.1%) of the PCR positive samples. Of the 333 N. meningitidis positive samples 127 (38.1%) were identified as serogroup W-135, 87 (26.1%) serogroup B, 28 (8.4%) serogroup A and 3 (0.9%) serogroup Y; 88 (26.4%) were non-groupable. As vaccines against the most frequent bacterial isolates in this study are available and licensed, these results highlight the need for broad based protection against meningococcal disease in Turkey.