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ÖZTÜRK YANAŞMA, HALİDE

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ÖZTÜRK YANAŞMA

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HALİDE

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2020 - 20232
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    Publication
    Treatment outcomes for primary retromolar trigone carcinoma: A single institution experience
    (Galenos Yayıncılık, 2020-04-09) Demir, Uygar Levent; Yanaşma, Halide Öztürk; DEMİR, UYGAR LEVENT; ÖZTÜRK YANAŞMA, HALİDE; Tıp Fakültesi; Kulak Burun Boğaz Ana Bilim Dalı; 0000-0002-9590-1420; 0000-0001-8544-6674; CNQ-7672-2022; EFV-2180-2022
    Objective: Retromolar trigone (RMT) is a rare location for oral cavity cancers. RMT cancers are aggressive malignancies that mostly present at an advanced stage. In this study, we aimed to evaluate treatment outcomes in patients who underwent initial radical surgical resection and postoperative radiotherapy or chemoradiotherapy with a diagnosis of primary RMT squamous cell carcinoma in our institution.Methods: The study included 20 primary RMT tumor patients out of 191 oral cavity cancer cases treated from January 2010 through December 2019. We retrospectively analyzed treatment details, histopathology reports, postoperative clinical course and survival outcomes.Results: The mean age at presentation was 59.4 years. Eighty percent of all patients were either stage 3 or stage 4. We performed mandibular resection in 14 patients (70%) and partial maxillectomy in eight patients (40%). Nineteen patients (95%) underwent unilateral neck dissection. The incidence of metastatic cervical lymph node was 13/20 (65%). Overall survival (OS) and disease-free survival (DFS) rates during follow-up (mean 26.3 months) were 60% and 75%, respectively. There was statistical significance between presence of multilevel metastatic lymph nodes and OS (p=0.013). DFS and OS of early stage and advanced stage groups were 100% vs 75% and 100% vs 50%, respectively, with no statistical significance (p=0.189 and p=0.084).Conclusion: The survival of advanced stage RMT cancer is poor despite appropriate treatment. Bone involvement that necessitates resection is common due to the proximity of the tumor to the mandible and the maxilla. Multilevel positive cervical lymph nodes and advanced stage are poor prognostic factors.
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    Publication
    Role of the neck dissection in early-stage lower lip cancers
    (Wolters Kluwer Medknow Publications, 2023-09-01) İNAN, HAKKI CANER; İnan, Caner; Yanaşma, H. O.; ÖZTÜRK YANAŞMA, HALİDE; Saraydaroğlu, O.; SARAYDAROĞLU, ÖZLEM; Aslier, Mustafa; ASLIER, MUSTAFA; Şahin, İ.; Basut, O.; BASUT, OĞUZ İBRAHİM; Kasapoğlu, F.; Özmen, A. O.; Demir, U. L.; Coşkun, H.; KASAPOĞLU, FİKRET; ÖZMEN, ÖMER AFŞIN; Tıp Fakültesi; Patoloji Ana Bilim Dalı; 0000-0001-6254-372X; O-2907-2018
    Background: In early-stage lip cancer, spread to cervical lymph nodes is extremely rare. Elective neck treatment options include suprahyoid or supraomohyoid neck dissection, sentinel lymph node biopsy, or close follow-up. Aim: In this study, our aim was to investigate the effect of elective surgery on survival in patients operated for early-stage lip cancer. Methods: Patients who underwent surgical treatment for lower lip squamous cell carcinoma between 2005 and 2020 were retrospectively analyzed. Age, gender, neck dissection status (yes/no), clinical and pathological T stage of the tumor, grade, and perineural invasion were recorded and 3-year and 5-year overall (OS) and disease-free survival (DFS) rates were estimated. Results: Thirty patients were included: 20 patients had pT1 and 10 patients had pT2 tumors. Neck dissection was performed in 13 patients. The 5-year OS rate was 90.9% and 87.8% with and without dissection, respectively. Neck dissection did not appear to affect OS (P = 0.534) in these patients. The 5-year DFS rate was 96.4% in the overall group, while it was 91.7% and 100% in patients who did or did not undergo neck dissection, respectively (P = 0.756). Discussion: Patients with or without neck dissection did not differ significantly in terms of OS and DFS. Watchful waiting with regular ultrasound imaging of the neck in patients with T1 and T2 lip tumors may be an appropriate therapeutic option.