Browsing by Author "Keser, Melike"

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Clinical and epidemiological features of Turkish children with 2009 pandemic influenza A (H1N1) infection: Experience from multiple tertiary paediatric centres in Turkey
(Informa Healthcare, 2011-12) Çiftçi, Ergin; Tuygun, Nilden; Özdemir, Halil; Tezer, Hasan; Şensoy, Gülnar; Devrim, İlker; Dalgıç, Nazan; Kara, Ateş; Turgut, Mehmet; Tapısız, Anıl; Keser, Melike; Bayram, Nuri; Kocabaş, Emine; Dinleyici, Ener Çağrı; Özen, Metehan; Soysal, Ahmet; Kuyucu, Necdet; Tanır, Gönül; Çelikel, Elif; Belet, Nursen; Evren, Gültaç; Aytaç, Didem Büyüktaş; Cengiz, Ali Bülent; Canoz, Perihan Yasemen; Derinoz, Oksan; İnce, Erdal; Hacımustafaoğlu, Mustafa; Anıl, Murat; Özgür, Özlem; Kuzdan, Canan; Özaydin, Eda; Aşılıoğlu, Nazik; Dizdarer, Ceyhun; Ceyhan, Mehmet; Bucak, İbrahim Hakan; Kendirli, Tanıl; Yakut, Halil İbrahim; Fisgin, Tunç; Unal, Nurettin; Altındağ, Hakan; Kılınç, Ayse Ayzit; Zohre, Seray Umut; Elhan, Atilla Halil; Doğru, Ülker; Çelebi, Solmaz; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Enfeksiyon Hastalıkları Anabilim Dalı.; 7006095295
Background: In April 2009 a novel strain of human influenza A, identified as H1N1 virus, rapidly spread worldwide, and in early June 2009 the World Health Organization raised the pandemic alert level to phase 6. Herein we present the largest series of children who were hospitalized due to pandemic H1N1 infection in Turkey. Methods: We conducted a retrospective multicentre analysis of case records involving children hospitalized with influenza-like illness, in whom 2009 H1N1 influenza was diagnosed by reverse-transcriptase polymerase chain reaction assay, at 17 different tertiary hospitals. Results: A total of 821 children with 2009 pandemic H1N1 were hospitalized. The majority of admitted children (56.9%) were younger than 5 y of age. Three hundred and seventy-six children (45.8%) had 1 or more pre-existing conditions. Respiratory complications including wheezing, pneumonia, pneumothorax, pneumomediastinum, and hypoxemia were seen in 272 (33.2%) children. Ninety of the patients (11.0%) were admitted or transferred to the paediatric intensive care units (PICU) and 52 (6.3%) received mechanical ventilation. Thirty-five children (4.3%) died. The mortality rate did not differ between age groups. Of the patients who died, 25.7% were healthy before the H1N1 virus infection. However, the death rate was significantly higher in patients with malignancy, chronic neurological disease, immunosuppressive therapy, at least 1 pre-existing condition, and respiratory complications. The most common causes of mortality were pneumonia and sepsis. Conclusions: In Turkey, 2009 H1N1 infection caused high mortality and PICU admission due to severe respiratory illness and complications, especially in children with an underlying condition.
