Browsing by Author "Canatan, Uygur"
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Publication A novel technique of pulmonary artery banding by means of radiofrequency ablation: An experimental study in rabbits(Bayçınar Tıbbi Yayıncılık, 2022-07-01) Uysal, Fahrettin; Akça, Tuğberk; Genç, Abdüsselam; Küpeli, Zehra Avcı; Özfırat, Erencan; Canatan, Uygur; Uysal, Berfin; Sığnak, Işık Şenkaya; UYSAL, FAHRETTİN; AKÇA, TUĞBERK; GENÇ, ABDÜSSELAM; KÜPELİ, ZEHRA AVCI; ÖZFIRAT, ERENCAN; CANATAN, UYGUR; ŞENKAYA SIĞNAK, IŞIK; 0000-0002-2747-974X; AAH-4421-2021; AEX-4557-2022; CQK-7120-2022; FHA-3247-2022; JHY-2022-2023; CJU-7194-2022; GPN-0680-2022Background: The aim of this study was to evaluate the efficacy and feasibility of a novel method of narrowing pulmonary arteries with catheter angiography using radiofrequency energy in rabbits. Methods: A total of nine New Zealand white rabbits weighing 3.0 to 4.2 kg each were utilized in this experimental study. After the location of pulmonary artery was confirmed by echocardiography and angiography, radiofrequency energy was applied by starting with 5 W energy for the first time and increasing by 5 W, if there was no rupture to a maximum of 20 W. Multiple applications of radiofrequency energy with different durations were performed at different levels of the pulmonary artery. Eight weeks later, surviving rabbits were sacrificed. The pulmonary arteries were removed for histological investigation. Results: Five rabbits remained alive after the experiment. There was a significant correlation between radiofrequency power and the degree of vessel thickness change in the pulmonary artery. The endothelial integrity of the tunica intima was impaired in all groups and the diameter of vessel was thickened by an average of 3.5 times. Conclusion: The narrowing of the pulmonary artery using radiofrequency energy was successfully performed in a small sample size of experimental animals in this study.Item Bursa ilindeki sığırlarda ayak biyomekaniğinin morfolojik, radyolojik, patolojik ve taban yük dağılımı bulguları ile karşılaştırmalı araştırılması: Randomize eks-vivo çalışma(Bursa Uludağ Üniversitesi, 2021-01-07) Canatan, Uygur; Salcı, Hakan; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Veteriner Cerrahi Anabilim Dalı.; 0000-0001-9650-0891Bu çalışmada; Bursa ilindeki sığırlarda ayak biyomekaniğinin morfolojik, radyolojik, patolojik ve taban ağırlık dağılım bulguları ile karşılaştırmalı araştırılması amaçlandı. Çalışmanın materyalini; Bursa ili ve ilçelerindeki mezbahalara getirilmiş 85 adet ineğe ait 340 adet ayak oluşturdu. İlçelerden randomize alınan 5 ineğe ait ayaklara ilçe ismi ve olgu numarası verilerek gerekli işaretlemeler yapıldı. Ayakların mekanik temizliği sonrası klinik olarak ayak derisi ile medial ve lateral tırnaklardaki lezyon varlığı incelendi. Morfolojik olarak tırnak açısı, paries ungulae uzunluğu, diyagonal paries ungulae uzunluğu, solea ungulae uzunluğu ve genişliği, iç ve dış tırnak yükseklikleri, ökçe yükseklikleri ölçüldü. Radyolojik olarak bulguların toplam sayı ve yüzdelik değerleri alındı. Histopatolojik inceleme için hastalıklı ayaklardan numune alındı, preparatlar hazırlandı ve hematoksilen eozin boyama sonrası mikroskobik incelemeler gerçekleştirildi. Footscan platformu kullanılarak taban ağırlık dağılımları belirlendi. İstatistiksel olarak morfolojik ve taban ağırlık dağılımı bulgularının grup içi değerlendirmesi ve ikili grup karşılaştırmalarında “t-testi”, ikiden fazla grup karşılaştırmalarında “tek yönlü varyans analizi” ve çoklu karşılaştırmalarda “Tukey testi” kullanıldı, gruplar arası değerlendirmelerde “Pearson Korelasyon” analizi kullanıldı. Klinik muayenede 84 inekte en az bir ayak hastalığı belirlendi. Ökçe erozyonu %80 oranda görülürken, diğer enfeksiyöz, non-enfeksiyöz ve tırnak deformasyonu gibi ayak problemleri de tespit edildi. Radyolojik olarak, en yaygın bulgu