Person: DÖNMEZ, OSMAN
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DÖNMEZ
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OSMAN
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Publication Our results of pediatric kidney transplantation; Single center experience, Uludag University department of pediatric nephrology(Springer, 2015-09-01) Dönmez, Osman; Akacı, Okan; Kaygısız, Onur; Uysal, Berfin; Ciğerdelen, Nuray; DÖNMEZ, OSMAN; Akacı, Okan; KAYGISIZ, ONUR; Uysal, Berfin; Ciğerdelen, Nuray; Tıp Fakültesi; Üroloji Ana Bilim Dalı; 0000-0002-2148-1160; 0000-0002-9790-7295; AFO-2965-2022; AAA-8778-2021; L-9439-2019; GRJ-8581-2022; AAM-9726-2020Publication Urinary hsp70 improves diagnostic accuracy for urinary tract infection in children: Utilise study(Springer, 2022-11-01) Yılmaz, Alev; Afonso, Alberto Caldas; Akil, İpek; Aksu, Bağdagül; Alpay, Harika; Atmış, Bahriye; Aydoğ, Özlem; Bayazıt, Aysun Karabay; Bayram, Meral Torun; Bilge, Ilmay; Bulut, Ipek Kaplan; Büyükkaragöz, Bahar; Çomak, Elif; Demir, Belde Kasap; Dincel, Nida; Durmus, Mehmet Akif; Dursun, Hasan; Dusunsel, Ruhan; Duzova, Ali; Ertan, Pelin; Gedikbaşı, Asuman; Göknar, Nilufer; Güven, Sercin; Hacıhamdioğlu, Duygu; Jankauskiene, Augustina; Kalyoncu, Mukaddes; Kavukçu, Salih; Kenan, Bahriye Uzun; Kücük, Nuran; Kural, Bahar; Litwin, Mieczyslaw; Montini, Giovanni; Morello, William; Nayir, Ahmet; Obrycki, Lukasz; Ömer, Beyhan; Özdemir, Ebru Mısırlı; Özkayın, Neşe; Paripovic, Dusan; Pehlivanoglu, Cemile; Saygılı, Seha; Schaefer, Susanne; Sönmez, Ferah; Tabel, Yilmaz; Taş, Nesrin; Taşdemir, Mehmet; Teixeira, Ana; Tekcan, Demet; Tulpar, Sebahat; Türkkan, Özde Nisa; Uysal, Berfin; Uysalol, Metin; Vaiciuniene, Daiva; Yavuz, Sevgi; Yel, Sibel; Yıldırım, Tarık; Yıldırım, Zeynep Yürük; Yıldız, Nurdan; Yüksel, Selçuk; Yurtseven, Eray; Schaefer, Franz; Topaloğlu, Rezan; DÖNMEZ, OSMAN; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; CCS-5304-2022Publication Extracorporeal treatment in childhood intoxications; 16 years of experience(Springer, 2015-09-01) Akacı, Okan; Dönmez, Osman; Uysal, Berfin; Oral, Orçun; Kara, Cansu; Çelenk, Mercan; Meydan, Ayfer; Akacı, Okan; DÖNMEZ, OSMAN; Uysal, Berfin; Oral, Orçun; Kara, Cansu; Çelenk, Mercan; Meydan, Ayfer; Tıp Fakültesi; Pediatri ve Nefroloji Bölümü; 0000-0002-2148-1160; AFO-2965-2022; AAA-8778-2021; GRJ-8581-2022; DKA-1762-2022; FGJ-3154-2022; CKH-9696-2022; FLT-6688-2022Publication Evaluation of claria sharesource system from the perspectives of patient/caregiver, physician, and nurse in children undergoing automated peritoneal dialysis(Springer, 2021-10-01) Kenan, Bahriye Uzun; Kılıç, Beltinge Demircioğlu; Kara, Mehtap Akbalık; Taktak, Aysel; Bayazıt, Aysun Karabay; Yıldırım, Zeynep Nagehan Yürük; Delibaş, Ali; Aytaç, Mehmet Baha; Conkar, Seçil; Aksoy, Gülşah Kaya; Dönmez, Osman; Yel, Sibel; Saygılı, Seha; Akacı, Okan; Buyukkaragöz, Bahar; Alpay, Harika; Bakkaloğlu, Sevcan A.; DÖNMEZ, OSMAN; Tıp Fakültesi; CCS-5304-2022Publication