Person: KUŞPINAR, GÖKTAN
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Publication Evaluation of endometrioma pathophysiology and related ovarian damage by PTEN / AKT apoptosis signaling pathway(Elsevier Science, 2020-09-01) Şen, Furkan; Aslan, Kiper; Kuşpınar, Göktan; Çakır, Cihan; Kasapoglu, Işıl; Avcı, Berrin; Uncu, Gürkan; ŞEN, HAMZA FURKAN; ASLAN, MÜNİR KİPER; KUŞPINAR, GÖKTAN; ÇAKIR, CİHAN; KASAPOĞLU, IŞIL; AVCI, BERRİN; UNCU, GÜRKAN; Tıp Fakültesi; Kadın Hastalıkları ve Doğum Ana Bilim Dalı; 0000-0002-9277-7735; 0000-0002-8332-7353; AAH-5119-2021; AAT-3479-2021; HTQ-5866-2023; AER-7173-2022; AAH-9694-2021; AAH-5249-2021; KEU-2073-2024; CXJ-7203-2022; ELU-2357-2022Publication The efficacy and molecular mechanism of dehydroepiandrosterone in diminished ovarian reserve(Oxford Univ Press, 2020-07-01) Avcı, Berrin; AVCI, BERRİN; Çakır, C.; Kuşpınar, Göktan; KUŞPINAR, GÖKTAN; Işıklar, S.; Aslan, Kiper; ASLAN, MÜNİR KİPER; Kasapoğlu, I.; Uncu, Gürkan; UNCU, GÜRKAN; Tıp Fakültesi; 0000-0002-9277-7735; HTQ-5866-2023; AAH-9694-2021; AAH-5119-2021; ABE-6685-2020; AER-7173-2022; AAT-3479-2021Publication The kisspeptin and kisspeptin receptor in follicular microenvironment: Is that really necessary for oocyte maturation and fertilisation?(Taylor & Francis Inc, 2022-08-19) Kuşpinar, Göktan; KUŞPINAR, GÖKTAN; Çakır, Cihan; ORAL, HALUK BARBAROS; ÇAKIR, CİHAN; KASAPOĞLU, IŞIL; Sarıbal, Seda; BUDAK, FERAH; Budak, Ferah; Avcı, Berrin; Uncu, Gürkan; UNCU, GÜRKAN; AVCI, BERRİN; Tıp Fakültesi; İmmunoloji Ana Bilim Dalı; 0000-0002-8332-7353; 0000-0001-7625-9148; IZP-9398-2023; AAH-5249-2021; F-4657-2014; HTQ-5866-2023The aim of this study was to determine whether Kisspeptin and Kisspeptin receptor in the follicular microenvironment is necessary for human oocyte maturation and fertilisation. The cumulus cell (CC) and follicle fluids (FF) obtained from the first aspirated follicles (n = 52) from 32 patients were divided into three groups considering nuclear maturation and fertilisation results of oocytes: (1) Metaphase I or germinal vesicle stage oocytes (incomplete nuclear maturation, n = 10), (2) unfertilised metaphase II oocytes (incomplete cytoplasmic maturation, n = 16), and (3) fertilised metaphase II oocytes (completed nuclear-cytoplasmic maturation, n = 26). The gene expression levels were assessed by RT-PCR. The levels of Kisspeptin (KISS1) and Kisspeptin receptor (KISS1R) were measured by ELISA. There were no significant efficacy KISS1 and KISS1R gene expressions in cumulus cells in terms of oocyte nuclear maturation stage (Group 1, vs Group 2 + Group 3) (respectively p = .49; p = .45). In terms of the cytoplasmic maturation stage (Group 2, vs Group 3); KISS1 and KISS1R expressions in CCs were comparable (respectively p = .07; p = .08). In FFs, KISS1 and KISS1R concentrations were similar between all groups (respectively p = .86; p = .26). In conclusion, the relative KISS1 and KISS1R expressions in CC and also KISS1 and KISS1R level of FF were independent of oocytes nuclear and/or cytoplasmic maturation. Impact statement What is already known on this subject? It has been demonstrated that Kisspeptin is an essential regulator of reproductive function and plays a key role in the modulation of GnRH secretion and gonadotropin release. Still, no information is available about the link between gene expression or concentration in the follicular microenvironment and oocyte development. What do the results of this study add? The study has shown that the relative Kisspeptin (KISS1) and Kisspeptin receptor (KISS1R) and expressions in cumulus cell (CC) and also KISS1 and KISS1R levels of follicle fluids (FF) were independent of oocytes nuclear and/or cytoplasmic maturation. What are the implications of these findings for clinical practice and/or further research? Based on the findings, it is difficult to establish a concept that kisspeptin can directly induce oocyte maturation. Nevertheless, to confirm these findings, further studies with a larger sample size are needed.Publication Effect of embryo morphology on maternal serum β-hCG level in pregnancies resulting from a fresh single cleavage embryo and a fresh single