Browsing by Author "Bayram, Ahmet Sami"
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Publication A case of spontaneous pneumomediastinum with unknown etiology(Derman Medical Publ, 2019-03-01) Alar, Timucin; Gedik, Ismail Ertugrul; Bayram, Ahmet Sami; BAYRAM, AHMET SAMİ; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-4719-002X; 0000-0003-0684-0900; ABB-7580-2020First described by Hamman in 1939, spontaneous pneumomediastinum (SPM) is a disease with the collection of air in the mediastinum without any underlying cause. It is usually seen in young males and its incidence is reported between 1/15000-1/25000 in different case series. We would like to present the case of a 16-year-old male patient who admitted to our hospital with the complaints of pleuritic chest pain and tenderness in the neck and was diagnosed as spontaneous pneumomediastinum. Patient spontaneously recovered without the need of an invasive procedure.Item Adenosquamous carcinoma of the lung: Comparison of surgical outcomes with squamous cell and adenocarcinoma(Elsevier, 2018-10) Melek, Hüseyin; Çetinkaya, G.; Bayram, Ahmet Sami; Akyıldız, Elif Ülker; Yenitürk, Eylem; Özer, Erhan; Sevinç, Tayhan; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0003-1822-8153; 0000-0003-0684-0900; 0000-0002-4848-1566; AAI-5039-2021; AAE-1069-2022; ABB-7580-2020; JCE-0097-2023; JDW-2654-2023Publication An alternative to VATS where VATS is not available(Springer India, 2023-01-11) Yentürk, Eylem; Bayram, Ahmet Sami; Sevinç, Tolga Evrim; Melek, Hüseyin; Özer, Erhan; Gebitekin, Cengiz; YENTÜRK, EYLEM; BAYRAM, AHMET SAMİ; SEVİNÇ, TOLGA EVRİM; MELEK, HÜSEYİN; ÖZER, ERHAN; GEBİTEKİN, CENGİZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; 0000-0002-9626-3600; 0000-0003-0684-0900; JCE-0097-2023; ABB-7580-2020; JRQ-2508-2023; JHZ-6813-2023; HNE-9801-2023; JKB-7387-2023Publication An incidental unique mediastinal mass in an asymptomatic young patient: Thymolipoma(Turkish Assoc Tuberculosis & Thorax, 2013-01-01) Uğraş, Nesrin; Akyıldız, Elif Ülker; Ünal, Nermin; Bayram, Ahmet Sami; UĞRAŞ, NESRİN; AKYILDIZ, ELİF ÜLKER; Ünal, Nermin; BAYRAM, AHMET SAMİ; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; 0000-0003-0684-0900; ABB-7580-2020; AAH-2716-2021; JHY-9777-2023; CDS-3138-2022Item Arterial lesions in Behcet's disease(Verlag Hans Huber, 2003-05) Saba, Davit; Sarıcaoğlu, Hayriye; Bayram, Ahmet Sami; Erdoğan, Cüneyt; Dilek, Kamil; Gebitekin, Cengiz; Özkan, Hayati; Özer, Z. Gökalp; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı.; ABB-7580-2020; 55987378200; 6603722836; 8347194000; 8293835700; 56005080200; 6602156436; 7103355993; 6701509634Background: Arterial involvement is a rare but serious condition in the course of Behcet's disease. We aimed to assess the results of therapeutic approaches in our patients with arterial lesions caused by Behcet's disease. Patients and methods: The records of 534 patients with Behcet's disease between 1987 and 2002 were retrospectively evaluated for the presence of arterial lesions. All patients were followed up regularly, at 3 to 6 months intervals. Results: Arterial lesions were diagnosed in 21 (3.9%) patients. Eight of these patients had pulmonary artery aneurysms (PAA), and the other 13 patients had non-pulmonary arterial lesions. Urgent surgical intervention was performed in three patients with PAA leading to death in all three. In addition, three other patients died due to massive haemoptysis at home despite to immunosuppressive therapy. Only two out of eight patients with PAA are still alive who were treated with cyclophophamide and corticosteroids. Thirteen operations were performed in 7 out of 13 patients having non-puhnonary arterial lesions. Although ten of the operations were primary operations, three reoperations had to be performed. A stent-graft was applied for the management of an iliac artery aneurysm in one patient. Only one patient died 8 years after the first non-pulmonary arterial involvement following a type IV thoracoabdominal aortic aneurysm repair Five patients with arterial occlusive lesions were successfully treated by corticosteroids. Conclusions: Pulmonary artery aneurysms in Behcet's disease patients have a poor prognosis despite any form of therapy. High dose corticosteroids