Person: BOSTAN, ÖZLEM MEHTAP
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BOSTAN
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ÖZLEM MEHTAP
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Publication The frequency of asymptomatic urinary system abnormalities in children detected with cineurography imaging during angiocardiography(Cambridge Univ Press, 2019-02-01) Oral, Orçun; Toprak, Muhammet Hamza Hata; Uysal, Fahrettin; Bostan, Özlem Mehtap; Çil, Ergün; Toprak, Muhammet Hamza Hata; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; ÇİL, ERGÜN; Bursa Uludağ Üniversitesi; 0000-0001-7707-2174; 0000-0003-3516-0082; AAG-9324-2021; AAH-4421-2021; AAG-8558-2021; AAH-3865-2021; ECM-4447-2022Introduction: Diagnostic and interventional catheter angiography of the heart is frequently used in paediatric cardiology. It is also possible to detect urinary system anomalies with cineurography images that may be obtained during angiocardiography. In this study, the aim was to determine the frequency, distribution, and properties of urinary system anomalies accompanying heart diseases, and to find out the effectiveness of cineurographic images in detecting the urinary system anomalies. Methods: The cineurographic images of 2022 children who had undergone angiocardiography between 1995 and 2015 were retrospectively examined. Results: Urinary system anomalies were detected in 261 of the 2022 cases (12.9%). Of these 261 cases, 148 were males (56.7%), whereas 113 were females (43.3%). Among the heart diseases, the group most accompanied by urinary system anomalies was the non-cyanotic left-to-right shunted heart diseases, which was detected in 120 (39.1%) patients. Pelvicalyceal ectasia was the most common urinary system anomaly encountered and was detected in 89 patients (34.1%). Of the urinary system anomalies cases, 94 detected by cineurography were determined to be clinically severe. When the effectiveness of the cineurography was evaluated using the ultrasonography records of the patients, it was found to have 63.8% accuracy. Conclusion: Many of the patients with CHDs concomitantly have urinary system anomalies. It is possible to determine asymptomatic urinary system anomalies using cineurographic imaging during angiocardiography. This may lead to earlier treatments and improved prognosis for the patients, thus making it possible to prevent potential future problems.Publication The role of external loop recorders in arrhythmia-related symptoms in children: A single center experience(Springer, 2021-08-13) Akça, Tuğberk; Uysal, Fahrettin; Bostan, Özlem Mehtap; Genç, Abdusselam; Türkmen, Hasan; AKÇA, TUĞBERK; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; GENÇ, ABDÜSSELAM; TÜRKMEN, HASAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Kardiyoloji Bölümü; 0000-0001-7707-2174; 0000-0002-2747-974X; AEX-4557-2022; AAH-4421-2021; AAG-8558-2021; CQK-7120-2022; JKC-8556-2023In this study, we report our experience with the use of external loop recorders (ELRs), in terms of diagnostic efficiency according to symptoms and symptom-rhythm correlation in pediatric patients. We evaluated ELRs applied to 178 patients between April 2017 and November 2020 at our center. The mean age of 172 patients included in the study was 13.6 +/- 3.8 years, and 69.8% were female. ELR indications were palpitations in 98 (56.9%) cases, chest pain and palpitations in 43 (25%) cases, presyncope/syncope in 28 (16.2%) cases, and pacemaker/ implantable cardioverter-defibrillator (ICD) problems in 3 (0.2%) cases. ELR recording times were 14.2 +/- 9.7 days on average, ranging from 2 to 67 days. While the symptom-rhythm correlation was 29.1% in total, when the indications were evaluated one by one, this correlation was found to be 30.2% in palpitations, 34.7% in chest pain and palpitations, and 10.7% in presyncope/syncope. The total diagnostic efficiency was 68.1%. In the follow-up of ELR cases, a total of 139 (80.8%) patients received clinical follow-up without medication, 15 (8.8%) patients received medical treatment, and 18 (10.4%) patients underwent EPS. The cardiac ELR system is useful in detecting underlying arrhythmias. Demonstrating sinus tachycardia