Browsing by Author "Marques-Garcia, Fernando"

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Big data and reference intervals: Rationale, current practices, harmonization and standardization prerequisites and future perspectives of indirect determination of reference intervals using routine data
(Walter De Gruyter Gmbh, 2021-03-10) Martinez-Sanchez, Luisa; Marques-Garcia, Fernando; Blanco, Albert; Brouwer, Nannette; Canalias, Francesca; Cobbaert, Christa; Thelen, Marc; den Elzen, Wendy; Özarda, Yeşim; ÖZARDA, YEŞİM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.
Reference intervals are commonly used as a decision-making tool. In this review, we provide an overview on "big data " and reference intervals, describing the rationale, current practices including statistical methods, essential prerequisites concerning data quality, including harmonization and standardization, and future perspectives of the indirect determination of reference intervals using routine laboratory data.