alone can be successfully used for isolated non-pulmonary arterial occlusive lesions, unless disabling symptoms occur. Surgery or stent-graft insertion is indicated,for non-pulmonary arterial aneurysms because these aneurysms entail high risk of complications.Item Assessment of the efficacy of bio-absorbable oxidized regenerated cellulose for prevention of post-operative pericardial adhesion in the rabbit model(Sage Publications, 2008-07-15) Biçer, Murat; Bayram, Ahmet Sami; Gürbüz, Orçun; Şenkaya, Işık; Yerci, Ömer; Tok, Mustafa; Ang, Esra; Moǧol, Elif Başaǧan; Saba, Davit; Uludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji Anabilim Dalı.; 0000-0001-8553-7939; 0000-0003-0684-0900; ABC-2231-2020; ABB-7580-2020; R-9389-2016; HKO-3722-2023; DTC-2331-2022; EIS-5114-2022; ECM-1587-2022; EJJ-5200-2022; DHL-3236-2022; DPS-9311-2022; 6507770944; 8347194000; 35819579300; 56495079800; 6603810549; 6506976035; 26026747400; 23982134100; 55987378200Pericardial adhesions complicate re-operative cardiac surgery and several attempts have been made to reduce adhesion formation. The efficacy of bio-absorbable oxidized regenerated cellulose in preventing post-operative pericardial adhesions was evaluated in the present study. Forty New Zealand white rabbits were divided into four groups of 10. In all rabbits an area of pericardium (2 x 2 cm) was excised. The wound was left open in groups I and 2 but replaced with bio-absorbable oxidized regenerated cellulose in groups 3 and 4. Rabbits in groups 1 and 3 were killed 3 weeks after surgery and those in groups 2 and 4 were killed at 6 weeks. Groups 1 and 2 showed more severe pericardial adhesions, more fibrous reaction and increased visibility of coronary vessels than groups 3 and 4, although there was no difference in inflammation. Light microscopy showed a mesothelium-like cell layer in groups 3 and 4. It is concluded that bio-absorbable oxidized regenerated cellulose may be suitable in patients receiving staged cardiac surgery and in those with a high probability of re-operation.vItem Basic interrupted versus continuous suturing techniques in bronchial anastomosis following sleeve lobectorny in dogs(Oxford University Press, 2007-09-03) Erol, Mehmet Muharrem; Bayram, Ahmet Sami; Salcı, Hakan; Özyiǧit, Özgür M.; Görgül, Sacit O.; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; 0000-0003-0684-0900; 8347194000; 8680329000; 22954215300; 22953784900; 6602156436Objective: Sleeve resection with or without lung resection is a valid conservative operation for patients with benign or malignant tumors; it enables the preservation of lung parenchyma. The aim of this prospective randomized study was to compare complications, operating time, and bronchial heating between the techniques of interrupted and continuous suturing for bronchial anastomosis in dogs. Methods: Twenty adult mongrel dogs each weighing 18-22 kg (average: 20 kg) were divided into two groups according to the anastomosis technique performed: group A, interrupted suturing and group B, continuous suturing. Each group comprised of 10 dogs. Following right thoracotomy, sleeve resection of the right cranial lobe was performed in all dogs. Basic interrupted sutures using 4/0Vicryl (Ethicon, USA)were used in group A, and continuous sutures were used in group B. Results: The median anastomosis time was 15.2 min (range: 13-21 min) in group A and 9.6 min (range: 8-13 min) in group B. In all dogs, the anastomosis line was resected via right pneumonectomy for histopathological investigation 1 month after sleeve resection. Histopathological examination revealed that the healing of the anastomosis was not affected by the suturing technique applied. One dog from each group died on the fourth postoperative day; Fisher's exact test, p = 0.763. Conclusions: Our research revealed that the heating of the anastomosis was not affected by the suturing technique performed.Publication Bronchial carcinoid tumors with massive osseous metaplasia: A case report and review of the literature(Türk Patoloji Derneği, 2020-05-01) Özşen, Mine; Yalçınkaya, Ulviye; Akyıldız, Elif Ülker; Bayram, Ahmet Sami; Gökalp, Gökhan; YALÇINKAYA, ÜLVİYE; AKYILDIZ, ELİF ÜLKER; BAYRAM, AHMET SAMİ; GÖKALP, GÖKHAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; 