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Contingent role of phoenixin and nesfatin-1 on secretions of the male reproductive hormones
(Wiley, 2019-12) Güvenç, Gökçen; Altınbaş, Burçin; Kaşıkçı, Esra; Özyurt, Ebru; Baş, Ayşenur; Udum, Duygu; Niaz, Nasir; Yalçın, Murat; Veteriner Fakültesi; 0000-0002-1413-3651; 000-0002-9534-736X; 0000-0003-1591-510X; 0000-0001-7052-1694; 0000-0002-5600-8162; AAR-6815-2021; IYS-2646-2023; CZB-8484-2022; GDW-7164-2022; AAH-5167-2021; AAC-4975-2022; AAG-6956-2021; 56529426800; 55356919300; 57209073902; 57211540698; 57211534062; 31967936400; 7060367600; 57192959734
Phoenixin (PNX) and nesfatin-1 are localised in the hypothalamus and the pituitary gland. Moreover, the most of the PNX-expressing neurons in the hypothalamus also co-express nesfatin-1. These outcomes may suggest that there is an interaction between PNX and nesfatin-1, at least in terms of neuroendocrine-mediated regulations. Hence, the study was planned to find out the effects of centrally delivered PNX and nesfatin-1 on male sex hormones or to show the interactive association of intracerebroventricularly (ICV) injected PNX+nesfatin-1 combination on the release of male hormones. PNX and nesfatin-1, single or together, were delivered ICV to different male Wistar Albino rat groups. Both PNX and nesfatin-1 induced a significant enhancement in plasma FSH, LH and testosterone without inducing any alteration in plasma GnRH in the rats. The central combinatorial treatment of both the neuropeptides produced a more potent rise in male plasma hormone levels than treating with single neuropeptide. In summary, our preliminary data show that centrally delivered PNX and nesfatin-1 can affect plasma male hormone levels. Moreover, that the combinatorial treatment with both the neuropeptides in male rats leading to a more potent effect on the plasma male hormone levels might suggest that both these neuropeptides act synergistically in terms of regulation of male HPGA.
Assessment of severity and risk factors of post-thrombotic syndrome in vascular Behcet disease: muticentered retrospective study
(Clinical and Experimental Rheumatology, 2018) Aksoy, Aysun; Çolak, Seda; Omma, Ahmet; Ergelen, Rabia; Direskeneli, Rafi Haner; Alibaz, Öner Fatma; Yağız, Burcu; Coşkun, Belkıs Nihan; Bolca, Naile; Tıp Fakültesi; Radyoloji Bilim Dalı; 0000-0003-0298-4157; JQW-5031-2023; AAG-7155-2021; EKW-9201-2022
How personal response systems promote active learning in mathematics in secondary education
(IATED, 2013) Göktalay, Şehnaz Baltacı; Eğitim Fakültesi; Bilgisayar ve Öğretim Teknolojileri Öğretmenliği Bölümü; 0000-0001-7826-7301; AAH-5144-2021
This study describes an initiative in a mathematics classroom where PRS technology was used to support in-class discussion and evaluation with students. The purpose of this study is to examine the factors that influence secondary school students' acceptance PRS integration in the classroom. The study examines the effects of Unified Theory of Acceptance and Use of Technology (UTAUT) variables on secondary school students' acceptance. The following research question is addressed: Do the UTAUT variables (performance expectancy, effort expectancy, social influence, perceived playfulness, anxiety, behavioural intentions) influence secondary school students' acceptance of PRS integration? Participants included 61 secondary school students. The quantitative component of this research utilized a 56-item survey examining students' perception and acceptance of PRS use. The qualitative component involved focus group discussion with a random sample of surveyed students. Students are also observed to see their use of PRSs in class. Students provided positive feedback regarding the use of PRSs. Students requested the increase in use because they felt the use of PRSs supported and improved their classroom learning. They also enjoyed the peer discussions that instructors facilitated with regard to the use of clickers.
Measurement of the branching fraction for ψ(3686) → ωK+K-
(American Physical Society, 2014-06-24) Tapan, İhan; Fen Edebiyat Fakültesi; Fizik Bölümü; CCD-9486-2022; 8905787000
With 1.06 x 10(8) psi(3686) events collected with the BESIII detector, the branching fraction of psi(3686) -> omega K+K- is measured to be (1.54 +/- 0.04 +/- 0.11) x 10(-4). This is the most precise result to date, due to the largest psi(3686) sample, improved signal reconstruction efficiency, good simulation of the detector performance, and a more accurate knowledge of the continuum contribution. Using the branching fraction of J/psi -> omega K+K-, the ratio B(psi(3868) -> K+K-)/B(J/psi -> K+K-) is determined to be (18.4 +/- 3.7)%. This constitutes a significantly improved test of the 12% rule, with the uncertainty now dominated by the J/psi branching fraction.
