Browsing by Author "CANITEZ, YAKUP"

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A comprehensive assessment of long-term complications in patients with stevens-johnson syndrome and toxic epidermal necrolysis
(Karger, 2023-07-26) Çekiç, Sükrü; Canıtez, Yakup; Yüksel, Hale; Gündüz, Gamze Ucan; Karalı, Zühal; Yalçınbayır, Özgür; Vural, Pınar; Sapan, Nihat; ÇEKİÇ, ŞÜKRÜ; CANITEZ, YAKUP; Yüksel, Hale; UÇAN GÜNDÜZ, GAMZE; KARALI, ZUHAL; VURAL, AYŞE PINAR; YALÇINBAYIR, ÖZGÜR; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Alerjisi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk ve Ergen Psikiyatrisi Anabilim Dalı.; 0000-0002-9574-1842; 0009-0002-4004-449X; 0000-0002-5458-1686; 0000-0002-7311-5277; 0000-0001-8929-679X; L-1933-2017; AAH-1789-2021; IZZ-9492-2023; AAH-6661-2021; CZC-9168-2022; IYJ-9408-2023; GIK-1690-2022; FUI-8766-2022
Introduction: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome are rare severe hypersensitivity reactions that lead to epithelial sloughing. Studies investigating the chronic multisystem effects of these syndromes and assessing patients in terms of quality of life (QOL), depression, and anxiety in the pediatric population are limited. In this study, we aimed to investigate the long-term effects of these diseases from a multisystem perspective. Method: Sixteen pediatric patients diagnosed with SJS, TEN, and SJS/TEN overlap syndrome were evaluated between September 2020 and March 2021. Physical and eye examinations were performed. To evaluate QOL and psychological status, Children's Dermatology Life Quality Index (CDLQI), Screen for Child Anxiety-Related Emotional Disorders (SCARED), and Children's Depression Inventory (CDI) were conducted. The patients' general characteristics, symptoms, and examination findings at their first admission were retrospectively obtained from the hospital's electronic records. Results: Nineteen percent of the patients were female (n = 3). There were 7 patients (44%) with the diagnosis of SJS, 5 patients (31%) with TEN, and 4 patients (25%) with SJS/TEN overlap. The median follow-up time of the subjects was 6.5 years. The most common sequelae in the chronic period were skin changes (n = 13, 81%). Hyperpigmentation was the most common skin change (n = 9, 56%). In the last evaluation, 9 cases had eye involvement. In two cases, eye examination was normal in the acute phase, while ocular involvement was present in the chronic period. In 4 (50%) patients, there was height and/or weight percentile loss. Three patients' SCARED scores and 2 patients' CDI scores were high. According to the CDLQI survey, SJS, TEN, or SJS/TEN overlap syndrome had a small to moderate effect on the QOL in the 43% (n = 6) of the patients. The ANA values of 3 patients (60%) were positive at the follow-up and negative at the first admission. Conclusion: SJS, TEN, and SJS/TEN overlap syndrome may cause sequelae even after a long time of the onset of the disease. Patients' QOL and psychological status can be affected negatively. Ocular symptoms may develop in the follow-up, even without involvement in the acute period. Patients with SJS, TEN, and SJS/TEN overlap syndrome should be followed up in the chronic period and approached multidisciplinary.
Airborne pollen grains of Turkey
(Bilimsel Tip Yayinevi, 2009-01-01) Bıçakçı, Adem; BIÇAKÇI, ADEM; CANITEZ, YAKUP; Altunoğlu, Mustafa Kemal; Bilişik, Aycan; Çelenk, Sevcan; ÇELENK, SEVCAN; SAPAN, NİHAT; Sapan, Nihat; Malyer, Hulusi; MALYER, HULUSİ; Bursa Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Biyoloji Bölümü.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0002-6333-3123; 0000-0003-4925-8902; O-1244-2018; K-2981-2012
In this evaluation, the results of aeropalynological studies carried out for 49 regions of Turkey have been assessed. The most common and greatest amounts of pollens in the atmosphere of Turkey were Cupressaceae, Pinus and Gramineae. The highest amount for pollen grains was recorded between March and June.
