Browsing by Author "Reisli, İsmail"

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Anaphylaxis in Turkish children: A multi-centre, retrospective, case study
(Wiley, 2011-12) Orhan, Fazıl; Bakırtaş, Arzu; Yılmaz, Özge; Boz, Ayşen Bingöl; Can, Demet; Kuyucu, Semanur; Harmancı, Koray; Tahan, Fulya; Reisli, İsmail; Karakaş, Taner; Baki, Ali Erdem; Çokuğraş, Haluk; Çakır, Murat; Canıtez, Yakup; Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Alerji ve İmmünoloji Anabilim Dalı.; 8988954700
Background Anaphylaxis is a serious and potentially lethal systemic reaction affecting more than one organ or system. Objective We aimed to describe the demographic characteristics, clinical features, causes, settings, and administered therapy in Turkish children. Methods This retrospective, case note study included all children referred to the outpatient clinics of the Pediatric Allergy Departments of the participating study centres from 1 July 1999 to 30 June 2009 for investigation of anaphylaxis or who were seen by us at the moment of the reaction during the same period and who met the clinical criteria of anaphylaxis. Results Two hundred and twenty-four cases of anaphylaxis were reported in 137 children (88 boys, P = 0.0001). The mean +/- SD age at the referral was 7.7 +/- 4.2 years (range: 4 months-17 years). Ninety-eight episodes (43.8%) occurred at home. The symptoms were cutaneous in 222 (99.1%) episodes, respiratory in 217 (96.9%), neuro-psychiatric in 118 (52.7%), cardiovascular in 92 (41.1%), and gastrointestinal in 88 (39.3%). Biphasic reaction was reported in seven episodes (3.1%, 95% CI: 1.5-6.3). Death occurred in one case (0.4%, 95% CI: 0.08-2.4). Treatment was available in 158 episodes (70.5%). Of them, 148 (93.7%) received antihistamines, 132 (83.5%) corticosteroids, 51 (32.3%) epinephrine, and 17 (10.8%) beta-2-mimetics. The causative agents were foods in 86 (38.4%) episodes, hymenoptera venom in 84 (37.5%), drugs and medications in 47 (21.0%), and latex in 5 (2.2%). In two episodes (0.9%), the causative agent was unidentified. Allergy to the trigger was known prior to anaphylaxis in 116 (51.8%) episodes. An epinephrine autoinjector had been prescribed for 70 children (51.1%). Conclusions and Clinical Relevance Anaphylaxis was seen significantly more in boys. Most of the reactions occurred at home. Foods were the most frequent cause. Epinephrine, the first-line treatment of anaphylaxis, was administered in only a third of the children.
Awareness of allergy in Turkey
(Wiley, 2010-06) Kalpaklıoğlu, Ayşe Füsun; Kalkan, İlkay Koca; Akçay, Ahmet Oğuz; Reisli, İsmail; Can, Demet; Yüksel, Hasan; Kırmaz, Cengiz; Gülen, Figen; Ediger, Dane; Uludağ Üniversitesi/Tıp Fakültesi/İmmunoloji Anabilim Dalı.; AAE-9142-2019
Characteristics and prognosis of childhood atopic dermatitis: A multi-center study in Turkey
(Wiley, 2009) Yüksel, Hasan; Can, Demet; Reisli, İsmail; Uzuner, Nevin; Orhan, Fazıl; Cevit, Ömer; Tahan, Fulya; Kuyucu, Semanur; Boz, Bingol A.; Akçay, Ahmet Oğuz; Yılmaz, Özge; Canıtez, Yakup; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.
Characteristics and prognosis of childhood atopic dermatitis: A multicenter study in Turkey
(Karger, 2010) Yüksel, Hasan; Can, Demet; Reisli, İsmail; Uzuner, Nevin; Orhan, Fazıl; Cevit, Ömer; Tahan, Fulya; Kuyucu, Semanur; Bingöl, Ayşen Boz; Akçay, Ahmet; Yılmaz, Özge; Canıtez, Yakup; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 8988954700
Background: Childhood atopic dermatitis (AD) is classically accepted as initial finding of atopic march; however, non-atopic cases do not follow this course. The aim of this study was to determine the characteristics and prognosis of AD in childhood in Turkey. Methods: The study included 531 children with AD that presented to pediatric allergy departments in 11 different regions of Turkey. Age at diagnosis, total serum and inhalant-specific immunoglobulin E (IgE) levels and allergen skin prick test results were recorded retrospectively. Clinical characteristics like additional allergic diseases at presentation or during follow-up were recorded as well as duration of follow-up. Results: Mean age at diagnosis was 37.8 +/- 36.2 months. Mean IgE level was 318.3 +/- 677.8 IU/ml (median 100 IU/ml). Skin prick tests yielded positive results in 47% of children. At presentation, 31.6% of children reported additional allergic disease, while 11.7% developed allergic disease during follow-up. Among all, 46.6% had additional allergic disease at any point. IgE levels were significantly higher in children with additional allergic diseases (p = 0.001). Allergen skin prick test positivity and family history of allergic diseases increased the risk of additional allergic diseases significantly (OR = 3.90, 95% CI = 2.3-6.6 and OR = 1.89, 95% CI = 1.3-2.8, respectively). Conclusions: Allergic sensitization is not present in all cases of AD. Coexistence of additional allergic diseases is not as high as expected but more common in children who have been demonstrated to have atopic sensitization with high IgE levels and allergen skin prick test positivity.
