Browsing by Author "ÇELEBİ, SOLMAZ"

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A comparison of chlorhexidine and povidone-iodine solutions in neonatal intensive care units
(Wiley, 2023-01) Küçüker, Hakan; Çakır, Salih Çağrı; Köksal, Nirgül; Özkan, Hilal; Kocael, Fatma; Dorum, Bayram Ali; Yıldırım, Cansu Sivrikaya; Çelebi, Solmaz; Hacımustafaoğlu, Mustafa; KÜÇÜKER, HAKAN; ÇAKIR, SALİH ÇAĞRI; KÖKSAL, FATMA NİRGÜL; ÖZKAN, HİLAL; KOCAEL, FATMA; SİVRİKAYA YILDIRIM, CANSU; ÇELEBİ, SOLMAZ; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Dorum, Bayram Ali; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0002-1636-5819; 0000-0001-5761-4757; 0000-0002-1787-6872; 0000-0003-4646-660X; 0000-0002-2823-8454; CZJ-5958-2022; HJZ-4508-2023; CZV-1969-2022; IGT-7005-2023; DXK-0792-2022; A-5375-2017; KGF-7434-2024; ENK-4130-2022; CTG-5805-2022
Background: Povidone-iodine (10%; PI) and 2% chlorhexidine in 70% isopropyl alcohol (CHG-IA) solutions are among the most widely used disinfectants in the neonatal intensive care units. This study compares the use of these disinfectants and helps decide which is superior to the other for neonatal use.Methods: All term and preterm infants born and hospitalized in Bursa Uludag University Hospital between July 2018-March 2020 were included. The infants were randomized into two disinfectant groups before birth. The application site was cleaned with the assigned disinfectant before intervention. The infants were screened for rates of neonatal sepsis, thyroid-stimulating hormone (TSH) levels, free thyroxine (fT4) levels, skin reactions to the assigned solution, and acute neurological side effects.Results: We enrolled 208 term and preterm infants (PI:104 vs. CHG-IA: 104) in the study. The prematurity rates were identical (PI: 74.0%; CHG-IA: 72.1%; p = 0.755). Neonatal sepsis rates among these groups were not statistically different (PI: 8.7%; CHG-IA: 4.8%; p = 0.406). The median TSH value of the PI group was high (4.05 mIU/L) in comparison with that of the CHG-IA group (3.09 mIU/L; p = 0.016). No cutaneous or neurological side effects were recorded in patients treated with CHG-IA solution.Conclusions: Although these two solutions were equally protective against infections, the CHG-IA solution was a better alternative to PI for neonatal use. Considering that the PI solution may be responsible for impaired thyroid function, the CHG-IA solution is a good alternative because it provides sufficient protection with a safer adverse effect profile.
A patient with breast mass and hyperemia
(Aves Yayıncılık, 2007-06-01) Aktürk, Berna; Çelebi, Solmaz; Aktürk, Berna; ÇELEBİ, SOLMAZ; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlıkları ve Hastalıkları Anabilim Dalı/Çocuk Enfeksiyon Hastalıkları Bilim; CAS-1783-2022; JOA-9028-2023
A three year-old child with persistent otalgia and fever
(Aves Yayincilik, Ibrahim Kara, 2007-03-01) Çelebi, Solmaz; ÇELEBİ, SOLMAZ; Hacımustafaoğlu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0003-4646-660X
Aspergillosis
(Galenos Yayincilik, 2007-09-01) HACIMUSTAFAOĞLU, MUSTAFA KEMAL; ÇELEBİ, SOLMAZ; Çelebi, Solmaz; Aktürk, Berna; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0003-4646-660X
Ubiquitous saprophytic molds, Aspergillus species are common on decaying material throughout the world. More than 900 species are included in the genus Aspergillus. Among human beings 3 different clinical presentations including invasive disease, non-invasive disease and hypersensitivity reactions may occur due to Aspergillus species. Especially immunosuppressed patients are under the risk of invasive aspergillosis, and in consequence of extensive use of immunosuppresor medications and broad spectrum use of antibiotics, Aspergillus species gain importance among infectious diseases. In this article, pathology, pathophysiology, clinical pictures, diagnosis and treatment of invasive aspergillosis are overwieved.
Brucellar brain abscess in a child
(Aves Yayıncılık, 2010-06-01) Çelebi, Solmaz; Hacımustafaoğlu, Mustafa; Sınırtaş, Melda; ÇELEBİ, SOLMAZ; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Sınırtaş, Melda; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Enfeksiyon Hastalıkları Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Anabilim Dalı.; 0000-0003-4646-660X; JHN-1091-2023; CTG-5805-2022; GAU-2987-2022
A ten-year-old boy developed symptoms consistent with brucellosis and was treated with combined tetracycline and streptomycin. Despite therapy, he abruptly developed dysarthria and fear of death. A cranial magnetic resonance imaging revealed an abscess. Brucella abortus was isolated from the blood culture. He recovered completely with doxycycline plus rifampicin therapy.
