Browsing by Author "Udum, Duygu Küçükşen"
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Item Effect of starvation and feeding on the plasma cortisol, ghrelin and lipid metabolite concentrations in lambs(Medwell Online, 2013) Udum, Duygu Küçükşen; Tanrıverdi, Meltem; Uludağ Üniversitesi/Veterinerlik Fakültesi/Biyokimya Anabilim Dalı.; 0000-0001-7052-1694; AAH-5167-2021; 31967936400; 55387309300Ghrelin affects not only growth hormone secretion but also nutrient utilization and metabolic hormone secretion in humans and experimental animals. The mechanisms controlling ghrelin secretion during fasting and postprandial suppression are unknown in ruminant species. In this study, researchers aimed to determine the effects of starvation and feeding on the relationship of plasma ghrelin, cortisol concentrations and plasma lipid metabolites in lambs. The lambs were randomly assigned to the following 4 groups with 4 animals per group according to both the frequency of food administration and ghrelin treatment. In group I, animals were fed ad libitum; in the group II, animals were fed ad libitum and intravenously injected with the ghrelin. twice a week; in the group III, animals were fed once a day and in the group IV, animals were fed twice a day. Blood samples were collected 30 min before feeding and 60 min after feeding to be analyzed for plasma ghrelin and cortisol hormone levels. Ghrelin levels in the highest peak values reached 2, period of fed twice a day lambs and cortisol levels also showed high peak values in animals fed twice a day. As plasma lipid metabolites, fasting NEFA and phospholipids levels showed high values in. the same group. At the present study, suggest that the ghrelin may stimulate cortisol hormone as in vivo ans increase NEFA and phospholipids levels in ruminant species.Item Effects of peripheral ghrelin treatment and the associations between leptin and ghrelin in growing ram lambs(Medwell Online, 2013) Şen, Cem; Udum, Duygu Küçükşen; Tanrıverdi, Meltem; Üstüner, Takan; Uludağ Üniversitesi/Veterinerlik Fakültesi/Gıda Hijyeni ve Teknolojisi Bölümü.; Uludağ Üniversitesi/Veterinerlik Fakültesi/Hayvan Bilimleri Bölümü.; Uludağ Üniversitesi/Veterinerlik Fakültesi/Biyokimya Anabilim Dalı.; 0000-0002-4341-5842; 0000-0001-7052-1694; AAG-9127-2021; AAH-5167-2021; 55928022600; 31967936400; 55387309300; 55927528200Leptin an adipocytes-derived hormone is an important regulator of bodyweight and energy metabolism. Ghrelin another hormone, influences energy and could directly influence the deposition of fat. In this study, researchers aimed to investigate the effect of long term ghrelin treatment the relationships between leptin and ghrelin and leptin per carcass measurements in Awassi ram lambs. The lambs were randomly assigned to the following 4 groups with 4 animals per group according to both the frequency of food administration and ghrelin treatment: in group I, animals were fed ad libitum in the group II, animals were fed ad libitum and intravenously injected with the ghi-elin twice a week in the group III, animals were fed once a day and in the group IV, animals were fed twice a day. Blood samples were collected 30 min before feeding and 60 min after feeding to be analyzed for plasma ghrelin and leptin hormone levels. The study was completed using the slaughter weight (43 kg) which was determined when the Awassi lambs in each group were slaughtered after 12 h of fasting. These results suggest that in ruminant species, ghrelin levels are affected by long-term programmed meal feeding; however, the relationships between leptin and carcass weight and MILD measurements showed no significant differences.Item The effects of varying levels of dietary starch on reproductive traits in lactating dairy cows(TÜBİTAK, 2015-11-26) Keskin, Abdülkadir; Gençoğlu, Hıdır; Mecitoğlu, Gülnaz; Çetin, İsmail; Kara, Çağdaş; Udum, Duygu Küçükşen; Bilen, Ebru; Güner, Barış; Orman, Abdülkadir; Gümen, Ahmet; Uludağ Üniversitesi/Veteriner Fakültesi/Jinekoloji Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Hayvan Besleme ve Beslenme Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Biyokimya Anabilim Dalı.; 0000-0003-4837-1858; 0000-0003-2817-3221; 0000-0001-9138-4422; AIF-3815-2022; AAH-3831-2021; AGY-3496-2022; HJZ-4775-2023; AAH-1406-2021; AAG-4440-2019; AAG-9134-2021; 24473229800; 15753357900; 36457964000; 56707038100; 31967678500; 31967936400; 57040965000; 57188841418; 24335834100; 6602393069The aim of this study was to determine the effects of three different dietary starch levels on postpartum milk yield, blood metabolites, and reproductive traits in cows. A total of 23 primiparous Holstein-Friesian cows were fed three different diets including different starch levels on a dry matter basis from parturition until day 80. Cows were randomly assigned into the three groups according to the starch levels: low (LS, 16%, n = 7), medium (MS, 20%, n = 8), and high (HS, 24%, n = 8). Milk yields were recorded daily, and body condition score (BCS) was determined every week. Transrectal ultrasonography was performed, and blood samples were taken three times each week to determine reproductive traits and blood metabolites. Although the milk yield was greater in the LS group compared to the other groups, BCS and blood metabolites did not differ among the groups. The postpartum follicular patterns, times of first postpartum ovulation, and involution processes did not differ among the groups. In addition, the ovulatory follicle and corpus luteum sizes and the progesterone levels after induced estrus were numerically greater in HS than other groups. Thus, there were no