Distribution of Streptococcus pneumoniae serotypes that cause parapneumonic empyema in Turkey
(American Society for Microbiology, 2013-04-15) Ceyhan, Mehmet; Özsürekçi, Yasemin; Gürler, Nezahat; Özkan, Şengül; Şensoy, Gülnar; Belet, Nurşen; Keser, Melike; Dinleyici, Ener Cağrı; Alhan, Emre; Baki, Ali; Öner, Ahmet Faik; Uzun, Hakan; Kurugöl, Zafer; Aycan, Ahmet Emre; Gürbüz, Venhar; Karadağ Öncel, Eda; Çelik, Melda; Parlakay, Aslınur Özkaya; Hacımustafaoğlu, Mustafa Kemal; Çelebi, Solmaz; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Enfeksiyon Hastalıkları Anabilim Dalı.; CTG-5805-2022; ENK-4130-2022; 6602154166; 7006095295
Streptococcus pneumoniae is the most common etiological cause of complicated pneumonia, including empyema. In this study, we investigated the serotypes of S. pneumoniae that cause empyema in children. One hundred fifty-six children who were diagnosed with pneumonia complicated with empyema in 13 hospitals in seven geographic regions of Turkey between 2010 and 2012 were included in this study. Pleural fluid samples were collected by thoracentesis and tested for 14 serotypes/serogroups using a Bio-Plex multiplex antigen detection assay. The serotypes of S. pneumoniae were specified in 33 of 156 samples. The mean age ± the standard deviation of the 33 patients was 6.17 ± 3.54 years (range, 0.6 to 15 years). All of the children were unvaccinated according to the vaccination reports. Eighteen of the children were male, and 15 were female. The serotypes of the non-7-valent pneumococcal conjugated vaccine (non-PCV-7), serotype 1, serotype 5, and serotype 3, were detected in eight (14.5%), seven (12.7%), and five (9.1%) of the samples, respectively. Serotypes 1 and 5 were codetected in two samples. The remaining non- PCV-7 serotypes were 8 (n = 3), 18 (n = 1), 19A (n = 1), and 7F/A (n = 1). PCV-7 serotypes 6B, 9V, 14, 19F, and 23F were detected in nine (16.3%) of the samples. The potential serotype coverages of PCV-7, PCV-10, and PCV-13 were 16.3%, 45.4%, and 60%, respectively. Pediatric parapneumonic empyema continues to be an important health problem despite the introduction of conjugated pneumococcal vaccines. Active surveillance studies are needed to monitor the change in S. pneumoniae serotypes that cause empyema in order to have a better selection of pneumococcal vaccines.
Meningitis caused by neisseria meningitidis, hemophilus influenzae type b and streptococcus pneumoniae during 2005-2012 in Turkey a multicenter prospective surveillance study
(Taylor & Francis Inc, 2014-09-01) Ceyhan, Mehmet; Gurler, Nezahat; Özsürekci, Yasemin; Keser, Melike; Aycan, Ahmet Emre; Gürbüz, Venhar; Salman, Nuran; Camcıoğlu, Yildiz; Dinleyici, Ener Cağrı; Özkan, Şengül; Şensoy, Gülnar; Belet, Nursen; Alhan, Emre; Uzun, Hakan; Öner, Ahmet Faik; Kurugol, Zafer; Taş, Mehmet Ali; Aygün, Denizmen; Öncel, Eda Karadağ; Çelik, Melda; Yasa, Olcay; Akın, Fatih; Coşkun, Yavuz; Hacimustafaoglu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Celebi, Solmaz; ÇELEBİ, SOLMAZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi
Successful vaccination policies for protection from bacterial meningitis are dependent on determination of the etiology of bacterial meningitis. Cerebrospinal fluid (CSF) samples were obtained prospectively from children from 1 month to <= 18 years of age hospitalized with suspected meningitis, in order to determine the etiology of meningitis in Turkey. DNA evidence of Neisseria meningitidis (N. meningitidis), Streptococcus pneumoniae (S. pneumoniae), and Hemophilus influenzae type b (Hib) was detected using multiplex polymerase chain reaction (PCR). In total, 1452 CSF samples were evaluated and bacterial etiology was determined in 645 (44.4%) cases between 2005 and 2012; N. meningitidis was detected in 333 (51.6%), S. pneumoniae in 195 (30.2%), and Hib in 117 (18.1%) of the PCR positive samples. Of the 333 N. meningitidis positive samples 127 (38.1%) were identified as serogroup W-135, 87 (26.1%) serogroup B, 28 (8.4%) serogroup A and 3 (0.9%) serogroup Y; 88 (26.4%) were non-groupable. As vaccines against the most frequent bacterial isolates in this study are available and licensed, these results highlight the need for broad based protection against meningococcal disease in Turkey.