Brucellosis in childhood
(Aves Yayıncılık, 2011-06-01) Çelebi, Solmaz; Hacomustafaoğlu, Mustafa; Demirtaş, Fatih; Salı, Enes; Gül, Ülkü; Özel, Mustafa; ÇELEBİ, SOLMAZ; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Demirtaş, Fatih; Salı, Enes; Gül, Ülkü; Özel, Mustafa; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Enfeksiyon Hastalıkları Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0003-4646-660X; 0000-0001-7708-3498; AAL-1515-2021; JHN-1091-2023; CTG-5805-2022; CNC-2567-2022; DPU-8078-2022; JBY-6966-2023
Objective: Brucellosis is still an important infectious disease, being widespread as endemic and sporadic cases in Turkey. The aim of this study was to evaluate clinical and laboratory findings, treatment modalities and final outcomes of brucellosis in children.Material and Methods: This is a retrospective record review of all patients 0-18 years of age with brucellosis admitted during a 8-year period between January 2003 and September 2010.Results: Of the 62 patients, 39 (63%) were male. The mean age and standard deviation of patients was 120 +/- 51.7 months (4 months-18 years). Most common symptoms on admission were fever (88%), arthralgia (64%) and dizziness (19%). On physical examination, the findings and percentages were as follows; arthritis (29%), lymphadenopathy (25%), hepatomegaly (24%) and splenomegaly (17%). Fiftyone percent of the patients had high sedimentation rate, 41% had high transaminase levels, and 40% had positivity for C-Reactive Protein. Brucella agglutination tests were positive in all cases. Brucella spp. was isolated from blood cultures in 27% of the cases. All of the cases were given combined drug therapy. Three of the cases (4.8%) had relapses during the follow up period. No mortality was seen in patients with brucellosis.Conclusion: Childhood brucellosis remains an important public health problem in our country. It may cause serious complications in children, and treatment with at least two antibiotics for not less than six weeks appears to be effective.
Clinical clues
(Aves Yayincilik, Ibrahim Kara, 2012-09-01) Gurpinar, Arif; GÜRPINAR, ARİF NURİ; Yazici, Zeynep; YAZICI, ZEYNEP; Celebi, Solmaz; ÇELEBİ, SOLMAZ; Hacimustafaoglu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Cerrahi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; 0000-0003-4646-660X; AAI-2303-2021
Clinical clues
(Aves Yayincilik, Ibrahim Kara, 2011-03-01) Hacimustafaoglu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Celebi, Solmaz; ÇELEBİ, SOLMAZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0003-4646-660X
Comparative evaluation of health care-related infections in pediatric and newborn intensive care units in a university hospital: The seven-year retrospective study
(Galenos Yayınevi, 2021-08-01) Özaslan, Zeynep; Çelebi, Solmaz; Köksal, Nilgün; Özkan, Hilal; Ocakoğlu, Gökhan; Yeşil, Edanur; Özer, Arife; Turan, Cansu; Bülbül, Beyhan; Hacımustafaoğlu, Mustafa Kemal; ÖZASLAN, NEBAHAT ZEYNEP; ÇELEBİ, SOLMAZ; Köksal, Nilgün; ÖZKAN, HİLAL; OCAKOĞLU, GÖKHAN; YEŞİL, EDANUR; Özer, Arife; TURAN, CANSU; BÜLBÜL, BEYHAN; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Çocuk Enfeksiyon Bilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Neonotoloji Bilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0001-9400-7825; 0000-0002-1114-6051; 0000-0002-8926-9959; 0000-0003-3146-6391; 0000-0002-5720-1212; 0000-0003-4646-660X; 0000-0003-2641-4140; 0000-0002-3536-0263; 0000-0001-5454-5119; 0000-0001-9232-0084; GSO-3630-2022; JCD-9679-2023; A-1302-2018; AAH-5180-2021; JHN-1091-2023; JGS-7600-2023; JJY-3921-2023; IVB-4013-2023; GAX-3172-2022; CTG-5805-2022; JHR-3083-2023
Introduction: In this study, it was aimed to evaluate the incidence, density and reciprocal relationships of Health Care Associated Infections (HCAIs) detected in the Pediatric Intensive Care Unit (PICU) and Neonatal Intensive Care Unit (NICU) in Bursa Uludag University Faculty of Medicine Hospital as a general perspective.Materials and Methods: In this study, data of 91 PICU and 158 NICU patients who developed HCAIs between 2012-2018 years, taking into account the criteria of the Centers for Disease Control and Prevention (CDC) 2015 and the Turkish National Hospital Infections Surveillance Network (UHESA) 2017, were retrospectively analyzed.Results: The HCAIs rate was higher in NICU (9.6% vs 14.9%; respectively, p <0.001), but the infection density was lower (9.9 versus 7.8/1000 patient days, p=0.061). Stay of length for all patients in NICU was found to be longer (19.1 days vs 9.7 days; p <0.001), and the median length of stay with HCAIs in PICU and in NICU was 41.5 days versus 49 days respectively (p=0.1). The median time of HCAIs diagnosis was 17 days in PICU vs 15 days in NICU, p=0.6). In NICU, according to birth weight, HCAIs rates and infection densities were 7.8% and 2.7/1000 patient-days in <750 g patients; 23.2% and 6.2/1000 patient-days in 751-1000 g patients, 6.1% and 4.9 patient-days in 1001-1500 g patients, 44.7% and 9.2/1000 patient-days in 1501-2500 g patients, and %24.6 and 13.8/1000 patient-days in >2501 g patients. HCAIs rates were found to be higher in babies with >1501 g.Conclusions: There may be differences in the rates and prevention strategies in PICU and NICU and continuous and high quality maintenance is important for infection control measures.
