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Browsing by Department "Acil Tıp ve Travma Merkezi"

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    Effects of vitamin E and cimetidine on peritonitis-induced lipid peroxidation
    (Springer, 1997-11) Tuncel, Pınar; Gür, Esma Sürmen; Kaya, Ekrem; Özbek, Resul; Öztürk, Ercan; Tokyay, Rıfat; Tıp Fakültesi; Tıp Fakültesi; Tıp Fakültesi; Biyokimya Ana Bilim Dalı; Acil Tıp ve Travma Merkezi; Cerrahi Ana Bilim Dalı; 0000-0001-7377-9682; AAG-7327-2021; 7801598700; 7801407302; 7004568109; 6507218522; 36967322600; 7003296847
    To investigate the effects of acute fecal peritonitis on plasma and tissue lipid peroxidation and possible protective effects of vitamin E (Vit E) and cimetidine at 4 h in a rat peritonitis model, four groups were designated as: controls, peritonitis, Vit E and cimetidine. Plasma, liver, lung and kidney thiobarbituric acid reactive substances (TBARS) and conjugated diene (CD) levels were measured to monitor oxidative injury. The present fecal peritonitis model caused a significant elevation in liver TBARS; however, neither Vit E nor cimetidine was effective in preventing TBARS formation. Administration of Vit E and cimetidine caused significant decrements from the peritonitis value in liver and lung CD levels.
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    Publication
    Is it necessary to retrieve dropped gallstones during laparoscopic cholecystectomy?
    (Springer, 1997) Zorluoğlu, Abdullah; Özgüç, Halil; Yılmazlar, Tuncay; Güney, Nejat; Tıp Fakültesi; Tıp Fakültesi; Tıp Fakültesi; Çocuk Cerrahisi Ana Bilim Dalı; Acil Tıp ve Travma Merkezi; Cerrahi Ana Bilim Dalı
    Background: An experimental study was planned to evaluate the effect of bile alone and bile in combination with gallstones on intraperitoneal adhesion and abscess formation in the peritoneal cavity of the rat, Methods: One hundred Sprague-Dawley rats were assigned to ten groups (n: 10). Groups 1-3 received a 1-ml intraperitoneal injection of saline, sterile bile, and infected bile, Groups 4-10 underwent a lower 5-mm midline abdominal incision, In groups 5, 7, and 9, a single gallstone (3-mm diameter) was placed in the right upper quadrant and injected with sterile saline, sterile bile, and infected bile, respectively. In groups 6, 8, and 10, four gallstones (3-mm diameter) were placed in the right upper quadrant together with sterile saline, sterile bile, and infected bile, respectively, Group 4 only underwent a 5-mm midline incision, All animals were sacrificed at the end of 4 weeks and the peritoneal cavity was carefully examined to investigate adhesions and abscess formation, The adhesions were graded according to Nair's gross pathologic grading of adhesions. The Kruskal-Wallis nonparametric test (KW) was used for statistical analysis. Results: No intraabdominal lesions were noted in groups 1-3, The adhesion score was increased by number of scene and infected bile (G4: 3, G5: 3, 66: 11, G7: 7, G8: 10, G9: 15, G10: 18), But there was only a significant difference between the groups that received sterile saline + single stone (G5) and that receiving infected bile + four stones (G10) (KW: 24.3 P < 0.05), There was abscess formation in three rats in group 9 and two in group 10, Conclusions: In conclusion, infected bile in combination with multiple stones increases the gross grading of adhesion and intraabdominal abscess formation, Thus, in cases with multiple stones and infected bile, the dropped stones should be retrieved and the peritonial cavity should be copiously irrigated during laparoscopic cholecystectomy.