0000-0002-5771-7649; 0000-0003-0684-0900; JHY-9777-2023 ; AAI-2336-2021; ABB-7580-2020; AAH-8924-2021Bronchial carcinoid tumors are primary lung neoplasms thought to originate from neuroendocrine cells, i.e. Kulchitsky cells, in the bronchial mucosa, although the type of cellular origin has not been clearly understood. A 61-year-old male patient underwent surgery and microscopic examination of the specimen revealed an anastomosing trabecular bony structure among the nests of tumor cells with round nucleus, granular chromatin, and large eosinophilic cytoplasm. Our case has been deemed worthy of being presented as bronchial carcinoid tumor with exaggerated osseous metaplasia.Item Bronş kanserli hastalarda mediastinal lenf bezi tutulumunun "p53 gen mutasyonu yöntemi" ve "histopatolojik yöntem" ile karşılaştırılması(Uludağ Üniversitesi, 2002) Bayram, Ahmet Sami; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Kalp ve Damar Cerrahisi Anabilim Dalı.Küçük Hücre Dışı Akciğer Kanseri (KHDAK)'nde tedavi metodunu ve prognozu belirleyen en önemli faktör hastalığın evresidir. Erken evre tümörlerde (Evre la ve Ib) yapılan küratif rezeksiyona rağmen 5-yıllık yaşam beklentisi hiçbir zaman mükemmel rakamlara (%55-85) ulaşamamıştır. Bölgesel lenf bezi metastazı bulunmayan "NO" olgularda lokal nüks ve/veya uzak metastazlara rastlanması ve beklenenden daha az 5-yıllık yaşam değerleri elde edilmesi patolojik "NO" evresinin sorgulanmasını gerektirmiştir. Günümüzde; mediastinoskopi ile mediastinal lenf bezi metastazı bulunan "N2" olgularda en ideal yaklaşım neo-adjuvant kemoterapi sonrası cerrahi rezeksiyondur. Bu çalışmadaki amaç mediastinoskopi sonrası histopatolojik "NO" değerlendirilen lenf bezlerindeki p53 genindeki mutasyon pozitifliğinin değerlendirilmesi ile gerçek "NO" evrelenmesinin karşılaştırılmasıdır. Ocak 2001-Ocak 2002 tarihleri arasında primer KHDAK'nin preoperatif evrelendirilmesinde toraks bilgisayarlı tomografisinde 1cm.' den daha küçük mediastinal lenf bezi bulunan ve servikal mediastinoskopi uygulanan olgulardan 30'u çalışmaya dahil edildi. Standart servikal mediastinoskopi tekniği ile alınan aynı lenf bezine ait biyopsi materyali taze olarak eşit iki parçaya ayrıldı. Biopsi materyali histopatolojik ve genetik inceleme için gerekli bölümlere gönderildi. Patolojide hazırlanan biopsi örnekleri Hematoxilene-Eosin (HE) ile boyandı diğer örnek ise Polimeraz Zincir Reaksiyonu (PZR) yöntemi ile p53 gen mutasyonu tespiti için hazırlandı. Çalışmaya alınan 30 olgunun 29'u (%97) erkek ve yaş ortalaması 61.2 (42-74) idi. Olguların tamamından alınan lenf bezlerinin histopatolojik incelemesi sonucunda metastaza rastlanmadı. Fakat bu olgulardan 6(%20),sının lenf bezlerinin PZR yöntemi ile moleküler biyolojik incelemesi sonucunda p53 gen mutasyonu tespit edildi (Genetik Metastaz). Sonuç olarak; histopatolojik inceleme sonrası "NO" olarak bildirilen fakat p53 mutasyonu bulunan olgularda lokal nüks ve/veya uzak metastaz dikkatli takip edilmelidir. Bu hastalarda histopatolojik negatifliğe rağmen neo-adjuvan veya adjuvan tedavi rejimlerinin uygulanması gündeme gelmelidir.Publication Can thoracic sympathetic nerve damage be reversed?(Georg Thieme Verlag, 2015-12-01) Erol, M. Muharrem; Salcı, Hakan; Melek, Hüseyin; İlhan, Tuncay; Özfiliz, Nesrin; Bayram, Ahmet Sami; Gebitekin, Cengiz; Erol, M. Muharrem; SALCI, HAKAN; MELEK, HÜSEYİN; İLHAN, TUNCAY; ÖZFİLİZ, NESRİN; BAYRAM, AHMET SAMİ; GEBİTEKİN, CENGİZ; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Histoloji Anabilim Dalı.; 0000-0003-0684-0900; 0000-0003-1822-8153; AAI-5039-2021; AAE-1069-2022; AAH-2756-2021; JCE-0097-2023; AAH-8859-2021; ABB-7580-2020; T-4623-2019; KHE-8874-2024Background Function of the thoracic sympathetic chain (TSC) reportedly recovers after surgical clips are removed. Hence, this study was designed to study nerve regeneration after unclipping the TSC.Methods The bilateral TSCs of six goats were studied; the goats were separated into three groups (groups I, II, and III) during excision, clipping, and unclipping. During surgery, the TSCs were excised with a scalpel in group I and clipped in groups II and III. In group III, the clips were removed 1 month postoperatively and observed for possible nerve healing for 1 month. All TSCs