blastocyst(Oxford Univ Press, 2018-07-01) Kuşpınar, Göktan; Kasapoğlu, Işıl; Sarıbal, Seda; Uncu, Gürkan; Avcı, Berrin; KUŞPINAR, GÖKTAN; KASAPOĞLU, IŞIL; Sarıbal, Seda; UNCU, GÜRKAN; AVCI, BERRİN; Sağlık Bilimleri Enstitüsü; Kadın Hastalıkları ve Doğum Ana Bilim Dalı; 0000-0002-0338-8368; AAH-5119-2021; HTQ-5866-2023; AAT-3479-2021; ABE-6685-2020; CXJ-7203-2022; FTW-2214-2022Publication Comparison of semen parameters in the same patients before and after diagnosis of COVID-19(Wiley, 2023-09-01) Çakır, Cihan; Kuşpınar, Göktan; Kurt, Gizem; Berber, Miray; Aslan, Kiper; Kasapoğlu, Işıl; Uncu, Gürkan; Avcı, Berrin; ÇAKIR, CİHAN; KUŞPINAR, GÖKTAN; Kurt, Gizem; Berber, Miray; ASLAN, MÜNİR KİPER; KASAPOĞLU, IŞIL; UNCU, GÜRKAN; AVCI, BERRİN; Tıp Fakültesi; Histoloji ve Embriyoloji Ana Bilim Dalı; 0000-0002-8332-7353; 0000-0002-9277-7735; AAH-5249-2021; HTQ-5866-2023; DBD-8926-2022; JLV-2420-2023; AER-7173-2022; CXJ-7203-2022; AAT-3479-2021; ELU-2357-2022Clinical and histopathological evidence suggest that the male reproductive system may be negatively impacted in patients with coronavirus disease (COVID-19). The objective of this study is to investigate the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on semen parameters by comparing semen analyses before and after COVID-19 diagnosis in the same patient. We retrospectively analyzed 342 semen analyses by reviewing medical records. The study included two groups of patients: (i) those who underwent two consecutive semen analyses within 6 months, one before (n = 114) and one after (n = 114) COVID-19 diagnosis, and (ii) a control group (n = 114) that was age-matched and did not receive a diagnosis of COVID-19. The study results indicated a significant decrease in semen volume, total sperm count per ejaculate, progressive motile sperm count, total motile sperm count, and normal sperm morphology after SARS-CoV-2 infection in comparison to their respective values before the infection. Subgroup analyses showed that the duration of COVID-19 diagnosis (short-term vs. long-term) did not impact the changes in semen parameters. However, fever during the COVID-19 process had a negative effect on semen parameters, particularly sperm concentration, unlike in patients without fever. In conclusion, our findings suggest that SARS-CoV-2 infection is associated with a decline in semen quality, which may potentially impact male fertility. Furthermore, it's important to note that the negative effects on semen parameters may persist in the long-term. Our results also indicate that fever during active infection could be a significant risk factor that negatively affects spermatogenesis.Publication The effect of premature elevated progesterone level in late follicular phase on oocyte quality.(Elsevier, 2019-09-01) Çakır, Cihan; Kuşpınar, Göktan; Kasapoğlu, Işıl; Ata, Mustafa Barış; Uncu, Gürkan; Avcı, Berrin; ÇAKIR, CİHAN; KUŞPINAR, GÖKTAN; KASAPOĞLU, IŞIL; UNCU, GÜRKAN; AVCI, BERRİN; Tıp Fakültesi; Kadın Hastalıkları ve Doğum; 0000-0002-8332-7353; AAT-3479-2021; HTQ-5866-2023; ABE-6685-2020; AAH-5119-2021; AAH-5249-2021; CXJ-7203-2022Publication Reliability of hypo-osmotic swelling test on fresh and frozen-thawed ejaculated or testicular immotile sperm: A sibling oocyte study(Elsevier, 2023-12-30) Ata, Barış; ÇAKIR, CİHAN; Çakır, Cihan; Kuşpınar, Göktan; KUŞPINAR, GÖKTAN; Ganiyev, Alim; ASLAN, MÜNİR KİPER; Kasapoğlu, Işıl; KASAPOĞLU, IŞIL; Kılıçarslan, Hakan; KILIÇARSLAN, HAKAN; Avcı, Berrin; UNCU, GÜRKAN; AVCI, BERRİN; Tıp Fakültesi; Kadın Hastalıkları ve Doğum Ana Bilim Dalı; 0000-0002-8332-7353; 0000-0002-9277-7735; 0000-0003-1106-3747; AER-7173-2022; AAH-5249-2021; AER-7173-2022; HTQ-5866-2023; AAH-5249-2021; AAT-3479-2021The viability of sperm is a crucial factor for achieving a successful pregnancy in intracytoplasmic sperm injection (ICSI) cycles. The aim of this study was to evaluate the accuracy of the hypo-osmotic swelling test (HOST) in fresh and frozen-thawed sperm samples of different origins (ejaculated/testicular). A retrospective analysis was conducted on the outcomes of 2167 oocytes subjected to ICSI using motile and immotile-HOST-positive sperm from 2011 to 2023. We