Clinical course of C3 glomerulopathy in Turkish children: A multicenter study(Springer, 2018-10-01) Dursun, İsmail; Pınarbaşı, Ayşe Seda; Gökçe, İbrahim; Çomak, Elif; Saygılı, Seha; Bayram, Meral Torun; Dönmez, Osman; Melek, Engin; Tekcan, Demet; Yılmaz, Dilek; Ezgü, Sevcan Azime Bakkaloğlu; Tabel, Yılmaz; Yildirim, Zeynep Y.; Bahat, Elif; Koyun, Mustafa; Soylu, Alper; Calışkan, Salim; Yavaş, Bağdagül; Celakil, Mehtap Ezel; Taşdemir, Mustafa; Benzer, Meryem; Özçelik, Gül; Düşünsel, Ruhan; DÖNMEZ, OSMAN; Tıp Fakültesi; Pediatri ve Nefroloji Bölümü; AAA-8778-2021Publication Urinary HSP70 improves diagnostic accuracy for urinary tract infection in children: UTILISE study(Springer, 2022-07-18) Yılmaz, Alev; Afonso, Alberto Caldas; Akıl, İpek; Aksu, Bağdagül; Alpay, Harika; Atmış, Bahriye; Aydog, Özlem; Bayram, Meral Torun; Bilge, Ilmay; Bulut, Ipek Kaplan; Buyukkaragoz, Bahar; Comak, Elif; Demir, Belde Kasap; Dincel, Nida; Dönmez, Osman; Durmus, Mehmet Akif; Dursun, Hasan; Dusunsel, Ruhan; Duzova, Ali; Ertan, Pelin; Gedikbaşı, Asuman; Göknar, Nilüfer; Güven, Sercin; Hacıhamdioğlu, Duygu; Jankauskiene, Augustina; Kalyoncu, Mukaddes; Kavukcu, Salih; Kenan, Bahriye Uzun; Küçük, Nuran; Kural, Bahar; Montini, Giovanni; Morello, William; Nayir, Ahmet; Obrycki, Lukasz; Ömer, Beyhan; Özdemir, Ebru Mısırlı; Özkayin, Nese; Paripovic, Dusan; Pehlivanoğlu, Cemile; Saygili, Seha; Schaefer, Susanne; Sönmez, Ferah; Tabel, Yılmaz; Taş, Nesrin; Taşdemir, Mehmet; Teixeira, Ana; Tekcan, Demet; Tulpar, Sebahat; Türkkan, Özde Nisa; Uysal, Berfin; Uysalol, Metin; Vaiciuniene, Daiva; Yavuz, Sevgi; Yel, Sibel; Yıldırım, Tarık; Yıldırım, Zeynep Yürük; Yıldız, Nurdan; Yüksel, Selçuk; Yurtseven, Eray; Schaefer, Franz; Topaloğlu, Rezan; Bayazıt, Aysun Karabay; Litwin, Mieczyslaw; DÖNMEZ, OSMAN; Tıp Fakültesi; Çocuk Nefrolojisi Ana Bilim Dalı; CCS-5304-2022Background The accuracy of conventional urinalysis in diagnosing urinary tract infection (UTI) in children is limited, leading to unnecessary antibiotic exposure in a large fraction of patients. Urinary heat shock protein 70 (uHSP70) is a novel marker of acute urinary tract inflammation. We explored the added value of uHSP70 in discriminating UTI from other infections and conditions confused with UTI.Methods A total of 802 children from 37 pediatric centers in seven countries participated in the study. Patients diagnosed with UTI (n = 191), non-UTI infections (n = 178), contaminated urine samples (n = 50), asymptomatic bacteriuria (n = 26), and healthy controls (n = 75) were enrolled. Urine and serum levels of HSP70 were measured at presentation in all patients and after resolution of the infection in patients with confirmed UTI.Results Urinary (u)HSP70 was selectively elevated in children with UTI as compared to all other conditions (p < 0.0001). uHSP70 predicted UTI with 89% sensitivity and 82% specificity (AUC = 0.934). Among the 265 patients with suspected UTI, the uHSP70 > 48 ng/mL criterion