Browsing by Author "Batmaz, Hasan"
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Publication Acute interstitial pneumonia in nongrazing cows(Kafkas Üniversitesi Veteriner Fakultesi Dergisi, 2021-09-01) Batmaz, Hasan; CangÜl, İbrahim Taci; BATMAZ, HASAN; CANGÜL, İBRAHİM TACİ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Tıp Bölümü; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Bölümü; 0000-0003-0537-2113; HXD-1722-2023; AAB-4360-2021Item Agresif köpeklerin tedavisinde amitriptilin ve klomipraminin karşılaştırılması(Uludağ Üniversitesi, 2009-03-18) Yalçın, Ebru; Batmaz, Hasan; Bursa Uludağ Üniversitesi/Veteriner Fakültesi.Bu çalışmanın amacı, agresyon problemi olan köpeklerin sağaltımında amitriptilin ve klomipraminin etkinliğinin karşılaştırılmasıdır. Çalışmada saldırganlık gösteren ve sahibinin sağaltımı kabul ettiği 24 köpek kullanıldı ve köpekler 3 eşit gruba ayrıldı. Altı hafta süresince, ağız yolu ile bir gruba 2 mg/kg dozda amitriptilin hidroklorid, bir gruba 1 mg/kg dozda klomipramin hidroklorid ve diğer gruba da plasebo uygulandı ve ikişer haftalık periyotlarla hasta sahipleriyle görüşülerek davranış değişiklikleri takip edildi. Çalışmanın sonunda, amitriptilin uygulanan grupta, 4 hastada hayvan sahiplerinin şikayetlerinin ortadan kalktığı ve 3 hastada bu durumun kısmi olduğu saptanmış ve grup içinde p<0.01 düzeyinde istatistiki farklılık bulunmuştur. Klomipramin uygulanan grupta 5 hastada hayvan sahiplerinin şikayetlerinin ortadan kalktığı ve 2 hastada da bu durumun kısmi olduğu görülmüş olup, grup içinde p<0.001 düzeyinde istatistiki farklılık gözlenmiştir. Kontrol grubunda ise 2 hastada hayvan sahiplerinin şikayetlerinin ortadan kalktığı, 2 hastada bu durumun kısmi olduğu görülmüş olup, 4 hastada ise şikayetlerin sürdüğü gözlenmiş ve grup içinde istatistiki farklılık saptanmamıştır. Gruplar arasında değerlendirme yapıldığında aynı haftaların karşılaştırılmasında önemli farklılık saptanmamıştır. Agresyon gösteren her 3 gruptaki köpeklerde sağaltım öncesi ve sonrasında total lökosit, hematokrit, üre ve ALT düzeylerinde farklılık tespit edilmemiştir. Sonuç olarak, saldırganlık belirtisi gösteren köpeklerin sağaltımında amitriptilin ve klomipraminin kullanımının etkili olabileceği ve bu iki ilacın birbirlerine belirgin bir üstünlüğünün olmadığı kanısına varılmıştır.Item Botulism (type A) in a horse - case report(Veterinarni a Farmaceuticka Univerzita Brno, 2016-02-10) Gessler, Frank; Kasap, Sevim; Batmaz, Hasan; Kocatürk, Meriç; Çatık, Serkan; Topal, Onur; Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı.; 0000-0003-1991-8957; 0000-0002-1933-7354; AAP-7998-2020; AAH-1712-2021; S-8278-2017; V-5578-2017; 36514844800; 6602783183; 36437200800; 56515323800; 56548777100This paper presents the case of a six year-old, male, thoroughbred horse with clinical signs of inappetence, weakness, and incoordination when walking. Clinical examination showed that the horse staggered and leaned to the left side. Feedstuff was present inside and around its mouth. Salivation was increased and there was no reflex at the palpebrae and tongue. The horse had difficulty swallowing and the tone of its tail was reduced. Botulism was diagnosed based on the clinical signs. Antibiotic (ceftiofur) and fluid-electrolyte treatment was commenced. Next day, neostigmin was added to the horse's treatment, and it became recumbent. The horse's palpebral, tongue and tail reflexes returned partially after neostigmine methylsulphate treatment on the same day and it stood up on day four. However, it could not swallow anything during the whole week, so after getting permission from the owner, the horse was euthanized on day 10. Samples of the colonic content and blood serum were sent by courier to the laboratory for toxin neutralization, however, botulinum neurotoxins could not be detected. After that, serum samples from days 6 and 10 were sent to another laboratory for testing for botulinum neurotoxin antibodies by ELISA. Specific antibodies against botulinum neurotoxin type A were measured, indicating a previous, immuno-relevant contact with the toxin. This seroconversion for type