Person: YERCİ, ÖMER
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Publication P53 expression in patients with nasopharyngeal cancer(Elsevier Ireland Ltd, 2008-09-01) DEMİRÖZ ABAKAY, CANDAN; Özkan, L.; Saraydaroglu, Özlem; SARAYDAROĞLU, ÖZLEM; Yerci, Ömer; YERCİ, ÖMER; Tıp Fakültesi; Patoloji Ana Bilim Dalı; AAH-3847-2021; AAH-9701-2021Publication Thymic tumors and outcomes after radiotherapy(Kare Yayın, 2013-01-01) Sarıhan, Süreyya; Bayram, Ahmet Sami; Gebitekin, Cengiz; Yerci, Ömer; Özkan, Lütfi; SARIHAN, SÜREYYA; BAYRAM, AHMET SAMİ; GEBİTEKİN, CENGİZ; YERCİ, ÖMER; Özkan, Lütfi; Tıp Fakültesi; Göğüs Cerrahisi Ana Bilim Dalı; 0000-0003-4816-5798; 0000-0003-0684-0900; AAE-1069-2022; ABB-7580-2020; AAH-4970-2021; EIS-5114-2022; JGQ-9310-2023OBJECTIVESWe evaluated the results of treatment in patients with thymic tumors treated with postoperative adjuvant radiotherapy.METHODSEighteen patients were treated median 5400 cGy radiotherapy between 1995-2010. Diagnosis of patients were thymoma (n=10), thymic carcinoma (n=7), thymic neuroendocrin carcinoma (n=1). RO resection was made on 12 of them. According to prognostic stratification with Masaoka stage and WHO classification, there were 5 good, 7 moderate, and 6 poor risk patients. Survival was calculated from diagnosis.RESULTSA total of 33% patients were recurred median 29.5 months with 34 months follow-up. Local control, median overall and disease-free survival for all patients were 77%, 113 months, and 105 months. Local control for good, moderate, poor risk groups were found 100%, 71%, 50%. There were significant differences survival rates for Masaoka stage, RO resection, and prognostic groups.CONCLUSIONPrognostic risk classification was found to be better predictive in terms of local control and survival.Publication Malignant glomus tumor with oncocytic features: An unusual presentation of dysphagia(Wiley, 2015-07-01) Uğras, Nesrin; Yerci, Ömer, I.; Yalçınkaya, Ulviye; Gülcü, Barış; Öztürk, Ersin; Yıldırım, Çınar; Çavuşoğlu, İlkin; UĞRAŞ, NESRİN; YERCİ, ÖMER; YALÇINKAYA, ÜLVİYE; Gülcü, Barış; Öztürk, Ersin; Yıldırım, Çınar; Çavuşoğlu, İlkin; Tıp Fakültesi; Histoloji ve Embriyoloji Ana Bilim Dalı; 0000-0002-9600-9418; AAH-8924-2021; AAH-2716-2021; JIO-2609-2023; JII-0241-2023; JGW-0566-2023; GCS-6830-2022; JIV-8745-2023Glomus tumors in the gastrointestinal tract are unusual, as the previous series in the literature have been mainly limited to the stomach. Less than 10 cases of esophageal glomus tumors have been described in the literature. Oncocytic glomus tumors are a recently identified, rare variant of the glomus tumor. We report a 47-year-old female who presented with an approximately 3-month history of dysphagia and weight loss. Upper gastrointestinal endoscopy showed a black-purple, hypervascular, protruding lesion measuring approximately 65mm at the 37th cm of the esophagus. The patient underwent an Ivor Lewis operation via open thoracotomy. The resected specimen had a protuberant, ulcerated mass measuring 80x35mm in the posterior wall of the esophagus. Based on the histopathological, immunohistochemical and electron microscope findings, the final diagnosis was a malignant glomus tumor with oncocytic features. To our knowledge, this is the first report of a malignant glomus tumor with oncocytic features in an esophageal location.Publication Liver metastasis of breast carcinoma: An unusual presentation and growth pattern(Wolters Kluwer Medknow Publications, 2023-10-01) Özsen, Mine; ÖZŞEN, MİNE; Ugraş, Nesrin; UĞRAŞ, NESRİN; Deligönül, Adem; DELİGÖNÜL, ADEM; Yerci, Ömer; YERCİ, ÖMER; Tıp Fakültesi; Onkoloji Ana Bilim DalıBreast carcinoma is one of