at the time of the symptom may be seen as negative finding, but while experiencing symptoms, it is diagnostically valuable and may help avoid further investigation with costly and invasive diagnostic procedures. For diagnostic efficiency and cost effectiveness, the optimal recording time is 2 weeks, but it should be extended to 4 weeks in cases such as of presyncope/syncope that cannot be explained with a 2-week ELR use.Publication Evaluation of six cases with alcapa syndrome: A rare but treatable cause of dilated cardiomyopathy(Bursa Uludag Univ, 2020-12-01) Özcan, Nur; Kızılkaya, Metehan; Akça, Tuğberk; Bostan, Özlem Mehtap; BOSTAN, ÖZLEM MEHTAP; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.INTRODUCTION: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital cardiac anomaly that can be cured with surgical treatment. It accounts for 0.25 to 0.5% of all congenital heart diseases. ALCAPA is generally asymptomatic in the neonatal period. Dilated cardiomyopathy (DCM) and mitral valve insufficiency (MVI) are detected in patients with symptoms of heart failure. ALCAPA, which is a rare cause of DCM, early surgical treatment provides quite good prognosis in the first year of life. However, mortality is high in patients who do not receive surgical treatment.MATERIALS and METHODS: Six patients diagnosed with DCM at our clinic between January, 2005 and December, 2017 and detected with ALCAPA syndrome in their etiological assessment we re-evaluated retrospectivelyRESULTS: Of the 6 patients, 5 were female and 1 was male. The average age of diagnosis was 4,75 months. All patients had the signs and symptoms of heart failure at admission. All cases had the signs of ischemia in the chest leads, D1 and aVL in the electrocardiograms (ECGs). In allcases, echocardiography (ECHO) showed mitral insufficiency and the dilation of the left ventricle and the mean ejection fraction was 29,3% (18-39%), and the mean shortening fraction was 12,6% (8-19%) in the ECHOs. Diagnostic catheter angiography was performed for all patients and the diagnosis of ALCAPA was confirmed. All patients under went correction surgery with there implantation method. Four of the patients completely recovered after surgery. One patient died 5 days after the surgery. One patient is being followed up with medical treatment since there was no improvement in her cardiac functions after surgery.CONCLUSIONS: The ALCAPA syndrome should definitely be considered in the etiology of cases diagnosed with dilated cardiomyopathy and it should be kept in mind that ALCAPA is completely treatable disease with early diagnosis and treatment.Publication Horseshoe lung associated with scimitar syndrome(Bmj Publishing Group, 2019-08-01) Gönen, Korcan Aysun; Canıtez, Yakup; CANITEZ, YAKUP; Bostan, Özlem Mehtap; BOSTAN, ÖZLEM MEHTAP; Yazıcı, Zeynep; YAZICI, ZEYNEP; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; 0000-0001-7707-2174; AAH-1789-2021Horseshoe lung is a rare congenital anomaly and mostly accompanied by scimitar syndrome. Most aspects of this complex anomaly can be demonstrated via multidetector CT (MDCT). We present two baby girls who had horseshoe lung associated with right lung hypoplasia and scimitar vein. The chest roentgenograms showed displacement of the heart and mediastinum to the right with smaller right lung. Echocardiography revealed dextroposition, secundum atrial septal defect and bilateral slight peripheral pulmonary stenosis in the first case and dextroposition, severe pulmonary hypertension, secundum atrial septal defect and tricuspid regurgitation in the other one. On thoracic MDCT, the right lung and pulmonary artery were hypoplastic with cardiomediastinal shift to the right. There was an abnormal right pulmonary vein draining into the inferior vena cava on the lower zone of the right lung (scimitar vein). The posterobasal portions of the both lungs were fused through a midline isthmus behind the heart.Publication Complete atrioventricular block as a complication of varicella infection in a child: Recovery with a single dose of intravenous immunoglobulin therapy(Sage Publications, 2016-06-01) Uysal, Fahrettin; Bostan, Özlem