A supports the clinical botulism diagnosis. Type A botulism is rarely seen in Europe and has been detected in a horse in Turkey for the first time.Item Bovine leukemia virusu (blv) ile doğal olarak infekte aleukemik sığırların humoral immun yanıtı ve in vivo t -hücresi cevabı(Uludağ Üniversitesi, 1992) Çarlı, K. Tayfun; Batmaz, Hasan; Şen, Ayşin; Minbay, Ahmet; Uludağ Üniversitesi/Veteriner Fakültesi.Bu çalışmada, aynı sayıda Enzootik Bovine Leukosis'li ve aleukemik (EBL + PL-) ve bu infeksiyona sahip olmayan (seronegatif; EBL-) 2 inek grubu in vivo T-hücresi ve humoral immun yanıtlan yönünden karşılaştınldılar. EBL + PL- gruba ait in vivo T-hücresi yanıtının EBLgrubunkine göre istatistiki olarak daha düşük (P s 0.01) oluştuğu belirlendi. T-independent antijen (Brncella S19)'e karşı humoral immun yanıt yönünden iki grup arasında bir fark olmadığı saptandı.Publication Butaphosphan and cyanocobalamin treatment of pregnant ewes: Metabolic effects and potential prophylactic effect for pregnancy toxaemia(Elsevier, 2015-04-01) Temizel, Ethem Mutlu; Batmaz, Hasan; Keskin, Abdülkadir; Orman, Abdülkadir; Gençoğlu, Hıdır; Çatık, Serkan; Topal, Onur; TEMİZEL, ETHEM MUTLU; BATMAZ, HASAN; KESKİN, ABDULKADİR; ORMAN, ABDÜLKADİR; GENÇOĞLU, HIDIR; Çatık, Serkan; TOPAL, ONUR; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı; 0000-0001-9138-4422; 0000-0002-1933-7354; 0000-0003-1991-8957; HJZ-4775-2023; AAH-1712-2021; AAH-3831-2021; AAG-9134-2021; S-8278-2017; ECV-4083-2022; CHM-0716-2022The effect of administration of butaphosphan and cyanocobalamin on the prophylaxis of pregnancy toxaemia in ewe was investigated. Moreover, the effects of these compounds on body weight gain and biochemical metabolism of pregnant ewe was assessed. A total of 59 pregnant Kivircik crossbred ewes were used in this study. Group I (n: 15) was administered butaphosphan and cyanocobalamin three times before delivery at 1-week intervals. Group II (n: 15) was administered butaphosphan and cyanocobalamin three times before delivery at 3-day intervals. Group III (n: 15) was administered 0.9% NaCl three times before delivery at 1-week intervals. Group IV (n: 14) was administered 0.9%NaCI three times before delivery at 3-day intervals. Six blood samples Were taken from each ewe four times before delivery and two times after delivery. Haematological and biochemical analyses were performed.The levels of BHB and NEFA in groups administered butaphosphan and cyanocobalamin were noticeably lower but there were no statistically significance. Elevated BHB (>0.8 mmol/L), subclinical pregnancies toxaemia were identified in 56.66% in test groups and 72.41% in control groups in all ewes and this was higher in the ewes bearing multiple pregnancies 71.42 in test groups and 82.35% in control groups. Subclinical pregnancy toxaemia in pregnant ewes with twins or triplets is lower than the levels for the control groups, despite the greater lamb counts and weights of the ewes in test groups.Based on our results, it was concluded that the butaphosphan and cyanocobalamin combination could be used as an alternative treatment for the prevention of pregnancy toxaemia. (C) 2015 Elsevier B.V. All rights reserved.Item Buzağı enzootik pneumonisinin tedavisinde enrofloxacin ile enrofloxacin+flunixin meglumine kombinasyonunun etkilerinin karşılaştırılması(Uludağ Üniversitesi, 1999-09-07) Yılmaz, Zeki; Şentürk, Sezgin; Batmaz, Hasan; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.Bu araştırmada enzootik pneumoni belirtileri (ateş, taşipne, öksürük ... ) gösteren 40 buzağıda (3-6 aylık) enrofloksasin ile enrofloksasin+fluniksin meglumin kombinasyonunun etkilerinin karşılaştırılması amaçlandı. Tedavi aşamasında iki farklı grup oluşturuldu; I.gruptan=20) enrofloksasin (5 mg/kg, i.m.,x 1, 5 gün), II. gruptan=20) bu tedavi ile birlikte fluniksin meglumin (2.2mg/kg, i.v., tek doz) kullanıldı. Klinik ve hematolojik muayeneler araştırmanın 1., 2., 3., 5. ve 7.günlerinde tekrar edildi. Temperaturun I.grupta 3.günden, ll.grupta ise 2.günden itibaren azaldığı (p<0.001); kalp frekansı ve solunum sayısının II.grupta I.gruba göre 2.günden itibaren