Allergenic airborne gramineae (grass) pollen concentrations in Turkey
(Bilimsel Tıp Yayınevi, 2009-01-01) Bıçakçı, Adem; Çelenk, Sevcan; Altunoğlu, Mustafa Kemal; Bilişik, Aycan; Canıtez, Yakup; Malyer, Hulusi; Sapan, Nihat; BIÇAKÇI, ADEM; ÇELENK, SEVCAN; Altunoğlu, Mustafa Kemal; Bilişik, Aycan; CANITEZ, YAKUP; MALYER, HULUSİ; SAPAN, NİHAT; Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Çocuk Allerji Bilim Dalı.; 0000-0002-6333-3123; 0000-0003-4925-8902; O-1244-2018; K-2981-2012; CBB-4116-2022; CGM-7523-2022; CJQ-2060-2022; DDS-8738-2022; FUI-8766-2022
One of the most important allergens which cause allergic disease of upper and lower respiratory system is the effect of the airborne pollen grains belonging to Gramineae (Grass) family. In this compilation, it was pointed out that airborne pollen studies was carried out in Turkey and the monthly changes of allergenic Grass pollens rates for 51 regions of Turkey were presented as a calendar. In the studies carried out, the highest Grass pollen grains were recorded between april and august.
Allergenic airborne olea (olive) and fraxinus (ash) pollen concentrations belonging to the oleaceae family in Turkey
(Bilimsel Tip Yayinevi, 2009-01-01) Bıçakcı, Adem; TOSUNOĞLU, AYCAN; BIÇAKÇI, ADEM; Altunoğlu, Mustafa Kemal; SAPAN, NİHAT; ÇELENK, SEVCAN; Çelenk, Sevcan; Canıtez, Yakup; CANITEZ, YAKUP; Canıtez, Yakup; Malyer, Hulusi; MALYER, HULUSİ; Sapan, Nihat; TOSUNOĞLU, AYCAN; Bursa Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Biyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; 0000-0002-6333-3123; 0000-0003-4925-8902; O-1244-2018; K-2981-2012
One of the most important allergens causing allergic diseases of the respiratory system is airborne tree, grass and weed pollen grains. Oleaceae family members are very important in tree pollen grains. In this study, airborne pollen studies were carried out in Turkey, and the monthly changes in Olea and Fraxinus pollens rates for 55 regions were evaluated. In the studies carried out, the highest Fraxinus pollen grains were recorded in spring, and Olea pollen grains were recorded in late spring and early summer. According to atmospheric pollen studies, although Fraxinus pollen grains were found in more regions than Olea, more Olea pollen grains were recorded than of Fraxinus.
Allergenic Cupressaceae (cypress family) pollen concentrations in Turkey
(Bilimsel Tip Yayinevi, 2010-01-01) Bıçakçı, Adem; BIÇAKÇI, ADEM; Tosunoğlu, Aycan; TOSUNOĞLU, AYCAN; Altunoğlu, Mustafa Kemal; Çelenk, Sevcan; ÇELENK, SEVCAN; Erkan, Perihan; ERKAN ALKAN, PERİHAN; Canıtez, Yakup; CANITEZ, YAKUP; Malyer, Hulusi; MALYER, HULUSİ; Sapan, Nihat; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Biyoloji Bölümü.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0002-6333-3123; 0000-0003-4925-8902; 0000-0002-8837-3375; K-2981-2012; AAK-4004-2021; O-1244-2018
Cupressus and Juniperus airborne pollen grains, belonging to the Cupressaceae family and causing respiratory system allergy by inhalation, have an important place among aeroallergens. In this study, airborne pollen studies were carried out in Turkey, and the monthly changes in Cupressaceae pollens rates in 57 regions were evaluated. Results of the studies showed that the highest numbers of Cupressaceae pollen grains were recorded between march and may.
Evaluation of the cases with non-cystic fibrosis bronchiectasis
(Galenos Yayıncılık, 2018-01-01) Korkmaz, Serpil; Canıtez, Yakup; Çekiç, Şükrü; Efe, Hülya Poyraz; Ocakoğlu, Gökhan; Sapan, Nihat; Korkmaz, Serpil; CANITEZ, YAKUP; ÇEKİÇ, ŞÜKRÜ; Efe, Hülya Poyraz; OCAKOĞLU, GÖKHAN; SAPAN, NİHAT; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Alerji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-9574-1842; 0000-0002-1114-6051; HLG-6346-2023; L-1933-2017; CJQ-2060-2022; CPN-6371-2022; FFE-8839-2022; FUI-8766-2022
INTRODUCTION: Bronchiectasis is a chronic inflammatory disease characterized by a permanent dilation of the bronchial wall. We aimed to evaluate pediatric cases diagnosed with non-cystic fibrosis bronchiectasis.METHODS: A total of 98 cases who were diagnosed with non-cystic fibrosis bronchiectasis and were being followed-up between January 2010 and January 2015 at our clinic were included. Clinical, laboratory and radiological evaluations were recorded from patients electronic files.RESULTS: Female to male ratio of the cases was 1.3 (56/42). The median age of the cases was 12.2 years (1-18), the median age of diagnosis was 6 years (1-17 years), and the median duration of follow-up was 38 months (3-140 months).The most common symptom of the cases was cough (n: 91, 93%) followed by sputum expectoration (n: 56, 57%). In the pulmonary function tests performed during the initial phase of diagnosis; restrictive pattern was seen in 29.1% (n = 21) of patients and obstructive pattern was seen in 23.2% (n = 17). Furthermore, in last control visit, restrictive pattern was seen in 17.3% (n=9) of them and obstructive pattern was seen in 44.2% (n = 23). The most frequent etiological cause was infectious diseases (n: 41, 42%). Bronchiectasis was seen most commonly in the left lower lobe of the lung (n: 52, 53%), followed by the right lower lobe (n=32, 33.7%).DISCUSSION and CONCLUSION: Bronchiectasis is still a major health problem in developing countries and causes irreversible damage to the lung when untreated. Postinfectious lung diseases are one of the most important causes of bronchiectasis in children. Early diagnosis improves treatment success.
