Browsing by Author "Koruk, Suda Tekin"
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Item Assessment of the requisites of microbiology based infectious disease training under the pressure of consultation needs(BMC, 2011) Erdem, Hakan; Koruk, Suda Tekin; Koruk, İbrahim; Keten, Derya Tozlu; Kılıç, Aysegül Ulu; Öncül, Oral; Güner, Rahmet; Birengel, Serhat; Mert, Gürkan; Alpat, Saygın Nayman; Tülek, Necla Eren; Demirdal, Tuna; Elaldi, Nazif; Hatipoglu, Çiğdem Ataman; Yılmaz, Emel; Mete, Bilgul; Kurtaran, Behice; Ceran, Nurgül; Karabay, Oğuz; İnan, Dilara; Cengiz, Melahat; Sacar, Suzan; Dede, Behiye Yücesoy; Yılmaz, Sibel; Agalar, Canan; Bayındır, Yaşar; Alpay, Yeşim; Tosun, Selma; Yılmaz, Hava; Bodur, Hürrem; Erdem, Hüseyin A.; Dikici, Nebahat; Dizbay, Murat; Öncu, Serkan; Sezak, Nurbanu; Sarı, Tuba; Sipahi, Oğuz R.; Uysal, Serhat; Yeniz, Esma; Kaya, Selcuk; Ulcay, Asım; Kurt, Halil; Beşirbellioğlu, Bulent A.; Vahaboğlu, Haluk; Taşova, Yeşim; Usluer, Gaye; Arman, Dilek; Diktaş, Hüsrev; Ulusoy, Sercan; Leblebicioğlu, Hakan; Yılmaz, Emel; Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.; 0000-0002-3894-1231; 22037135100Background: Training of infectious disease (ID) specialists is structured on classical clinical microbiology training in Turkey and ID specialists work as clinical microbiologists at the same time. Hence, this study aimed to determine the clinical skills and knowledge required by clinical microbiologists. Methods: A cross-sectional study was carried out between June 1, 2010 and September 15, 2010 in 32 ID departments in Turkey. Only patients hospitalized and followed up in the ID departments between January-June 2010 who required consultation with other disciplines were included. Results: A total of 605 patients undergoing 1343 consultations were included, with pulmonology, neurology, cardiology, gastroenterology, nephrology, dermatology, haematology, and endocrinology being the most frequent consultation specialties. The consultation patterns were quite similar and were not affected by either the nature of infections or the critical clinical status of ID patients. Conclusions: The results of our study show that certain internal medicine subdisciplines such as pulmonology, neurology and dermatology appear to be the principal clinical requisites in the training of ID specialists, rather than internal medicine as a whole.Item Efficacy and tolerability of antibiotic combinations in Neurobrucellosis: Results of the Istanbul study(American Society of Microbiology, 2012-03) Erdem, Hakan; Kılıç, Ayşegül Ulu; Kılıç, Selim; Karahocagil, Mustafa; Shehata, Ghaydaa; Tülek, Necla Eren; Yetkin, Funda; Çelen, Mustafa Kemal; Ceran, Nurgül; Gül, Hanefi Cem; Mert, Gürkan; Koruk, Suda Tekin; Dizbay, Murat; İnal, Ayşe Seza; Alpat, Saygın Nayman; Bosilkovski, Mile; İnan, Dilara; Saltoğlu, Neşe; Abdel-Baky, Laila; Adeva-Bartolome, Maria Teresa; Ceylan, Bahadır; Saçar, Suzan; Turhan, Vedat; Elaldı, Nazif; Tufan, Zeliha Koçak; Uğurlu, Kenan; Dokuzoğuz, Başak; Yılmaz, Hava; Gündeş, Sibel; Güner, Rahmet; Özgüneş, Nail; Ulçay, Asım; Ünal, Serhat; Dayan, Saim; Görenek, Levent; Karakaş, Ahmet; Tasova, Yeşim; Usluer, Gaye; Bayındır, Yaşar; Kurtaran, Behice; Sipahi, Oğuz Reşat; Leblebicioğlu, Hakan; Yılmaz, Emel; Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.; 22037135100No data on whether brucellar meningitis or meningoencephalitis can be treated with oral antibiotics or whether an intravenous extended-spectrum cephalosporin, namely, ceftriaxone, which does not accumulate in phagocytes, should be added to the regimen exist in the literature. The aim of a study conducted in Istanbul, Turkey, was to compare the efficacy and tolerability of ceftriaxone-based antibiotic treatment regimens with those of an oral treatment protocol in patients with these conditions. This retrospective study enrolled 215 adult patients in 28 health care institutions from four different countries. The first protocol (P1) comprised ceftriaxone, rifampin, and doxycycline. The second protocol (P2) consisted of