Comparison of c-reactive protein, procalcitonin and serum amyloid-a levels in diagnosis of bacterial infection in children
(Aves Yayincilik, Ibrahim Kara, 2013-12-01) Çelebi, Solmaz; ÇELEBİ, SOLMAZ; ÖZAKIN, CÜNEYT; Bulur, Nurcan; Hacımustafaoğlu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Özakın, Cüneyt; Çakır, Deniz; Bozdemir, Şefika Elmas; Çetin, Benhur Şirvan; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı.; 0000-0003-4646-660X; 0000-0002-7056-0615; 0000-0002-8470-4907; GQP-2135-2022; AAG-8392-2021; H-2691-2017
Objective: The aim of the study was to compare C-reactive protein (CRP), procalcitonin (PCT) and serum amyloid A (SAA) levels in children with bacterial infection.Material and Methods: In this prospective study, 120 pediatric patients who were hospitalized with bacterial infection in the Uludag University Medical Faculty Pediatric Clinic between June 2009 and June 2011 were included. Patients were evaluated in 5 groups as sepsis, pneumonia, meningitis, pyelonephritis and other infection groups. Before initiating the antimicrobial therapy, blood samples for whole blood count, blood culture, CRP, PCT and SAA were obtained from children with bacterial infection. This procedure was repeated three times at 48 h, 7 and 10 days. Whole blood count was performed using an automated counter, Cell Dyn 3700 (Abbott Diagnostics Division, Santa Clara, CA, USA). CRP and SAA were determined by an immunonephelometric method using BN II device (Dade Behring Marburg GMBH, Marburg, Germany). PCT was measured by EnzymeLinked Fluorescent Assay (VIDAS PCT; Brahm Diagnostica GMBH, Lyon, France).Results: Of the patients, 66 (55%) were male and 54 (45%) were female. The median age was 37.5 months (1-209). PCT levels of the sepsis group was significantly higher than those of the pneumonia and other infection groups (respectively, p=0.001, p=0.003). SAA levels were higher in the meningitis group than those of the pneumonia group (p=0.007). When patients were divided into two groups as invasive bacterial infection group and localised bacterial infection group; PCT levels were found significantly higher in the invasive bacterial infection group than those of the localised bacterial infection group. Also, percentage change of PCT at the 48th hour, 7 and 10 days was determined as significantly higher in the invasive bacterial infection group than that of the localised bacterial infection group.Conclusion: In this study, PCT seems to be a more valuable parameter in diagnosing invasive bacterial infections.
Diagnostic value of mediastinal lymphadenopathy in differentiating pulmonary tuberculosis from community-acquired pneumonia in children
(Briefland, 2022-08-01) Uçar, Ayşe Kalyoncu; Yeşil, Edanur; YAZICI, ZEYNEP; Yazıcı, Zeynep; ÇELEBİ, SOLMAZ; Hacımustafaoğlu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Ocakoğlu, Gökhan; OCAKOĞLU, GÖKHAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Bioistatistik Anabilim Dalı.; 0000-0003-4646-660X; 0000-0002-1114-6051; AAH-5180-2021
Background: Diagnosis of childhood pulmonary tuberculosis (TB) is often based on clinical features in combination with radiologic findings because of paucibacillary nature of the disease in children. It may be difficult to make a clinical diagnosis because of the overlapping clinical features of pulmonary TB and community-acquired pneumonia (CAP). On computed tomography (CT) scanning, the presence of typical LAP can suggest TB as a possible cause. Objectives: To compare the features of mediastinal LAPs between two patient groups based on contrast-enhanced chest CT. Methods: A total of 45 pulmonary patients with TB and 38 patients with CAP (aged <= 18 years) were enrolled in this retrospective study. The presence and CT features of lymph node involvement and the incidence of associating parenchymal/pleural findings were analyzed in two groups. Results: All patients with TB and 36 of the 38 patients with CAP had at least one mediastinal LAP. There was no significant difference between the two groups according to the incidence of lymph node and multiple site involvement and also involved lymph node stations (P > 0.05). However, lymph node size was larger in the TB group (P = 0.04). Twenty-two percent of patients with TB had mediastinal LAP without parenchymal/pleural involvement. Conclusions: Although the lymph node size was larger in TB group than in CAP group, CT features of mediastinal lymph node involvement overlapped between two groups. Nevertheless, mediastinal LAP without parenchymal/pleural involvement on CT is seen in a significant number of TB patients.