daha az olduğu belirlendi. Total lökosit sayılarının her iki grupta da tedavi ile birlikte arttığı, II.gruptaki nötrofil oranının 2.günden itibaren azaldığı, ancak normal sınırlar içinde kaldıkları tespit edildi. Beş günlük tedavi sonrasında tam olarak iyileşmediği belirlenen I.gruptaki 13, II.gruptaki 4 buzağıya 2 gün süreyle enrofloksasin uygulamasına devam edildi. Sonuç olarak bu araştırma ile buzağı enzootik pneumonilerinin tedavisinde enrofloksasin ile tek doz fluniksin meglumin kombinasyonunun etkili bir şekilde kullanılabileceği ve beraberinde tedavi süresinin kısaltılabileceği kanısına varıldı.Item Buzağılarda farklı pasif transfer durumlarının sütten kesim öncesi ishal durumları ile vücut ağırlıkları arasındaki ilişki(Bursa Uludağ Üniversitesi, 2020-05-11) Topal, Onur; Batmaz, Hasan; Bursa Uludağ Üniversitesi/Karacabey Meslek Yüksekokulu.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0002-1933-7354; 0000-0003-1991-8957Buzağılarda neonatal dönem çok önemli olduğundan yeni doğan buzağıların doğumdan sonra yeterli miktarda kolostrum almaları ve yakından takip edilerek bu dönemin iyi yönetilmesi gerekmektedir. Bu çalışmada buzağıların farklı pasif transfer durumları ile ilk 15 gün ve 16-60 günlük dönemdeki ishal durumları ve sütten kesilme dönemine kadar olan vücut ağırlıkları arasındaki ilişkilerinin araştırılması amaçlan- mıştır. Çalışmada 82 adet Holştayn buzağı yer almıştır. Buzağılarda 24.saatteki serum immunoglobulin G seviyelerine göre pasif transfer yetmezliği (PTY) %29,26 oranında saptanmıştır. İlk 15 günlük dönemde buzağıların %64,63’ünde ishal görülmüştür. İshalli buzağıların %56,60’nı erkek ve %43, 40’nı dişi buzağılar oluşturmuştur. Neonatal dönemdeki ishallerin yaklaşık %75’i ilk 15 günde görülürken, bu dönemde de ishallerin %73,58’i 6-10 günlük dönemde gözlenmiştir. İlk 15 günde ishal olan buzağıların %32,08’i 16-60 günlük dönemde tekrar ishal olmuştur. On altı-altmış günlük dönemde immunoglobulin G seviyesi 20 g/L’den yüksek olan buzağılarda hastalık görülme oranı en düşük olmuştur. Her iki dönemde de ishal görülen buzağıların vücut ağırlıkları yalnız ilk 15 günlük dönemde ishal olan buzağılar ile karşılaştırıldığında 30., 45. ve 60. gündeki ağırlıkları daha düşük bulunmuştur (p<0,05). Sonuç olarak çok iyi pasif transfer durumuna sahip buzağıların ilk 15 gün içerisinde daha az ishale yakalandığı, bu durumun 16-60 günlük dönemdeki sağlık durumunu ve sütten kesim dönemi sonundaki vücut ağırlığını olumlu etkilediği saptanmıştır.Item Buzağılarda neonatal dönem sağlığını değerlendirmede ilk onbeş günde önemli olan klinik bulguların belirlenmesi(Bursa Uludağ Üniversitesi, 2018-02-16) Topal, Onur; Batmaz, Hasan; Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/İç Hastalıkları Anabilim Dalı.Bu çalışmada buzağıların ilk 15 gününde günlük klinik parametrelerin izlenerek hastalık oluşmadan önce erken tanı kriteri olup olmadıklarının araştırılması ve hastalık durumlarının pasif transfer yetmezliği ve d-laktik asit bulgularıyla da ilişkilendirilerek gerek bu dönemde ve gerekse sütten kesime kadar olan dönemde ortaya çıkacak sağlık problemleri için ön belirti olup olmadıklarının araştırılması amaçlanmıştır. Ayrıca buzağıların 60. güne kadar sağlık durumları ve canlı ağırlıkları izlenerek, ilk 15 günlük dönemdeki hastalıkların 16-60 günlük dönem üzerindeki etkileri incelenmiştir. Çalışmada 82 adet holştayn buzağı incelenmiştir. Buzağılar her gün sistematik olarak muayene edilerek günlük skorlandırma yapılmıştır. İlk 15 günde buzağıların %64,63'ünde ishal oluşmuştur. Sağlıklı buzağılar ile ishalli buzağılar karşılaştırıldığında dışkının kötü kokulu olması (p<0,01), dışkıdaki kıvam ve renk değişikliği, burun akıntısı olması (p<0,001) ishal olmadan bir gün önce ishalli buzağılarda daha sık gözlenmiştir. Buzağılarda 1. ve 3. gündeki pasif transfer yetmezliği %29,26 oranında saptanmıştır. Ayrıca ilk 15 günde ishal olan buzağıların %32,08'i 16-60 günlük dönemde tekrar ishal olmuşlardır. On altı altmış günlük dönemde immunoglobulin G seviyesi 20 g/L'den yüksek olan buzağılarda hastalık görülme oranı en düşük olmuştur. Her iki dönemde de ishal olan buzağıların