Browsing by Author "Tiryaki, Mehmet"
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Publication The evaluation of survivin and bcl-2 expression on the medical radiation doses for neural tube defect development(Türk Nöroloji Derneği, 2021-01-01) Adilay, Huseyin Utku; Katar, Salim; Güçlü, Bülent; Altun, Eren; Ozdek, Recep; Tiryaki, Mehmet; Bekar, Ahmet; Taşkapılıoğlu, Mevlüt Özgur; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0001-5472-9065; 0000-0001-9110-8364; 0000-0002-2646-1775; ITU-7284-2023; P-1338-2019; ABX-9081-2022AIM: To investigate the effects of different radiation doses on the development of the neural tube defect in chick embryos using computed tomography (CT), and assess its correlation with survivin and Bcl-2 expressions.MATERIAL and METHODS: A total of 150 chicken eggs were used and grouped into five categories. In Group 1 (n=30), the embryos were not exposed to radiation. In Group 2 (n=30), the embryos were irradiated using lung cancer screening chest CT protocol. In Groups 3 and 4 (n=30 each), the abdominopelvic and adult routine head CT protocols, respectively, were used to irradiate the embryos. In Group 5 (n=30), the embryos were irradiated using adult brain perfusion CT protocol. Subsequently, the embryos were examined under a stereomicroscope to assess the presence of neural tube developmental abnormalities. Moreover, immunohistochemical staining was performed to determine the survivin and Bcl-2 expression levels.RESULTS: The risk of developing neural tube defect increased with the amount of exposed radiation. Moreover, no significant correlation was observed between the survivin and Bcl-2 expression levels and the radiation dose.CONCLUSION: Overall, the results of this study indicate that the radiation from CT may cause neural tube defect in chicken embryos.