Education of healthcare personnel working with pediatric patients during covid-19 pandemic within the framework of infection control
(Aves Yayıncılık, 2020-11-28) Oygar, Pembe Derin; Büyükcam, Ayşe; Bal, Zümrüt Şahbudak; Dalgıc, Nazan; Bozdemir, Sefika Elmas; Karbuz, Adem; Çetin, Benhur Şırvan; Kara, Yalçın; Çetin, Ceren; Hatipoğlu, Nevin; Uygun, Hatice; Aygün, Fatma Deniz; Torun, Selda Hançerli; Okur, Dicle Şener; Çiftdoğan, Dilek Yılmaz; Kara, Tuğçe Tural; Yahşi, Aysun; Özer, Arife; Demir, Sevliya Ocal; Akkoç, Gülsen; Turan, Cansu; Salı, Enes; Şen, Semra; Erdeniz, Emine Hafize; Kara, Soner Sertan; Emiroğlu, Melike; Erat, Tuğba; Aktürk, Hacer; Gürlevik, Sibel Laçinel; Sütcü, Murat; Aydın, Zeynep Gökçe Gayretli; Atıkan, Başak Yıldız; Yeşil, Edanur; Güner, Gizem; Çelebi, Emel; Efe, Kadir; İsançlı, Didem Kızmaz; Durmuş, Habibe Selver; Tekeli, Seher; Karaarslan, Ayşe; Bülbül, Lida; Almış, Habip; Kaba, Özge; Keles, Yıldız Ekemen; Yazıcıoğlu, Bahadir; Oğuz, Şerife Bahtiyar; Ovalı, Hüsnü Fahri; Doğan, Hazal Helin; Çelebi, Solmaz; Çakır, Deniz; Karasulu, Burcugül; Alkan, Gülsüm; Yenidoğan, İrem; Gül, Doruk; Küçükalioğlu, Burcu Parıltan; Avcu, Gülhadiye; Kukul, Musa Gürel; Bilen, Melis; Yaşar, Belma; Üstün, Tuğba; Kılıç, Ömer; Akın, Yasemin; Cebeci, Sinem Oral; Turgut, Mehmet; Yanartaş, Mehpare Sarı; Şahin, Aslıhan; Arslanoğlu, Sertaç; Elevli, Murat; Öz, Sadiye Kübra Tuter; Hatipoğlu, Halil; Erkum, İlyas Tolga; Demirbuğa, Asuman; Özçelik, Taha; Sarı, Emine Ergül; Akkuş, Gökhan; Hatipoğlu, Sadık Sami; Dinleyici, Ener Cağrı; Hacımustafaoğlu, Mustafa; Özkinay, Ferda; Kuruğol, Zafer; Cengiz, Ali Bülent; Somer, Ayper; Tezer, Hasan; Kara, Ateş; ÇELEBİ, SOLMAZ; TURAN, CANSU; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Çocuk Enfeksiyon Hastalıkları Bilim Dalı.; IVB-4013-2023; JHN-1091-2023; CTG-5805-2022
Objective: In the early stages of any epidemic caused by new emerging pathogens healthcare personnel is subject to a great risk. Pandemic caused by SARS-CoV-2, proved to be no exception. Many healthcare workers died in the early stages of pandemic due to inadequate precautions and insufficient protection. It is essential to protect and maintain the safety of healthcare personnel for the confinement of pandemic as well as continuity of qualified healthcare services which is already under strain. Educating healthcare personnel on appropiate use of personal protective equipment (PPE) is as essential as procuring them.Material and Methods: A survey is conducted on 4927 healthcare personnel working solely with pediatric patients from 32 different centers. Education given on PPE usage were questioned and analyzed depending on age, sex, occupation and region.Results: Among four thousand nine hundred twelve healthcare personnel from 32 different centers 91% (n=4457) received education on PPE usage. Of those who received education only 36% was given both theoretical and applied education. Although there was no differences among different occupation groups, receiving education depended on regions.Conclusion: It is essential to educate healthcare personnel appropiately nationwidely for the continuity of qualified healthcare services during the pandemic.