the tumors that frequently metastasize to the liver. Extramedullary hematopoiesis (EMH) usually occurs due to insufficient medullary hematopoiesis. In this case report, we present a female patient with sinusoidal breast carcinoma metastasis and extramedullary hematopoiesis in liver biopsy. A 63-year-old female patient with history of breast carcinoma was admitted to our center with respiratory distress. Pleural effusion was detected and thoracentesis was planned. Treatment was given after detection of non-mycobacterial tuberculosis bacillus in the thoracentesis fluid. Antibiotherapy was terminated due to elevation of liver enzymes and bilirubin. The patient's clinical status was evaluated and treatment was re-initiated. The patient did not have any mass lesion in the liver. Tru-cut biopsy was performed to evaluate a possible tuberculosis involvement in the liver. The diagnosis of metastatic breast carcinoma located in the sinusoidal area and cholestatic liver with extramedullary hematopoiesis foci was given using the histomorphological, immunohistochemical and histochemical findings. Radiological evaluation has an important role in staging of malignancies. However, it should be kept in mind that hepatic metastases may present without formation of a mass lesion, and unexpected laboratory results of cases without abnormal radiological features should raise the suspicion of a metastasis. Such materials should be evaluated in detail by making multiple serial sections in the pathology laboratory. Rare metastatic tumor growth patterns not causing a mass lesion such as sinusoidal or portal pattern, should also be kept in mind.Publication Our results of fine-needle aspiration cytology of the head and neck masses excluding thyroid: Experience of Uludag(Galenos Yayıncılık, 2005-06-01) Dilber, Muhammet; Erisen, L.; Yerci, Ömer; Coşkun, Hakan; Basut, O.; Onart, Selçuk; Hızalan, İbrahim; Dilber, Muhammet; Erisen, L.; YERCİ, ÖMER; COŞKUN, HAMDİ HAKAN; Basut, O.; Onart, Selçuk; Hızalan, İbrahim; Tip Fakültesi; Kulak Burun Boğaz Ana Bilim Dalı; 0000-0002-0881-1444; CMI-5616-2022; ETY-7294-2022; EIS-5114-2022; DVC-7511-2022; CFJ-8210-2022; FQP-9099-2022; EZI-7933-2022Objectives: To evaluate the results of fine needle aspiration cytology (FNAC) used for extra-thyroidal masses of the head and neck in our institution.Methods: The results of 542 FNAC done on 487 patients, referred to our university hospital in five years period from 1998 to 2002, with extra-thyroidal masses of the head and neck were evaluated retrospectively by examining the files in the department of pathology. FNAC results of 127 patients, who also had permanent biopsy results, were evaluated according to age and localization of the pathology. The rates of accuracy, specificity, sensitivity, positive and negative predictive values were calculated.Results: During this period, 62.5% of the all FNACs were done on head and neck masses, and 12.9% of those to extra-thyroidal pathologies. Accuracy rates of FNAC were 94.3% for congenitaldevelopmental pathologies, 89.4% for infectious-inflammatory pathologies (93.5% for specific infections), and 83.7% for neoplastic pathologies (85.9% for malignancies). There were no statistically significant differences between the accuracy rates of FNAC according to patient's age and localization of the pathology. False negative rate was higher than false positive rate in malignant lesions. Correct diagnostic rate based on the cellular differentiation in the malignant pathologies was 50%.Conclusion: 1. FNAC has a high accuracy rate for head and neck masses. 