osteofitti ve phalanx proximalis’te (%89,41), procesus extensorius’ta (%78,82) ve tuberculum flexorium’da (%67,06) görüldü. Morfolojik muayenede, gruplar arasında, tırnak açısı sağ ön lateral tırnakta, iç kenar yüksekliği sağ ön lateral-medial ve sol arka lateral tırnaklarda, dış kenar yüksekliği de sağ ön medial, sağ arka medial, sol arka lateral ve sol arka medial tırnaklarda anlamlı farklılık saptandı. Grup içinde ise tırnak açısının negatif korelasyonları mevcuttu. Taban ağırlık dağılımının gruplar arası yapılan değerlendirmesinde sağ ön lateral, sağ ön medial, sol ön lateral ve sağ arka medial tırnaklarda anlamlı farklılık vardı. Grup içi taban ağırlık dağılımı ile Osmangazi ilçesi diyagonal uzunluk parametresi arasında iyi dereceli pozitif yönlü korelasyon saptandı. Sonuç olarak, sığırlarda ayak biyomekaniğini değerlendirmede ayak taban ağırlık dağılımının anlamlı sonuçlar verdiği görülmüş, bu nedenle morfolojik, radyolojik ve histopatolojik bulgular ile birlikte yapılacak biyomekanik incelemenin sığır ayaklarında daha detay bulgular sunacağı rapor edilmiştir.Item Bir buzağıda salter-harris tip ı metacarpus kırığının açılı kama plağı ile sağaltımı(Uludağ Üniversitesi, 2016-12-12) Salcı, Hakan; Canatan, Uygur; Çetin, Melike; Uludağ Üniversitesi/Veteriner Fakültesi.Bu olgu sunumu ile bir buzağıda Salter-Harris Tip I metacarpus kırığında uyguladığımız 90° açılı kama plağının postoperatif klinik ve radyolojik bulgularının rapor edilmesi amaçlanmıştır. Holstein melezi, 3,5 aylık, dişi bir buzağı ön bacağında kırık şikayeti ile kliniklerimize getirildi. Klinik muayenede, buzağının vital parametreleri normaldi ancak inspeksiyonda sağ ön ekstremitede şiddetli topallık, metacarpophalangeal eklem proksimalinde şişkinlik ve sıyrık yarası gözlendi. Ortopedik muayenede, bölgede spesifik kırık bulguları saptandı. Radyografik muayenede, sağ metacarpusun distal fizeal hattan kırılarak (Salter-Harris Tip I) disloke olduğu belirlendi. Hasta sahibine bilgi verildi ve genel anestezi hastanın operasyonuna karar verildi. Kırığın redüksiyonu sonrası fiksasyon için 90° açılı kama plağı kullanıldı. Plağın kama kısmı epifiz kısma çakıldı ve plaka vidalarla proksimal fragmente tespit edildi. Postoperatif atel destekli bandaj uygulandı. Rutin analjezik ve antibiyotik uygulama prosedürü reçete edildi. Buzağının postoperatif 15. gün kontrolünde, kırık bölgesinde stabilizasyonun devam ettiği, buzağının ilgili ekstremitesini bandajsız kullanabildiği gözlendi.Item Diagnostic importance of transesophageal echocardiography for detecting patent ductus arteriosus (PDA) in a puppy(Kafkas Üniversitesi, 2016) Yılmaz, Zeki; Kocatürk, Meriç; Salcı, Hakan; Levent, Pınar; Canatan, Uygur; Sağ, Saim; Güllülü, Sümeyye; Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0001-8404-8252; T-4623-2019; AAW-9185-2020; V-5578-2017; 35944810500; 36437200800; 8680329000; 56690616700; 57189443508; 12140008100; 57204660708Item Histologic and electromyographic evaluation of neuroregenerative effect of stromal vascular fraction following neuroanastomosis(Kafkas Üniversitesi, 2020-03-23) Acar, Hilal; Çerçi, Ece; Khezri, Marzieh Karimi; Çetin, Melike; Canatan, Uygur; Şen, Mehmet Metin; Aslan, Vildan; Sarıl, Canan Altıncı; Temiz, Elif Mekik; Taşkapılıoğlu, Mevlüt Özgür; Erdost, Hatice; Salcı, Hakan; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroşirürji Anabilim Dalı.; 0000-0001-5472-9065; 0000-0003-0154-9938; 0000-0001-9650-0891; 0000-0001-5323-6891; 000-0003-1547-7293; 0000-0001-6548-8754; AAH-9216-2021; AAI-6861-2021; AAW-5254-2020; ABB-8161-2020; 57209653860; 57212212053; 57216947212; 56393942900; 57189443508; 57216950078; 57200994296; 57216954758; 57216945905; 25936798300; 6505787570; 8680329000In this study, histologic and electromyographic (EMG) evaluation of neuroregenerative effect of stromal vascular fraction (SVF) following periferal nerve anastomosis was aimed. Totally, 31 