Person: GÜLDEREN, ESRA
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GÜLDEREN
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ESRA
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Publication Severe aplastic anemia and a healthy pregnancy immediately following syngeneic transplantation: An extremely rare case report(Elsevier Science Inc, 2023-04-27) Gürsoy, Vildan; PINAR, İBRAHİM ETHEM; Pınar, İbrahim Ethem; Özkalemkaş, Fahir; ÖZKALEMKAŞ, FAHİR; Ersal, Tuba; ERSAL, TUBA; GÜLDEREN, ESRA; Özkocaman, Vildan; ÖZKOCAMAN, VİLDAN; Tıp Fakültesi; İç Hastalıkları Ana Bilim dalı; 0000-0001-9907-1498; JWP-2738-2024; JGM-6601-2023Aplastic anemia is potentially fatal, particularly if the disease does not respond to immunotherapy and progresses to severe pancytopenia. Allogeneic hematopoietic stem cell transplant from an HLA-matched sibling donor, the first-line treatment in patients younger than 40 years, is used as a curative treatment option in severe aplastic anemia. The availability of an identical twin donor is infrequent, and there is limited experience in this context. Additionally, the choices for a conditioning regimen for a syngeneic transplant to prevent engraftment failure and the necessity of graft-vs-host disease prophylaxis are controversial. Although long-term survival gradually increases after an allogeneic hematopoietic stem cell transplant, hypogonadism and infertility are the main problems that significantly affect patients' quality of life. We present a patient diagnosed with severe aplastic anemia who has had a healthy pregnancy immediately after a syngeneic transplant.