Browsing by Author "Nak, Deniz"

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Anöstrus ve üreme mevsimindeki koyunlarda kızgınlıkların uyarılması, toplulaştırılması ve dölverimi üzerinde araştırmalar
(Uludağ Üniversitesi, 1992) Gökçen, Hazım; Ünal, E. Fatih; Tümen, Hüseyin; Nak, Deniz; Uludağ Üniversitesi/Veteriner Fakültesi/Doğum ve Reprodüksiyon Hastalıkları Anabilim Dalı.
Materyal olarak 50 Meriııos koyummun kullamldıgı bu araştınnada, üreme mevsimi ile anöstrns dönemindeki koyunlarda kızgm/ıkiann uyanl ması ve sinkronizasyonu denendi. 12 giln süre ile uygulanan, 30 mg. Florogestone acetate (FGA) içeren vagilıaf. sünger/er, geri almdıgtnda, koyun/ann hepsine 600 /U PMSG enjekte edildi. Her iki uygulama döneminde östrns oram % 100 olarak bulundu. Elde sıfat yöntemiyle tabii tohumlama ılan koyunlarda dogıtm oranı, anöstrus döneminde % 80, üreme mevsiminde ise % 76 oldu.
Clinical laboratory findings, vaginal cytology and pathology in a controlled study of pyometra in cats
(Australian Small Animal Veterinary Association, 2005-03) Nak, Deniz; Mısırlıoğlu, Deniz; Nak, Yavuz; Keskin, Abdülkadir; Uludaǧ Üniversitesi/Veterinerlik Fakültesi.; AAH-3831-2021; AAH-5494-2021; 9280090000; 6507455482; 8615464000; 24473229800
Pyometra was diagnosed in 17 cats with a mean (+/-SE) age of five years. The most common signs detected by owners included vaginal discharge, anorexia and lethargy. Main clinical findings on physical examination were vaginal discharge, abdominal distention and dehydration. During ultrasonographic examinations, the uteri in cats with pyometra appeared as hypoechoic and anechoic areas with linear and disordered tubular structures. Cats with pyometra were found to have normocytic, normocromic anaemia, leukocytosis, neutrophilia and thrombocytopaenia. In cats with pyometra, decreased ALT levels were recorded compared to the results from healthy cats. Increased parabasal cell density was detected in vaginal cytology. Histopathologic diagnosis of pyometra was classified as types III and IV and most of the ovaries had corpi lutea.
A clinico-pathological study on the effect of vincristine on transmissible venereal tumour in dogs
(Blackwell Publishing, 2005-09) Nak, Deniz; Nak, Yavuz; Cangül, I. Taci; Bilginer, Tuna; Uludağ Üniversitesi/Veteriner Fakültesi.; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; 0000-0003-0537-2113; AAB-4360-2021; AAH-5494-2021
Transmissible venereal tumour (TVT) is a coitally transmitted neoplasm of dogs and is common among sexually active dogs where sexual behaviour is not under control. Several treatment options are available for the treatment of the tumour, with chemotherapy being the most commonly employed. In this study, we investigated the clinical and cytological changes after weekly vincristine sulphate administration in 38 cases of naturally occurring TVT. Tumours totally regressed in 31 dogs after two to seven doses (mean 3.54 +/- 1.01) of vincristine. One dog died after the fifth dose of vincristine, and in six dogs, an additional treatment with doxorubicin was needed. Masses were still present in four dogs and the histopathological examination revealed small nodules of granulation tissue in two dogs, while viable tumour cells were identified in the remaining two cases. No recurrences were observed in a follow-up period of 7-49 months (mean 13.64 +/- 9.66); in one dog, granulation tissue was detected in the surgery site after 2 months. Treatment success could easily be followed by the cytological changes. In conclusion, vincristine was found to be effective chemotherapeutic agent.
