Browsing by Author "Gürler, Nezahat"

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    Characterization of invasive Neisseria meningitidis isolates recovered from children in Turkey during a period of increased serogroup B disease, 2013-2017
    (Elsevier, 2020-04-23) Ceyhan, Mehmet; Özsürekçi, Yasemin; Lucidarme, Jay; Borrow, Ray; Gürler, Nezahat; Emiroğlu, Melike Keser; Öz, Fatma Nur; Kurugöl, Zafer; Çelik, Ümit; Parlakay, Aslınur Özkaya; Dinleyici, Ener Çağrı; Karbuz, Adem; Belet, Nursen; Devrim, İlker; Gülfidan, Gamze; Gündeşlioğlu, Özlem; Yücel, Mihriban; Ulusoy, Emel; Cengiz, Ali Bülent; Çelebi, Solmaz; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Enfeksiyon Hastalıkları Anabilim Dalı.; ENK-4130-2022; 7006095295
    Diverse Neisseria meningitidis strains belonging to various serogroups and clonal complexes cause epidemic and endemic life-threatening disease worldwide. This study aimed to investigate the genetic diversity of recent invasive meningococci in Turkey with respect to multilocus sequence type (MLST) and also meningococcal serogroup B (MenB) vaccine antigens to enable assessment of potential MenB strain coverage using the genetic Meningococcal Antigen Typing System (gMATS). Fifty-four isolates, representing 37.5% of all pediatric (ages 0-18 years) invasive meningococcal disease cases in Turkey from January 2013 to December 2017, underwent genome sequence analysis. Thirty-six (66.7%) isolates were MenB, 10 (18.5%) were serogroup W (MenW), 4 (7.4%) were serogroup A (MenA), 3 (5.6%) were serogroup Y (MenY) and 1 (1.8%) was serogroup X (MenX). The MenB isolates were diverse with cc35 (19.4%), cc41/44 (19.4%) and cc32 (13.8%) as the most prevalent clonal complexes. The MenW isolates (n = 10) comprised cc11 (n = 5), ST-2754 (cc-unassigned; n = 4) and cc22 (n = 1). gMATS was indicative of high 4CMenB coverage (72.2-79.1%) of Turkish invasive MenB strains from pediatric patients. Strain coverage of several clonal complexes differed from that seen elsewhere in Europe highlighting the importance of performing local assessments and also the use of phenotypic methods, i.e. MATS, where possible. All of the isolates possessed in-frame fhbp alleles and so were potentially covered by MenB-fHbp. Continued surveillance is essential to guide recommendations for current and future vaccines as well as understanding changes in epidemiology.
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    Distribution of Streptococcus pneumoniae serotypes that cause parapneumonic empyema in Turkey
    (American Society for Microbiology, 2013-04-15) Ceyhan, Mehmet; Özsürekçi, Yasemin; Gürler, Nezahat; Özkan, Şengül; Şensoy, Gülnar; Belet, Nurşen; Keser, Melike; Dinleyici, Ener Cağrı; Alhan, Emre; Baki, Ali; Öner, Ahmet Faik; Uzun, Hakan; Kurugöl, Zafer; Aycan, Ahmet Emre; Gürbüz, Venhar; Karadağ Öncel, Eda; Çelik, Melda; Parlakay, Aslınur Özkaya; Hacımustafaoğlu, Mustafa Kemal; Çelebi, Solmaz; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Enfeksiyon Hastalıkları Anabilim Dalı.; CTG-5805-2022; ENK-4130-2022; 6602154166; 7006095295
    Streptococcus pneumoniae is the most common etiological cause of complicated pneumonia, including empyema. In this study, we investigated the serotypes of S. pneumoniae that cause empyema in children. One hundred fifty-six children who were diagnosed with pneumonia complicated with empyema in 13 hospitals in seven geographic regions of Turkey between 2010 and 2012 were included in this study. Pleural fluid samples were collected by thoracentesis and tested for 14 serotypes/serogroups using a Bio-Plex multiplex antigen detection assay. The serotypes of S. pneumoniae were specified in 33 of 156 samples. The mean age ± the standard deviation of the 33 patients was 6.17 ± 3.54 years (range, 0.6 to 15 years). All of the children were unvaccinated according to the vaccination reports. Eighteen of the children were male, and 15 were female. The serotypes of the non-7-valent pneumococcal conjugated vaccine (non-PCV-7), serotype 1, serotype 5, and serotype 3, were detected in eight (14.5%), seven (12.7%), and five (9.1%) of the samples, respectively. Serotypes 1 and 5 were codetected in two samples. The remaining non- PCV-7 serotypes were 8 (n = 3), 18 (n = 1), 19A (n = 1), and 7F/A (n = 1). PCV-7 serotypes 6B, 9V, 14, 19F, and 23F were detected in nine (16.3%) of the samples. The potential serotype coverages of PCV-7, PCV-10, and PCV-13 were 16.3%, 45.4%, and 60%, respectively. Pediatric parapneumonic empyema continues to be an important health problem despite the introduction of conjugated pneumococcal vaccines. Active surveillance studies are needed to monitor the change in S. pneumoniae serotypes that cause empyema in order to have a better selection of pneumococcal vaccines.
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    Serotype prevalence and antibiotic resistance among adult invasive Streptococcus pneumoniae isolates in Turkey, 2005-2011
    (Elsevier, 2014-04) Hasçelik, Ayşe Gülsen; Gürler, Nezahat; Ceyhan, Mehmet; Öksüz, Lütfiye; Bayramoğlu, Gülçin; Gülay, Zeynep; Yaman, Akgün; Söyletir, Güner; Perçin, Duygu; Özakın, Cüneyt; Uludağ Üniversitesi/Tıp Fakültesi.; JJY-6657-2023