Characterization of th17 and treg cells in leucocyte adhesion deficiency 1 patients
(Wiley, 2021-08-01) Erdem, Şerife; Haliloğlu, Yeşim; Haskaloğlu, Şule; Arık, Elif; Keskin, Özlem; Karadağ, Şefika İlknur Kokcu; Eltan, Sevgi Bilgiç; Yücel, Esra; Avcılar, Hüseyin; Yılmaz, Ebru; Ünal, Ekrem; Karakükcu, Musa; Çeliksoy, Mehmet Halil; Gültekin, Sara Şebnem Kılıç; Barış, Safa; Köker, Mustafa; Metin, Ayşe; Reisli, İsmail; Keleş, Sevgi; Doğu, Esin Figen; İkincioğulları, Aydan; Eken, Ahmet; KILIÇ GÜLTEKİN, SARA ŞEBNEM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Çocuk İmmunoloji Bilim Dalı.; CTB-3710-2022
Economic burden of primary immunodeficiency (PIDD) in Turkey
(Elsevier, 2016-11) Malhan, Simten; İkincioğulları, Aydan; Doğu, Figen; Kütükcüler, Necil; Reisli, İsmail; Tezcan, İbrahim; Güner, N. S.; Karaca, Neslihan; Öksüz, Ergün; Kılıç, Sara; Çekiç, Şükrü; Uludağ Üniversitesi/Tıp Fakültesinde/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0002-9574-1842; L-1933-2017; IDK-5744-2023
Inherited and acquired immunodeficiencies underlying tuberculosis in childhood
(Wiley, 2015-03-01) Boisson-Dupuis, Stephanie; Bustamante, Jacinta; El-Baghdadi, Jamila; Camcioglu, Yildiz; Parvaneh, Nima; El Azbaoui, Safaa; Agader, Aomar; Hassani, Amal; El Hafidi, Naima; Mrani, Nidal Alaoui; Jouhadi, Zineb; Ailal, Fatima; Najib, Jilali; Reisli, İsmail; Zamani, Adil; Yosunkaya, Sebnem; Gülle-Girit, Saniye; Yıldıran, Alişan; Cipe, Funda Erol; Torun, Selda Hançerli; Metin, Ayşe; Atıkan, Başak Yıldız; Hatipoğlu, Nevin; Aydoğmuş, Çiğdem; Kılıç, Sara Şebnem; Doğu, Figen; Karaca, Neslihan; Aksu, Güzide; Kütükcüler, Necil; Keser-Emiroğlu, Melike; Somer, Ayper; Tanır, Gönül; Aytekin, Caner; Adimi, Parisa; Mahdaviani, Seyed Alireza; Mamishi, Setareh; Bousfiha, Aziz; Sanal, Ozden; Mansouri, Davood; Casanova, Jean-Laurent; Abel, Laurent; KILIÇ GÜLTEKİN, SARA ŞEBNEM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik İmmünoloji Anabilim Dalı.; 0000-0001-8571-2581; AAH-1658-2021
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb) and a few related mycobacteria, is a devastating disease, killing more than a million individuals per year worldwide. However, its pathogenesis remains largely elusive, as only a small proportion of infected individuals develop clinical disease either during primary infection or during reactivation from latency or secondary infection. Subacute, hematogenous, and extrapulmonary disease tends to be more frequent in infants, children, and teenagers than in adults. Life-threatening primary TB of childhood can result from known acquired or inherited immunodeficiencies, although the vast majority of cases remain unexplained. We review here the conditions conferring a predisposition to childhood clinical diseases caused by mycobacteria, including not only M.tb but also weakly virulent mycobacteria, such as BCG vaccines and environmental mycobacteria. Infections with weakly virulent mycobacteria are much rarer than TB, but the inherited and acquired immunodeficiencies underlying these infections are much better known. Their study has also provided genetic and immunological insights into childhood TB, as illustrated by the discovery of single-gene inborn errors of IFN- immunity underlying severe cases of TB. Novel findings are expected from ongoing and future human genetic studies of childhood TB in countries that combine a high proportion of consanguineous marriages, a high incidence of TB, and an excellent clinical care, such as Iran, Morocco, and Turkey.