Cationic Pd(II)/Pt(II) 5,5-diethylbarbiturate complexes with bis(2-pyridylmethyl)amine and terpyridine: Synthesis, structures,DNA/BSA interactions, intracellular distribution, cytotoxic activity and induction of apoptosis
(Elsevier Science, 2015-11) Büyükgüngör, Orhan; İçsel, Ceyda; Yılmaz, Veysel Turan; Kaya, Yunus; Durmuş, Selvi; Sarımahmut, Mehmet; Ulukaya, Engin; Fen Edebiyat Fakültesi; Tıbbi Biyokimya Ana Bilim Dalı; 0000-0003-3792-1607; 0000-0003-2647-5875; 0000-0002-2849-3332; 0000-0002-2717-2430; AAI-3342-2021; L-7238-2018; DWM-5900-2022; JCN-7113-2023; K-5792-2018; 55551960400; 7006269202; 35181446100; 49060997200; 44661687400; 6602927353
Four new cationic Pd(II) and Pt(II) 5,5-diethylbarbiturate (barb) complexes, [M(barb)(bpma)]X center dot H2O [M = pd(II), X = Cl (1); M = Pt-II, X = NO3- (2)] and [M(barb)(terPY)]NO3 center dot 0.5H(2)O [M = Pd-II (3); M = Pt-II (4)], where bpma = bis(2-pyridylmethyl)amine and terpy = terpyridine, were synthesized and characterized by elemental analysis, IR, UV-vis, NMR, ESI-MS and X-ray crystallography. The DNA binding properties of the cationic complexes were investigated by spectroscopic titrations, displacement experiments, viscosity, DNA melting and electrophoresis measurements. The results revealed that the complexes effectively bind to FS-DNA (fish sperm DNA) via intercalative/minor groove binding modes with intrinsic binding constants (Kb) in the range of 0.50 x 10(4) - 1.67 x 10(5) M-1. Absorption, emission and synchronous fluorescence measurements showed strong association of the complexes with protein (BSA) through a static mechanism. The mode of interaction of complexes towards DNA and protein was also supported by molecular docking. Complexes 1 and 3 showed significant nuclear uptake in HT-29 cells. In addition, 1 and 3 showed higher inhibition than cisplatin on the growth of MCF-7 and HT-29 cells and induced apoptosis on these cells much more effectively than the rest of the complexes as evidenced by pyknotic nuclear morphology. The levels of caspase-cleaved cytokeratin 18 (M30 antigen) in HT-29 cells treated with 1 and 3 increased in a dose-dependent manner, suggesting apoptosis. Moreover, qRT-PCR experiments showed that I and 3 caused significant increases in the expression of TNFRSF10B in HT-29 cells, indicating the initiation of apoptosis via cell surface death receptors.
Effects of ethephone application on different harvesting methods and hulling of walnut husk
(International Society for Horticultural Science, 2014) Yalçın, M.; AcıcaN, T.; Akça, Yaşar; Polat, Refik; Alibaş, Kamil; Ertürk, Ümran; Ziraat Fakültesi; Biyosistem Mühendisliği Bölümü; CAZ-9851-2022; AAG-7343-2021; 20733393300; 7801661220
It is necessary to benefit from mechanization applications to decrease costs in walnut growing. Mechanical harvest especially plays a very important role in decreasing cost of harvesting in the growing period. The kernel of walnut ripens approximately three weeks before the husk (outer green skin) cracks. The husk not ripening at the same time with the kernel makes both traditional and mechanical harvests difficult. In this study, the efficiency of different harvesting methods and the effect on hulling of applied ethephon in walnut trees were investigated. Ethephon at 1000 ppm dose was applied with a turbo pulverizer which is P.t.o. driven until the run-off of the whole trees in the early morning hours. Just before and seven days after (at harvesting time) the ethephon applications, removal force of fruit was measured. After different harvesting methods such as tree trunk shaker, tree branch shaker, and traditional (stick beating) were completed, the comparisons of efficiency and time saving of these methods were carried out. At the end of the study, it was determined that applying ethephone increased the efficiency of the machine. It was investigated that facilitating of disjunction of the fruit by ethephon application increased the success of the mechanical harvest. It was also determined that positive contribution of ethephon was apparent in the hulling of the husk.