were examined histologically following en block resection at 1 month postoperatively in groups I and II and at 2 months postoperatively in group III.Results Inflammation in nerve sections was noted following clip removal. Furthermore, there was significant degeneration and cell infiltration in the nerve fibers of the clipped regions. The Schwann cells around the peripheral nerve endings in the unclipped regions facilitated nerve transmission by reconstitution of myelin.Conclusion Clipping the TSC can cause histologic degeneration; however, histologic nerve regeneration occurs after unclipping.Item A case of Hodgkin's lyphoma which caused pericardial tamponade in a young female patient(Bayçınar Tıbbi Yayıncılık, 2012-07) Coşkun, Funda; Bayram, Ahmet Sami; Özdemir, Bülent; Biçer, Murat; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı.; 0000-0003-3604-8826; ABC-2231-2020; AAD-1271-2019; ABB-7580-2020; 21734137500; 8347194000; 7004168959; 6507770944Malignant pericardial effusions (MPE) account for approximately 21% of all patients with advanced malignancies. The standard approach to management of MPE has remained controversial. In this article, we present the case of an 18-year-old female who was admitted to our clinic with pericardial tamponade. A cytological examination of the pericardial effusion revealed malignant cells, and the biopsy confirmed the diagnosis of Hodgkin's lymphoma of the nodular sclerosing type.Item Case of solitary eosinophilic granuloma of the sternum(Georg Thieme, 2008-03) Bayram, Ahmet Sami; Köprücüoǧlu, Mustafa; Filiz, Çaǧla; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; ABB-7580-2020; AAE-1069-2022; 8347194000; 23987533500; 23987838700; 6602156436We report a rare case of eosinophilic granuloma of the sternum in a 13-year-old male patient, who presented with anterior chest pain and a tender mass over the sternum.Item Clinical outcomes of lung metastasectomy in patients with colorectal cancer(Baishideng Publishing Group, 2012-02-21) Ölmez, Ömer Fatih; Çubukçu, Erdem; Bayram, Ahmet Sami; Akçalı, Ünsal; Evrensel, Türkkan; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0002-9732-5340; AAJ-1027-2021; ABB-7580-2020; 26435400000; 53986153800; 8347194000; 16027743900; 6603942124; 6602156436AIM: To investigate prognostic factors of survival following curative, non-palliative surgical removal of lung metastases secondary to colorectal cancer (CRC). METHODS: Between 1999 and 2009, a radical metastasectomy with curative intent was performed on lung metastases in 21 patients with CRC (15 male and 6 female; mean age: 57.4 +/- 11.8 years; age range: 29-74 years) who had already undergone primary tumour resection. RESULTS: The mean number of lung metastases ranged from one to five. The mean overall survival was 71 +/- 35 mo (median: 25 mo). After adjusting for potential confounders, multivariable Cox regression analyses predicted only the number of lung metastases (1 vs >= 2; hazard ratio: 7.60, 95% confidence interval: 1.18-17.2, P = 0.03) as an independent predictor of poor survival following lung resection for metastatic CRC. CONCLUSION: Resection of lung metastases is a safe and effective treatment in selected CRC patients with single lung metastases. (C) 2012 Baishideng. All rights reserved.Item Combination of tissue biopsy and fine needle aspiration cytology reduces false negativity of mediastinoscopy for non-small cell lung cancer(Bayçınar Medical-Bayçınar Tıbbi Yayıncılık, 2012-04) Erol, Mehmet Muharrem; Bayram, Ahmet Sami; Dülger, Hüseyin; Balaban, Şaduman Adım; Aygün, Mert; Yerci, Ömer; Gebitekin, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; ABB-7580-2020; 8347194000; 57225229141; 7003295230; 23666403500; 6603810549; 6602156436Background: This study aims to compare tissue biopsy with fine needle aspiration (FNA) and investigate whether the combination reduces false negativity of mediastinoscopy. Methods: Between January 2004 and October 2005, 92 patients with non-small cell lung cancer (NSCLC) who underwent cervical video mediastinoscopy were included in this prospective study. Tissue biopsy samples and FNAs were obtained from the same lymph node and were sent for a pathologic examination. Tissue samples and FNAs were stained with Hematoxilene-Eosine. All