Browsing by Author "Willke, Ayşe"
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Item HIV-1 transmitted drug resistance mutations in newly diagnosed antiretroviral-naive patients in Turkey(Mary Ann Liebert, 2016-01-01) Sayan, Murat; Sargın, Fatma; İnan, Dilara; Sevgi, Dilek Y.; Çelikbaş, Aysel K.; Yaşar, Kadriye; Kaptan, Figen; Kutlu, Selda; Fışgın, Nuriye T.; İnci, Ayşe; Ceran, Nurgül; Karaoğlan, İlkay; Çağatay, Atahan; Çelen, Mustafa K.; Koruk, Suda T.; Ceylan, Bahadir; Yıldırmak, Taner; Korten, Volkan; Willke, Ayşe; Akalın, Halis; Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları Anabilim Dalı.; AAU-8952-2020; 57207553671HIV-1 replication is rapid and highly error-prone. Transmission of a drug-resistant HIV-1 strain is possible and occurs within the HIV-1-infected population. In this study, we aimed to determine the prevalence of transmitted drug resistance mutations (TDRMs) in 1,306 newly diagnosed untreated HIV-1-infected patients from 21 cities across six regions of Turkey between 2010 and 2015. TDRMs were identified according to the criteria provided by the World Health Organization's 2009 list of surveillance drug resistance mutations. The HIV-1 TDRM prevalence was 10.1% (133/1,306) in Turkey. Primary drug resistance mutations (K65R, M184V) and thymidine analogue-associated mutations (TAMs) were evaluated together as nucleos(t)ide reverse transcriptase inhibitor (NRTI) mutations. NRTI TDRMs were found in 8.1% (107/1,306) of patients. However, TAMs were divided into three categories and M41L, L210W, and T215Y mutations were found for TAM1 in 97 (7.4%) patients, D67N, K70R, K219E/Q/N/R, T215F, and T215C/D/S mutations were detected for TAM2 in 52 (3.9%) patients, and M41L + K219N and M41L + T215C/D/S mutations were detected for the TAM1 + TAM2 profile in 22 (1.7%) patients, respectively. Nonnucleoside reverse transcriptase inhibitor-associated TDRMs were detected in 3.3% (44/1,306) of patients (L100I, K101E/P, K103N/S, V179F, Y188H/L/M, Y181I/C, and G190A/E/S) and TDRMs to protease inhibitors were detected in 2.3% (30/1,306) of patients (M46L, I50V, I54V, Q58E, L76V, V82A/C/L/T, N83D, I84V, and L90M). In conclusion, long-term and large-scale monitoring of regional levels of HIV-1 TDRMs informs treatment guidelines and provides feedback on the success of HIV-1 prevention and treatment efforts.Item A prospective, multi-center study: Factors related to the management of diabetic foot infections(Springer, 2012-09) Ertuğrul, Bülent M.; Öncül, Oral; Tülek, Necla; Willke, Ayşe; Saçar, Suzan; Tunçcan, Özlem Güzel; Kaya, Özlem; Öztürk, Bülent; Turhan, Özge; Yapar, Nur; Türe, Mevlüt; Akın, Fulya; Yılmaz, Emel; Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.; 22037135100The Turkish Association of Clinical Microbiology and Infectious Diseases, Diabetic Foot Infections Working Group conducted a prospective study to determine the factors affecting the outcomes of diabetic foot infections. A total of 96 patients were enrolled in the study. Microbiological assessment was performed in 86 patients. A total of 115 causative bacteria were isolated from 71 patients. The most frequently isolated bacterial species was Pseudomonas aeruginosa (n = 21, 18.3%). Among cases with bacterial growth, 37 patients (43%) were infected with 38 (33%) antibiotic-resistant bacteria. The mean (+/- SD) antibiotics cost was 2,220.42 (+/- 994.59) USD in cases infected with resistant