evaluated embryonic development, as well as clinical, obstetric, and neonatal outcomes in four groups based on different sperm origins (ejaculated/testicular) and processing (fresh/frozen). When comparing the results of ICSI between motile and immotile-HOST-positive sperm within each group, it was observed that there were no significant differences in the outcomes for fresh samples. However, for frozenthawed samples, fertilization rates and blastocyst development rates were significantly lower when ICSI was performed with immotile-HOST-positive sperm compared to motile sperm. Of note, clinical, obstetric, and neonatal outcomes were statistically similar across all groups. Our findings indicate that HOST is more reliable in fresh samples than in those subjected to the freeze-thaw process. Nonetheless, HOST is considered a safe method for selecting viable sperm in all subgroups.Publication Does adjuvant usage in the luteal phase improve live birth rates of icsi - et patients with previous implantation failure?(Oxford Univ Press, 2022-07-01) UNCU, GÜRKAN; Uncu, Gürkan; Kasapoğlu, I.; KASAPOĞLU, IŞIL; ASLAN, MÜNİR KİPER; Çınar, C.; Kuşpınar, G.; KUŞPINAR, GÖKTAN; Avcı, B.; AVCI, BERRİN; Tıp Fakültesi; Kadın Hastalıkları ve Doğum Ana Bilim Dalı; 0000-0002-9277-7735; HTQ-5866-2023; AER-7173-2022Publication Which is more predictive ovarian reserve marker when there is discordance between anti - mullerian hormone and antral follicle count in patients with diminished ovarian reserve, amh or afc?.(Elsevier, 2020-09-01) Aslan, Kiper; ASLAN, MÜNİR KİPER; Kasapoglu, Isil; KASAPOĞLU, IŞIL; Koç, Meltem; KOÇ ÇAKAR, MELTEM; Kuşpınar, Göktan; KUŞPINAR, GÖKTAN; Avcı, Berrin; AVCI, BERRİN; Uncu, Gürkan; UNCU, GÜRKAN; Tıp Fakültesi; Kadın Hastalıkları ve Doğum Ana Bilim Dalı; 0000-0002-9277-7735; 0000-0001-6456-8779; HTQ-5866-2023; AAH-9694-2021; AAH-5119-2021; AER-7173-2022; AAT-3479-2021Amer Soc Reprod MedPublication What is the effect of embryo morphology on serum β-hCG levels?(Elsevier, 2019-02-01) Kuşpınar, Göktan; Kasapoğlu, Işıl; Çakır, Cihan; Ata, Barış; Uncu, Gürkan; Avcı, Berrin; KUŞPINAR, GÖKTAN; KASAPOĞLU, IŞIL; ÇAKIR, CİHAN; UNCU, GÜRKAN; AVCI, BERRİN; Tıp Fakültesi; Kadın Hastalıkları ve Doğum Ana Bilim Dalı; 0000-0002-8332-7353; 0000-0002-0338-8368; HTQ-5866-2023; ABE-6685-2020; AAT-3479-2021; AAH-5249-2021; CXJ-7203-2022 ; AAH-5119-2021Objective: To determine the effect of embryonic factors on serum beta human chorionic gonadotropin (beta-hCG) levels in pregnancy and live birth resulting after a single fresh cleavage embryo and blastocyst transfer.Study design: This was a retrospective cohort study conducted at a tertiary care hospital. All fresh single embryo transfers (sETs) between September 2011 and December 2016 were included. The correlation analysis was performed to determine the association of embryo morphological parameters on mean serum beta-hCG levels on day 12 after the transfer of a fresh single cleavage embryo and a fresh single blastocyst embryo.Results: Out of a total of 455 fresh sETs, 60 positive beta-hCG results after the transfer of a single fresh cleavage-stage embryo and 82 after the transfer of a single fresh blastocyst. The mean beta-hCG level resulting from a single fresh blastocyst ET was 371.7 +/- 52.7 IU/L, which was similar to the mean beta-hCG level resulting from a cleavage ET (314.5 +/- 36.9 IU/L) (p=.70). Interestingly, serum beta-hCG levels resulting from a single fresh blastocyst ET showed a correlation with day 5 blastocoele expansion, trophectoderm cell number and blastocyst quality score in ongoing pregnancy (r = .33, p = .02; r = .29, p = .04; and r = .31, p = .03, respectively). Moreover, day 5 blastocoele expansion and blastocyst quality score showed a correlation with the serum beta-hCG levels resulting from a single fresh blastocyst ET in live birth (r = .36, p = .02; r = .31, p = .04, respectively).Conclusion: Our study suggests that serum beta-hCG levels resulting from a single fresh blastocyst ET showed a correlation with day 5 blastocoele expansion and blastocyst quality score in both ongoing pregnancy and live birth. (C) 2018 Elsevier B.V. All rights reserved.