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ALP, ALEV

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ALP

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ALEV

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    Publication
    Kinesiophobia and related factors in fibromyalgia syndrome
    (Galenos Yayıncılık, 2023-04-01) Ertem, Uğur; Alp, Alev; ERTEM, UĞUR; ALP, ALEV; Tıp Fakültesi; Fiziksel Tıp ve Rehabilitasyon Ana Bilim Dalı; 0000-0003-2142-2264; AAD-2089-2021; EKZ-2544-2022
    Objective: This study aimed to determine the kinesiophobia levels in female patients with fibromyalgia (FMS). In addition, we intended to search the factors associated with kinesiophobia in patients with FMS and to evaluate the effect of kinesiophobia on work outcomes in this patient population.Materials and Methods: Between January 2021 and May 2021, 50 female patients with FMS and 44 female patients with musculoskeletal pain but not meeting the diagnostic criteria for FMS were included in the study. Pain was evaluated using the numeric scale, kinesiophobia levels with the Tampa Scale for Kinesiophobia (TSK), and the work outcomes with a questionnaire form prepared by us.Results: The median TSK scores were 41,50 (21-61) in the FMS group and 37 (23-61) in the control group. TSK score was significantly higher in the FMS group (p=0.030). Pain scores (p<0.001), and symptom duration (p<0.001) were significantly associated with high levels of kinesiophobia. When multiple linear regression analysis was performed, it was found that body mass index (p=0.411) was not associated with kinesiophobia levels, whereas age (p<0.001) was associated with kinesiophobia levels. Increased levels of kinesiophobia in patients with FMS patients have been associated with worse work outcomes.Conclusion: Evaluating the level of kinesiophobia in patients with FMS and developing preventive strategies in the presence of kinesiophobia can provide useful information when creating a treatment program.
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    Evaluation of the relationship between proinflammatory cytokine levels and clinical findings of fibromyalgia syndrome
    (Shiraz Inst Cancer Res, 2021-01-01) Ellergezen, Pınar; Alp, Alev; Çavun, Sinan; ELLERGEZEN, PINAR; ALP, ALEV; ÇAVUN, SİNAN; Tıp Fakültesi; Fiziksel Tıp ve Rehabilitasyon Ana Bilim Dalı; AAC-9702-2019; ICM-4005-2023; EKZ-2544-2022
    Background: Immune system has an important effect on pain related disorders such as fibromyalgia syndrome (FMS). There is no specific laboratory technique for the diagnosis of FMS, but measuring serum proinflammatory cytokines may help. Objective: The purpose of our study was to determine the serum levels of immune mediators and their relationship with FMS symptoms. Methods: 25 healthy individuals and 29 FMS patients receiving pregabalin 150 mg/day for a minimum of 3 months were included in this study. FMS patients were diagnosed according to diagnostic criteria of the American College of Rheumatology (ACR 2010). Widespread pain index (WSI), fatigue, waking unrefreshed, cognitive symptoms, somatic symptoms, and Fibromyalgia Impact Questionnaire (FIQ) scores were evaluated in patients with FMS. Serum levels of proinflammatory cytokines (IL-2, IL-6, IL 12, IL-17, IFN-gamma, TNF-alpha) were assessed using enzyme-linked immunosorbent assay (ELISA). Results: Proinflammatory cytokine levels were higher in the control group than patients with FMS (P<0.05). A positive correlation was found between age and WSI (P=0.037). In addition, a significant positive relationship was determined between IL-17 level and waking unrefreshed (P=0.049). There was no significant relationship between other cytokines and clinical findings. Conclusion: Lower proinflammatory cytokine levels identified in FMS patients may be related to pregabalin treatment, and there may be an impairment in the inflammatory response. On the contrary, IL-17 showed positive correlation with waking unrefreshed.
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    The effectiveness of carpal bone mobilization accompanied by night splinting in idiopathic carpal Tunnel syndrome
    (Bayınar Tıbbi Yayıncılık, 2015-03-01) Günay, Berna; Alp, Alev; Günay, Berna; ALP, ALEV; Tıp Fakültesi; Fiziksel Tıp ve Rehabilitasyon Ana Bilim Dalı; ABG-2019-2020; CRT-3055-2022
    Objective: The aim of this study was to investigate the effectiveness of carpal bone mobilization (CBM) and night splinting and to compare it with night splinting as a control group in the treatment of Carpal Tunnel Syndrome (CTS).Methods: In the single-blind (assessor) prospective randomised controlled trial, a total of 40 patients with mild to moderate CTS were diagnosed by electroneuromyography (ENMG). In Group 1 (n=20), patients received CBM three times a week, total of 10 times, and used neutral volar wrist splint at night for 3 weeks. Patients in Group 2 (n=20) used only neutral volar wrist splint at night for 3 weeks. All of the patients were assessed at baseline and at the 3rd month with respect to pain intensity using a numerical rating scale (0-10), handgrip and pinchgrip strength, functional status and symptom severity using the Boston Carpal Tunnel Questionnarie (BCTQ), and ENMG measurements.Results: There were improvements in all of the clinical variables, distal sensory latancy, and sensory nerve action potentials of the median nerve in Group 1. In Group 2, there was improvement in only BCTQ symptom severity and night/day pain intensity at the 3rd month. Improvement in pinchgrip strength and BCTQ functional status were superior in Group 1 when compared with that in Group 2 at the 3rd month.Conclusion: Both of the treatment modalities may be recommended for symptomatic relief. However, CBM combined with splinting may be a better choice for functional and strength amelioration as a noninvasive alternative treatment modality in CTS.