Evaluation of the patients diagnosed with stevens johnson syndrome and toxic epidermal necrolysis: A single center experience
(Aves, 2016-09-01) Çekiç, Şükrü; Canıtez, Yakup; Sapan, Nihat; ÇEKİÇ, ŞÜKRÜ; CANITEZ, YAKUP; SAPAN, NİHAT; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı,/Çocuk Alerji Bilim Dalı; 0000-0002-9574-1842; 0000-0001-8929-679X; AAH-1789-2021; L-1933-2017
Aim: Stevens Johnson syndrome and toxic epidermal necrolysis are severe acute mucocutaneous diseases. In this study, we evaluated the clinical aspects of Steven Johnson syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap patients who admitted to our clinics in the last five years.Material and Methods: Eleven patients diagnosed as Stevens-Johnson syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in Department of Pediatric Allergy in Uludag University School of Medicine were included in this study. Clinical findings, laboratory tests and response to treatments were evaluated via electronic files.Results: Two of the patients had Stevens-Johnson syndrome, four had Stevens-Johnson syndrome/toxic epidermal necrolysis overlap, and five had toxic epidermal necrolysis. The median period for drug usage was 10 days (2-44 days). Herpes simpleks virus IgM antibody was detected two patients. The median healing time was 38 days 26-94 days). Maculopapular eruptions and oral mucositis were seen in all patients. Vesicul or bullae, epidermal detachment and ocular involvement in 10 of patients. Wound care, H1 antihistamine and methyl prednisolon were used in all patients, intravenous immunoglobulin were used in 7 patients and cyclosporine in 1 patient. Sequel lesions developed in 2 of the patients and there was no death.Conclusion: Anticonvulsants, antibiotics and non steroid anti-inflammatory drugs play a major role in the etiology of Stevens-Johnson syndrome and toxic epidermal necrolysis. Anticonvulsants are associated with severe disease. The patients with proper wound care and treatment with immunosuppressive drugs can be recovered without or with minimal sequelae.
Full title: The effects of health literacy on disease control in adolescents with asthma
(Taylor & Francis Ltd, 2022-12-19) Çekiç, Şükrü; Karalı, Zühal; Canıtez, Yakup; Esmen, Selin; Ortaç, Hatice; Abdu, Selin; Sapan, Nihat; ÇEKİÇ, ŞÜKRÜ; KARALI, ZUHAL; CANITEZ, YAKUP; Esmen, Selin; Ortaç, Hatice; ABDU, SELİN; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Alerji Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi İstatistik Anabilim Dalı.; 0000-0002-9574-1842; 0000-0002-1199-1706; AAH-1789-2021; L-1933-2017; CZC-9168-2022; HKI-1858-2023; HJF-9598-2022; HKH-2991-2023; FUI-8766-2022
Objective: Increased health literacy (HL) improves the management of chronic diseases. Data on the HL levels of adolescents with asthma are limited. In this study, we aimed to investigate the HL levels of adolescents with asthma and the effect of HL levels on asthma control.Methods: Our research included 81 adolescents with asthma and 47 age and sex-matched controls. The validated version of the European Health Literacy Survey Questionnaire (HLS-EU-Q16) was utilized to estimate the participants' health literacy levels. In addition, the Asthma Control Test (ACT) was used to determine the degree of asthma control.Results: No significant difference between the asthmatic adolescents (n = 45, 55.6%) and the control group (n = 28, 59.6%) has been established in terms of the number of participants who were considered to have adequate HL (p = 0.658). The difference between the patient and control groups in health care, disease prevention, health promotion, and overall HL scores was determined non-significant. According to the ACT scores, the overall median HL score was significantly higher in patients with controlled asthma {34.4 (14.6:50)} than in those with uncontrolled asthma {32.3 (16.7:48.9)} (p = 0.037). It was determined that there was a difference in the distribution of controlled asthma, uncontrolled asthma, and controls in HL subgroups (poor, problematic-limited, sufficient, and perfect HL) (p = 0.002).Conclusion: The level of HL is associated with asthma control. A significant proportion of asthmatic adolescents who participated in our research displayed low HL scores. Further studies should be conducted to increase the HL levels of adolescents to achieve better asthma control.