bacteria, while it was 1,206.60 (+/- 1,160.6) USD in patients infected with susceptible bacteria (p < 0.001). According to the logistic regression analysis, the risk factors related to the growth of resistant bacteria were previous amputation (p = 0.018, OR = 7.229) and antibiotics administration within the last 30 days (p = 0.032, OR = 3.796); that related to the development of osteomyelitis was wound size > 4.5 cm(2) (p = 0.041, OR = 2.8); and that related to the failure of the treatment was the growth of resistant bacteria (p = 0.016, OR = 5.333). Diabetic foot osteomyelitis is usually a chronic infection and requires surgical therapy. Amputation is the accepted form of treatment for osteomyelitis. Limited limb-saving surgery and prolonged antibiotic therapy directed toward the definitive causative bacteria are most appropriate. This may decrease limb loss through amputations. As a result the infections caused by resistant bacteria may lead to a high cost of antibiotherapy, prolonged hospitalization duration, and failure of the treatment.Item Su kaynaklı küçük bir tularemi salgını(Ankara Mikrobiyoloji Derneği, 2008-01) Meriç, Meliha Koç; Sayan, Murat; Willke, Ayşe; Gedikoǧlu, Suna; Uludaǧ Üniversitesi/Tıp Fakültesi/Klinik Mikrobiyoloji ve Mikrobiyoloji Anabilim Dalı.; 6603407548Bu çalışmada 22 Ocak – 8 Mart 2005 tarihleri arasında Kocaeli ili, Karamürsel ilçesi Pazarköy köyünde saptanan küçük bir tularemi salgının incelenmesi ve alınan kontrol önlemlerinin sunulması amaçlanmıştır. Aynı köyden gelen iki hastaya orofarinjiyal tularemi tanısı konulmasının ardından, o bölgede saha taraması yapılmış, hastalar muayene edilmiş, hastalardan ve salgının kaynağı olabileceği düşülen pınar sularından örnekler alınmıştır. Boğaz sürüntüsü, lenf nodu aspiratları ve filtre edilen su örneklerinden kültür yapılmış, hastaların serum örneklerinde mikroaglütinasyon (MA) testi ile Francisella tularensis antikorları taranmıştır. Filtre edilmiş su örneklerinde gerçek zamanlı polimeraz zincir reaksiyonu (PCR) ile F.tularensis DNA’sı araştırılmıştır. Klinik özellikleri ve MA test sonuçlarına (≥1/80) dayanarak toplam 17 hastaya tularemi tanısı konulmuş; hastaların 16’sı orofarinjiyal, biri ülseroglandüler tularemi olarak tanımlanmıştır. Hastaların yaşları 27-80 yıl arasında değişmekte olup (ortalama yaş: 48±17 yıl), 10’u (%59) kadındır. En yaygın saptanan semptomlar halsizlik (%100), boyunda şişlik (%94) ve boğaz ağrısı (%88), en sık belirlenen klinik bulgu ise servikal lenfadenopati (%94) olmuştur. Yapılan kültürlerin hiçbirisinde F.tularensis üretilememiş, buna karşın pınar sularından alınan örneklerde gerçek zamanlı PCR ile F.tularensis DNA’sı gösterilmiştir. Hastalar streptomisin, doksisiklin ya da siprofloksasin ile tedavi edilmiş ve tümünde iyileşme saptanmıştır. Pınar sularının toplandığı deponun temizlenmesi ve suların klorlanması ile salgın kontrol altına alınmıştır.Item Transmitted antiretroviral drug resistance mutations in newly diagnosed HIV-1 positive patients in Turkey(John Wiley & Sons Ltd, 2014-11) Sayan, Murat; Sargın, Fatma; Dilara, İnan; Sevgi, Dilek Yıldız; Kocagül Çelikba, Aysel; Kart Yaşar, Kadriye; Kaptan, Figen; Kutlu, Selda; Fışgın Taşdelen, Nuriye; İnci, Ayşe; Ceran, Nurgül; Karaoğlan, İlkay; Çağatay, Atahan; Celen, Mustafa K.; Koruk, Suda Tekin; Ceylan, Bahadır; Yıldırmak, Taner; Korten, Volkan; Willke, Ayşe; Akalın, Halis; Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.