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    Magnetotherapy in hand osteoarthritis: A pilot trial
    (Churchill Livingstone, 2013-12-01) Kanat, Elvan; Alp, Alev; Yurtkuran, Merih; ALP, ALEV; Yurtkuran, Merih; Tıp Fakültesi; Fizik Tedavi ve Rehabilitasyon Bölümü; ABG-2019-2020; GLB-5791-2022
    Objective: To evaluate the effectiveness of magnetotherapy in the treatment of hand osteoarthritis (HO).Methods: In this randomized controlled single-blind follow-up study, patients with HO were randomly assigned into 2 groups (G1 and G2). The subjects in G1 (n = 25) received 25 Hz, 450 pulse/s, 5-80G, magnetotherapy of totally 10 days and 20 min/day combined with active range of motion/strengthening exercises for the hand. G2 (n =25) received sham-magnetotherapy for 20 min/day for the same duration combined with the same hand exercises. Outcome measures were pain and joint stiffness evaluation, handgrip and pinchgrip strength (HPS), Duruoz and Auscan Hand Osteoarthritis Indexes (DAOI) and Short Form-36 Health Questionnaire (SF-36) administered at baseline, immediately after treatment and at the follow up.Results: When the groups were compared with each other, improvement observed in SF-36 Pain (p < 0.001), SF-36 Social Function (p = 0.030), SF-36 Vitality (p = 0.002), SF-36 General Health (p = 0.001), Pain at rest (p < 0.001), Pain at motion (p < 0.001), Joint stiffness (p < 0.001), DAOI (p < 0.001) were in favor of G1.Conclusions: Changes in pain, function and quality of life scores showed significant advantage in favor of the applied electromagnetic intervention in patients with HO.
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    Fibromiyalji sendromunda sistemik immün-inflamasyon indeksi ve hematolojik laboratuvar bulgularına genel bakış
    (Bursa Uludağ Üniversitesi Tıp Fakültesi Dergisi, 2024-05-21) Ellergezen, Pınar; Alp, Alev; Çavun, Sinan; Çeçen, Gülce Sevdar; ELLERGEZEN, PINAR; ALP, ALEV; ÇAVUN, SİNAN; SEVDAR ÇEÇEN, GÜLCE
    Bu çalışmada fibromiyalji sendromunda (FMS) Sistemik İmmün-İnflamasyon İndeksi (SII) ile kan parametreleri arasındaki ilişki değerlendirilerek hastalık aktivitesinin belirlenmesi amaçlanmıştır. Çalışmaya Ocak 2021 ve Ocak 2022 tarihleri arasında Fizik Tedavi ve Rehabilitasyon Kliniğine başvuran 109 FMS hastası ve 82 sağlıklı kontrol dahil edilmiştir. Yaş, cinsiyet, C-reaktif protein (CRP), eritrosit sedimentasyon hızı (ESR), beyaz kan hücresi (WBC), hemoglobin (HGB), ortalama korpusküler hacim (MCV), ortalama korpusküler hemoglobin (MCH), ortalama korpusküler hemoglobin konsantrasyonu (MCHC), kırmızı hücre dağılımı (RDW), trombosit dağılım genişliği (PDW), ortalama trombosit hacmi (MPV), trombosit (PLT), trombosit kriteri (PCT), lenfosit (LYM), monosit (MONO), nötrofil (NEU) düzeyleri hastane bilgi sisteminden retrospektif olarak taranmıştır. Trombosit-lenfosit oranı (PLR), nötrofil-lenfosit oranı (NLR), monositlenfosit oranı (MLR) ve sistemik immün-inflamasyon indeksi (SII) hesaplanmıştır. CRP ve ESR düzeyleri FMS hastalarında sağlıklı kontrollere göre daha yüksekti ancak değer aralığının dışında değildi (p<0,001). PDW (p<0,001), HGB (p<0,001), MCV (p<0,001), MCH (p<0,001) ve MCHC (p=0,02) düzeyleri hastalarda sağlıklı gruba göre daha düşüktü. Hasta ve kontrol grupları arasında yaş, WBC, NEU, LYM, MONO, RDW, MPV, PLT, PCT, SII, PLR, NLR ve MLR değerleri açısından istatistiksel olarak anlamlı fark yoktu. FMS hastalarında WBC düzeyleri ile SSS değerleri arasında (r=0,2; p=0,005) ve lenfosit düzeyleri ile WPI değerleri arasında (r=0,2; p=0,01) anlamlı pozitif korelasyon bulunmuştur. Çalışma sonuçlarına göre, SII'nin FMS'de belirleyici bir rolü yoktur, ancak hastalığın tanıda yararlı olabilecek bazı inflamatuvar bileşenleri vardır ve daha ayrıntılı çalışmalara ihtiyaç vardır.
