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SAĞDİLEK, ENGİN

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SAĞDİLEK

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ENGİN

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2015 - 20192
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    Publication
    Cytidine 5′-diphosphocholine differentially affects hemostatic parameters in diverse conditions in rats: An investigation via thromboelastography
    (Lippincott Williams & Wilkins, 2015-04-01) Çam, Betül; Sağdilek, Engin; Yıldırım, Nalan; Savcı, Vahide; Çam, Betül; SAĞDİLEK, ENGİN; Yıldırım, Nalan; SAVCI, VAHİDE; Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyofizik Anabilim Dalı.; 0000-0001-8696-4035; KHD-9454-2024; AAH-4397-2021; CGO-3719-2022; GIK-1812-2022
    Cytidine 5'-diphosphocholine (CDP-choline) has several physiological and pharmacological effects on various bodily functions, including hemostasis. This study determined the impact of CDP-choline on hemostasis in a trauma-hemorrhage (T-H) model in rats or under in vitro conditions or after chronic treatment via thromboelastography. Trauma-hemorrhage resuscitation was induced, and either saline (1 mL/kg) or CDP-choline (50 mg/kg) was injected intravenously just prior to resuscitation in the T-H group and at the same time point in the sham-control group. The effects of CDP-choline on thromboelastogram parameters, coagulation markers, and platelet aggregation were investigated under in vitro conditions (1.5 mM, 30- or 3-min incubation in blood or plasma) and after chronic use (50 mg/kg, i.p., 10 days). Acute CDP-choline treatment was shown to decrease the initial and maximum clot formation time, accelerate clotting rapidity, reduce the lysis percentage, and increase the coagulation index in the T-H resuscitation group, whereas the same treatment in the sham-control rats did not alter any of the thromboelastogram parameters. However, the incubation of whole blood with CDP-choline prolonged the initial and maximum clot formation time, and CDP-choline treatment significantly decreased the slopes of the disaggregation and aggregation curves when platelets were stimulated with ADP and collagen, respectively. Interestingly, the chronic use of this drug did not influence any of these hemostatic parameters. These data implicate that acute but not chronic CDP-choline administration may differentially alter the hemostatic parameters under diverse conditions. The drug may produce a hypercoagulable state in activated situations but cause opposite effects under normal in vitro conditions.
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    Publication
    Instruction-based selective action pattern (IBSAP): A novel method for talent identification in sports
    (Iermakov S S, 2019-01-01) Sağdilek, E.; Sahin, S. K.; SAĞDİLEK, ENGİN; Şahin, Şengül K.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyofizik Anabilim Dalı; Bursa Uludağ Üniversitesi/Spor Bilimleri Fakültesi/Sporda Antrenörlük Eğitimi Bölümü; 0000-0001-8696-4035; 0000-0002-5670-7166; AAH-4397-2021; AAI-2398-2019
    Purpose: Talent identification/development programs are utilized by sports federations to select or train elite athletes. In addition to the established tests that assess perceptive and motor skills, it was deemed significant that cognitive skills should be evaluated as well. The present study was undertaken to assess the utility of Instruction-Based Selective Action Pattern (IBSAP), a novel method that we developed, in estimating perceptive, motor as well as cognitive skills of athletes in order for talent identification. We also investigated the relationship between IBSAP and auditory reaction times (ARTs).Material: Forty-three students (average age: 12.6 years) participated in the study. Random/fixed-interval ARTs were recorded. IBSAP was applied using a table tennis robot that was set up to throw 30 balls in three different colors to different spots on the table with a frequency of 1 ball/s. The subjects were instructed to ignore the white balls, to touch the yellow balls, and to catch the pink balls before the first trial and their scores were calculated in two consecutive trials according to a scoring system.Results: Our results showed that motor learning, adaptation and reinforcement of the participants were significantly greater in second trial compared with the first trial and that IBSAP values were correlated with ARTs.Conclusions: We conclude that the IBSAP method reliably provides quantitative data on perception, motor as well as cognitive skills and it can be considered as a useful tool for talent identification.