Enterococcal infections in children: Results of a 8 year study
(Aves Yayıncılık, 2010-12-01) Çelebi, Solmaz; Hacımustafaoğlu, Mustafa; Demiral, Meliha; Sınırtaş, Melda; Demirtaş, Fatih; İpek, Kezban; Bayram, Gönül; ÇELEBİ, SOLMAZ; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Demiral, Meliha; Sınırtaş, Melda; Demirtaş, Fatih; İpek, Kezban; Bayram, Gönül; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Enfeksiyon Hastalıkları Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Anabilim Dalı.; 0000-0003-4646-660X; JHN-1091-2023; CTG-5805-2022; EVQ-9906-2022; DSE-4824-2022; CNC-2567-2022; CUO-6602-2022; EKC-9935-2022
Objective: Enterococci have become a leading cause of nosocomial infection. These microorganisms are normal inhabitants of the human gastrointestinal tract. The aim of this study was to evaluate the enterococcal infection in children.Material and Methods: All patients with enterococcal infection between January 1, 2000 and December 31, 2007 were included in this study. Our study is a retrospective analysis of prospectively collected data. American Centers for Disease Control and Prevention criteria were used as standard definitions for nosocomial infections.Results: Enterococcus spp. infections were diagnosed in 164 of the 15.558 patients hospitalized in our center between January 1, 2000 and December 31, 2007 (overall incidence, 10.5 per 1,000 admissions). During the study period, a total of 209 Enterococcus spp. isolates were recovered from sterile body site cultures. Seventy-seven percent of enterococcal infections were nosocomial. The mean age of patients was 53.1 +/- 61.5 months (9 days-17 years) and 56% were male. The most common species of enterococci causing clinical infection were Enterococcus faecalis (55.5%), Enterococcus faecium (42.1%) and Enterococcus durans (2.4%). Most of the Enterococcus spp. (44.5%) were isolated from urine, followed by blood (19.5%), peritoneal fluid (14.6%), cerebrospinal fluid (12.1%) and catheter segment (4.8%). Vancomycin resistance was seen in 2.4 percent of Enterococcus spp., all of which were E. faecium. The most frequently seen enterococcal infections were urinary tract infections (32.3%), neonatal sepsis (22%), sepsis (14.6%), peritonitis (11.5%) and shunt meningitis (10.3%). Previous therapy with broad-spectrum antibiotics, underlying disease and prolonged hospitalization were commonly seen in patients with enterococcal infections. The mortality rate was found as 3.6% of all children with enterococcal infections.Conclusions: The two most common species of enterococci causing clinical infection were E. faecalis (55.5%) and E. faecium (42.1%). The most frequently enterococcal infections were urinary tract infections (32.3%), followed by neonatal sepsis (22%).
Epidemiology and prevention of bacterial meningitis and meningococcal serogroup B infection
(Aves Yayıncılık, 2014-03-01) Çelebi, Solmaz; ÇELEBİ, SOLMAZ; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Enfeksiyon Hastalıkları Bilim Dalı; JHN-1091-2023
Acute bacterial meningitis (ABM) continues to be associated with high mortality and morbidity, despite advances in antimicrobial therapy. The causative organism varies with age, immune function, immunization status, and geographic region, and empiric therapy for meningitis is based on these factors. Haemophilus influenzae type b (Hib), Streptococcus pneumoniae, and Neisseria meningitidis cause the majority of cases of ABM. Disease epidemiology is changing rapidly due to immunization practices and changing bacterial resistance patterns. Hib was the leading cause of meningitis in children prior to the introduction of an effective vaccination. In those countries where Hib vaccine is a part of the routine infant immunization schedule, Hib has now been virtually eradicated as a cause of childhood meningitis. Vaccines have also been introduced for pneumococcal and meningococcal diseases, which have significantly changed the disease profile. Where routine pneumococcal immunization has been introduced, there has been a reported increase in invasive pneumococcal disease due to non-vaccine serotypes. In those parts of the world that have introduced conjugate meningococcal vaccines, there has been a significant change in the epidemiology of meningococcal meningitis. Antibiotic resistance is an increasing problem, and early diagnosis and prevention of ABM are important. In infants, 60% of cases are caused by serogroup B in the United States and Europe. Asymptomatic colonization of the upper respiratory tract provides the source from which the organism is spread. It has been demonstrated that conjugate meningococcal B vaccine is immunogenic in infants.