Interactions of human chorionic gonadotropin with genotype and parity on fertility responses of lactating dairy cows
(Elsevier, 2019-01) Zolini, A. M.; Ortiz, W. G.; Estrada-Cortes, E.; Ortega, M. S.; Sosa, F.; Hansen, P. J.; Giordano, Julio O.; Dikmen, Serdal; Veteriner Fakültesi; Zootekni ve Hayvan Besleme Bölümü; 0000-0002-5611-4993; A-5731-2018; 8280302600
Fertility-promoting effects of treatment of lactating dairy cattle with human chorionic gonadotropin (hCG) after artificial insemination (AI) have been variable. Here, we tested whether fertility response to hCG in lactating Holstein cows interacts with genotype and parity. Primiparous (n = 538) and multiparous (n = 613) cows were treated with hCG (3,300 IU) or vehicle 5 d after AI. Pregnancy was diagnosed on d 32 and 60 after AI. A subset of cows (n = 593-701) was genotyped for 4 single nucleotide polymorphisms (SNP) previously associated with fertility. Treatment with hCG increased progesterone concentration on d 12 after AI regardless of genotype or parity. Pregnancy per AI was improved by hCG in primiparous cows but riot in multiparous cows. Moreover, hCG treatment interacted with a SNP in coenzyme Q9 (COQ9) to affect fertility. Fertility of cows treated with vehicle was greatest for the AA allele, whereas fertility was lowest for the same genotype among cows treated with hCG. Pregnancy per AI was also affected by genotype for heat shock protein AI-like (HSPA1L) and progesterone receptor (PGR), but no interactions were observed with treatment. Genotype for a SNP in prostate androgen-regulated mucin-like protein 1 (PARM1) was not associated with fertility. Overall, results show that variation in response to hCG treatment on fertility depends on parity and interacts with a SNP in COQ9.
Tumoral mass on a phalangeal bone in a 19-year-old
(Lippincott Williams & Wilkins, 2007-05) Öztürk, Alpaslan; Özkan, Yüksel; Yalçınkaya, Ülviye; Atıcı, Teoman; Tıp Fakültesi; Patoloji Ana Bilim Dalı; AAH-8924-2021; A-5095-2018; 6508300295; 7801647288
Burnout syndrom and job satisfaction level in the medical technicians and technologists
(Elsevier Ireland, 2006) Arslan, Kağan; Aydın, Berrin; Özkaya, Güven; Özkan, L.; Tıp Fakültesi; 0000-0003-0297-846X; DUV-9600-2022; CEJ-2613-2022; A-4421-2016; DLG-8766-2022
Transnasal transsphenoidal surgical method in pediatric pituitary adenomas
(Karger, 2014) Taşkapılıoğlu, Mevlüt Özgür; Yılmazlar, Selçuk; Eren, Erdal; Tarım, Ömer Faruk; Güler, Tuğba Moralı; Tıp Fakültesi; Endokrinoloji Ana Bilim Dalı; 0000-0001-5472-9065; 0000-0003-3633-7919; 0000-0002-1684-1053; AAW-5254-2020; AAH-5070-2021; JPK-3909-2023; CCU-8073-2022; HPH-3049-2023; 25936798300; 6603059483; 36113153400; 6701427186; 56729201700
Aim: To evaluate the clinical outcome in a 13-year consecutive series of children operated for pituitary adenomas with transnasal transsphenoidal surgery. Methods: All patients < 18 years who were operated on at our center by transsphenoidal surgery for pediatric pituitary adenomas were included in the study. Clinical features, hormonal profile, radiology, surgical approach, results and complications were analyzed. Results: Eighteen patients (90%) had functional pituitary adenomas and 2 (10%) patients had nonfunctional pituitary adenoma. The most common type was prolactin-secreting adenoma (n = 12), followed by corticotropinoma (n = 4), growth hormone-secreting adenoma (n = 2), and nonfunctioning adenoma (n = 2). Prolactin-secreting adenomas in children occurred more commonly with suprasellar expansion than did other adenomas. Conclusion: Transsphenoidal surgery was effective for decompression of suprasellar extension and relieved the chiasmal compression immediately. Prolactin-secreting tumors required postoperative medical therapy for persistently elevated prolactin levels.