trimethoprim-sulfamethoxazole, rifampin, and doxycycline. In the third protocol (P3), the patients started with P1 and transferred to P2 when ceftriaxone was stopped. The treatment period was shorter with the regimens which included ceftriaxone (4.40 +/- 2.47 months in P1, 6.52 +/- 4.15 months in P2, and 5.18 +/- 2.27 months in P3) (P = 0.002). In seven patients, therapy was modified due to antibiotic side effects. When these cases were excluded, therapeutic failure did not differ significantly between ceftriaxone-based regimens (n = 5/166, 3.0%) and the oral therapy (n = 4/42, 9.5%) (P = 0.084). The efficacy of the ceftriaxone-based regimens was found to be better (n = 6/166 [3.6%] versus n = 6/42 [14.3%]; P = 0.017) when a composite negative outcome (CNO; relapse plus therapeutic failure) was considered. Accordingly, CNO was greatest in P2 (14.3%, n = 6/42) compared to P1 (2.6%, n = 3/ 117) and P3 (6.1%, n = 3/ 49) (P = 0.020). Seemingly, ceftriaxone-based regimens are more successful and require shorter therapy than the oral treatment protocol.Item HCV NS3 inhibitors resistance mutations in the telaprevir started Turkish patients with chronic HCV(Elsevier, 2014-04) Sayan, Murat; Akhan, Sıla; Aygen, Bilgehan; Koruk, Suda Tekin; Demirtürk, Nurbanu; Ural, Onur; Mıstık, Reşit; Uludağ Üniversitesi.Item Management of Brucella endocarditis: Results of the Gulhane study(Elsevier, 2012-08) Koruk, Suda Tekin; Erdem, Hakan; Koruk, İbrahim; Erbay, Ayşe; Tekce, Yasemin Tezer; Erbay, Ali Rıza; Dayan, Saim; Deveci, Özcan; İnan, Asuman; Engin, Derya Öztürk; Güner, Rahmet; Dikici, Nebahat; Kartal, Elif Doyuk; Kurtaran, Behice; Pehlivanoğlu, Filiz; Sipahi, Oğuz Reşat; Yalcı, Aysun; Yemişen, Mücahit; Çavuş, Sema Alp; Gençer, Serap; Güzel, Gökhan; Öncül, Oral; Parlak, Mehmet; Tülek, Necla; Ulçay, Asım; Savaşçı, Ümit; Kazak, Esra; Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.; AAG-8459-2021; 24921238200Brucella endocarditis (BE) is a rare but life-threatening complication of human brucellosis. The aim of this study was to investigate the course of BE along with the therapeutic interrelations. A total of 53 patients with BE hospitalised in 19 health institutions between 2006 and 2011 were included in the Gulhane study. Diagnosis of brucellosis was established by either isolation of Brucella sp. or the presence of antibodies, and the definition of endocarditis was made according to Duke's criteria. There were four treatment groups: ceftriaxone combined with oral antibiotics (Group 1); aminoglycosides combined with oral antibiotics (Group 2); oral antibiotic combinations (Group 3); and aminoglycoside plus ceftriaxone combined with an oral antibiotic (Group 4). Involvement rates of the aortic, mitral and tricuspid valves were 49.1%, 43.4% and 5.7%, respectively. Thirty-two patients (60.4%) had an underlying cardiac valvular problem, including previous prosthetic valve replacement (n = 18). Medical treatment was provided to 32 patients (60.4%), whilst concordant medical and surgical approaches were provided to 21 patients (39.6%). Mortality in Group 1 was 15% (3/20), whilst in Group 2 it was 5.3% (1/19). In Group 3, 25.0% (3/12) of the cases died, whereas none of the cases in Group 4 died. In conclusion, mortality increased 47-fold with pericardial effusion and 25-fold due to congestive heart failure that developed after BE. Although mortality was lower in the aminoglycoside-containing arm (Groups 2 and 4), statistical analysis could not be performed owing to the small number of patients.Item Transmitted antiretroviral drug resistance mutations in newly diagnosed HIV-1 positive patients in Turkey(John Wiley & Sons Ltd, 2014-11) Sayan, Murat; Sargın, Fatma; Dilara, İnan; Sevgi, Dilek Yıldız; Kocagül Çelikba, Aysel; Kart Yaşar, Kadriye; Kaptan, Figen; Kutlu, Selda; Fışgın Taşdelen, Nuriye; İnci, Ayşe; Ceran, Nurgül; Karaoğlan, İlkay; Çağatay, Atahan; Celen, Mustafa K.; Koruk, Suda Tekin; Ceylan, Bahadır; Yıldırmak, Taner; Korten, Volkan; Willke, Ayşe; Akalın, Halis; Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.