Cloning of anatolian grey bull
(Csiro Publishing, 2009) Arat, Sezen; Taş, A.; Bağış, Haydar; Akkoç, Tolga; Çetinkaya, Gaye; Sağırkaya, Hakan; Nak, Yavuz; Nak, Deniz; Uludağ Üniversitesi/Veterinerlik Fakültesi/Doğum & Jinekoloji Anabilim Dalı.; AAH-5494-2021; AAH-8821-2021
Comparison of the use of cabergoline and gonadotrophin to treat primary and secondary anoestrus in bitches
(Wiley, 2012-05) Nak, Deniz; Nak, Yavuz; Şimşek, Gözde; Uludağ Üniversitesi/Veteriner Fakültesi/Doğum ve Jinekoloji Anabilim Dalı.; AAH-5494-2021; 9280090000; 8615464000; 26435497200
Objective To determine the efficacy and reliability of cabergoline and pregnant mare's serum gonadotrophin (PMSG) for induction of oestrus in bitches with primary or secondary anoestrus. Procedures We studied 39 healthy bitches of various breeds aged 2-6 years and in primary or secondary anoestrus: 20 bitches were administered 5 mg/kg/day cabergoline orally until day 2 after the onset of pro-oestrus or for a maximum of 42 days, and 19 bitches were administered 20 IU/kg/day PMSG intramuscularly for 5 consecutive days, followed by an additional single injection of 25 IU/kg of human chorionic gonadotrophin on the fifth day. Results The rates of oestrus induction in the primary and secondary anoestrous bitches treated with cabergoline and PMSG were found to be similar. Pregnancy and whelping rates in the cabergoline group were statistically different from the rates in the PMSG group (P < 0.001). Conclusion Cabergoline is more effective and reliable for the induction of a fertile oestrus in bitches with primary or secondary anoestrous.
Course and severity of postpartum metritis cases following antibiotic and PGF2α administration in postpartum metritis cows infected with BoHV-4
(Wiley, 2011-02) Bilge, Seval Dağalp; Alkan, Feray; Nak, Yavuz; Çetin, Cengiz; Nak, Deniz; Borum, Ebru; Tuna, Bilginer; Uludağ Üniversitesi/Veterinerlik Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; Uludağ Üniversitesi/Veterinerlik Fakültesi/Mikrobiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Keleş Meslek Yüksek Okulu/Hayvancılık ve Süt Ürünleri Bölümü.; 0000-0002-1166-721X; AAH-5494-2021; ABE-5581-2021; 8615464000; 7003489234; 9280090000; 36738850800; 9280090300
Forty cows between day 1 and day 21 post-calving were examined for the presence of postpartum metritis in a dairy herd that had recently experienced an increase in metritis and that had previously tested positive against bovine herpes virus 4 (BoHV-4) by various methods. Antibodies against BoHV-4 were detected in sera from 15 of 22 cows. For the virological study, uterine swab samples of 22 cows with metritis were used and tested for BoHV-4 using polymerase chain reaction (PCR), virus isolation (VI), and immunofluorescence techniques. Twenty-two point seven per cent (5/22) of the vaginal discharge samples obtained from cows with metritis were found positive for BoHV-4 DNA by PCR. All of these samples were also positive in VI and/or immune fluorescence assay (IF). Swab samples were also tested for bacteria. Empirical therapy with a broad spectrum antibiotic (oxytetracycline) was administrated, pending culture and antibiotic sensitivity result. All cows with puerperal metritis or clinical metritis (CM) were treated with intra-uterine (i.u.) administration of oxytetracycline and with intramuscular (i.m.) injections of dinoprost tromethamine (PGF(2)alpha) for three consecutive days. Concurrently, with the administration of oxytetracycline and PGF(2)alpha, cows with a rectal temperature >39.5 degrees C received an additional treatment with oxytetracycline (i.m) for three consecutive days. According to the antibiotic test result, on day 3 after the last oxytetracycline and PGF(2)alpha administrations, all cows were treated with a combination of amoxicillin and clavulanic acid (i.u.) for three consecutive days. All cows with metritis and that were positive for BoHV-4 recovered clinically after the administration of antibiotic and PGF(2)alpha. In conclusion, postpartum metritis cases in cows infected BoHV-4 recovered clinically following early diagnosis and prolonged treatments with a combination of antibiotics and PGF(2)alpha.