Perceptions of parents and physicians concerning the childhood asthma control test
(Taylor & Francis, 2012-10) Soyer, Özge Uysal; Öztürk, Fadıl; Keskin, Özlem; Asilsoy, Suna; Altınel, Nazan; Karaman, Özkan; Yazıcıoğlu, Mehtap; Zeyrek, Dost; Kuyucu, Semanur; Özmen, Serap; Reisli, İsmail; Aydoğan, Metin; Altıntaş, Derya Ufuk; Orhan, Fazıl; Yüksel, Hasan; Boz, Ayşen Bingöl; Gürkan, Fuat; Tahan, Fulya; Cevit, Ömer; Şekerel, Bülent Enis; Sapan, Nihat; Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Alerji ve İmmünoloji Ünitesi.; 6602156485
Background. The Childhood Asthma Control Test (C-ACT) has been proposed to be a simple, patient-based test that is able to reflect the multidimensional nature of asthma control. In this analysis, the aim was to evaluate the perceptions of physicians and caregivers concerning C-ACT and its predictive value for future asthma-related events. Method. In a multicenter prospective design, 368 children aged 4-11 years with asthma who were either well-or not well-controlled were included in the study. The study participants were evaluated during three visits made at 2-month intervals and the Turkish version of C-ACT was completed each month. Parents completed questionnaires concerning their perception of asthma (before and after the study) and the C-ACT (after the study). Physicians completed a survey about their perception of a control-based approach and the C-ACT. Results. The C-ACT scores increased from visit 1 to visit 3, with improvement seen in all domains of the test. At the end of the study period, the parents more strongly agreed that asthma could be controlled completely and that asthma attacks and nocturnal awakenings due to asthma were preventable (p < .05). Most of the parents reported that the C-ACT helped them to determine asthma treatment goals for their children and also that the C-ACT improved communication with their physicians. The physicians indicated that a control-centered approach was more convenient (95%) and simpler (94.5%) thana severity-centered approach and provided better disease control (93.4%). A higher C-ACT score was associated with a decreased risk of asthma attack and emergency department admittance in the 2 months following the administration of C-ACT. Conclusion. Our findings indicated that the C-ACT improved both parental outlook on asthma control and the communication between the physician and parents. There was a good correlation between the C-ACT score and the level of asthma control achieved, as described by the physician. Additionally the C-ACT score was predictive of future asthma-related events. These findings suggest that the C-ACT may have an important role in asthma management in the future.
Primary antibody deficiencies in Turkey: Molecular and clinical aspects
(Humana Press, 2021-09-30) Fırtına, Sinem; Ng, Yuk Yin; Ng, Özden H.; Kıykım, Ayça; Özek, Esra Yücel; Kara, Manolya; Aydıner, Elif; Nepesov, Serdar; Camcıoğlu, Yıldız; Sayar, Esra H.; Güngören, Ezgi Yalçın; Reisli, İsmail; Torun, Selda H.; Haskoloğlu, Şüle; Çoğurlu, Tuba; Kaya, Ayşenur; Çekiç, Şükrü; Barış, Safa; Özbek, Uğur; Özen, Ahmet; Sayitoğlu, Müge; ÇEKİÇ, ŞÜKRÜ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik İmmünoloji Anabilim Dalı.; 0000-0002-9574-1842; L-1933-2017
Primary antibody deficiencies (PAD) are the most common subtype of primary immunodeficiencies, characterized by increased susceptibility to infections and autoimmunity, allergy, or malignancy predisposition. PAD syndromes comprise of immune system genes highlighted the key role of B cell activation, proliferation, migration, somatic hypermutation, or isotype switching have a wide spectrum from agammaglobulinemia to selective Ig deficiency. In this study, we describe the molecular and the clinical aspects of fifty-two PAD patients. The most common symptoms of our cohort were upper and lower respiratory infections, bronchiectasis, diarrhea, and recurrent fever. Almost all patients (98%) had at least one of the symptoms like autoimmunity, lymphoproliferation, allergy, or gastrointestinal disease. A custom-made next-generation sequencing (NGS) panel, which contains 24 genes, was designed to identify well-known disease-causing variants in our cohort. We identified eight variants (15.4%) among 52 PAD patients. The variants mapped to BTK (n = 4), CD40L (n = 1), ICOS (n = 1), IGHM (n = 1), and TCF3 (n = 1) genes. Three novel variants were described in the BTK (p.G414W), ICOS (p.G60*), and IGHM (p.S19*) genes. We performed Sanger sequencing to validate pathogenic variants and check for allelic segregation in the family. Targeted NGS panel sequencing can be beneficial as a suitable diagnostic modality for diagnosing well-known monogenic PAD diseases (only 2-10% of PADs); however, screening only the coding regions of the genome may not be adequately powered to solve the pathogenesis of PAD in all cases. Deciphering the regulatory regions of the genome and better understanding the epigenetic modifications will elucidate the molecular basis of complex PADs.
What is the contribution of the childhood asthma control test to asthma care?
(Wiley, 2010-06) Soyer, Özge; Kılıç, Mehmet; Keskin, Özlem; Asilsoy, Suna; Altınel, Nazan; Karaman, Özkan; Yazıcıoğlu, Mehtap; Zeyrek, D.; Kotan, Çağlar; Özmen, Serap; Reisli, İsmail; Aydoğan, Metin; Altıntaş, Derya Ufuk; Orhan, Fazıl; Yüksel, Hasan; Boz, Bingöl A.; Gürkan, Fuat; Tahan, Fulya; Cevit, Ömer; Şekerel, Bülent Enis; Sapan, Nihat; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.