2. FNAC should be first step of pathological examination in all head and neck masses with an intact overlying mucosa or skin. 3. There are no differences between the accuracy rates of the FNAC of the childhood or the adulthood period. 4. There are no differences between the accuracy rates of the FNAC of the pathologies of the neck or the salivary glands. 5. Clinically, FNAC should only be used as a guide for preliminary diagnosis, especially in malignant pathologies. Final treatment decision should not be made according to the results of FNAC and tissue biopsy should be obtained before definitive treatment.Publication Histopathological changes of neoadjuvant chemoradiation and relation with the pre-treatment tumor stage in rectal carcinoma(Gazi Univ, Fac Med, 2017-01-01) Özgün, Gonca; ÖZ ATALAY, FATMA; Ugraş, Nesrin; UĞRAŞ, NESRİN; Yerci, Ömer; YERCİ, ÖMER; Tıp Fakültesi; Patoloji Ana Bilim Dalı; 0000-0002-7188-6115; AAH-2716-2021Objective: Neoadjuvant chemoradiotherapy has considered one of the standard treatment modalities for locally advanced rectal cancers. Chemoradiotherapy has a variety of different effects and responses on tumor, tumor bed and peritumoral tissues. The purpose of the present study was to evaluate the stromal responses in tumor bed between the different treatment modalities and different clinical T stages.Methods: Fifty-seven consecutive patients with median age of 62.4 years were treated for rectal adenocarcinoma between January 2005 and July 2012 in Uludag University Medical Faculty. Twenty-three of the patients were treated with neoadjuvant chemoradiation therapy and following surgery, 34 patients treated with surgery only.Results: When we compared the stromal responses in the tumor bed between the two different treatment modalities, the amount of fibrosis and intensity of inflammatory cell infiltration were found considerably marked. The existence of calcification, hemosiderin-laden macrophages and mucin lakes were found also significant marked. There was no difference found in between the patients with different clinical stages which were received neoadjuvant CRT.Conclusion: The stromal response in the tumor bed increases with the neoadjuvant chemoradiotherapy but the excess of the response doesn't have any relation with the clinical T stage.Publication Lower gastrointestinal tract hemorrhage due to ectopic pancreatic tissue in a renal transplant recipient: : A case report(Elsevier, 2002-06-01) Ersoy, Alpaslan; Yavuz, M; Tokyay, R; Yerci, Ömer; Kıyıcı, Murat; Usta, M; Güllülü, Mustafa; Dilek, Kamil; Oktay, B; Yurtkuran, Merih; ERSOY, ALPARSLAN; Yavuz, M; Tokyay, R; YERCİ, ÖMER; KIYICI, MURAT; Usta, M; GÜLLÜLÜ, MUSTAFA; DİLEK, KAMİL; Oktay, B; Yurtkuran, M.; Uludağ Tıp Fakültesi; Tıp Fakültesi; Nefroloji Bölümü; 0000-0002-3208-6211; AAH-5054-2021; AAI-4213-2021; IHY-2104-2023; DZX-1258-2022; EIS-5114-2022; GGE-6952-2022; JGS-9425-2023; EUU-1912-2022; FRV-0139-2022; EGT-2006-2022Publication Investigation of apc mutations of a patient with fap and her family members by heterodublex analyses(Nature Publishing Group, 2002-05-01) Menigatti, M; Benatti, P; Pedroni, M; Scarselli, A; Borghi, F; Sala, E; Yerci, O; de Leon, MP; TUNCA, BERRİN; Çeçener, Gülşah; YILMAZLAR, AHMET TUNCAY; ÇEÇENER, GÜLŞAH; Yılmazlar, Tuncay; Zorluoglu, A; EGELİ, ÜNAL; Yerci, Ömer; YERCİ, ÖMER; Tıp Fakültesi; Medikal Biyoloji ve Genetik Ana Bilim Dalı; 0000-0002-1619-6680; 0000-0002-3820-424X; 0000-0001-7904-883X; AAH-1420-2021; ABI-6078-2020Publication The diagnostic value of endoscopic narrow band imaging in helicobacter pylori gastritis in children(Aves, 2015-03-01) Özgür, Taner; Özkan, Tanju Başarır; Erdemir, Gülin; Özakın, Cüneyt; Yerci, Ömer; ÖZGÜR, TANER; Özkan, Tanju