Diagnosis of various teat lesions in dairy cows by ultrasonography
(Indian Veterinary Journal, 2005-11) Nak, Deniz; Nak, Yavuz; Keskin, Abdulkadir; Uludaǧ Üniversitesi/Veterinerlik Fakültesi.; AAH-5494-2021; 9280090000; 8615464000; 24473229800
In this study, 62 teats obtained from slaughtered cows and 51 teats obtained from live cows were compared by ultrasonography and classic clinical examination methods. After examining by classic clinical examination methods, all teats were examined using B-mode ultrasound equipment, with a 5 MHz linear array transducer. When compared with classic clinical examination methods, ultrasonographic examination more readily detected stenosis, obstruction and other anomalies in all parts of the teats except for those in the ductus papillaris. Ultrasonographic examination was also beneficial for the determination of the shape and size of the stenosis, obstruction and other anomalies of the teats.
Diaphragmatic hernia of gravid uterus and right sided displacement of heart in a domestic short-haired cat
(Pakistan Agricultural Scientists Forum, 2016-04) Shahzad, Abid Hussain; Nak, Deniz; Çelimli, Nureddin; Karakaya, Ebru; Kurt, Hasan; Akbala, Melike; Güner, Biliana; Uludağ Üniversitesi/Veteriner Fakültesi/Jinekoloji Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; 0000-0003-4837-1858; FPJ-3706-2022; CHO-1373-2022; AIF-3815-2022; HXK-0999-2023; EJC-7120-2022; AAE-6146-2019; 9280090000; 8680328800; 36457784500; 56514876900; 56515472500; 57188841418
Present case report is about very rare condition of gravid uterus herniation into the thoracic cavity and right sided heart displacment in a three year old queen. Cat was presented to obstetrics and gynecology clinic with a history of overdue kittening date. Abdominal cavity was found to have an unusual solid mass in cranial part with little fluid oozing from vulva. Roentgenogram assesment revealed a fetus skeleton in abdomen with two similar skeletons in thoracic cavity and missing a normal diaphragmatic line. Similar findings were recorded on ultrasonography. Midline coeliotomy was done under general gas anesthesia. Diaphragmatic wall had 6 cm left-sided vertically oriented rent in the dorsal aspect with gravid uterine and a 2 cm right-sided vertically oriented in the middle of the diaphragm with liver lobe and gall bladder herniation. Three partially mummified fetuses were recovered. Both diaphragmatic tears were reduced and cat was neutered to avoid future complication. According to available data this is first atypical report in pet practice particularly in feline.
Doğum kliniğinde sık rastlanan tümör olguları 1. genital kanal tümörleri
(Uludağ Üniversitesi, 1994) Mısırlıoğlu, Deniz; Ünal, E. Fatih; Nak, Deniz; Nak, Yavuz; Özlem, Özmen; Uludağ Üniversitesi/Veteriner Fakültesi.
Bu çalışmada son yıllarda U. Ü. Veteriner Fakültesi Doğum ve Jinekoloji Kliniğine getirilençeşitli evcildişi hayvanlarda rastlanılan genital kanal tümörlerinin yapısal özellikleri ile, tür. yaş ve organlara göre dağılımları incelendi. Köpekler tümör oluşma insidansı açısından ilk sırada bulunurken, bu sırasıyla inek ve kısrak izledi. Genital kanal tümörleri içinde vaginal tümörler en sık gözlenirken, uterus, serviks ve vulva tümörüne daha az sayıda rastlandı. Vaginal tümör oluşumu için ortalama yaş köpeklerde 5.5, inekte ise 3.4 olarak saptandı.
Doğum kliniğinde sık rastlanan tümör olguları ll. meme tümörleri
(Uludağ Üniversitesi, 1994) Ünal, E. Fatih; Nak, Deniz; Mısırlıoğlu, Deniz; Kahraman, M. Müfit; Nak, Yavuz; Özmen, Özlem; Uludağ Üniversitesi/Veteriner Fakültesi.
Bu çalışmada son yıllarda U.Ü. Veteriner Fakültesi Doğum ve Jinekoloji Kliniğine getirilen çeşitli evcil dişi hayvanlarda rastlanılan meme tümörlerinin yapısal özellikleri ile, für ve yaşa göre dağılımları incelendi. Köpeklerdeki meme tümörü insidansı kedilerden daha fazla bulundu. Meme tümörlerinin görülme yaşı ortalama 9.75 olarak saptandı.