Wistar Albino, male rats (weighing about 300 g) were studied, and these rats were grouped according to surgical techniques performed on the right sciatic nerve: group I (GRI) micro suture (n=7), group II (GRII) micro suture + SVF (n=7), group III (GRIII) fibrin glue (n=7) and group IV (GRIV) fibrin glue + SVF (n=7). Fat tissue was taken from 3 rats to prepare SVF, and SVF was produced by non-enzymatic method. The left sciatic nerve of all rats was evaluated for EMG as control. Under general anesthesia, after transversal incision of the sciatic nerve, microsurgical epineural repair technique was performed with 10/0 nonabsorbable suture. EMG examinations were performed in terms of conduction rate, amplitude, distal latency and spontaneous muscle activity at 0th day and postoperative (PO) 1st and 8th weeks. EMG results between and within the groups were statistically evaluated by one-way analysis of variance. Rats in all groups were sacrificed by decapitation at PO 8th week and histological examinations of the sciatic nerves were performed following preparation of the neural tissues. EMG examination results showed the highest nerve conduction in GRI, the highest amplitude in GRIII, normal latency in GRII and longer distal latency in GRIV at PO 8th week. Amplitude and conduction velocity increased gradually in all groups. In needle EMG, the best muscle membrane stabilization was achieved in GRII and GRIV at PO 8th week. Statistically, the values of amplitude, distal latency, conduction velocity, and spontaneous muscle activity were found to be at normal levels at PO 8th week in all groups (P>0.05). In the histological results, although fibroconnective tissue reactions in the anastomosis area had similar scores in GRII and GRIV, maximum fibroconnective tissue reaction and the best axonal regeneration was seen in GRI and GRIII, respectively. In addition, GRI and GRII had the most inflammatory cells accumulation in the suture region, and less inflammatory cells were seen in the anastomosis area of GRIII and GRIV. As a conclusion, fibrin glue presents good electrophysiological and histological results; however, it is clear that local SVF usage on the nerve anastomosis area can be a good choice to decrease fibroconnective tissue reaction and inflammation.Publication How effective is individual claw trimming in cattle? An ex-vivo study(Sivar-soc Italiana Veterinari Animali Reddito, 2021-02-01) Canatan, Uygur; Akbala, Melike; Akbala, Melike; Cetin, Melike; Acar, Hilal; ACAR, HİLAL; Aslan, Vildan; ASLAN, VİLDAN; Saril, Canan Altinci; Temiz, Elif Mekik; Yigitgor, Pelin; Salci, Hakan; SALCI, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.; JDC-5958-2023; JPN-6878-2023Claw trimming is an application to give a functional shape to the claws, to maintain foot weight distribution and to prevent foot diseases. Claw trimming should be done by experts. In this study, it was aimed to show the effectiveness of individual claw trimming applied in cattle claws by morphometric measurements.As material, 85 ex-vivo cattle feet of different races were used. The feet were divided into four groups as right front (n=17), left front (n=17), right hind (n=24) and left hind (n=27). In addition, the claws were divided laterally and medially. After the mechanical cleaning of the claws, functional nail cutting (Dutch method) was applied by different people and morphometric measurements of the claws (claw angle, dorsal wall length, claw height, diagonal length, heel height, inner heel height, sole length, sole width, abaxial white line width and axial white line width).The claw angle was 49 degrees on the right hind lateral, 47 degrees on the right hind medial, 49 degrees on the left hind medial and within reference ranges on the other claws. Statistically, dorsal wall length of right anterior lateral (p=0.006) and left posterior medial (p=0.01) claws were significant. Significance