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    Correlation of femoral cartilage thickness and osteoporosis in female patients with knee osteoarthritis
    (Galenos Yayıncılık, 2021-08-01) Özövez, Gamze Altuğ; Alp, Alev; Özövez, Gamze Altuğ; ALP, ALEV; Tıp Fakültesi; Fiziksel Tıp ve Rehabilitasyon Ana Bilim Dalı; 0000-0002-3147-6357; 0000-0002-3904-5463; DML-7159-2022; EKZ-2544-2022
    Objective: To evaluate the relationship between ultrasonographic femoral cartilage thickness and presence of concomitant osteoporosis in a group of female patients with knee osteoarthritis (OA).Materials and Methods: This study included 118 women with knee OA who visited our outpatient clinic. Demographic data were collected, radiologic grading using Kellgren Lawrence (K-L) scale, ultrasonographic femoral cartilage thickness (FCT) evaluation, pain intensity evaluation, disability evaluation using OA index [Western Ontario and McMaster Universities Osteoarthritis index (WOMAC)], quality of life measurement using Short Form-36 (SF-36) and bone density measurement using dual-energy X-ray absorptiometry (DXA) were conducted for each patient.Results: We found that 58 patients (median age: 64.5 years, range: 50-75) had osteoporosis (group 1) and 60 patients (median age: 62 years, range: 51-75) did not have osteporosis (group 2). Group 2 had higher body mass index (BMI) in addition to lower WOMAC, SF-36 physical function, physical role limitation, pain and social function scores. The severity of osteoporosis and K-L staging were negatively correlated. The DXA femoral neck and total lumbar T-scores were higher in the advanced stages of OA. FCT had no significant correlation with age, WOMAC index and SF-36 scores. Moreover, the left knee FCT was negatively correlated with BMI.Conclusion: Radiologic staging of OA had a negative correlation with osteoporosis but no significant correlation with the quantitative measurement of FCT using ultrasonography.
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    Evaluation of the physical and emotional effects of the COVID-19 pandemic on patients with fibromyalgia and chronic low back pain: A multicenter cross-sectional controlled study
    (Baycinar Medical Publ-Bayçınar Tibbi Yayıncılık, 2022-09-12) Bagcier, Fatih; Kibar, Sibel; Evcik, Deniz; Ketenci, Ayşegül; Sindel, Dilşad; Tur, Birkan Sonel; Ünlü, Zeliha; Tikiz, Canan; Keskin, Dilek; Alp, Alev; Ay, Saime; Yanık, Burcu; Kulcu, Duygu Geler; Karakaş, Merve; Nazlıkul, Fatma Gülçin Ural; Oktay, Kubra Neslihan Kurt; Aksoy, Meliha Kasapoğlu; Findikoğlu, Gülin; Eser, Filiz; Atıcı, Arzu; Yurdakul, Ozan Volkan; Koçak, Fatmanur Aybala; Kurt, Emine Eda; Özkan, Yasemin; Doğan, Şebnem Koldas; Sultanoğlu, Tuba Erdem; Ordahan, Banu; Umay, Ebru Karaca; Demirhan, Esma; Yağcı, Hanife Çağlar; Balbaloğlu, Özlem; Tezel, Nihal; Satış, Serap; Atar, Sevgi; Akaltun, Mazlum Serdar; ALP, ALEV; Tıp Fakültesi; Fiziksel Tıp ve Rehabilitasyon Ana Bilim Dalı; EKZ-2544-2022
    Objectives: This study aimed to investigate the physical and emotional effects of the coronavirus disease 2019 pandemic in patients with fibromyalgia syndrome (FMS) and chronic low back pain (CLBP) patients.Patients and methods: The cross-sectional controlled study was performed with 1,360 participants (332 males, 1,028 females; mean age: 42.3 +/- 12.5 years; range, 18 to 65 years) between September 2020 and February 2021. The participants were evaluated in three groups: the FMS group (n=465), the CLBP group (n=455), and the healthy control group (n=440). Physical activity, pain levels, and general health status before and during the pandemic were evaluated in all participants. Stress levels were analyzed with the perceived stress scale (PSS) in all groups, and disease activity was analyzed with the fibromyalgia impact questionnaire (FIQ) in patients with FMS.Results: Patients with FMS had worsened general health status and pain levels during the pandemic compared to the other groups (p<0.01). The FMS group showed significantly higher PSS scores than those in other groups (p<0.01). There was a weak-positive correlation between FIQ and PSS parameters in patients with FMS (p<0.05, r= 0.385).Conclusion: The general health status, pain, and stress levels of the patients with FMS and CLBP tended to worsen during the pandemic. This high-stress level appeared to affect disease activity in patients with FMS.