The efects of ovsynch, ovsynch with progestin and progestin plus double tai on pregnancy rates in unobserved oestrus dairy cows and heifers
(Kafkas Üniversitesi, 2011) Nak, Yavuz; Tuna, Bilginer; Nak, Deniz; Karakaş, Emin; Şimşek, Gözde; Uludağ Üniversitesi/Veterinerlik Fakültesi/Doğum & Jinekoloji Anabilim Dalı.; Uludağ Üniversitesi/Yenişehir İbrahim Orhan Meslek Yüksekokulu.; AAH-5494-2021; 8615464000; 9280090300; 9280090000; 12243636400; 26435497200
The objective of this study was to determine whether progestin (norgestomet) supplementation and double-timed artificial insemination (TAI) during the Ovsynch protocol enhances fertility in dairy cows and heifers when the state of oestrus was not determined. In group I (Ovsynch), cows (269), heifers (152) were treated with GnRH on day 0, PGF2 alpha on day 7, GnRH on day 9. TAI was performed approximately 16 h after the second GnRH. In group II (Ovsynch, norgestomet), cows (268) and heifers (152) were treated as in group I, but the implant was received at the time of first GnRH. All implants were removed at the time of the PGF2 alpha. Cows (268) and heifers (150) in group III were treated as in Group II, but a double TAI was performed. First TAI was administrated at the time of the second GnRH and the second TAI was administered approximately 18-20 h later. Cows (270) and heifers (153) detected as being in natural oestrus were used as untreated control animals. The use of the norgestomet implant at the same time as the Ovsynch protocol did not increase pregnancy rates in cows and heifers that were classified as cyclic or noncyclic before treatments began. Total pregnancy rates were significantly greater for group III heifers than for group I, II, control heifers and group III cows.
Effect of butylated hydroxytoluene on post-thawed semen quality of beetal goat buck, capra hircus
(Zoological Soc Pakistan, 2015-02-01) Iqbal, Z.; Ijaz, A.; Aleem, M.; Shahzad, A. H.; Sohail, M. U.; Nak, Deniz; Nak, Yavuz; Abbas, S.; NAK, DENİZ; NAK, YAVUZ; Uludağ Üniversitesi/Tıp Fakültesi/Doğum ve Jinekoloji Bölümü; AAH-5494-2021; FPJ-3706-2022
Present study was conducted to evaluate the effect butylated hydroxytoluene (BHT) on post-thawed semen quality of Beetal goat buck semen. Semen was obtained from six bucks using artificial vagina and cryopreserved in tris egg yolk extender and semen quality was assessed on the basis of post-thaw sperm motility, viability, plasma membrane integrity, and acrosomal membrane status. Ejaculates were pooled and extended to the concentration of 2 x 10(9) spermatozoa per mL in tris egg yolk extender (300 mOsmol/L). Tris egg yolk extender containing various concentrations of BHT (0.0, 2.0 and 5.0 mM) was prepared. French straws (0.5 mL) were manually filled with semen, gradually cooled from 39 degrees C to 4 degrees C and finally, cryopreserved in liquid nitrogen at -196 degrees C. Five straws from each treatment [BHT (0.0, 2.0 and 5.0 mM)] were thawed and evaluated under phase-contrast microscope (40 x) for sperm motility, whereas sperm viability, plasma membrane integrity and acrosomal integrity were assessed by the supravital staining, hypo-osmotic swelling test (HOST) and normal acrosomal reaction, respectively. The results showed that only acrosomal integrity was improved (P < 0.05) by the addition of BHT in semen extender. Motility was suppressed (P < 0.05) by increasing BHT concentration. The maximum motility of sperm was achieved with 0.0 mM BHT. The HOST response and viability of spermatozoa were increased by addition of 2 and 5 mM BHT, but this increment was not statistically significant. In conclusion, the addition of BHT to semen extender can partially improve semen quality of Beetal goat.