canlı ağırlıkları sadece ilk 15 günlük dönemde ishal olan buzağılar ile karşılaştırıldığında 30., 45. ve 60. gündeki ağırlıkları daha düşük bulunmuştur (p<0,05). Sonuç olarak buzağılarda ilk 15 günlük dönemde ishal morbiditesi yüksek olmasına rağmen bu dönem ve sonrasında hiç ölüm gözlenmemesi buzağıların günlük olarak izlenmesinin önemini ortaya koymuş, bu dönemdeki ishalin erken klinik belirleyici bulguları olarak dışkının kötü kokulu olması, dışkıdaki renk ve kıvam değişikliği ön plana çıkmıştır.Item Clinical neosporosis in a dog in Turkey(Australian Small Animal Veterinary Assoc, 2004-09) Batmaz, Hasan; Şentürk, Sezgin; Aydın, Levent; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabi̇li̇m Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Parazi̇toloji̇ Anabi̇li̇m Dalı.; 0000-0003-0483-0071; 0000-0003-1991-8957; AAO-9568-2021; AAH-1712-2021; 6602783183; 56257771200; 55808198600A nine-week-old female Doberman Pinscher pup was presented with paraplegia and progressive pelvic limb hyper-extension. The pup had a 1:800 serum antibody titre to Neospora caninum by indirect fluorescent antibody test. Diagnosis was based on clinical signs and serologic examination. The dog died after 18 days therapy with sulphadiazine-trimethoprim (15mg/kg po bid), clindamycin (10mg/kg im bid) and pyrimethamine (1mg/kg po bid).Item Comparing clinical effects of marbofloxacin and gamithromycin in goat kids with pneumonia(Medpharm Publications, 2018-06-20) Kaçar, Yiğit; Batmaz, Hasan; Yılmaz, Özge E.; Meci̇toğlu, Zafer; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Mikrobiyoloji Bölümü.; 0000-0002-5557-121X; 0000-0003-1991-8957; 0000-0002-8389-4833; AAH-1677-2021; AAH-1712-2021; AAG-7421-2021; AAH-4972-2021; 57193763918; 6602783183; 56524019400; 36457647300The aim of this study was to compare the clinical efficacy of a single-dose of gamithromycin (GM) or marbofloxacin (MR) in kids with naturally occurring pneumonia. Thirty-six kids, aged 2-2.5 months, with body weight ranging from 12 kg to 18 kg were presented with clinical signs of pneumonia. The most prominent clinical findings were an increase in the respiratory rate, crackling lung sounds on auscultation, coughing, nasal discharge and an increased rectal temperature. Mannheimia haemolytica and Mycoplasma spp. colonies were isolated from microbiological examination of six transtracheal washes and lung tissues of one necropsied kid. The severity of pneumonia was evaluated by using cumulative clinical score (CCS). The CCS of the 36 kids used in the study were four and above. Kids were randomly divided into two equal groups; the GM group received a single subcutaneous dose of GM at a dosage of 6 mg/kg and the MR group received MR intramuscularly at a dosage of 8 mg/kg as a single-dose. No side effects related to the drugs were detected in either group. All 36 kids were clinically examined 3 weeks after the initiation of the treatment. Clinical signs in both groups were almost completely absent at the end of the study. A single administration of GM or MR was successfully used in the treatment of kids with pneumonia.Publication Comparing the effect of ammonium molybdate versus ammonium molybdate and menbutone on hepatic functions of sheep with subclinical copper poisoning(Wiley, 2022-09-27) Kaçar, Yiğit; Mecitoğlu, Zafer; Batmaz, Hasan; KAÇAR, YİĞİT; MECİTOĞLU, ZAFER; BATMAZ, HASAN; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı; AAH-4972-2021; FQB-3477-2022; HXD-1722-2023This study aimed to investigate the effect of using menbutone in addition to ammonium molybdate on liver enzymes in sheep naturally poisoned with copper. Merino lambs (n = 30), naturally poisoned with copper and which also had high liver enzyme levels, were divided into two groups, each with 15 lambs. The AM + MEN group received ammonium molybdate and menbutone and the AM group received only ammonium molybdate solution. Both groups received 1.7% ammonium molybdate solution (1 mL per 10 kg body weight [BW]) subcutaneously on 0, 2nd and 4th days of the study. Menbutone (Genabil (R), Boehringer Ingelheim, Germany) was administered intramuscularly at a dose