Mehtap; Çetin, Benhur; Uysal, Berfin; Güney, Begüm; Çil, Ergün; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; Çetin, Benhur; Güney, Begüm; ÇİL, ERGÜN; Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0001-7707-2174; 0000-0002-8470-4907; 0000-0003-3516-0082; AAH-3865-2021; AAG-8558-2021; AAG-9324-2021; AAH-4421-2021; H-2691-2017Publication A rare anomaly: Recurrent congenital aorto-azygos fistula after two procedure of transcatheter occlusion(Springer, 2015-10-01) Uysal, Fahrettin; Bostan, Özlem Mehtap; Çil, Ergün; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; ÇİL, ERGÜN; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Kardiyoloji Anabilim Dalı; 0000-0001-7707-2174; 0000-0003-3516-0082; AAH-3865-2021; AAH-4421-2021; AAG-9324-2021; AAG-8558-2021Publication Evaluation of the endocrine functions in pediatric patients with cyanotic congenital heart disease(Scientific Publishers India, 2013-01-01) Eren, Erdal; Çakır, Esra Deniz Papatya; Bostan, Özlem; Sağlam, Halil; Tarım, Ömer; EREN, ERDAL; Çakır, Esra Deniz Papatya; BOSTAN, ÖZLEM MEHTAP; SAĞLAM, HALİL; TARIM, ÖMER FARUK; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Çocuk Endokrinolojisi Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Çocuk Kardiyoloji Bilim Dalı.; 0000-0002-1684-1053; 0000-0003-4664-7435; 0000-0001-7707-2174; 0000-0002-6598-8262; 0000-0002-5322-5508; GQO-9634-2022; AAG-8558-2021; JPK-3909-2023; C-7392-2019; GLN-8241-2022; CCU-8073-2022Our aim was to investigate effects of chronic hypoxia on endocrine function in pediatric patients with cyanotic congenital heart disease (CHD). Thirty patients with cyanotic CHD (16 boys, 14 girls), and 35 control subjects (22 boys, 13 girls) were enrolled. Age means of patients and controls were 4.37 +/- 4.51 and 4.28 +/- 4.96 years, respectively. Standard deviation scores (SDS) of height and weight were significantly lower among patients compared to controls. Mean fasting glucose levels were 75 +/- 15 mg/dL and 83 +/- 12 mg/dL among patients and controls, respectively (p=0.033). Insulin-like growth factor (IGF) 1 and its SDS were significantly lower among patients (p=0.010). There was no significant difference in ACTH and cortisol levels between groups. ACTH levels were very low in six patients. Oxygen saturation level was positively correlated with ACTH (p=0.041, r=0.439) and negatively correlated with HOMA-IR (p=0.046, r=-0.420) and insulin (p=0.017, r=-0.494). There was no difference in insulin resistance between groups. Chronic hypoxia has negative impact on growth by reducing IGF-1 along with the nutritional deficiency in children with cyanotic CHD. ACTH-adrenal axis is also affected. While cyanotic CHD has decreased serum glucose level, it had no effect on insulin level and insulin resistance. Negative correlations between oxygen saturation, and HOMA-IR, fasting insulin levels, have suggested that these patients should be monitorized for insulin resistance.Publication Ventricular extrasystole in children: Single-center experience(Aves, 2023-07-01) Uysal, Fahrettin; Özalp, Şule; Genç, Abduesselam; Akca, Tugberk; Türkmen, Hasan; Bostan, Özlem M.; UYSAL, FAHRETTİN; Özalp, Şule; Genç, Abduesselam; TÜRKMEN, HASAN; BOSTAN, ÖZLEM MEHTAP; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Kardiyoloji Anabilim Dalı.; AAH-4421-2021; JAQ-0729-2023; JAV-5863-2023; EBR-6819-2022; JAT-4036-2023Objective: Ventricular extrasystole is one of the most common rhythm disorders in children, and almost all of them are characterized by normal cardiac functions without structural cardiac abnormalities. The aim of this study was to assess the clinical course of ventricular extrasystole in children who did not have cardiac structural abnormalities.Materials and Methods: This retrospective study analyzed 24-hour rhythm Holter recordings performed in our clinic in children. Patients diagnosed with isolated ventricular extrasystole in Holter records and without structural heart disease on echocardiography were included in the evaluation.Results: A total of 20 160 Holter results were evaluated in the study, and 226 patients (male; 66%) met the criteria. The mean follow-up time was 8.7 & PLUSMN; 3.2 years. While 81.8% of the patients were asymptomatic, the most