Horseshoe lung associated with scimitar syndrome
(Bmj Publishing Group, 2019-08-01) Gönen, Korcan Aysun; Canıtez, Yakup; CANITEZ, YAKUP; Bostan, Özlem Mehtap; BOSTAN, ÖZLEM MEHTAP; Yazıcı, Zeynep; YAZICI, ZEYNEP; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; 0000-0001-7707-2174; AAH-1789-2021
Horseshoe lung is a rare congenital anomaly and mostly accompanied by scimitar syndrome. Most aspects of this complex anomaly can be demonstrated via multidetector CT (MDCT). We present two baby girls who had horseshoe lung associated with right lung hypoplasia and scimitar vein. The chest roentgenograms showed displacement of the heart and mediastinum to the right with smaller right lung. Echocardiography revealed dextroposition, secundum atrial septal defect and bilateral slight peripheral pulmonary stenosis in the first case and dextroposition, severe pulmonary hypertension, secundum atrial septal defect and tricuspid regurgitation in the other one. On thoracic MDCT, the right lung and pulmonary artery were hypoplastic with cardiomediastinal shift to the right. There was an abnormal right pulmonary vein draining into the inferior vena cava on the lower zone of the right lung (scimitar vein). The posterobasal portions of the both lungs were fused through a midline isthmus behind the heart.
Knowledge levels of mothers of asthmatic children about asthma
(Dr Behcet Uz Cocuk Hastaliklari Ve Cerrahisi, 2020-01-01) Çekiç, Şükrü; ÇEKİÇ, ŞÜKRÜ; Canıtez, Yakup; CANITEZ, YAKUP; Küçüker, Hakan; KÜÇÜKER, HAKAN; Karali, Yasin; KARALI, YASİN; Çiçek, Fatih; ÇİÇEK, FATİH; Sapan, Nihat; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0002-9574-1842; L-1933-2017
Objective: Compliance of the family with asthma treatment is one of the main factors determining the success of treatment. This study aimed to investigate the knowledge level of the mothers with asthmatic children about symptoms, diagnosis and treatment of asthmaMethod: A questionnaire consisting of 42 questions was used in the study. The questionnaire was composed of questions prepared by us and adapted from a validated asthma knowledge level questionnaire. Each correct answer was evaluated as 2.38 points. Those receiving 67.7 points above were considered sufficient.Results: 323 mothers of children with asthma were included in the study. None of the mothers answered all the questions correctly among. The total mean score of the mothers was 57.8 +/- 11.9 (median: 58.5, minimum: 26.8, maximum: 87.8). The median scores of the mothers who graduated from university (median: 65.9, minimum: 36.6, maximum: 85.4) was higher than those who graduated from primary school (median: 53.7, minimum: 29.3, maximum: 87.8), middle school (median: 58.5, minimum: 29.3, maximum: 78) and high school (median: 61, minimum: 26.8, maximum: 80.5) (p<0.001, p<0.001 and p=0.003). The median score of working mothers (median: 65.9, minimum: 34.1, maximum: 87.8) was higher than those who were housewives (median: 56.1, minimum: 26.8, maximum: 87.8) (p<0.001). The median score of mothers who breastfed for more than six months (median: 61, minimum: 29.3, maximum: 87.8) was higher compared to those who breastfed less than six months (median: 56.1, minimum: 26.8, maximum: 85.4) (p=0.005).Conclusion: Education levels of the mothers and being a working mother were significant factors affecting the level of asthma knowledge among mothers.