of 10 mg/kg BW on days 0 and 2, in addition to ammonium molybdate in the AM + MEN group. Blood samples were collected on days 0 and 7, and aspartate aminotransferase (AST), gamma-glutamyltranspeptidase (GGT) and creatinine levels were evaluated. Over 7 days, AST levels decreased from 351.04 +/- 63.50 IU/L to 286.40 +/- 55.68 IU/L in the AM group (P > 0.05) and from 425.00 +/- 119.25 IU/L to 240.83 +/- 29.62 IU/L in the AM + MEN group (P <= 0.05). GGT levels decreased from 121.16 +/- 15.88 IU/L to 110.39 +/- 10.13 IU/L in the AM group (P > 0.05) and 124.52 +/- 15.50 to 98.60 +/- 9.08 IU/L in the AM + MEN group (P <= 0.05). Based on these findings, the use of menbutone, in addition to ammonium molybdate, has significantly reduced the level of liver enzymes.Item Comparing the effects of treatment with ammonium molybdate versus ammonium molybdate and phenoxy-2-methyl-2-propionic acid on liver functions in natural copper poisoning of sheep(Elsevier, 2017-03-11) Mecitoğlu, Zafer; Topal, Onur; Kaçar, Yiğit; Batmaz, Hasan; Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı.; 0000-0002-5557-121X; 0000-0002-1933-7354; 0000-0002-8389-4833; 0000-0003-1991-8957; AAH-1677-2021; S-8278-2017; AAH-4972-2021; AAH-1712-2021; 36457647300; 56548777100; 57193763918; 6602783183Aim of the presented study is to compare the effects of treatment with ammonium molybdate versus ammonium molybdate and phenoxy-2-methyl-2-propionic acid on liver functions in natural copper poisoning of sheep and overall treatment responses in sheep naturally poisoned with copper (Cu). Study was conducted on 80 yearlings aging between 6-9 months. AM + PMPA group (n =50) received ammonium molybdate and PMPA and AM group (n =30) received only ammonium molybdate. First blood samples were collected before the treatments. PMPA was administered once daily intramuscularly at dose of 10 mg/kg for the first three days of the study to AM + PMPA group. AM + PMPA and AM groups both received ammonium molybdate two times with one week interval at dose of 1.34 mg/kg (1 cc per 10 kg BW, of %1.34 ammonium molybdate in saline solution) subcutaneously. Second blood samples were collected from all 80 animals on day 21 of the study. Cu levels were measured in a subgroup of randomly selected 9 (5 from AM + PMPA and 4 from AM group) animals on days 0 and 21 of the study. Mean Cu levels were 158.25 +/- 14 mu g/dl and 156.75 +/- 9 mu g/dlon day 0 and 129 +/- 9 mu g/dl and 154.5 +/- 22 mu g/dl in AM + PMPA and AM group respectively. AST levels decreased from 502 +/- 67.2114 to 168 +/- 10.1 IU/L in AM + PMPA group (P < 0.001) and from 423 +/- 71.1 IU/Lto 202 +/- 17.1 IU/L in AM group (P = 0.005) on day 21 of the study. GGT levels were 250 +/- 24.2 IU/L and 248 +/- 28.1 IU/L on day 0 and decreased to 160 +/- 16.41 U/L and 166 +/- 22.2 IU/L on day 21 in AM + PMPA and AM group with significance of P=0.001 and P=0.037 respectively. Two animals from AM group and one from AM + PMPA group died during the study period. Based on the more pronounced decrease in AST and GGT levels in AM + PMPA group we conclude that PMPA has beneficial effects on liver functions in chronic copper poisoning of sheep probably as a result of decreased lipid peroxidation in hepatocytes and/or increased Cu elimination by cholerectic effects of PMPA.Item Comparison of IgG and semiquantitative tests for evaluation of passive transfer immunity in calves(Bilimsel ve Teknolojik Araştırma Kurumu, 2018-04-22) Topal, Onur; Batmaz, Hasan; Mecitoğlu, Zafer; Uzbacı, Ender; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-1933-7354; 0000-0003-1991-8957; 0000-0002-5557-121X; 0000-0002-9634-0055; S-8278-2017; AAH-1712-2021; AAH-1677-2021; 56548777100; 6602783183; 36457647300; 55347697800Serum immunoglobulin (IgG) and semiquantitative tests are used for the evaluation of passive transfer immunity (PTI) in calves. We aimed to evaluate PTI in calves by using a Brix refractometer, total protein (TP), gamma-glutamyl transferase (GGT), and glutaraldehyde coagulation test (GCT) on days 1, 3, and 7 after birth; to compare the results with serum IgG; and to evaluate which day these tests are