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Browsing by BUU Author "Abakay, Candan Demiroz"

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    A multicenter retrospective analysis of patients with nasopharyngeal carcinoma treated in imrt era from a nonendemic population: Turkish society for radiation oncology head and neck cancer group study (trod 01-001)
    (Wiley, 2023-02-28) Yıldırım, Halil Cumhur; Kupik, Gülnihan Eren; Mustafayev, Teuta Zoto; Berber, Tanju; Yavuz, Berrin; Çetinayak, Oğuz; Akagündüz, Özlem; Bıcakcı, Beyhan Ceylaner; Arslan, Süheyla Aytaç; Soykut, Ela Delikgöz; Gündoğ, Mete; Figen, Metin; Teke, Fatma; Canyılmaz, Emine; Birgi, Sümerya Duru; Düzova, Mürsel; Igdem, Şefik; Atasoy, Beste; Kaydihan, Nuri; Parvizi, Murtaza; Uslu, Gonca Hanedan; Sagınç, Halil; Akman, Fadime; Özyar, Enis; Abakay, Candan Demiroz; DEMİRÖZ ABAKAY, CANDAN; Tıp Fakültesi; Radyasyon Onkolojisi Ana Bilim Dalı; 0000-0001-5380-5898; AAH-3855-2021
    BackgroundWe aimed to evaluate patients with nasopharyngeal carcinoma (NPC) in a nonendemic population. MethodsIn a national, retrospective, multicenteric study, 563 patients treated with intensity modulated radiotherapy at 22 centers between 2015 and 2020 were analyzed. ResultsMedian age was 48 (9-83), age distribution was bimodal, 74.1% were male, and 78.7% were stage III-IVA. Keratinizing and undifferentiated carcinoma rates were 3.9% and 81.2%. Patients were treated with concomitant chemoradiotherapy (48.9%), or radiotherapy combined with induction chemotherapy (25%) or adjuvant chemotherapy (19.5%). After 34 (6-78) months follow-up, 8.2% locoregional and 8% distant relapse were observed. Three-year overall survival was 89.5% and was lower in patients with age >= 50, male sex, keratinizing histology, T4, N3 and advanced stage (III-IVA). ConclusionsPatients with NPC in Turkey have mixed clinical features of both east and west. Survival outcomes are comparable to other reported series; however, the rate of distant metastases seems to be lower.
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    Publication
    Transforming growth factor-β1 gene polymorphism as a potential risk factor in Turkish patients with laryngeal squamous cell carcinoma
    (Wolters Kluwer Medknow Publications, 2020-01-01) Abakay, Candan Demiroz; DEMİRÖZ ABAKAY, CANDAN; Pashazadeh, Mehrdad; Ardahanli, Elif; Oral, Haluk Barbaros; ORAL, HALUK BARBAROS; Tıp Fakültesi; Onkoloji Ana Bilim Dalı; 0000-0001-9103-6276; 0000-0003-0463-6818; K-7285-2012; AAH-3855-2021
    Introduction: Laryngeal cancer is the most common head-and-neck malignancies with more than 20% of all cases. The vast majority of tumors are squamous cell carcinoma (SCC). Several genes encoding different cytokines may play crucial roles in host susceptibility to cancer because cytokine production capacity varies among individuals and depends on cytokine gene polymorphisms. Materials and Methods: The association between cytokine gene polymorphisms with primary laryngeal SCC was investigated. DNA samples were obtained from a Turkish population of eighty patients with primary cancer and fifty healthy controls. Results: All genotyping (interferon-gamma, transforming growth factor-beta 1 [TGF-beta 1], tumor necrosis factor-alpha [TNF-alpha], interleukin [IL]-6, and IL-10) experiments were performed using polymerase chain reaction sequence-specific primers. When compared to the healthy controls, the frequencies of TGF-beta 1 codon 25 (rs1800471) GC genotype and 25 C allele were significantly more common in the patient group. Conclusions: These results suggest that TGF-beta 1 gene polymorphisms may affect host susceptibility to laryngeal cancer.