effects of starch levels on postpartum reproductive traits.Item Intracerebroventricular injection of histamine induces the hypothalamic-pituitary-gonadal axis activation in male rats(Elsevier, 2018-11-15) Niaz, Nasir; Güvenç, Gökçen; Altınbaş, Burçin; Toker, Mehmed Berk; Aydın, Begüm; Udum, Duygu Küçükşen; Alçay, Selim; Gökçe, Elif; Üstüner, Burcu; Yalçın, Murat; Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Üreme ve Suni Tohumlama Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Biyokimya Anabilim Dalı.; 0000-0002-9534-736X; 0000-0002-7678-3289; 0000-0003-4033-9749; 0000-0002-5600-8162; AAR-6815-2021; IYS-2646-2023; ABA-6294-2020; A-2794-2014; AAC-4975-2022; AAG-6956-2021; AAG-7238-2021; 57060367600; 56529426800; 55356919300; 56780223500; 57194022849; 31967936400; 56099810300; 56779799700; 18937724600; 57192959734Brain histamine holds a key position in the regulation of behavioral states, biological rhythms, body weight, energy metabolism, thermoregulation, fluid balance, stress and reproduction in female animals. However, it is not clear whether central histamine exerts any effect on hypothalamic-pituitary-testicular in male rats and if so, the involvement of type of central histamine receptors. The current study was designed to determine the effect of centrally administrated histamine on plasma gonadotropin hormone-releasing hormone (GnRH), luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone level, and sperm parameters, and to show the mediation of the central histaminergic H1, H2 and H3/H4 receptors on histamine-evoked hormonal and sperm parameters' effects. Studies were performed in male Sprague-Dawley rats. A total of 50 or 100 nmol doses of histamine were injected intracerebroventricularly (icy). 100 nmol dose of histamine significantly caused increases in plasma GnRH, LH, FSH and testosterone levels of animals, but not 50 nmol dose of histamine. Moreover, central pretreatment with chlorpheniramine, histaminergic H1 receptor antagonist (100 nmol), ranitidine and histaminergic H2 receptor antagonist (100 nmol) completely prevented histamine evoked increase in plasma GnRH, LH, FSH and testosterone levels, while thioperamide, histaminergic H3/H4 receptor antagonist (100 nmol) pretreatment failed to reverse sex hormones responses to histamine. Both central histamine treatment alone and central histamine treatment after central histaminergic receptors antagonists' pretreatments did not alter any sperm parameters in rats. In conclusion, our findings show that centrally administered histamine increases plasma GnRH, LH, FSH and testosterone levels of conscious male rats without change any sperm parameters. Moreover, according to our findings, central histaminergic H1, and H2 receptors mediate these histamine-induced effects.Item Parturition induction in ewes by a progesterone receptor blocker, aglepristone, and subsequent neonatal survival: Preliminary results(Elsevier, 2016-08-14) Şeker, İbrahim; Rişvanlı, Ali; Demiral, Ömer Orkun; Wehrend, Axel; Özalp, R. Gözde; Yavuz, A.; Orman, Abdülkadir; Udum, Duygu Küçükşen; Uludağ Üniversitesi/Veteriner Fakültesi.; Uludağ Üniversitesi/Veteriner Fakültesi/Zootekni Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Biyokimya Anabilim Dalı.; 0000-0003-4694-6937; 0000-0001-9138-4422; AAE-3607-2019; AAG-9134-2021; 23985781000; 57191907999; 24335834100The clinical effects of aglepristone treatment to induce parturition in ewes and their newborns were reported. Three experimental groups were defined: group AG5 (n = 5), group AG10 (n = 5), and group CG (n = 5) in which ewes were injected twice with 5, 10 mg/kg of aglepristone, and saline solution of ewes, respectively. Different parameters associated with parturition in ewes and their newborns were investigated. Serum progesterone, oxytocin, and free and conjugated total estrogens were measured after treatments until parturition. No statistical difference was found from first aglepristone administration to onset of lambing between AG5 and AG10 (23.90 +/- 6.20, 40.00 +/- 6.71 hours). Parturition induction in two groups shortened the gestational length significantly compared with the control group (P = 0.003). Dystocia was observed in two ewes in group AG10. The placental weight showed statistically significant difference only between the AG10 and CG (P = 0.039), but no difference was observed in the placental expulsion period between the groups. Decrease in food consumption 24 to 36 hours after parturition in all ewes and skin necrosis in an ewe in group AG5 were observed. Progesterone concentration was significantly lower in AG5 than that in ewes in group AG10 and CG (P < 0.05). No difference was observed in concentrations of free total estrogens and oxytocin between groups. The body temperature of lambs was significantly different between AG10 and CG groups both right after (P = 0.011) and 12 hours after parturition (P = 0.014). The lambs in CG had the highest mean birth weight (4.29 +/- 0.28 kg), which was significantly different from the induced groups. No significant difference of blood pH and blood gases values between groups was identified both at birth and 12 hours after parturition for lambs. Significant differences could clearly be observed in total protein and blood urea nitrogen and total protein findings 12 hours after parturition (P < 0.05), whereas no difference was found in blood glucose, albumin, inorganic phosphor, triglyceride, or total cholesterol parameters. The results of this study show that the administration of aglepristone to induce parturition can precisely control lambing time without any side effects in either mothers or lambs.