Başarır; Erdemir, Gülin; ÖZAKIN, CÜNEYT; YERCİ, ÖMER; Tıp Fakültesi; Mikrobiyoloji Ana Bilim Dalı; 0000-0002-9726-8219; 0000-0001-5740-9729; 0000-0001-5428-3630; AAG-8381-2021; AAG-8392-2021; DKU-2575-2022; GBW-0079-2022; EIS-5114-2022Background/Aims: In this study we aimed to investigate the sensitivity and specificity of Narrow Band Imaging (NBI) in H. pylori gastritis and compare them with those of rapid urease test and urea breath test.Materials and Methods: A hundred sixty-five children who admitted to Uludag University Pediatric Gastroenterology Unit between October 2009-March 2011 with upper gastrointestinal symptoms were consecutively enrolled. During the endoscopy procedure gastric corporeal, antral and fundal images were obtained, afterwards the same areas were visualized with narrow band imaging and images were recorded again.Results: The study included 68 (41.2%) boys and 97(58.8%) girls. The mean age of the patients were 11.88 +/- 4.55. Tissue culture positivity and/or histopathological staining for H. pylori was determined in 56 (33.9%) patients (Group 1) and the other patients (n:109, 43.6%) didn't have an evidence of H. pylori infection (Group 2). Narrow band images have supported H. pylori infection in 56.4%. The sensitivity of narrow band images for determining H. pylori infection was 92.86% (95% CI 82.7-98), specificity was 62.39% (95% CI 52.6-71.5).Conclusion: Our study is the first to show the role of NBI in diagnosing H. pylori infection in children, as well as determining the sensitivity and specificity of the technique. The specificity is low; however, we suggest that the specific mucosal view of H. pylori gastritis provided by NBI is useful for identifying the areas from which the biopsies should be taken. Moreover, by using this technique, treatment of H. pylori infection may be initiated immediately without performing rapid urease test and without waiting for histopathology report and tissue culture.Publication Igg4-related disease of the ovary(Türk Patoloji Derneği, 2021-01-01) Akyol, Sevda; Öz Atalay, Fatma; Hasdemir, Seçil; Yerci, Ömer; AKYOL, SEVDA; ÖZ ATALAY, FATMA; HASDEMİR, SEÇİL; YERCİ, ÖMER; Tıp Fakültesi; Patoloji Ana Bilim Dalı; 0000-0003-1769-7484; 0000-0002-3107-207X; 0000-0002-1275-7743; 0000-0001-7118-5258; CBY-0641-2022; FUC-3875-2022; GBY-7549-2022; EIS-5114-2022Immunoglobulin G4-related disease is characterized by dense fibrosis, obliterative phlebitis, and lymphoplasmacytic infiltration that contains abundant IgG4 positive plasma cells. It causes tumefactive lesions in the involved organs and is most commonly seen in the salivary glands, pancreas, and retroperitoneum. Ovarian involvement has been reported in only two cases. In our case, a 58-year-old female patient presented with abdominal distention and pain. Pelvic computed tomography revealed a soft tissue lesion compatible with the omental cake, several intraabdominal implants, and bilateral adnexal fullness. A laparotomy was performed under suspicion of peritoneal carcinomatosis secondary to bilateral adnexal mass. In the histopathologic examination, abundant lymphoplasmacytic infiltration and dense fibrosis were observed in both ovaries and the peritoneum. In the areas of greatest density, the density of IgG4-positive plasma cells was found to range from 40 to 50 per high-power field. The patient was accepted as suffering from probable IgG4-related disease because of the bilateral involvement of the ovaries and the histopathological findings. In conclusion, we present this case to draw attention to the fact that IgG4-related disease can also be seen in the ovary.
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