Erythema nodosum in children
(Aves Yayincilik, Ibrahim Kara, 2011-12-01) ÇELEBİ, SOLMAZ; Çelebi, Solmaz; Hacımustafaoğlu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Yüceer, Meryem Berfu; Aygün, Fatma Deniz; Yenigül, Cengiz; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0003-4646-660X; AAC-9239-2021
Objective: Erythema nodosum (EN) is a rare inflammatory disease of the subcutaneous tissue. EN has been associated with various infections and chronic inflammations. The aim of this study was to evaluate the epidemiology, etiology, clinical findings and course of EN in children.Material and Methods: A total of 14 patients diagnosed with EN between January 2005 and March 2011 at Uludag University, Pediatric Infectious Diseases Outpatient Clinic, were studied retrospectively.Results: The mean age of patients was 9.2 +/- 3.7 years (range, 3-15 years) and 57% were male. The mean duration of the skin manifestation before admission was 20.7 +/- 13.8 days (range, 7-60 days). Tularemia was the most common cause (28.6%), followed by tuberculosis (21.4%), streptococcal infection (14.2%) and gastroenteritis due to Salmonella spp. (14.2%). In one-fifth of cases, no specific cause could be identified. The duration of the recovery of lesions varied from 6 to 15 days (mean, 10.1 +/- 3.2 days). Recurrences were noted in 2 children (2 episodes in 1 child and 4 episodes in the other).Conclusion: EN has been associated with numerous diseases. This study revealed tularemia and tuberculosis as the main etiologies of EN.
Evaluation of cases with hydatid diseases
(Aves Yayincilik, Ibrahim Kara, 2009-09-01) Çakır, Deniz; GÜRPINAR, ARİF NURİ; Çelebi, Solmaz; ÇELEBİ, SOLMAZ; Gürpınar, Arif; Ağın, Mehmet; Bozdemir, Şefika Elmas; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Cerrahisi Anabilim Dalı.; 0000-0002-7056-0615; GQP-2135-2022
Objective: We aimed to evaluate the clinical data and prognosis of the cases of hydatid disease during a 8-year period who were followed up by the Pediatric Infectious Diseases Clinic.Methods: Demographic, clinical, laboratory data and prognosis of 41 patients with hydatid disease were evaluated between the period of 2000 to 2008 years retrospectively.Results: A total of 41 children were included in this study. There were 21 females (51%) and 20 males (49%). The patients were aged between 5 and 17 years with a mean of 11.50 +/- 3.14 years. Most children presented with the complaint of cough (36%), abdominal pain (29%) and rash (17%). Decreased breath sounds were observed in 46% of patients, urticarial rash in 12% of patients. The hydatid disease was located in the lung only in 37%, in the liver only in 35%, simultaneously in the lung and liver in 17%, and the spleen only in 5% of the all patients. A positive indirect hemagglutination assay result was obtained (titration >= 1/32) in 32 (78%) patients and a negative result was obtained in 9 (22%) patients initially. Albendazole was given as 15 mg/kg/day in two divided doses. The cure times were between 3 and 27 cycles with a mean of 7.31 +/- 5.75. In all, 71% of the patients were given medical treatment and underwent surgery, 12% of patients were given medical and invasive radiological procedures, 10% of patients were given medical treatment only and 7% of patients were given medical treatment, invasive radiological procedure and underwent surgery. All of the patients were cured. Recurrence of hydatid disease was not seen during the follow up period.Conclusion: Planning of the optimal treatment regimen of hydatid disease according to clinical involvement and characteristics of the patients can increase the treatment success. The cure may take a long time, although the patient undergoes surgery and invasive drainage.
Evaluation of children cases admitted for tick bite in uludag university medicine of faculty
(Aves Yayincilik, Ibrahim Kara, 2010-12-01) ÇELEBİ, SOLMAZ; Çelebi, Solmaz; KILIÇ, UĞUR; Aydın, Levent; AYDIN, LEVENT; Hacımustafaoğlu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Çelik, Uğur; Çakır, Deniz; Emir, Begüm Runa; Çetin, Meryem; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Parazitoloji Bilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları Anabilim Dalı.; 0000-0003-4646-660X; 0000-0002-7056-0615; GQP-2135-2022
Objective: Crimean-Congo hemorrhagic fever (CCHF) virus causes a severe disease in humans, with a mortality of up to 30%. The geographical environment of our country is suitable for ticks. The aim of this study was to evaluate the clinical, and laboratory characteristics of children admitted for tick bites and determine the species of tick removed from the children.Material and Methods: Between April 2009 and September 2009, a total of 104 cases who had tick bites were included in the study. Detailed demographic, laboratory and clinical data were prospectively collected for each patient using a standardized questionnaire.Results: During the study period, a total of 104 children were admitted for tick bite. The mean age of patients was 7.3 +/- 4.4 years (1-18 years) and 71% were female. Most of the children (58%) were living in the rural region of Bursa. Of the 104 reported tick bites, most were nymphs of Rhipicephalus spp (42.3%) and larvae of Rhipicephalus spp (22.1%). Larvae of Ixodes spp (8.6%), nymphs of Ixodes spp. (6.7%), nymphs of Hyalomma spp. (4.8%) and adults of H. marginatum (2.7%) and R. sanguineus (10.5%) were also recorded. The records of H. aegyptium (0.9%) and R. turanicus (0.9%) were unremarkable. Clinical findings were normal on admission and follow up. The levels of liver enzymes, creatinine phosphokinase, lactate dehydrogenase, bleeding markers and complete blood count were normal. No CCHF infection was detected among the children admitted for tick bite.Conclusion: Tick bites and CCHF are important public health problems and it is crucial to publish information on tick bite prevention, which would play an important role in reducing the incidence of direct parasitic contact and the occurrence of transmittable diseases.