Lung functions during long term follow-up after pleural empyema treatment in children
(Galenos Yayıncılık, 2009-12-01) Kırkpınar, Ayhan; Canıtez, Yakup; Çelebi, Solmaz; Sapan, Nihat; Hacımustafaoğlu, Mustafa; Gürpınar, Arif; Kırkpınar, Ayhan; CANITEZ, YAKUP; ÇELEBİ, SOLMAZ; SAPAN, NİHAT; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; GÜRPINAR, ARİF NURİ; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı Hastalıkları Anabilim Dalı.; 0000-0003-4646-660X; CXY-2332-2022; CJQ-2060-2022; JHN-1091-2023; FUI-8766-2022; CTG-5805-2022; ISV-9154-2023
Introduction: Studies on lung functions at the long term follow-up of pleural empyema treatment in children are limited. The aim of this study was to evaluate the long term pulmonary function test results in childhood empyema cases treated with antibiotic (AB) or AB+tube thoracostomy (TT) or AB+TT+fibrinolytics (FT).Materials and Method: In this study, 45 cases (1 to 13 years old) treated for empyema were included. The age, gender, clinical characteristics, radiological findings and laboratory results at baseline and during the follow-up periods and the treatment modalities (AB or AB+TT or AB+TT+FT) were evaluated. Pulmonary function tests were performed at the end of the follow-up periods.Results: The mean ages at baseline and at the end of follow-up period of 30.4 +/- 13.5 (6-54) months were 6.3 +/- 3.3 (1-13) years and 9.3 +/- 3.4 (4-17) years, respectively. Stages of the disease at admission was acute exudative (stage 1) in 14 (31.1%) cases, fibrinopurulent (stage 2) in 19 (42.2%) and chronic organizing (stage 3) in 12 (26.7%). Twenty one cases (46.7%) were treated with AB, 8 (17.8%) with AB+TT and 16 (35.5%) with AB+TT+FT. Chest roentgenograms showed abnormal findings in 15 cases (33.3%) at the 3rd month, in 3 cases (6.6%) at the 6th month and none at the 12th month. Pulmonary function tests were available in 25 children. The mean follow-up period of these cases was 32.7 +/- 11.9 months after the empyema treatment. Three cases (12%) with a shorter mean follow-up (8.3 +/- 3.3 months) had minimal restrictive patterns. Six of 25 (24%) cases having pulmonary function tests were classified as stage 1, 12 (48%) as stage 2, and 7 (28%) as stage 3 empyema at admission. Of 25 cases having pulmonary function tests, 12 (48%) were treated with AB, 4 (16%) with AB+TT and 9 (36%) with AB+TT+FT. Mean VC, FVC, FEV1/FVC, FEV1, FEF25-75% and PEF values did not significantly differ according to stages and treatment modalities (p>0.05).Conclusion: It was seen that after the treatment of empyema, remarkable improvements were seen in chest roentgenographic findings between 3rd and 6th months and in general, pulmonary function tests revealed normal results in long term. Our results suggest that lung functions are not significantly compromised at long term after empyema treatment.
Omalizumab treatment in childhood chronic urticaria
(Wiley, 2018-08-01) Çekiç, Şükrü; Karali, Yasin; Canıtez, Yakup; Sapan, Nihat; ÇEKİÇ, ŞÜKRÜ; KARALI, YASİN; CANITEZ, YAKUP; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri ve Alerji Bölümü; 0000-0002-9574-1842; L-1933-2017; FFS-1974-2022; CJQ-2060-2022; FUI-8766-2022
Retrospective evaluation of cases with cow's milk allergy
(Bursa Uludağ Üniversitesi, 2021-12-01) Efe, Hülya Poyraz; Canıtez, Yakup; Sapan, Nihat; Efe, Hülya Poyraz; CANITEZ, YAKUP; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Alerji Anabilim Dalı; 0000-0001-8929-679X; 0000-0002-2226-7035; 0000-0002-7601-8392; AAH-1789-2021; CPN-6371-2022; FUI-8766-2022
Introduction: Cow's milk allergy (CMA) is described as immunological reaction against to one or more milk proteins. It is known that CMA which affects about 1-3% of the general population is the most commonly seen food allergy in infants and children. It is well known that a tolerance develops and prognosis is better during the first three years of the life. In the present study, we aimed to investigate the natural course of cases diagnosed with CMA and to determine the factors which have impact on the tolerance development.Materials and Methods: Medical records of cases who have been followed for CMA were retrospectively reviewed. Gender, age at first symptom, breastfeeding duration, family atopy history, multiple food allergies, concomitant allergic diseases, inhalant allergy sensitivity and clinical manifestation of cases were assessed. Also, prick test results, milk-specific IgE, casein-specific IgE and the reactions that developed during food challenge test were evaluated.Results: The age at first symptom was mean 4 +/- 2,3 months. Twenty-two percent of patients had a positive family history of atopy and 30% had multiple food allergies. There were concomitant allergic disorders in 58% of patients. Skin (93.8%), gastrointestinal system (GIS) (24.7%) and respiratory system (18.5%) symptoms were most commonly seen. The percentage of tolerance development by the years was determined as 41% for the first year, 64% for the second year and 75% for the third year. Milk-specific IgE level at the time of diagnosis (p=0.010) and asthma presence (p=0.010) were found significant risk factors for persistent CMA.Conclusion: Clinical parameters and allergy tests may help to predict the prognosis of CMA. Milk-specific IgE level at the time of diagnosis is the risk factor for persistent CMA.