common symptom was palpitation and 5 patients had syncope. Of the patients, 72 (31.8%) received medical therapy. Beta-blockers were the most often prescribed medication. Cardiomyopathy did not develop in any of the patients during the followup period. A partial reduction in the frequency of ventricular extrasystole was observed in 42% of the patients, while complete recovery was observed in 22%.Conclusion: Ventricular extrasystole in children generally has a good prognosis; most of them are asymptomatic, and the rates of spontaneous regression over time are quite high, regardless of the origin.Publication Cardiac involvement in costello syndrome: Evaluation of six cases(Galenos Yayıncılık, 2013-08-01) Uysal, Fahrettin; Bostan, Özlem Mehtap; Semizel, Evren; Akaltun, Filiz; Üner, Gülcan; Çil, Ergün; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; Akaltun, Filiz; Üner, Gülcan; ÇİL, ERGÜN; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı Anabilim Dalı.; 0000-0001-7707-2174; 0000-0003-3516-0082; CCJ-6951-2022; AAG-8558-2021; AAH-4421-2021; AAG-9324-2021; GHF-4123-2022Introduction: Costello syndrome is probably an autosomal dominant inherited disorder that is characterized by postnatal growth retardation, developmental delay, coarse facies, loose skin, nonprogressive cardiomyopathy and friendly behavior. The aim of this study was to evaluate a variety of clinical findings and cardiac involvement of six patients diagnosed as Costello syndrome.Materials and Methods: Six cases that had a typical features of Costello syndrome admitted to pediatric cardiology department due to cardiac murmur between 2002-2013 years were evaluated. Their complaints, clinical findings, treatments and clinical courses were examined.Results: Three of the patients were male and the mean age of patients was 34 +/- 12 months (7 months to 11 years). All of the cases had coarse faces, deep palmar and plantar creases, hypertelorism, epicanthal folds, depressed nasal bridges and cardiac murmur at auscultation. Congenital heart disease was found in all patients. Five patients had pulmonary stenosis and balloon pulmonary valvuloplasty was performed in 3 of these patients. Atrial septal defect was detected in 3 patients and 1 of the patient had hypertrophic cardiomyopathy. Mental retardation was found in 2 patients.Conclusions: Costello syndrome must be keep in mind in all patients with psychomotor retardation, coarse faces, sparse hairs, deep palmar and plantar creases, phenotypical features resembling a storage disease especially in association with pulmonary stenosis and hypertrophic cardiomyopathy.Publication The retrospective analysis of fetal echocardiograpy results at the uludag university hospital(Galenos Yayincilik, 2007-12-01) Kimya, Yalçın; Bostan, Özlem Mehtap; BOSTAN, ÖZLEM MEHTAP; Alyamaç, Funda Akpınar; Özdil, Murat; Bayram, Feyza; Çelik, Nurhan; Cengiz, Candan; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; 0000-0003-1735-6997Objective: In this study indications, findings and results of fetal echocardiography performed in our department were evaluated.Materials and Methods: The records of fetal echocardiography findings, pregnancy and postpartum period were retrospectively evaluated in 208 patients and had fetal echocardiography who were in high risk for congenital heart diseases, in our department between May 2003-January 2007.Results: The mean age of 208 patients was 21,8 and mean gestational age 25 weeks and 3 days. The two most common indications for fetal echocardiography were congenital heart: disease in the family and suspicion of cardiac anomaly during routine ultrasonogrraphy; 88/208 (42.3%) and 43/208 (20.7%); respectively. Incidence of abnormal findings in fetal echocardiographic examination was 26.9% (56/208). While congenital heart disease ratio in patients with family history of congenital heart disease was 4.6% (4/88), it was 74.4% (32/43) in patients with suspicion of cardiac. anomaly during routine ultrasonography.Discussion: The most common request for fetal echocardiography was presence of congenital heart disease in the family. Routine prenatal ultrasonography has the most important role in detection of cardiac anomalies.