given on will give the best results. The blood samples were collected from 60 Holstein dairy calves on day 0, just after birth, and on the 1st, 3rd, and 7th days after birth. The serum IgG concentration was measured by ELISA, the Brix % and TP concentrations with refractometers, and GGT activity using a dry chemistry system. The duration of the GCT was determined in the first 60 min. The IgG, TP concentration, and Brix % all peaked on the 3rd day of the study. GGT showed a significant decline after 24 h. Evaluating the Brix %, IgG, TP, and GCT levels more than 24 h after birth gives better results. However, GGT activity was observed as an early indicator of failure of passive transfer, as the GGT levels were highest 24 h after birth.Item Comparison of serum, milk and urine as samples in an enzyme immunoassay for bovine leukaemia virus infection(British Veterinary Assoc, 1993) Çarlı, Kamil Tayfun; Batmaz, Hasan; Şen, A.; Minbay, Ahmet; Uludağ Üniversitesi/Veteriner Fakültesi.; 0000-0003-1991-8957; AAH-1712-2021Serum, milk and urine specimens were taken from 15 bovine leukaemia virus (BLV)-positive and 20 BLV-negative cattle which had been determined previously to be infected or not by the use of a monoclonal enzyme-linked immunosorbent assay (ELISA). An ELISA was performed on the samples for the detection of IgG1 antibodies to the BLV surface glycoprotein, gp 51. The three types of samples had parallel optical density (OD) values apart from three urine samples which, although accepted as negative for anti-BLV antibodies, had numerically higher ODS than those of control BLV-negative animals. Therefore, detection of IgG, antibodies against BLV in the urine of naturally infected animals could be an indication for the use of urine for diagnosis of BLV infection.Item Cryptosporidiosis’li buzağılarda inek kolostrumunun tedavideki etkinliğinin ve kan serumundaki proteomik yapı üzerine etkisinin değerlendirilmesi(Bursa Uludağ Üniversitesi, 2020-12-15) Kaçar, Yiğit; Batmaz, Hasan; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Veteriner İç Hastalıkları Anabilim Dalı.; 0000-0002-8389-4833Cryptosporidiosisli buzağılarda tedavi amaçlı kolostrumun, bikarbonatlı veya bikarbonatsız şekilde paramomisin ile kombine edilmesinin, etkinliği ve serum proteomik profiline etkisinin araştırılması amaçlanmıştır. Ayrıca ilk kez yüksek ve düşük kaliteli kolostrumların proteomik analizlerle karşılaştırılması amaçlanmıştır. Çalışmada, yalnızca Cryptosporidium ile enfekte, 21 günden küçük 30 Holştayn buzağı üç eşit gruba ayrılmıştır. Her üç gruba 1x100 mg/kg dozunda paramomisin (5 gün) ilave olarak, Grup 1 ve 2’ ye 2x250 ml kolostrum (3 gün) ve Grup 1’e kolostrum öncesinde 2x6 g sodyum bikarbonat uygulanmıştır. Tedavi öncesinde ve sonrasındaki 10 gün buzağıların klinik muayeneleri, dışkı skorlaması ve ookist sayımları yapılmıştır. Tedavinin 0, 1, 2, 3, 5 ve 7. gün serumlarından Brix% ve total protein (TP), 0 ve 3. günde immunglobulin G (IgG), gamma-glutamyltransferase (GGT) ölçümleri ve proteomik analizler yapılmıştır. Dışkı skorları, Grup 1 ve 2’ de 2. günde tedavi öncesine göre belirgin şekilde (p<0,05) azalırken, Grup 3 (kontrol grubu)’te bu fark 8. günde belirginleşmiştir. Benzer şekilde ookist sayıları Grup 1’de 2. gün, Grup 2’de 3. gün düşmesine karşın Grup 3’te ancak 10. günde fark belirlenmiştir (p<0,05). Kolostrum tedavisine rağmen IgG, TP, Brix% ve GGT düzeylerinin azalması büyük moleküllü proteinlerin yeterince emilmediğini; kolostral tedavi ile Grup 1’de A1AT, SAA, ACTG, HP20; Grup 2’de ise A1BG, S39AB, CTHL1, ACTB APOA4 proteinlerinde değişim olması, ancak Grup 3’te hiçbir proteinde anlamlı değişim olmaması tedavide kolostrum kullanımının buzağı serum proteomiğine etkileri olduğunu göstermiştir. Ayrıca, yüksek kaliteli kolostrumda 8, düşük kaliteli kolostrumda ise 11 protein daha yüksek konsantrasyonda tespit edilmiştir. Sonuçta, cryptosporidiosis tedavisinde paramomisine ilaveten özellikle bikarbonat ve kolostrum kullanımının daha iyi sonuç verdiği gözlenmiştir.Item Current status of Bovine Leukemia Virus (BLV) infection in Turkey(British Cattle Veterinary Association, 