Right lung agenesis; isolated and with accompanied anomalies
(Galenos Yayincilik, 2013-12-01) Canitez, Yakup; ÇEKİÇ, ŞÜKRÜ; CANITEZ, YAKUP; GÜRPINAR, ARİF NURİ; Gürpınar, Arif; Sapan, Nihat; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0002-9574-1842; L-1933-2017
Right lung agenesis is a rare anomaly that can be isolated or accompanied by system anomalies such as cardiac, skeletal or urinary systems. Case 1, a four-month-old girl, was brought because of respiratory distress. Patient had polydactyly, syndactyly of right thumb, right mandibular hypoplasia and low-set dysmorphic ears. Lung x-ray and thorax computerized tomography (CT) were consistent with right pulmonary agenesis and butterfly vertebra was evident in the 7th thoracic level. Thoracic CT angiography revealed narrowing of the left main bronchus and esophagus due to compression of aorta, left pulmonary artery and right atrium. In bronchoscopy, narrowing due to compression at the carina level was seen and right main bronchus was not seen. In abdominal ultrasonography, right kidney placement anomaly (pelvic ectopia) was present and renal scintigraphy revealed fusion in both kidneys. With these findings, it was found that right pulmonary agenesis was accompanied by ipsilateral radial ray anomaly, renal anomaly, vertebral anomaly and hemifacial microsomia. Case 2, a fifteen-year-old male patient, was diagnosed as pulmonary agenesis via chest x-ray, pulmonary CT and bronchoscopy after a wheezing episode when he was 2 months old. Patient had no complaint except for exhaustion that is aggravated by exercise during last year. In physical examination, he had a mild scoliosis toward right, respiratory sounds were diminished on right hemithorax and heart sounds were heard on right side. Chest x-ray and thoracic CT were consistent with right lung agenesis. No abnormality was found in echocardiography and abdominal ultrasonography was normal. Accompanied cardiovascular anomalies, distortions of intrathoracic structures and recurrent infections are main factors that affect mortality and morbidity. Here, two cases with right lung agenesis, isolated and accompanied by multiple anomalies, were presented.
Risk factors for bronchopulmonary dysplasia
(Galenos Yayıncılık, 2008-09-01) Özkan, Hilal; Köksal, Nilgün; Çetinkaya, Merih; Canıtez, Yakup; ÖZKAN, HİLAL; Köksal, Nilgün; Çetinkaya, Merih; CANITEZ, YAKUP; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Neonatoloji Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Çocuk Alerji Bilim Dalı.; AFP-9671-2022; DLD-6099-2022; DBJ-8788-2022; CJQ-2060-2022
Aim: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that develops in premature infants who were treated with oxygen and positive pressure ventilation. Although there are recent advances in neonatal care, it has been still the most common long term complication in preterm infants. The aim of this study was to evaluate infants who developed BPD throughout the clinical course of hospitalisation and to determine BPD frequency and also the risk factors associated with BPD.Materials and Method: A total of 276 infants who admitted to neonatal intensive care unit between January 2005 and January 2006 were included to this study. The infants with and without BPD were compared according to characteristic features and risk factors.Results: The mean gestational age and birth weight of all infants were 31 +/- 3.1(range, 24-36) weeks, and1607 +/- 610 (range, 500-4000) gram, respectively. BPD was diagnosed in 30% (84/276) of all infants. The mean gestational age and birth weight of infants with BPD were 30 +/- 3 (range, 24-36) weeks, and 1171 +/- 423 (range, 530-3700) gram, respectively. The 36% (31/84) of infants were smaller than 28 gestational age and 41.9% (26/84) were smaller than 1000 gram. Gestational age and birth weight were found to be the most important risk factors for development of BPD, and BPD risk increased as the gestational age and birth weight decreased. The duration of mechanical ventilation in infants with BPD and without BPD were found to be 40 +/- 4.3 days and, 17 +/- 2 days, respectively and this difference was found to be statistically significant (p<0.05). Similarly, the duration of oxygen therapy was found to be statistically higher in infants with BPD compared with the infants without BPD (p<0.05). Also, respiratory distress syndrome, intraventricular hemorrhage, chorioamnionitis in mother, prolonged total parenteral nutrition, and frequent blood transfusion were also other risk factors that were significantly associated with development of BPD.Conclusion: The risk for BPD is multifactorial. It was observed that the most important risk factors for BPD were prematurity, low birth weight, mechanical ventilation and prolonged oxygen therapy. Preventing small gestational age and low birth weight prematurity, decreasing the duration of mechanical ventilation and also to give minimum oxygen supply in premature infants.
Steven's johnson syndrome and toxic epidermal necrolysis in children
(Galenos Yayincilik, 2008-12-01) Turan, Hakan; Vatansever, Sevgül; Özdemir, Özlem; Canitez, Yakup; CANITEZ, YAKUP; Sarmaoglu, Hayriye; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.