was also detected left posterior lateral (p=0.01) and left posterior medial (p=0.01) claws in diagonal length. Inner heel height was significant on claws of left posterior lateral (p=0.01), and there was significant difference on right front lateral (p=0.02), left anterior medial (p=0.03) and left posterior medial (p=0.002) claws in terms of sole width. A positive correlation was found in the correlation analysis between all parameters except claw angle.As a conclusion, the claw trimming is important manipulation in large animal practice, regardless of the applied claw trimming technique, individual claw trimming has some difference on morphometric shape of the claws, and it should be performed by masters on this.Item Infectious keratoconjunctivitis due to Pseudomonas stutzeri in cattle(Ecole Nationale Veterinaire, 2016) Salcı, Hakan; Goncagül, Gülşen; Canatan, Uygur; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Mennan Pasinli Meslek Yüksekokulu.; T-4623-2019; AAK-6555-2021; CJU-7194-2022; 8680329000; 8350555500; 57189443508The aim of this clinical case was to report Pseudomonas stutzeri microorganism as a causative agent of infectious keratoconjunctivitis in cattle. In totally, 20 Holstein cattle (n=20) with keratoconjunctivitis in a herd were referred. Initially, microbiological samples were taken from the conjunctival recessus of all cases with sterile swaps for culture and antibiotic susceptibility. Following clinical examinations, the cases were classified as mild, moderate and severe according to type of eye disease. As an initial therapy, local 3% acid boric irrigation was given, perpalpebral oxytetracicline was injected and tetracycline pomade was applied before diagnosis took place. The prevalence of the disease was 12.12% in the herd and there was 9 bilateral (n=9) and 11 unilateral (n=11) eye problems. Epiphora and conjunctivitis were the clinical finding in mild cases (n=17). Photophobia, blepharospasm, chemosis, keratoconjunctivitis and ocular pain were observed in moderate cases (n=2). Anterior uveitis and associated symptoms of moderate cases was inspected in a severe case (n=1). Microbiologically, P stutzeri was identified in all cases and antibiogram result of this germ pointed out the 75% sensitivity to oxytetracycline. Initial therapy was continued as curative treatment to all cases. All cases healed; healing time for mild and moderate cases were mean 8.3 +/- 2.9 and 19.5 +/- 2.1 days, respectively. The symptoms of the anterior uveitis in the severe case were terminated at 42 days, but there was minimal lens opacity as a sequel.Item Palatoschisis, brachygnathia inferior and accessory mandibular mass in a Simmental breed calf(Sivar-Soc Italiana Veterinari Animali Reddito, 2020-06) Şen, Mehmet; Canatan, Uygur; Özfırat, Erencan; Çetin, Melike; Salcı, Hakan; Bursa Uludağ Üniversitesi/Veteriner Fakültesi.; 0000-0001-9650-0891; 0000-0001-6548-8754Congenital anomalies in calves are encountered in different regions of the body. Generally, anomalies are seen in fronto-nasal, maxillar or mandibular regions. In addition several pathologies such as meningocele, cleft palate, nasal dermoid cyst, gingival vascular hamartoma are reported on the head. The aim of the present case report was to describe clinical and surgical result of palathoschisis, brachygnathia inferior and accessory mandibular mass in a Simmental calf. A 3-day-old male calf was referred with the complaint of milk discharge from the nose after suckling and an atypical structure in the mouth. At clinical examination, submandibular lymph nodes were swollen and physical examination results were normal. Oral examination revealed a cleft palate (palatoschisis), short lower jaw (brachygnathia inferior) and a pedunculated accessory mandibular mass midway between palatum durum and molle. However, the calf presented a good suction reflex. The accessory mandible was