specimens were evaluated by two histopathologists. Results: Using tissue biopsy samples, no metastasis was found in 54 patients, while 38 patients were metastatic. Forty-eight patients had no metastasis, while 44 patients were metastatic using FNA samples. The difference was statistically non-significant (p>0.05). The false negativity of the FNA and tissue biopsy were 5.4% and 12%, respectively. Subsequently, 43 patients with negative FNA and tissue biopsy underwent lung resection with thoracotomy and sistematic lymph node dissection. Following lymph node dissection, lymph node metastases were found in two cases (4.6%). As a result, false negativity of mediastinoscopy was reduced to 4.6% when two techniques were combined. There was no complication related to the technique. Conclusion: The FNA of mediastinal lymph nodes is a safe and effective method, compared to tissue biopsy and reduces the false negativity of mediastinoscopy when combined with tissue biopsy.Item Comparison of different bronchial closure techniques following pneumonectomy in dogs(Korean Soc Veterinary Science, 2007-12) Salcı, Hakan; Bayram, Ahmet Sami; Özyiğit, Özgür M.; Gebitekin, Cengiz; Görgül, Osman Sacit; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.; 0000-0003-0684-0900; AAE-1069-2022; ABB-7580-2020; T-4623-2019; 8680329000; 8347194000; 22954215300; 6602156436; 6507730974The comparison of the histologic healing and bronchopleural fistula (BPF) complications encountered with three different BS closure techniques (manual suture, stapler, and manual suture plus tissue flab) after pneumonectomy in dogs was investigated for a one-month period. The dogs were separated into two groups: group I (GI) (n = 9) and group II (GII) (n = 9). Right and left pneumonectomies were performed on the animals in GI and GII, respectively. Each group was further divided into three subgroups according to BS closure technique: subgroup I (SGI) (n = 3), manual suture; subgroup II (SGII) (n = 3), stapler; and subgroup III (SGIII) (n = 3), manual suture plus tissue flab. The dogs were sacrificed after one month of observation, and the bronchial stumps were removed for histological examination. The complications observed during a one-month period following pneumonectomy in nine dogs (n = 9) were: BPF (n = 5), peri-operative cardiac arrest (n = 1), post-operative respiratory arrest (n = 1), post-operative cardiac failure (n = 1) and cardio-pulmonary failure (n = 1). Histological healing was classified as complete or incomplete healing. Histological healing and BPF complications in the subgroups were analyzed statistically. There was no significant difference in histological healing between SGI and SGIII (p = 1.00; p > 0.05), nor between SGII and SGIII (p = 1.00; p > 0.05). Similarly, no significant difference was observed between the subgroups in terms of BPF (p = 0.945; p > 0.05). The results of the statistical analysis indicated that manual suture, stapler or manual suture plus tissue flab could be alternative methods for BS closure following pneumonectomy in dogs.Item Comparison of early stage electrocardiographic, echocardiographic and histopathologic results of partial pericardiectomy and thoracoscopic pericardial window techniques in an animal model(Hellenic Veterinary Medical, 2017) Salcı, Hakan; Kocatürk, Meriç; İpek, Volkan; Biçer, Murat; Yılmaz, Zeki; Bayram, Ahmet Sami; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; 0000-0003-0684-0900; 0000-0001-9836-0749; 0000-0001-5874-7797; ABC-2231-2020; V-5578-2017; T-4623-2019; ABB-7580-2020; A-9637-2008; ABZ-7197-2022; 8680329000; 36437200800; 57201970309; 6507770944; 35944810500; 8347194000This study aimed to compare early stage electrocardiographic (ECG), echocardiographic (ECHO) and histopathologic results of the pericardial surgery techniques. Partial pericardiectomy by lateral thoracotomy and thoracoscopic pericardial window techniques was performed under general anesthesia in goats (n=6), which were separated into two groups; partial pericardiectomy was performed in group I (GRI) (n=3) and thoracoscopic pericardial window was performed in group II (GRII) (n=3). ECG and ECHO examinations were performed pre- and postoperatively on days 1, 7 and 30. All experimental animals were sacrificed