1996) Batmaz, Hasan; Çarlı, Kamil Tayfun; Kennerman, Engin; Şen, Ayşin; Yılmaz, Zeki; Uludağ Üniversitesi/Veteriner Fakültesi.; 0000-0003-1991-8957; E-3867-2010; AAH-1712-2021Bovine Leukemia Virus (BLV) infection is common in the world. This infection has also been in Turkey since 1942. Between the years of 1991 and 1994, 941 cattle over the age of six months were investigated using commercially prepared kits for anti-BLV antibodies by ELISA in the Bursa Region of Turkey. Five hundred-fifty blood samples were obtained from cattle of 133 stables in 51 villages found in 10 counties, and also 391 blood samples from the cattle in Bursa abattoir. BLV anti-gp 51 antibodies were determined in 80 (8.50%) out of 941 cattle. BLV antibodies were also determined in 68 cattle (12.36%) in the 10 counties and it was observed that 13 (19.11%) of them had persistent lymphocytosis (1.47%) of them was in lymphosarcoma form. The highest infection rates in Karacabey (25.00%) and Nilufer (18.80%) counties were because of the two semi-intensive farms found there. The results also revealed that BLV infection was most common in animals between five and six years old. For control of transmission of BLV, iatrogenic transmission should be prevented; for this aim, different needles and other tools should be used for each animal. The cattle with persistent lymphocytosis must be particularly eradicated as soon as possible. An eradication programme should be implemented in Turkey as in other countries.Item Detection of IgG antibody to Bovine Leukaemia Virus in urine and serum by two enzyme immunoassays(Wiley, 1999) Çarlı, Kamil Tayfun; Şen, Ayşin; Batmaz, Hasan; Kennerman, Engin; Uludağ Üniversitesi/Veteriner Fakültesi/Mikrobiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0003-1991-8957; AAH-1712-2021; E-3867-2010; 6601971539; 7401592869; 6602783183; 16031244000Four hundred blood sera from a cattle production unit were tested for BLV-(Bovine Leukaemia Virus) antibody with IP (Institut Porquier) and SE (Svanova Biotech) ELISA kits. Seventy-seven cattle with BLV-antibody (19.25%) and 77 without the antibody were used. No significant difference was found between O.D. of sera of PL + (Persistent Lymphocytosis Positive) and PL-(Negative) cattle. The mean O.D. of urine samples of 77 seropositive cattle was significantly higher than that of 77 seronegative cattle (P < 0.01). There were also differences between urine O.D.s of seropositive (PL +) and seropositive (PL-) groups of cattle with IP (P < 0.05) and SB (P < 0.01) kits. All the results revealed the presence of BLV-antibody in the urine of the cattle without any urinary dysfunction.Publication Early clinical predictors of diarrhea in the first fifteen days in dairy calves and their relationship with passive transfer status(Polish Soc Veterinary Sciences Editorial Office, 2020-05-01) Topal, Onur; Batmaz, Hasan; BATMAZ, HASAN; Bursa Uludağ Üniversitesi/Veteriner Fakültesi.; 0000-0002-1933-7354; AAH-1712-2021; S-8278-2017The neonatal period is very important in calves. It is extremely important to closely monitor newborn calves with good colostrum management during this period. In this study, the aim was to investigate whether the clinical parameters in the first 15 days after calves are born are correlated with diarrhea and whether those values are the early clinical predictors of the diarrhea that will occur in this period and also to investigate the correlation between diarrhea and the failure of transfer of passive immunity (FTPI). Eighty-two Holstein calves were used in the study. The calves were examined systemically every day and were scored according to a standard form. In the first 15 day period, 64.63% of the calves had diarrhea. In diarrheic calves, the most common findings on the previous day without diarrhea were fetid feces (43.40%), changes in the consistency and color of feces, and a decrease in the temperature of the ears (35.85%). According to non diarrheic calves, fetid feces (P < 0.01), changes in the consistency and color of feces, and nasal discharge were more common among diarrheic calves on the day before diarrhea (p < 0.001). The