Effect of number of PGF₂α doses in 5-d CO-Synch progesterone-based synchronization protocol on fixed-time artificial insemination pregnancy rate in Holstein heifers in Cukurova Region in Turkey
(Wiley, 2016-10) Say, Eduardo; Çoban, S.; Kara, Uğur; Keser, Neslihan; Mutlu, Hasan; Nak, Yavuz; Nak, Deniz; Uludağ Üniversitesi/Veteriner Fakültesi/Jinekoloji Anabilim Dalı.; AAH-5494-2021; FPJ-3706-2022
The effects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specific for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor
(Scientific and Technological Research Council Turkey, 2014-02-03) Akşıt, Hasan Z.; Seyrek, Kamil; Özyiğit, Musa Özgür; Nak, Deniz; İnan, Sevda; Şimşek, Gözde; Nak, Yavuz; Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0001-8138-5851; 0000-0002-9634-0055; AAH-2873-2021; AAH-5494-2021; E-3364-2018; 6507338060; 9280090000; 56320836200; 26435497200; 8615464000
Vincristine sulfate is one of the most effective chemical agents used in canine transmissible venereal tumor (CTVT) chemotherapy. Its therapeutic effectiveness is pronounced and significant at the beginning of treatment. The present study was designed to investigate vincristine sulfate treatment and the relationship between CTVT tumor regression and apoptosis [estimated by TdT-mediated dUTP-biotin nick end labeling (TUNEL)], galectin-3 (H-160), Bcl-2 (N-9), and lectin [EEL (B-135), GSL I (L-1100), and RCA I (BA-0084)] expression using immunohistochemical staining in 20 bitches with naturally occurring CTVTs. Evaluation was semiquantitatively performed by HSCORE values using light microscopy All observed staining was intracytoplasmic and increased endothelial staining was noted with the Bcl-2 marker in tumor vessels. Apoptosis, TUNEL, and lectin scoring was higher in vincristine sulfate-treated tumors than in untreated tumors, while expression of antiapoptotic factors galectin-3 and Bcl-2 were lower in treated than in untreated CTVTs. These results show that galectin-3, Bcl-2, and lectins (EEL, GSL-1, and RCA-1) are suitable indicators/markers for CTVT tumor regression after treatment with vincristine sulfate.
Effects on reproductive parameters of cosynch, ovsynch and ovsynch plus cosynch administration in unobserved estrous cows and heifers
(British Cattle Veterinary, 2009-03) Karakaş, Emin; Nak, Yavuz; Nak, Deniz; Uludağ Üniversitesi/Yenişehir İbrahim Orhan Meslek Yüksekokulu.; Uludağ Üniversitesi/Veteriner Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; AAH-5494-2021; 12243636400; 8615464000; 9280090000
This study was carried out to compare effects on the pregnancy rates achieved by timed AI (TAI) of cosynch, ovsynch and cosynch+ovsynch protocols in lactating dairy cows (60 d postpartum) and heifers (16-18 m old) in which the state of estrus is not determined. In group I (cosynch) cows (n: 97) and heifers (n: 43) were treated with an intramuscular. injection of synthetic GnRH (10 mu g) on day 0.7 d after the GnRH injection they were given an i.m. injection of PGF(2)alpha (25 mg) and a second injection of GnR-H (10mg) 48 h after the PGF(2)alpha injection. All cows and heifers were served by TAI at the second GnRH injection. In group 11 (ovsynch) cows (n: 94) and heifers (n: 43) were treated as in group 1, but TAI was performed about 16 h after the second GnRH injection. In group III (cosynch+ovsynch) cows (n: 95) and heifers (n: 43) were treated as in group 11 and 1, but double TAI was performed. The first TAI was administered at the time of the second GnRH injection and the second TAI was administered about 18-20 h later. Pregnancy was diagnosed by rectal palpation after similar to 45 d following AI. Pregnancy rates for heifers in group III were significantly greater than in group 1. The pregnancy rate was numerically greater for cows in group 111, but it was not significantly different from those in group I and II. The effect of treatment on the total pregnancy rate was similar in all three treatment groups. However, the total pregnancy rate was higher in group III than in group I and II. Combining pregnancy results of all treatment groups, the pregnancy rate for heifers with a corpus luteum (CL) was significantly greater than without a CL. In summary, in dairy herds which have poor detection of estrus, in unobserved estrous dairy heifers treated with a GnRH-PGF(2)alpha-GnRH protocol and double TAI can achieve significantly greater pregnancy rates than those using the cosynch procedure. In addition, pregnancy rates in heifers can probably be improved by more careful time of the second AI.