connected to the cleft palate and contained tooth-like structures. At palpation, the end portion of this mass was hard while its peduncle was soft in consistency. Radiographic exams on latero-lateral and ventro-dorsal projections of the cranium were carried out. The patient was subjected to surgical treatment; it was sedated with xylazine chloridrate (0.1 mg/kg im) and general anaesthesia was induced with ketamine chloridrate (4 mg/kg im). After tracheal intubation, general anesthesia was maintained with 2% isoflurane plus oxygen. The accessory mandible was removed by dissecting the surrounding tissues. Congenital cleft was closed through application of n degrees 0 suture silk with simple interrupted stitches. On the following day, the calf was discharged from the clinic with a postoperative recommended therapy including antibiotics (penicillin-streptomycin, 1x1.5 cc, im, for 5 days), analgesic (flunixin meglumin, 1.1 mg/kg, iv, for 3 days) and oral antiseptic (10% glycerin iode) drugs. According to the information obtained from the owner on the 15th postoperative day, calf 's appetite was normal and chewing movements were reported to be relatively good. As a result, multiple anomaly including palatoschisis, brachygnathia inferior and accessory mandible in a calf may occured in clinical practice and as in this case, the observed pathology was corrected by surgical intervention, and postoperative results were favorable.Item Tracheobronchoscopic, cytological and microbiological results of tracheal and bronchial collapse in dogs(Polish Soc Veterinary Sciences Editorial Office, 2017-07-31) Salcı, Hakan; Çetin, Melike; Kahya, Serpil; Akkoç, Ahmet; Yılmaz, Özge; Canatan, Uygur; Çeşme, Hilal; Aslan, Vildan; Altıncı, Canan; Khider, Mohammed; Yılmaz, Zeki; Bayram, Ahmet Sami; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Mikrobiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; 0000-0001-9836-0749; 0000-0003-0684-0900; 0000-0002-6227-1098; AAI-6861-2021; AAH-2842-2021; AAG-7421-2021; T-4623-2019; A-9637-2008; ABB-7580-2020; 8680329000; 56393942900; 35368679200; 55584229300; 56524019400; 57189443508; 56951171800; 57200994296; 57200984827; 57200991560; 35944810500; 8347194000The aim of this study was to evaluate the tracheobronchoscopic, cytological and microbiological results of tracheal and bronchial collapse in dogs. In total, 8 dogs were included in the study. Clinically, tracheal palpations of the dogs were reflective of tracheal disease, and all dogs coughed on tracheal palpation. Vital parameters and hematological values of the dogs were within the normal ranges. Radiological views of the respiratory tracts and thorax were largely normal, but distinctive tracheal contours were noted in cases 3 and 6. Tracheobronchoscopy was performed under general anesthesia, and endoscopic findings (mucosal surfaces and color, prominent appearance of vessels, chondral ring abnormalities of the trachea, and the presence of bronchial and tracheal collapse) were scored. Bronchoalveolar lavage (BAL) was performed to collect samples for cytological and microbiological analysis. Five cases had tracheal collapse, and two cases had right bronchial collapse. Concurrent tracheal and right bronchial collapse were diagnosed in one case. Cytological results were not indicative of inflammation or infection, but Escherichia coli was isolated from case 2 (bronchial collapse) and case 3 (tracheal collapse). Antibiotic susceptibility results revealed that the organisms were susceptible to sulfamethoxazole/trimethoprim. Statistically, there were no significant differences between the cases in terms of total endoscopic scores. In conclusion, tracheal and/or bronchial collapse should only be diagnosed by tracheobronchoscopic examination. Cytological and microbiological analyses of the BAL fluid in these cases do not always provide valuable data for clinical practitioners.