duration of diarrhea in calves with FTPI was longer than without FTPI. As a result, it is important for calves to be monitored daily in the first 15 days, looking for early signs of diarrhea in this period, namely fetid feces and changes in the consistency and the color of the feces. In addition, coexistence of any fecal changes with the decrease in the temperature of the ears may be clinical predictors of diarrhea. As a result of the daily monitoring of the calves, although the morbidity rate was high, none of the animals died.Item Effects of hypertonic sodium chloride, hypertonic sodium chloride plus sodium bicarbonate and hypertonic sodium chloride plus ringer's lactade solution in the treatment of dogs with experimentally induced endotoxaemia(TÜBİTAK, 2003) Batmaz, Hasan; Yılmaz, Zeki; Topal, Ayşe; Görgül, Osman Sacit; Şentürk, Sezgin; Uludağ Üniversitesi/Veterinerlik Fakültesi/İç Hastalıkları Anabi̇li̇m Dalı.; Uludağ Üniversitesi/Veterinerlik Fakültesi/Cerrahi̇ Anabi̇li̇m Dalı.; 0000-0003-1991-8957; AAH-1712-2021; A-9637-2008; 6602783183; 35944810500; 9740699300; 6507730974; 56257771200The aim of this study was to compare the effects of isotonic sodium chloride (ISS-0.9%), hypertonic sodium chloride (HSS-7.2%), HSS + lactate ringer solution (LRS) and HSS + sodium bicarbonate solution (SBS-1.3%) in the treatment of dogs with endotoxaemia. Endotoxaemia was induced by slow injection of a I mg/kg/i.v. dose of E. coli endotoxin (0111:B4). At the treatment stage, four groups, each composed of six dogs, were formed and a different treatment plan was carried out in each group: ISS, HSS, HSS + LRS and HSS + SBS. Clinical, haematological and biochemical examinations were performed before and after endotoxaemia. Hypotension (MAP < 60 mm Hg), leukopaenia and trombocytopaenia were observed during endotoxaemia in all dogs. MAP and plasma volume were increased in all groups except the ISS group. HCO3- values were increased in the HSS + SBS group and decreased in the other groups. Therefore, it was concluded that the HSS + SBS combination was the most effective model of fluid therapy in the treatment of dogs with endotoxaemia.Publication Effects of vitamin d administration at the beginning of lactation in dairy cows on inflammatory response and liver metabolism(Tubitak Scientific & Technological Research Council Turkey, 2021-11-26) Kaya, Feyyaz; Batmaz, Hasan; Kaya, Feyyaz; Batmaz, Hasan; BATMAZ, HASAN; Bursa Uludağ Üniversitesi/Veteriner Fakültesi.; 0000-0001-8820-1509; IXN-7700-2023This study aimed to investigate the effect of vitamin D administered 24 h after calving of dairy cows on calcium-phosphorus metabolism, carbohydrate, lipid and liver metabolism, and inflammatory response. Twenty multiparous Holstein cows were randomly assigned to the experimental (EG) and control group (CG). The EG received 5,000,000 IU vitamin D 3 (5 mL) 24 h after parturition intramuscularly, whereas the CG group received 5 mL of 0.9% NaCl. Blood samples were taken 24 h after parturition before treatments and at the 3rd, 7th, 14th, and 28th days of lactation. Serum NEFA, BHBA, haptoglobin, serum amyloid A (SAA), ceruloplasmin, calcium, phosphorus, parathormone, total protein, triglyceride, AST, and GGT were measured. In addition, total bilirubin, albumin, total cholesterol, and vitamin A concentrations were also measured to calculate liver activity index and the liver functionality index. Subclinical hypocalcemia (SCH) was observed in only one cow in the EG and five in the CG after the 3rd day postpartum. NEFA levels in the EG significantly differed on days 7, 14, and 28 when compared to vitamin D pretreatment values. However, NEFA levels in the CG differed only between day 28 postpartum and the 1st day (p < 0.05). Negative correlation was determined between vitamin D and NEFA (p < 0.01). Conversely, negative correlations were observed between calcium and NEFA, haptoglobin, SAA (p < 0.05). In conclusion, it can be suggested that vitamin D administration can prevent SCH after the 3rd day and has limited positive effects on postpartum NEFA levels.
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