identified the 172 children with subsequently confirmed UTI with 90% sensitivity and 82% specificity (AUC = 0.862), exceeding the individual diagnostic accuracy of leukocyturia, nitrite, and leukocyte esterase positivity. uHSP70 had completely normalized by the end of antibiotic therapy in the UTI patients. Serum HSP70 was not predictive.Conclusions Urine HSP70 is a novel non-invasive marker of UTI that improves the diagnostic accuracy of conventional urinalysis. We estimate that rapid urine HSP70 screening could spare empiric antibiotic administration in up to 80% of children with suspected UTI.Publication Results of Turkish multicentric national cystinosis registry(Springer, 2015-09-01) Topaloğlu, Rezan; Gülhan, Bora; Özaltın, Fatih; Bodur, İlknur; Beşbaş, Nesrin; Dursun, Hasan; Yılmaz, Alev; Gürgöze, Metin Kaya; Gökçe, İbrahim; Akıncı, Nurver; Erdoğan, Özlem; Dursun, İsmail; Canpolat, Nur; Dönmez, Osman; Çaycı, Fatma Şemsa; Serdaroğlu, Erkin; Çomak, Elif; Nalcacıoğlu, Hülya; Gök, Faysal; Yüksel, Selçuk; Soylu, Alper; Bahat, Elif; Hacıhamdioğlu, Duygu Ovunç; Candan, Cengiz; Baştuğ, Funda; DÖNMEZ, OSMAN; Tıp Fakültesi; Çocuk Nefroloji Ana Bilim Dalı; AAA-8778-2021Publication Complement gene mutations in children with C3 glomerulopathy: Do they affect the response to mycophenolate mofetil?(Springer, 2023-12-02) Günay, Neslihan; Dursun, İsmail; Gökce, Ibrahim; Kara, Mehtap Akbalik; Tekcan, Demet; Çiçek, Neslihan; Bayram, Meral Torun; Koyun, Mustafa; Dincel, Nida; Dursun, Hasan; Saygılı, Seha; Yıldırım, Zeynep Nagehan Yürük; Yüksel, Selçuk; Yel, Sibel; Kılıç, Beltinge Demircioğlu; Aydoğ, Özlem; Atmıs, Bahriye; Yılmaz, Aysun Çaltık; Bakkaloğlu, Sevcan A.; Aytaç, Mehmet Baha; Taşdemir, Mehmet; Kasap Demir, Belde; Soylu, Alper; Çomak, Elif; Özşahin, Aslı Kantar; Kaçar, Alper; Canpolat, Nur; Yılmaz, Alev; Girişgen, İlknur; Alpay, Harika; Poyrazoğlu, Hakan M.; DÖNMEZ, OSMAN; AKKOYUNLU, BETÜL; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim DalıBackgroundC3 glomerulopathy (C3G) is a complement-mediated disease. Although genetic studies are not required for diagnosis, they are valuable for treatment planning and prognosis prediction. The aim of this study is to investigate the clinical phenotypes, kidney survival, and response to mycophenolate mofetil (MMF) treatment in pediatric C3G patients with and without mutations in complement-related genes.MethodsSixty pediatric C3G patients were included, divided into two groups based on complement-related gene mutations. Demographic and clinical-pathological findings, treatment modalities, and outcome data were compared, and Kaplan-Meier analysis was performed for kidney survival.ResultsOut of the 60 patients, 17 had mutations. The most common mutation was in the CFH gene (47%). The mean age at diagnosis was higher in the group with mutation (12.9 +/- 3.6 vs. 11.2 +/- 4.1 years, p = 0.039). While the patients without mutation most frequently presented with nephritic syndrome (44.2%), the