Aim: The aim of this study was to consider clinical features, laboratory findings, treatment alternatives, complications and responsible agents of Steven's Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) in childhood.Materials and Method: The patients who were diagnosed with Steven's Johnson syndrome (SJS) or Toxic Epidermal Necrolysis (TEN) and followed by Department of Dermatology, Division of Pediatric Neurology and Division of Pediatric Allergy of Uludag University Faculty of Medicine, between 2000-2008 were evaluated retrospectively.Results: Records of 14 patients (7 females/7 males) were examined, Nine of the patients had SJS, 2 had SJS-TEN overlap syndrome and the rest 3 had TEN. Nine patients had history of using drugs for epilepsy and the others for anxiety, tooth abscess, cryptic tonsillitis, otitis media and bronchiolitis, Eleven of the patients (78.5%) had multiple drug intake. In 7 patients (50%) Lamotrigine (4 of 7 patients was also taken Valproic acid) and in other patients oxcarbamazepine, azytromicine, phenytoin, imipra mine, cefuroxime axetil, ciprofloxacin, ceftriaxone were responsible for SJS and TEN. Twelve 13atients were treated with systemic corticosteroid and 2 vvith intravenous All of the patierits vvere cured.Conclosion: Although drug reactions were seen less frequently ill childreri coniipared to adults,. it nitist be taken.. into ci3risideration that there is the risk i3f developing severe drug reactions like SJS and TEN in children who have been using such drugs for a long time or using multipl drugs for extended periods.
The effect of allergen immunotherapy on the development of new sensitization in children
(Aves, 2021-07-01) Çekiç, Şükrü; Canıtez, Yakup; Çiçek, Fatih; Ocakoğlu, Gökhan; Sapan, Nihat; ÇEKİÇ, ŞÜKRÜ; CANITEZ, YAKUP; ÇİÇEK, FATİH; OCAKOĞLU, GÖKHAN; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Alerji Bilim Dalı; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı; 0000-0002-9574-1842; 0000-0002-1114-6051; 0000-0001-8929-679X; 0000-0001-7348-7081; L-1933-2017; AAH-5180-2021; AAH-1789-2021; JKI-5906-2023; FUI-8766-2022
Aim: The protective effect of allergen immunotherapy against a new allergic sensitization is controversial. This study aimed to investigate the effect of allergen immunotherapy on new allergic sensitization in children.Materials and Methods: The study included 50 patients who received immunotherapy for at least 3 years, and whose skin prick tests were repeated at intervals of at least 3 years (31 patients for house dust mite immunotherapy, 19 patients for pollen immunotherapy), and 69 controls with similar characteristics.Results: The number of patients who developed a new sensitization was similar both in the groups of patients who received house dust mite and pollen immunotherapy, and the control group. There was no significant difference between the first and last skin prick tests of the patients who received house dust mite and pollen immunotherapy; however, in the control groups, a significant increase in sensitivity to tree pollens (n = 2, 5.4%; n = 8, 21.6%) and weed pollens (n = 7, 26.9%; n = 14, 53.8%) was detected (P = .031 and P = .039). While allergen sensitivities in the first tests of the pollen immunotherapy group and the control group were similar, weed pollen sensitivity was significantly higher in the last tests of the control group (n = 14, 53.8%; n = 4, 21.1%, P = .027). It was determined that the presence of weed pollen sensitization (OR: 8.1, 95% CI: 1.5-42.4) and having asthma (OR: 3.5, 95% CI:1.3-10.8) increases the risk of new sensitization in all groups.Conclusion: Allergen immunotherapy has been found to protect against new sensitization to tree and weed pollens. However, this effect was insignificant in the multivariate analysis. Weed pollen sensitization and the presence of asthma are related to the development of new sensitization.
The evaluation of local and systemic reactions to subcutaneous house dust mite allergen immunotherapy
(Galenos Publ House, 2022-06-15) Canitez, Yakup; CANITEZ, YAKUP; Karali, Zuhal; KARALI, ZUHAL; ÇEKİÇ, ŞÜKRÜ; SAPAN, NİHAT; Şadırvan, Yağmur Hazal; ŞADIRVAN OĞUZKAYA, YAĞMUR HAZAL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; L-1933-2017
Objective: Allergen -specific immunotherapy is an effective treatment method that enables the development of immunotolerance against allergens in allergic rhinitis, asthma, and venom allergy. This study investigated the local and systemic reactions during subcutaneous house dust mite allergen immunotherapy. Methods: Injection -related local and systemic reactions of 45 patients who received subcutaneous mite immunotherapy were evaluated retrospectively. Results: Forty-five children, 15 (33.3%) females and 30 (66.4%) male were included in the study. A total of 582 injections were administered. A local reaction was observed in 23 (3.94%) of all injections and the systemic reaction was observed in only 1 (0.17%) injection. Sixteen (37.7%) of the children had local reactions during the immunotherapy process and 1 (2.2%) had a systemic reaction. Conclusion: Although subcutaneous mite immunotherapy is a safe treatment, it should only be applied in centers with appropriate emergency equipment and trained healthcare professionals due to possible systemic reactions.