at the end of day 30 and macroscopic investigations were performed. Histopathological examinations were performed on the lung, visceral pleura, epicardium and myocardial tissues. ECG findings included sinus tachycardia, small complex QRS and T wave peak on day 1 in both groups., The left atrial and ventricular diameters as well as the stroke volume were lower on the 1st postoperative day in both groups. The stroke volume was lower on postoperative days 1 and 30 in GRII. The observed ejection fraction was lower in GRII and higher in GRI on postoperative day 30 compared with their baselines. Macroscopic and histopathological findings of the lung and heart tissues were more severe in GRI, but there was no meaningful variation in the epicardium or visceral pleura. There was no significant difference in the histopathological results between the groups. Although the thoracoscopic pericardial window technique seem less traumatic and better tolerated than partial pericardiectomy, our ECHO and histopathologic results indicate that both techniques can safely be performed by surgeons according to the pericardial disease indication.Publication Comparison of intraoperative and post-operative effects of serratus anterior plane block performed with ultrasound and infiltration block in patients undergoing video-assisted thoracoscopic surgery(Kare Publ, 2022-01-01) Dikici, Mustafa; Akesen, Selcan; YAVAŞCAOĞLU, BELGİN; AKESEN, SELCAN; BAYRAM, AHMET SAMİ; Bayram, Ahmet Sami; Kaya, Fatma Nur; KAYA, FATMA NUR; Gurbet, Alp; GURBET, ALP; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı.; 0000-0003-0684-0900; 0000-0002-6503-8232; A-7994-2018; ABB-7580-2020Objectives: We aimed to compare the intraoperative and post-operative analgesic activities of the preventive applied serratus anterior plane (SAP) block and infiltration block in patients undergoing video-assisted thoracoscopic surgery (VATS).Methods: The study was carried out in 60 patients aged between 18 and 80 who were eligible for elective VATS, with the American Society of Anesthesiologists classification I-II, following ethical committee approval and written informed consent form. Patients were divided into two groups as SAP (group serratus anterior plane block [SAPB]) and group infiltration block after routine monitoring and general anesthesia induction by recording demographic data after randomization. Hemodynamic data of all patients were recorded before, after induction and within intraoperative 30 min period. Patient controlled analgesia (PCA) prepared with morphine was applied to all patients postoperatively. Intraoperative hemodynamic data and opioid consumption of patients, resting time, and coughing visual analog scale, time to first PCA dose, post-operative opioid consumption, rescue analgesic requirement, mobilization times, opioid side effects, and patient and surgical team's satisfaction were evaluated.Results: Intraoperative hemodynamic data and opioid consumption were similar between the two groups. Post-operative pain scores (0 and 30 min, 1, 2, 4, 8, and 12 h) were lower in the SAPB group (p<0.005) and time to use the first PCA (p=0.002) was longer in the SAPB group. Post-operative PCA and rescue analgesic requirement were lower in the SAPB group (p=0.002, p=0.00). It was found that the first mobilization time was shorter in the SAPB group (p=0.003), and opioid-related side effects were similar in both groups (p=0.067). Patient and surgical team satisfaction was high in the SAPB group (p=0.004, p=0.000).Conclusion: As a result, more effective post-operative analgesia was provided with preventively SAPB, compared to infiltration block in patients undergoing VATS.Publication Comparison of survival results of patients with t0 and t1-2-3 in pathological t staging in patients with non-small cell lung cancer who underwent surgery after neoadjuvant treatment(Termedia Publishing House, 2020-01-01) Kermenli, Tayfun; Melek, Hüseyin; Bayram, Ahmet Sami; Gebitekin, Cengiz; MELEK, HÜSEYİN; BAYRAM, AHMET SAMİ; GEBİTEKİN, CENGİZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0003-0684-0900; 0000-0003-1822-8153; AAE-1069-2022; AAI-5039-2021; JCE-0097-2023; ABB-7580-2020Aim: In this study, we aimed to compare the survival results of patients who underwent