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KASTAMONİ, MENEKŞE

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KASTAMONİ

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MENEKŞE

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2015 - 201912020 - 20231
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    Publication
    The effects of fat graft and platelet-rich fibrin combination after epineurectomy in rats
    (Assoc Medica Brasileira, 2023-01-01) Kastamoni, Menekşe; KASTAMONİ, MENEKŞE; Yavaş, Senem Esin; Ersoy, Semiha; ERSOY, SEMİHA; Özgenel, Güzin Yeşim; ÖZGENEL, GÜZİN YEŞİM; Bursa Uludağ Üniversitesi/Tıp Fakültesi
    OBJECTIVE: One of the most important factors that adversely affects the outcome of peripheral nerve surgery is the formation of epineural and extraneural scar tissue after surgery. Many surgical methods and pharmacological and chemical agents have been used to prevent the formation of epineural scar tissue, but satisfactory results have not been achieved in clinical applications. The purpose of this study was to investigate the combined effect of fat graft and platelet-rich fibrin on the formation of epineural scar tissue and on nerve healing in the mature rat model.METHODS: A total of 24 female Sprague-Dawley rats were used. A circumferential segment of epineurium was excised from both bilateral sciatic nerves. The epineurectomized right nerve segment was wrapped with a combination of fat graft and platelet-rich fibrin (experimental group), while the left nerve segment did not receive any surgical procedure other than the epineurectomy (sham group). Notably, 12 randomly selected rats were sacrificed in the fourth week for histopathological examination of early results. The other 12 rats were sacrificed in the eighth week for late results.RESULTS: The formation of fibrosis, inflammation, and myelin degeneration were less common in the experimental group, while nerve regeneration was found to be higher at both 4 and 8 weeks.CONCLUSION: The intraoperative application of a combination of fat graft and platelet-rich fibrin appears to be effective on nerve healing after surgery at both the early and late periods.
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    Clinical and histopathological analysis of 152 pigmented skin lesion excisions apart from melanocytic nevus due to cosmetic reasons
    (Springer, 2015-08-01) Erşen, Burak; Akın, Selçuk; Saki, Mehmet Can; Aksu, İsmail; Tunalı, Orhan; Kalay, Ayşe; Karabulut, Furkan; Çeçen, Süleyman; Köse, Mehmet; Kastamoni, Menekşe; Erşen, Burak; AKIN, SELÇUK; Saki, Mehmet Can; Aksu, İsmail; Tunalı, Orhan; Kalay, Ayşe; Karabulut, Furkan; ÇEÇEN, SÜLEYMAN; Köse, Mehmet; KASTAMONİ, MENEKŞE; Uludağ Üniversitesi/Tıp Fakültesi/Plastik Estetik ve Rekonstrüktif Cerrahi Anabilim Dalı.; 0000-0002-3003-918X; 0000-0003-1683-0722; 0000-0003-2430-727X; EUI-8874-2022; AAH-5064-2021; FYF-8484-2022; HLD-8732-2023; EEM-7276-2022; CXB-2978-2022; FCR-7958-2022; HIK-0761-2022; GWJ-7397-2022; JMZ-7639-2023
    Background Melanocytic naevus (MN) is a normal, benign proliferation of melanocytes, which may be acquired or congenital, and it is the most common pigmented lesion posing an aesthetic problem for many patients and can be found anywhere on the skin. There are several other types of pigmented skin lesions apart from MN such as seborrhoeic keratosis (SK) which mimics both MN and basal cell carcinoma (BCC).Methods A retrospective study was designed in order to investigate the characteristics of 152 non-MN pigmented skin lesion excisions performed between June 2009 and October 2014. All patients desired their lesions to be removed for only cosmetic reasons. None of our patients described their lesions as 'suspicious'. All patients were evaluated for age and gender in addition to the clinical characteristics of the lesion such as location, size and morphology. Twenty-two different types of pigmented lesion were identified.Results A total of 152 patients underwent surgery. Of the 152 patients, 83 were female (54.6 %) and 69 were male (45.4 %). The average age of our patient group was 51.4 (12-87) years. The average size of the lesions was 1.27 cm(2) (0.01-6 cm 2).Conclusions Seborrhoeic keratosis was the most common lesion type (49.6 %), followed by dermatofibroma, haemangioma, fibroepithelial polyp and BCC. These five lesions in total constituted 79.4 % of all lesions. It was also observed that approximately 19 % of all excised lesions were malignant, pre-malignant or a feature of a systemic disease. The main complaint for all of our patients was cosmetic disturbance. None of the lesions were symptomatic, and none of the patients considered their lesions as 'suspicious'.