The impact of the Covid-19 pandemic in adolescents with asthma
(Korean Acad Medical Sciences, 2021-12-20) Çekiç, Şükrü; Karali, Zuhal; Çiçek, Fatih; Canıtez, Yakup; Sapan, Nihat; ÇEKİÇ, ŞÜKRÜ; KARALI, ZUHAL; ÇİÇEK, FATİH; CANITEZ, YAKUP; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Alerji Bilim Dalı; 0000-0002-9574-1842; 0000-0001-7348-7081; 0000-0001-8929-679X; JKI-5906-2023; AAH-1789-2021; L-1933-2017; CZC-9168-2022; FUI-8766-2022
Background: The coronavirus disease 2019 (COVID-19) pandemic is affecting people at any age and there is limited information about the effect of the COVID-19 pandemic on quality of life (QoL) in adolescents with asthma. In the present study, it was aimed to assess the attitudes of adolescents with asthma toward the COVID-19 pandemic and determine the effects of the pandemic on their QoL. Methods: In total, 125 adolescents with asthma and 98 healthy adolescents participated in the present study. The questionnaire form consisted of three parts. In the first part, all the participants were asked whether they complied with the protective measures against COVID-19. The second part included questions for measuring the participants' level of concern about COVID-19, while the third part consisted of EUROHIS-QOL 8. Results: The patient and control groups were similar in terms of the female/male ratio (55/70 and 48/50, respectively) and mean participant age (14.6 +/- 2 and 15.1 +/- 1.65 years, respectively) (P = 0.459 and P = 0.062, respectively). The prevalence of COVID-19 in the patients (n = 2, 1.6%) was lower than that in the controls (n = 6, 6.1%); however, the difference was not statistically significant (P = 0.142). The total EUROHIS-QOL score was significantly lower in the patients (31.2 +/- 6.7) than in the controls (33.7 +/- 4.4) (P < 0.001). The total QoL scores of asthmatic adolescents without other allergic disease (31.4 +/- 6.7) was also lower than those of the controls (33.7 +/- 4.4) (P = 0.009). Treatment disruption was significantly more common in patients who received subcutaneous immunotherapy (n = 20, 48.8%) than in those who did not (n = 8, 9.5%) (P < 0.001). Moreover, the patients had lower EUROHIS-QOL scores in the overall QoL, general health, finance, and home domains. Conclusion: Our results indicate that the mean QoL score of asthmatic adolescents during COVID-19 pandemic is lower than in the healthy population. Disruption in their treatment was most common in patients with asthma who were receiving subcutaneous immunotherapy.
The prevalence of reactions related to insect (hymenoptera) stings in children
(Galenos Yayınevi, 2020-12-10) Canıtez, Yakup; Sapan, Nihat; CANITEZ, YAKUP; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Alerji Anabilim Dalı.; 0000-0001-8929-679X; 0000-0002-7601-8392; CJQ-2060-2022; FUI-8766-2022
INTRODUCTION: There has a few number of studies in children that looked for the prevalence of reactions caused by insect (hymenoptera) stings. This study was planned with the aim of investigating the prevalence of systemic, large local and local reactions due to hymenoptera stings in the general population in children.MATERIALS and METHODS: In this study, four different schools in Bursa city center and its villages were selected for research by random sampling method. A total of 3243 children in the 6-15 age group were evaluated using the questionnaire method in the study.RESULTS: Of the children, 1714 (52.9%) were boys and 1529 (47.1%) were girls. The mean age was 9.80.0,04 years. The number of children who were stung at least once in their lifetime was 1992 (61.4%), and the number of children who were stung in the last 12 months was 711 (21.9%). The frequency of reactions due to hymenoptera stings in the study population (lifetime prevalences), systemic reaction in 9 children (0.3%), large local reaction in 19 children (0.6%), local reaction in 1964 children (60.5%) were found. There were higher numbers of lifetime hymenoptera sting and rates of systemic or large local reactions in boys compared to girls (p<0,001, p<0,05, p<0,01 respectively).CONCLUSIONS: In our region, children between the ages of 6-15 frequently encounter hymenoptera stings. Since reactions due to hymenoptera stings occur at certain rates, it would be appropriate to consider these data in terms of defining possible reactions and approach.