Efficacy and toxicity of doxorubicin and cyclophosphamide for the neoadjuvant treatment of locally advanced stage canine mammary tumors
(Kafkas Univ, Veteriner Fakultesi Dergisi, 2020-11-01) Shahzad, Abid Hussain; Kuruoglu, Fikriye Ecem; Özyiğit, Musa Özgür; ÖZYİĞİT, MUSA ÖZGÜR; Nak, Deniz; NAK, DENİZ; Küpeli, Zehra Avcı; Ekici, Zeynep Merve; Koca, Davut; KOCA, DAVUT; Avcılar, Talha; Nak, Yavuz; NAK, YAVUZ; Sahin, Mustafa Eren; ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Doğum ve Jinekoloji Anabilim Dalı.; 0000-0002-6715-8529; 0000-0003-1853-4679; 0000-0002-7962-6959; 0000-0001-7034-9644; 0000-0002-8623-8292; AAH-5494-2021; AAH-2873-2021; AAI-6709-2021; AAR-6478-2021
The aim of this study was to investigate the effect and toxicity of a doxorubicin cyclophosphamide combination for neoadjuvant use in dogs with locally advanced mammary tumors. A total of 16 dogs with locally advanced mammary tumors aged 8-14 years was used in this study. Samples were taken from all the dogs via Tru-Cut biopsy and fine needle aspiration biopsy of the lymph nodes prior to neoadjuvant chemotherapy. The samples were sent to the pathology laboratory for histopathological examination. Based on the histopathology results, mammary tumors were diagnosed as adenocarcinoma (n=13), tubulopapillary carcinoma (n=2) and malignant mixed tumors (n=1). For the neoadjuvant chemotherapy, doxorubicin (25-30 mg/m(2)) and cyclophosphamide (100 mg/m(2)) were administered via slow IV injection 4 times at 3-week intervals. Clinical findings such as fever, vomiting, anorexia, lethargy, weight loss, alopecia, enteritis, hematuria, and skin ulceration and laboratory findings such as a decrease in neutropenia and hematocrit values were observed. Based on the longest diameter of the tumors before and after four weeks of chemotherapy, a complete response was detected in 2 dogs (12.5%), a partial response was observed in 9 dogs (56.25%) and the disease was stable in 5 dogs (31.25%). According to results, the toxicity, and efficacy of a doxorubicin and cyclophosphamide combination for neoadjuvant chemotherapy in dogs with locally advanced mammary tumors is acceptable, and the treatment is promising.
Evaluation of ovsynch and cidr plus ovsynch protocols to improve reproductive efficiency in lactating dairy cows
(Zoological Soc Pakistan, 2019-10-01) Shahzad, Abid Hussain; Sattar, Abdul; Ahmad, Nasim; Ahmad, Ijaz; Nak, Yavuz; NAK, YAVUZ; Nak, Deniz; NAK, DENİZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; 0000-0002-8623-8292; 0000-0002-8153-0075; 0000-0002-4280-6673; AAH-5494-2021
Appropriate postpartum reproductive management plays a vital role in dairy farm economics. Primary objective of the present study was to compare the efficiency of standard Ovsych protocol (OVP0) and its modified forms (OVP5 and OVP7) as postpartum reproductive management tools in cyclic dairy cows. In total, 167 Holstein cows were randomly divided into three treatment groups. The OVP0 group was comprised of 58 cows. Other two groups, OVP5 (n=55) and OVP7 (n=54), were similar to OVP0 except the intravaginal insertion of controlled internal drug release (CIDR) inserts for 5 or 7 days, respectively. Pregnancy was diagnosed using ultrasonography on d30, d60 and d90 post AI. Ovulatory follicle diameter was measured at timed AI and progesterone profile (ng/mL) on d30 and d60 post AI. Pregnancy rate was analyzed by Chi-square procedure while ovulatory follicle diameter and Progesterone profile by one way ANOVA (alpha=0.05). Ovulatory follicle diameter (Mean +/- SEM) was 15.19 +/- 0.17 (OVP0), 15.30 +/- 0.21 (OVP5) and 15.24 +/- 0.19 (OVP7), respectively. The P4 concentration has significant (P<0.05) difference among OVP0 (6.52 +/- 0.32), OVP5 (7.75 +/- 0.38) and OVP7 (7.58 +/- 0.26) on d30 post AI. This difference was non-significant (P > 0.05) on d60 post AI in OVP0 (6.37 +/- 0.49), OVP5 (6.75 +/- 0.36) and OVP7 (6.80 +/- 0.41), respectively. On d30 post AI, pregnancy rate was 39.70, 42.60 and 45.50% in OVP0, OVP5 and OVP7 groups, respectively (P=0.48). Corresponding pregnancy rate on d60 (P=0.39) and d90 (P=0.61) was 36.20, 32.80% in OVP0, 43.80, 41.80% in OVP5 and 37% in OVP7 group. Overall pregnancy loss was 17 (OVP0), 08 (OVP5) and 13% (OVP7), respectively (P=0.62). In conclusion, although pregnancy rate has non-significant difference among all three breeding protocols but numerically, improved pregnancy rate and reduced pregnancy loss was observed in OVP5 group.