The outcome of children ALL in single center from Turkey: The results of 13 years experience with all BFM 90 and 95
(Wiley, 2007-10-01) Meral, Adalet; Baytan, Birol; Tıp Fakültesi; Hematoloji ve Onkoloji Ana Bilim Dalı; INA-1070-2023; DVW-8108-2022
qPCR analysis to verify large deletions in the F8 gene
(Wiley, 2008) Fidancı, İnanç Değer; A, Çağlayan; Sayılan, Hasan; Çetin, Timur; A, Meral; Uludağ Üniversitesi; DFY-4681-2022
The omega-3 index in the Turkish population
(Wiley, 2008-06) Aslan, Diler; Ilcol, Yeşim Özarda; Eröz, Esma; AAL-8873-2021; ETY-5351-2022
The malnutrition and inflammation in children on chronic peritoneal dialysis
(Springer, 2008-09) Dönmez, Osman; Aynacı, D; CER-4590-2022; AAA-8778-2021
The outcome of children treated with MRC-AML protocols in six referral centres, Turkey
(Wiley, 2008-04) Turkiz, Gürsel; Hazar, V; Sarper, Nazan; Özgen, U; Anak, Sema; Güneş, Adalet Meral; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları; EXD-8400-2022
Use of complementary and alternative medicine in children with humoral immune deficiency
(Oxford University Press, 2008-11) Kılıç, Sara Şebnem; Kezer, Esra; Kezer, Melinda; Tıp Fakültesi; AAH-1658-2021; CZP-5110-2022; FCG-0006-2022
University students in two distinct branches show performance differences on the Mangina-Test scores
(Elsevier, 2008-09-01) Karataş, Sirel; Can, Handan; Dikeç, Banu Elmastaş; Fen Edebiyat Fakültesi; Psikoloji Bölümü; AAH-8501-2021; AAH-8826-2021
Trace metals in olive oil
(International Society for Horticultural Science, 2008) Saban, Yakup; Başoğlu, Fikri; Ziraat Fakültesi; Gıda Mühendisliği Bölümü; FXK-5616-2022; CFO-6874-2022
One of the most important quality criteria of olive oil is its metal content. Trace levels of metal ions, such as Fe and Cu, are known to have adverse effects on the oxidative stability of olive oil. Transition metals catalyse the decomposition of hydro-peroxides, aldehydes, ketones, acids and epoxide. These compounds may develop pathological effects on the digestive system. They also increase carcinogenic effect by reacting with other food components such as proteins and pigments. Hence, it is important to monitor and control the presence of elements in the olive oil.
Uniformly Starlike functions and uniformly convex functions related to the Pascal distribution
(Institute of Mathematics of the Czech Academy of Sciences, 2020) Murugusundaramoorthy, Gangadharan; Yalçın, Sibel; Fen Edebiyat Fakültesi; Matematik Bölümü; 0000-0002-0243-8263; AAE-9745-2020; 56207790300
In this article, we aim to find sufficient conditions for a convolution of analytic univalent functions and the Pascal distribution series to belong to the families of uniformly starlike functions and uniformly convex functions in the open unit disk U. We also state corollaries of our main results.
Current smoking is increased in axial psoriatic arthritis and radiographic sacroiliitis
(Journal of Rheumatology Publishing Co., 2020-09-01) Solmaz, Dilek; Kalyoncu, Umut; Tinazzi, Ilaria; Bakirci, Sibel; Bayindir, Ozun; Dogru, Atalay; Omma, Ahmet; Can, Meryem; Yilmaz, Sema; Erden, Abdulsamet; Aydın, Sibel Zehra; Dalkılıç, Ediz; İç Hastalıkları Bölümü; Romatoloji Ana Bilim Dalı; CMF-4757-2022; 6506739457
OBJECTIVE: This study aims to examine how internalized stigma differs in opioid use disorder (OUD) based on sociodemographic and clinical variables, and to what extent internalized stigma is related to treatment motivation, perceived social support, depression, and anxiety levels. METHODS: One hundred forty-five individuals with OUD included. Sociodemographic and clinical data form, the Internalized Stigma of Mental Illness Scale (ISMI), Treatment Motivation Questionnaire (TMQ), Multidimensional Scale of Perceived Social Support, the Beck Depression Inventory, and the Beck Anxiety Inventory were utilized in the study to collect data. Bivariate and partial correlation coefficients between variables were computed. ISMI and TMQ scores were compared between patients with depressive symptoms and patients without depressive symptoms by using t-test and Mann Whitney U test. RESULTS: Internalized stigma was high among male patients with heroin use disorder. There was a positive correlation between internalized stigma score and treatment motivation, depression, and anxiety levels. On the other hand, there was a negative correlation between internalized stigma score and multidimensional perceived social support. CONCLUSION: Internalized stigma occupies an important place in the treatment of OUD, which occurs with frequent relapses and which is hard to treat. Not only application for treatment but also adherence to treatment and treatment motivation at maintenance phase bestow a complicated relationship with depression and anxiety. In the struggle against internalized stigma, it plays a vital role to mobilize people’s social support systems, to educate families on the issue and to get in touch with support units exclusive to heroin users.

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