neoadjuvant treatment with NSCLC between March 1997 and August 2014 and were found to have T0N0 and T1-2-3/N0.Material and methods: A hundred ninety-five patients who had complete neoadjuvant therapy, complete lung resection and lymph node dissection, and pathologically diagnosed as T0 or T1-2-3/N0, M0 were included in the study.Results: Of the 195 patients included in the study, 181 were male, 14 were female and the mean age of the patients was 57.9. The mean age of the groups was as follows: group 1: 58.1, group 2: 57.7, group 3: 59.7 and group 4: 56.8. In our series the most common complication was atelectasis (n = 19). Others were prolonged air leak (n = 16), pneumonia (n = 12), apical pleural space (n = 6), wound infection (n = 3), cardiac problems (n = 3), hematoma (n = 3), bronchopleural fistula (n = 3), empyema (n = 2), chylothorax (n = 1). The 5-year survival rate for patients in the T0N0 group was 76.3%. This rate was 71.8% in group 2, 63.6% in group 3 and 44.1% in group 4.Conclusions: Survival was found to be better in patients who underwent surgery after neoadjuvant therapy and had a complete pathological response. We believe that we can provide better results with the increase in the number of cases detected as TxN0 after the neoadjuvant treatment and prolongation of the follow-up period.Publication Comparison of the 7th and 8th edition of tnm staging for nsclc in patients undergoing pulmonary resection after neoadjuvant/induction treatment(Elsevier Science Inc, 2019-10-01) Melek, Hüseyin; Çubukçu, E.; Evrensel, Türkkan; Gebitekin, Cengiz; Sarıhan, Süreyya; Bayram, Ahmet Sami; Tanrıkulu, Gamze; Sevinç, T.; Deligönül, A.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Onkoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.; 0000-0003-0684-0900; 0000-0003-4816-5798; AAI-5039-2021; JDW-2654-2023; ABB-7580-2020; AAH-4970-2021; JCE-0097-2023; AAE-1069-2022; AAJ-1027-2021Item Comparison of two suturing techniques in tracheobronchial anastomosis following the wedge carinal resection in dogs(Kafkas Üniversitesi, 2011) Erol, Mehmet Muharrem; Salcı, Hakan; Bayram, Ahmet Sami; Özyiğit, Musa Özgür; Görgül, O. Sacit; Gebitekin, Cengiz; Uludağ Üniversitesi/Veterinerlik Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Veterinerlik Fakültesi/Patoloji Anabilim Dalı.; 8680329000; 53264883600; 53264680300; 53264877700; 6602156436Tracheobronchial resection in humans is a still problem in lung cancer invading the carina, because there is not a standard surgical procedure. This study aimed to compare postoperative complications and histopathological results of simple continuous and simple interrupted suturing techniques in tracheobronchial anastomosis following the wedge carinal resection in dogs. Twelve mongrel dogs were divided into A and B groups. Right pneumonectomy with wedge carinal resection technique was performed under general anesthesia, and then tracheobronchial resection line was sutured simple continuously in group A and simple interruptedly in group B. The dogs were checked during two months in terms of postoperative complications, and euthanized at the end of two months to evaluate tracheobronchial anastomosis lines histopathologically. No postoperative complication was encountered in group A; but, 2 dogs in group B died due to respiratory failure on postoperative 4(th) and 12(th) days. Autopsy of the dogs revealed tracheobronchial dehiscence and opening of the simple interrupted suturing line, which was considered operative technique failure of suturing. Histopathologically, the sections taken from tracheobronchial anastomosis line had similar microscopic results in both group. Statistically, Fisher's exact test was applied between groups to determine the differences with regard to postoperative complications and histopathological results. There was no statistically significant differences between the groups in postoperative complications and histopathological results. In conclusion, operative technique failure of suturing is still common in tracheobronchial anastomosis; however, taking the histopathological results of the study into consideration, it has been implied that both suturing technique can be performed in tracheobronchial anastomosis following the wedge carinal resection.