Evaluation of children with arthritis: 9 years retrospectif study
(Galenos Yayınevi, 2020-08-01) Yeşil, Edanur; Çelebi, Solmaz; Özcan, Nur; Özer, Arife; Turan, Cansu; Bülbül, Beyhan; Ermutlu, Cenk; Sarısözen, Bartu; Hacımustafaoğlu, Mustafa; YEŞİL, EDANUR; ÇELEBİ, SOLMAZ; Özcan, Nur; Özer, Arife; TURAN, CANSU; BÜLBÜL, BEYHAN; ERMUTLU, CENK; SARISÖZEN, MEHMET BARTU; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Çocuk Enfeksiyon Bilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Ortopedi ve Travmatoloji Anabilim Dalı.; 0000-0002-8926-9959; 0000-0003-3146-6391; 0000-0002-5720-1212; 0000-0003-4071-8052; 0000-0003-4646-660X; GSO-3630-2022; AEQ-5464-2022; JCD-9679-2023; ENK-4130-2022; JRU-9977-2023; DLB-3888-2022; IVB-4013-2023; GAX-3172-2022; ABI-7283-2020; CTG-5805-2022
INTRODUCTION: The aim of this study was to evaluate the clinical and laboratory findings and treatment responses of patients with arthritis.MATERIALS and METHODS: The medical records of 111 children (0-18 years) were evaluated who were hospitalized with the diagnosis of arthritis between January 2010 and January 2019 retrospectively. The aim of this study was to evaluate the clinical and laboratory findings and to investigate the treatment and prognostic features of the patients.RESULTS: : A total of 111 patients, 66% were male and the mean age was 91+56 (median 83,1-215) months. The most of the patients (n=62,56%) were between 3-10 years of age. Septic arthritis was diagnosed in 60% (n=67) of the patients. This diagnosis was followed by reactive arthritis (10%), juvenile idiopathic arthritis (10%), toxic/transient synovitis (5%) and other arthritis. On admission, there were pain in 96%, joint swelling in 63%, redness in 21%, increased temperature of the joint in 41%, decreased range of motion in 64%, and inability to walk in 38% of the patients. The most frequently involved joints were knee (51%) and hip (35%). The possibility of septic arthritis was significantly higher in patients with high fever (p=0,0001). The response to ibuprofen was higher in non-septic arthritis (p=0,0001). Arthrocentesis was performed in 55% (n=61) of the cases and 34% (n=38) of the patients had underwent intra-articular debridement surgery. Staphylococcus aureus and Streptococcus pyogenes were the most common microorganisms growth in joint fluid culture. When septic arthritis and other arthritis cases were compared, the effusion amount, the amount of fluid taken by puncture were significantly higher and the level of CRP and leukocytes were higher in septic arthritis group (p=0,001;p=0,025;p=0,018;p=0,032,respectively). Osteomyelitis was observed in 19%(n=21) of the cases.CONCLUSIONS: In this study, the probability of septic arthritis was found to be statistically significant in patients with fever, leukocyte>12100/mm(3), CRP>3 mg/dl, and effusion measured 8.5 mm or more by ultrasonography. Also, ibuprofen response was higher in non-septic arthritis group.