Evaluation of ovulation synchronization protocols and alternative pregnancy diagnosis tools in lactating dairy cows
(Oxford Univ Press Inc, 2018) Shahzad, Abid; Abbas, A.; Khan, I.; Mughal, Zia; Nak, Deniz; Nak, Yavuz; Uludağ Üniversitesi/Veteriner Fakültesi/Havyan Hastanesi/Doğum ve Jinekoloji Anabilim Dalı.; AAH-5494-2021
Evaluation of some systemic inflammatory biomarkers in canine malignant mammary tumors [i]
(Kafkas Univ, Veteriner Fakultesi Dergisi, 2023-09-01) Koca, Davut; Ekici, Zeynep Merve; Özyiğit, Musa Özgür; ÖZYİĞİT, MUSA ÖZGÜR; Nak, Deniz; NAK, DENİZ; Avcı Küpeli, Zehra; Kuruoğlu, Fikriye Ecem; Avcılar, Talha; Gümüş, Oğulcan; Nak, Yavuz; NAK, YAVUZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0002-6715-8529; 0000-0002-7962-6959; 0000-0001-7034-9644
The aim of this study is to investigate whether neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), albumin-to-globulin ratio (AGR), and prognostic nutritional index (PNI) parameters could be used as biomarkers for canine malignant mammary tumors (MMTs), and the changes in these parameters according to different tumor (T), lymph node (N), and metastasis (M) stages (TNM I-II-III, TNM IV, TNM V) and the number of affected mammary glands (single, multiple). Thirty-seven with MMT and 20 healthy dogs were used in this study. Complete blood count and biochemistry analysis were performed in all dogs. Tumor material is removed by tru-cut and sent to the pathology laboratory for diagnosis. NLR, PLR, and SII values increased, and LMR and PNI values decreased in dogs with MMT. Median NLR values increased and median LMR and PNI values decreased as the TNM stage progressed. In dogs with a single MMT, median NLR, and PLR values were found to be lower than in dogs with multiple MMTs, and median LMR, SII, AGR, and PNI values were higher. The present results indicated that NLR, LMR, PLR, SII, and PNI parameters could be used as biomarkers for canine MMT. Also, NLR, LMR, PLR, SII, PNI, and AGR parameters may be valuable biomarkers that reveal the degree of systemic immune response according to different TNM stages and the number of affected mammary glands.
Evaluation of the renal function in bitches with pyometra
(Indian Veterinary Journal, 2004-07) Nak, Yavuz; Şentürk, Sezgin; Nak, Deniz; Çetin, Cengiz; Gölcü, Esin; Keskin, Abdülkadir; Uludağ Üniversitesi/Veteriner Fakültesi/Doğum ve Ji̇nekoloji̇ Anabi̇li̇m Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Mi̇krobi̇yoloji̇ Anabi̇li̇m Dalı.; 0000-0002-2465-9913; AAH-5069-2021; AAH-5494-2021; 8615464000; 56257771200; 9280090000; 7003489234; 6508125894; 24473229800
Pyometra is the accumulation of purulent material within the lumen of the uterus (Leib et al., 1997). It is regarded as one of the most common illnesses in bitches. Pyometra must be considered if depression, lethargy, anorexia and polyuria with poydipsia occur in the intact bitch (Borresen, 1980; Leib et al., loc. cit.) Renal failure and urinary tract infection may occur in bitch with pyometra (De Schepper et al., 1987: Stone et al., 1988, Leib et al., loc. cit.). The aim of this study was to investigate the link between renal failure and pyometra.