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ÇAVAŞ, TOLGA

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ÇAVAŞ

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TOLGA

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2019 - 201912020 - 20233
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  • No Thumbnail Available
    Publication
    The evaluation of radiosensitivity in patients with STAT3 deficiency
    (Springer, 2021-04-01) Çekiç, Şükrü; Hüriyet, Hüzeyfe; Hortoğlu, Melika; Barış, Safa; Metin, Ayşe; Özen, Ahmet; Aydıner, Elif Karakoç; Abakay, Candan; Çavaş, Tolga; Kılıç, Sara; ÇEKİÇ, ŞÜKRÜ; Hüriyet, Hüzeyfe; BEKTAŞ HORTOĞLU, MELİKA; DEMİRÖZ ABAKAY, CANDAN; ÇAVAŞ, TOLGA; KILIÇ GÜLTEKİN, SARA ŞEBNEM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Çocuk İmmunoloji Bilim Dalı.; 0000-0002-9574-1842; 0000-0001-8494-601X; 0000-0003-4150-5200; AAA-4154-2022; JBJ-7521-2023; R-6749-2017; L-1933-2017; HKN-1599-2023
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    Publication
    Cancer tendency in a patient with ZNF341 deficiency
    (Springer/Plenum Publishers, 2020-01-20) Çekiç, Şükrü; Hartberger, Julia Maria; Frey-Jakobs, Stefanie; Hüriyet, Hüzeyfe; Hortoğlu, Melika Bektaş; Neubauer, Johanna Charlotte; Karalı, Yasin; Abakay, Candan Demiröz; Saraydaroğlu, Özlem; Çavaş, Tolga; Grimbacher, Bodo; Kılıç, Sara Şebnem; ÇEKİÇ, ŞÜKRÜ; Huriyet, Huzeyfe; BEKTAŞ HORTOĞLU, MELİKA; KARALI, YASİN; DEMİRÖZ ABAKAY, CANDAN; SARAYDAROĞLU, ÖZLEM; ÇAVAŞ, TOLGA; KILIÇ GÜLTEKİN, SARA ŞEBNEM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik İmmünoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-9574-1842; 0000-0003-1620-1918; 0000-0002-6897-6806; 0000-0001-8571-2581; 0000-0002-5617-8313; L-1933-2017; JBJ-7521-2023; AAH-3855-2021; AAA-4154-2022; AAH-1658-2021; AAH-9701-2021; AAH-3508-2021; CVI-9578-2022; FFS-1974-2022
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    Publication
    Evaluation of cytotoxic and genotoxic potential of avobenzone and octocrylene on human skin fibroblast cells
    (Taylor & Francis Ltd, 2023-12-31) Vatan, Özgür; Sevinç, Duygu; Yılmaz Çelik, Dilek; Aurelie Allounan, A. Carine; Teksoy, Özgün; Oral, Neylan; Hüriyet, Hüzeyfe; Çavaş, Tolga; Çinkılıç, Nilüfer; VATAN, ÖZGÜR; Sevinç, Duygu; Yılmaz Çelik, Dilek; Aurelie Allounan, A. Carine; Teksoy, Özgün; Oral, Neylan; Hüriyet, Hüzeyfe; ÇAVAŞ, TOLGA; ÇİNKILIÇ, NİLÜFER; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.; 0000-0002-7687-3284; 0000-0003-1620-1918; AAH-5296-2021; ISV-0209-2023; O-7508-2015; JOX-7778-2023; JOR-9588-2023; JOL-2743-2023; EDJ-3505-2022; JOX-5573-2023; CVI-9578-2022; EQD-6980-2022
    We investigated the cytotoxic and genotoxic effects of the organic UVA filter avobenzone (AVB), and the UVB filter octocrylene (OCT), found alone or in combination in different sunscreen formulations, on normal human skin fibroblast cells (CCD-1118Sk). To achieve this purpose, we used XTT viability assay, single cell gel electrophoresis (comet) assay and reactive oxygen species (ROS) assay. For cytotoxicity, CCD-1118Sk cells were exposed to various concentrations of AVB (32-800 mu M), and OCT (130-6500 mu M). The IC50 values were 100.2 and 1390.95 mu M for AVB and OCT, respectively. IC12.5, IC25 and IC50 concentrations were chosen for genotoxicity testing. The comet assay revealed DNA damage at the two highest concentrations of AVB and all OCT concentrations. The rate of DNA damage was significantly higher than in the control groups. Co-treatment with AVB and OCT increased the level of DNA damage and intracellular oxidative stress compared with AVB and OCT treatment alone. Finally, our study showed that the UVA filter AVB, with the UVB filter OCT, may induce cytotoxic and genotoxic effects on human skin fibroblast cells.Highlights Avobenzone and octocrylene are UV filters used in sunscreen products. Healthy human skin fibroblast cell line CCD-1118Sk was used for cytotoxic and genotoxic assays. Cotreatment with avobenzone and octocrylene caused more severe DNA damage than their treatment alone. Our findings will contribute to the limited number of cytotoxicity and genotoxicity studies and lead to more detailed studies on the use of these two chemicals.
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    Publication
    In vitro cytotoxic and genotoxic effects of donkey milk on lung cancer and normal cells lines
    (Czech Academy Agricultural Sciences, 2019-01-01) Akça, Çetin; YILMAZ, DİLEK; Vatan, Özgür; VATAN, ÖZGÜR; Yılmaz, Dilek; Hüriyet, Huzeyfe; Cinkılıç, Nilufer; ÇİNKILIÇ, NİLÜFER; Çavaş, Tolga; ÇAVAŞ, TOLGA; Bursa Uludağ Üniversitesi/Fen Edebiyat Fakültesi.; 0000-0002-7687-3284; 0000-0001-7269-8493; 0000-0002-3595-6286; 0000-0003-1620-1918; AAH-3508-2021; O-7508-2015; ISV-0209-2023; AAH-5296-2021
    In vitro cytotoxic and genotoxic effects of donkey milk on cancer (A549) and normal (BEAS-2B) lung cell lines were investigated. The XTT and WST-1 tests as well as clonogenic assays were used to evaluate cytotoxicity. The comet assay and micronucleus test were used as genotoxicity endpoints. Donkey milk showed lower cytotoxic effects against normal lung cell line BEAS-2B in comparison to the tumor cell line A549. Genotoxicity experiments revealed dose dependent increases in the frequencies of micronuclei and single stranded DNA breaks in A549 cells whereas no significant damage was observed in BEAS-2B cells. The results indicate that donkey milk has anti-proliferative and genotoxic effects on lung cancer cells at concentrations which are non-toxic to normal lung cells.