Evaluation of children with tuberculosis: A 10-year retrospective study
(Galenos Publishing House, 2022-12) Yeşil, Edanur; Sezer, Çisel; Çelebi, Solmaz; Turan, Cansu; Bülbül, Beyhan; Hacımustafaoğlu, Mustafa; SEZER, ÇİSEL; ÇELEBİ, SOLMAZ; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı; 0000-0002-3928-3453; 0000-0002-3536-0263; 0000-0003-4646-660X; FVE-4013-2022; JHN-1091-2023; CTG-5805-2022
Introduction: Childhood tuberculosis is a perspective that adult tuberculosis is not well controlled in the community. In this study, it was aimed to evaluate the epidemiological and clinical data of the cases we followed up with the diagnosis of tuberculosis.Materials and Methods: The clinical data of the cases who admitted to the Pediatric Infection Clinic and Outpatient Clinic of our hospital between 2010 and 2020 and were diagnosed with tuberculosis were retrospectively analyzed. Approval for the study was obtained from the Ethics Committee of Uludag University Medical Faculty with the decision no. 2020-5/3.Results: The mean age of 175 cases was 125 +/- 66,038 (median 132, 3-216) months, and 51% were female. 88% of the cases (n=154) live in Bursa and the majority of the admissions are from Osmangazi (n=41, 23.4%), Yildirim (n=40, 22.9%), Inegol (n=20, 11.5%) and Nilufer (n=19, 10.9%). Pulmonary tuberculosis was seen in 55% (n=96) of the cases, extrapulmonary tuberculosis in 42% (n=74), and pulmonary and extrapulmonary tuberculosis in 3% (n=5). 25.7% (n=45) of all cases had a history of contact with tuberculosis. 6.3% (n=11) of the cases had a history of taking prophylaxis before. Cough in 46% (n=81) of cases, fever in 29% (n=50), weight loss in 14% (n=24), night sweats in 13% (n=22), 5% (n=8) had complaints of hemoptysis. The mean sedimentation value of the cases was 36 +/- 28.85 (median 27. 5-140) mm/hour, and the mean CRP value was 16 +/- 41.94 (median 1. 1-258) mg/L. The tuberculin skin test was positive in 65% (n=114) of the cases. Mycobacter ARB (acid-resistant bacillus) was positive in 19% (n=27) and culture was positive in 18% (n=25) of the cases evaluated microbiologically (n=142). PCR was positive in 45% (n=47) of the 104 cases in which mycobacterial PCR was examined. Side effects were observed in 11% of the cases, and hepatotoxicity was observed most frequently (n=11, 6.3%). One patient died in the seventh month of treatment due to complications related to cystic fibrosis.Conclusion: Tuberculosis is a highly contagious disease caused by Mycobacterium tuberculosis and may result in mortality if left untreated. In this study, culture positivity was found to be 18%, and the most common side effect was hepatotoxicity.
Evaluation of deep neck infections in childhood
(Aves Yayincilik, Ibrahim Kara, 2015-09-01) ÇELEBİ, SOLMAZ; Salı, Enes; Çelebi, Solmaz; Çelik, Taylan; Kızılay, Nesrin Özdinç; Yakut, Uğur; Güneş, Muhammed; CANDEMİR, MUHAMMED MUSA; Hacımustafaoğlu, Mustafa; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; 0000-0002-8470-4907; 0000-0003-4646-660X; KPY-7514-2024; KGL-8832-2024; H-2691-2017
Objective: Deep neck infections are characterized by infections in the potential spaces of the fascial planes of the neck. The objective of the study was to evaluate the characteristics of patients with deep neck infections who were admitted to pediatric infectious disease clinics.Materials and Methods: The data of patients with deep neck infection was analyzed retrospectively for demographic characteristics, clinical presentation, microbiological and radiological findings, complications, and outcomes between January 2010 and December 2014.Results: During the study period, a total of 18 patients diagnosed with deep neck infection were followed. Of these, 10 patients (55.6%) were male and the mean age was 84 +/- 60.5 months (18-192 months). The most common symptoms at presentation were neck mass (72%) and fever (67%). Three patients (16.6%) had peritonsillar, 7 (39%) had parapharyngeal, 7 (39%) had retropharyngeal, and 1 (5.4%) had parapharyngeal-retropharyngeal infection. Cefotaxime+clindamycin or cefotaxime+clindamycin+gentamicin were the most frequently (78%) used antibiotics. Eleven patients (61%) recovered with only antibiotic treatment. Surgical drainage was performed in 7 patients (39%) who were unresponsive to antibiotic treatment (5 with parapharyngeal, 1 with retropharyngeal, and 1 with peritonsillar abscess). Microorganisms were isolated from 6 (33%) patients' drainage samples. The median length of hospitalization was 14 (7-21) days. The mean duration of antibiotic treatment was 19.3 +/- 4.4 days. Acute glomerulonephritis developed in 1 patient with retropharyngeal abscesses. No recurrence/relapse or mortality was observed.Conclusion: Deep neck infections should be considered in the differential diagnosis of children who present with fever and neck mass. Most patients with deep neck infections can be treated with antibiotics; however, if there is no clinical improvement, surgical drainage must be performed immediately. (J Pediatr Inf 2015; 9: 114-21)