mutation group was most likely to have asymptomatic urinary abnormalities (47.1%, p = 0.043). Serum parameters and histopathological characteristics were similar, but hypoalbuminemia was more common in patients without mutation. During 45-month follow-up,10 patients progressed to chronic kidney disease stage 5 (CKD5), with 4 having genetic mutation. The time to develop CKD5 was longer in the mutation group but not significant. MMF treatment had no effect on progression in either group.ConclusionsThis study is the largest pediatric C3G study examining the relationship between genotype and phenotype. We showed that the mutation group often presented with asymptomatic urinary abnormalities, was diagnosed relatively late but was not different from the without mutation group in terms of MMF treatment response and kidney survival.Graphical abstractA higher resolution version of the Graphical abstract is available as Supplementary informationPublication Covid-19 in pediatric nephrology centers in Turkey(Springer, 2021-10-01) Bakkaloglu, Sevcan A.; Atikel, Yesim Ozdemir; Leventoğlu, Emre; Nalcacioglu, Hulya; Dursun, IsmaIl; PoyrazoGlu, Hakan; Dursun, Hasan; Yildirim, Zeynep Yuruk; Yildiz, Nurdan; Aksoy, Gulsah Kaya; Akman, Sema; Tasdemir, Mehmet; Bilge, Ilmay; Celakil, Mehtap; Kilic, Beltinge Demircioglu; Selcuk, Senay Zirhli; Canpolat, Nur; Cakici, Evrim Kargin; Ozlu, Sare Gulfem; Tulpar, Sebahat; Yuksel, Selcuk; Atmis, Bahriye; Doven, Serra Surmeli; Taner, Sevgin; Ertan, Pelin; Kavaz, Asli; Bayram, Meral Torun; Kalyoncu, Mukaddes; GUlleroGlu, Kaan; Kabasakal, Caner; Demir, Belde Kasap; Cicek, Rumeysa Yasemin; Donmez, Osman; Kara, Aslihan; Yavascan, Onder; Ozcelik, Gul; Yildirim, Deniz Gezgin; Guler, Muhammet Akif; Sonmez, Ferah; Topaloglu, Rezan; Alpay, Harika; Dönmez, Osman; DÖNMEZ, OSMAN; Tıp Fakültesi; 0000-0001-6530-9672; 0000-0001-5304-3125; 0000-0002-0504-7911; 0000-0002-0686-9714; 0000-0002-0191-4344; 0000-0003-2891-2231; 0000-0003-0293-1581; 0000-0001-7131-8911; 0000-0002-5579-6339; 0000-0002-4852-989X; 0000-0002-1697-6206; 0000-0001-9415-1640; 0000-0001-9109-859X; 0000-0002-2994-7201; 0000-0003-1434-3824; 0000-0003-4410-0444; 0000-0001-9394-2977; 0000-0002-6423-0927; GQP-4951-2022; F-3294-2013; AAA-8957-2021; JLL-9304-2023; JCE-7313-2023; C-5473-2015; AAJ-8833-2021; AAW-7097-2020; AAP-7394-2020; HTL-5515-2023; L-1713-2016; JDW-3813-2023; AAM-2913-2021; C-1642-2016; W-7320-2018; V-7413-2017; AAA-4023-2020; IAP-2930-2023; GSI-4238-2022; AAE-1511-2020; HCH-8357-2022; JAO-2810-2023; JYQ-2668-2024Publication Post-transplant lymphoproliferative disease in pediatric kidney transplant recipients in Turkey(Springer, 2022-11-01) Dursun, Ismail; Koyun, Mustafa; Canpolat, Nur; Poyrazoğlu, Hakan; Bakkaloğlu, Sevcan; Çomak, Elif; Gülmez, Rüveyda; Bayram, Meral Torun; Bilge, Ilmay; Table, Yılmaz; Dönmez, Osman; DÖNMEZ, OSMAN; Tıp Fakültesi; Pediatri Nefroloji Bölümü; JHC-5766-2023
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