Person: KARLI, HAMDİ NECDET
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KARLI
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HAMDİ NECDET
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Publication Transthyretin familial amyloid polyneuropathy (TTR-FAP): A database analysis(Lippincott Williams & Wilkins, 2020-04-14) Erdoğan, Çağdaş; Bayrak, Ayşe Oytun; Uluç, Kayıhan; Karlı, Necdet; Koç, Filiz; Öztürk, Şerefnur; Şengün, İhsan Şükrü; Seçil, Yaprak; Tütüncü, Melih; Akalın, Mehmet Ali; Uysal, Hilmi; Özdamar, Sevim Erdem; Parman, Yeşim; KARLI, HAMDİ NECDET; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; JDE-9380-2023Publication Neuropathic pain frequency in neurology outpatients: A multicenter study(Wiley, 2020-12-01) Bekircan-Kurt, Can Ebru; İnan, Berin; Şengün, İhsan; Karlı, Necdet; Güneş, Nalan; Çokal, Burcu Gökçe; Güler, Selda Keskin; Yoldaş, Tahir Kurtulus; Özcanyüz, Duygu Güner; Koç, Filiz; Ünlutürk, Zeynep; Erdoğan, Çağdaş; Uludağ, Burhanettin; Boz, Cavit; Tütüncü, Melih; Akalın, Mehmet Ali; Kamışlı, Özden; Özcan, Abdulcemal; Koytak, Pınar Kahraman; Uluç, Kayıhan; Erdem-Özdamar, Sevim; Tan, Ersin; KARLI, HAMDİ NECDET; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; JDE-9380-2023Publication Insight into pain syndromes in acute phase of mild-to-moderate covid-19: Frequency, clinical characteristics, and associated factors(Wiley, 2021-10-26) Karli, Necdet; KARLI, HAMDİ NECDET; Gullu, Gizem; GÜLLÜ, GİZEM; Kilic, Erhan; KILIÇ, ERHAN; Dinc, Yasemin; DİNÇ, YASEMİN; Ursavas, Ahmet; URSAVAŞ, AHMET; Yilmaz, Emel; YILMAZ, EMEL; Zarifoglu, Mehmet; ZARİFOĞLU, MEHMET; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-3894-1231; IUQ-6999-2023; AAI-3169-2021; IZQ-0662-2023; AAD-1271-2019Background Pain has been frequently described as a clinical feature of COVID-19, and the main pain syndromes that have been associated with the acute phase of this disease so far are headache, myalgia, arthralgia, and neuropathic pain. Understanding the characteristics of pain symptoms is crucial for a better clinical approach. Methods Patients who were diagnosed as having COVID-19 using reverse transcription-polymerase chain reaction were included in the study. Patients were asked to complete a 51-item questionnaire via a phone interview, which included questions on demographics, acute COVID-19 symptoms, the presence of pain symptoms, and their characteristics in the acute phase of COVID-19. Results A total of 222 out of 266 patients with COVID-19 participated in the study, yielding a response rate of 83.5%. A total of 159 patients reported at least one kind of pain syndrome with a prevalence of 71.6%. Myalgia was reported in 110 (49.6%) patients, headache in 109 (49.1%), neuropathic pain symptoms in 55 (24.8%), and polyarthralgia in 30 (13.5%) patients. A total of 66 patients reported only one type of pain, 46 reported two types, 42 reported three types, and five patients reported all four types of pain. Logistic regression analysis showed that there were significant associations between these pain syndromes and a strong association was found between neuropathic pain and headache. Conclusion Pain is a frequently observed symptom of mild-to-moderate COVID-19. There are significant relationships between pain syndromes in COVID-19, which may be due to a sequence of common etiologic factors. Significance This study described the main pain syndromes associated acute phase of mild-to-moderate COVID-19 and its associated features. Headaches and pain of neuropathic characteristics were prevalent in this sample.Publication Reply: "Spinal nerve pathology in Guillain-Barre syndrome associated withCOVID-19 infection"(Wiley, 2020-08-10) Oğuz-Akarsu, Emel; Özpar, Rıfat; Hakyemez, Bahattin; Karlı, Necdet; OĞUZ AKARSU, EMEL; ÖZPAR, RİFAT; HAKYEMEZ, BAHATTİN; KARLI, HAMDİ NECDET; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; 0000-0001-6649-9287; 0000-0001-6649-9287; 0000-0002-3425-0740; AAI-2318-2021; AAA-8936-2021; AAN-4912-2021; AAH-5062-2021; IZQ-0662-2023Publication A database for screening and registering late onset pompe disease in Turkey(Elsevier, 2018-03-01) Gökyiğit, Munevver Çelik; Ekmekçi, Hakan; Durmuş, Hacer; Karlı, Necdet; Köseoğlu, Emel; Aysal, Fikret; Kotan, Dilcan; Ali, Asuman; Koytak, Pınar Kahraman; Karasoy, Hatice; Yaman, Aylin; Şengün, İhsan Şükrü; Sayın, Refah; Tiftikcioğlu, Bedile İrem; Soysal, Aysun; Tutkavul, Kemal; Bayrak, Ayşe Oytun; Kisabay, Ayşin; Elçi, Mehmet Ali; Yayla, Vildan; Yılmaz, İbrahim Arda; Çzdamar, Sevim Erdem; Erdoğan, Cagdas; Taşdemir, Nebahat; Oflazer, Piraye Serdaroğlu; Turkish Study Grp Late Onset Pompe; KARLI, HAMDİ NECDET; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı; FCA-7755-2022The aim of this study was to search for the frequency of late onset Pompe disease (LOPD) among patients who had a myopathy with unknown diagnosis registered in the pre-diagnostic part of a novel registry for LOPD within a collaborative study of neurologists working throughout Turkey.Included in the study were 350 patients older than 18 years who have a myopathic syndrome without a proven diagnosis by serum creatine kinase (CK) levels, electrodiagnostic studies, and/or muscle pathology, and/or genetic tests for myopathies other than LOPD. Acid alpha glucosidase (GAA) in dried blood spot was measured in each patient at two different university laboratories. LOPD was confirmed by mutation analysis in patients with decreased GAA levels from either both or one of the laboratories. Pre-diagnostic data, recorded by 45 investigators from 32 centers on 350 patients revealed low GAA levels in a total of 21 patients; from both laboratories in 6 and from either one of the laboratories in 15. Among them, genetic testing proved LOPD in 3 of 6 patients and 1 of 15 patients with decreased GAA levels from both or one of the laboratories respectively. Registry was transferred to Turkish Neurological Association after completion of the study for possible future use and development. Our collaborative study enabled collection of a considerable amount of data on the registry in a short time. GAA levels by dried blood spot even from two different laboratories in the same patient may not prove LOPD. LOPD seemed to be rarer in Turkey than in Europe.Publication Evaluation of the effects of botulinum toxin therapy on the clinical characteristics of pain and pain threshold value in patients with primary cervical dystonia(Journal Neurological Sciences, 2015-01-01) Özbek, Sevda Erer; Karlı Necdet; Yurtoğulları, Şükran; Zarifoğlu, Mehmet; Ocakoğlu, Gökhan; ERER ÖZBEK, ÇİĞDEM SEVDA; KARLI, HAMDİ NECDET; YURTOĞULLARI, ŞÜKRAN; ZARİFOĞLU, MEHMET; OCAKOĞLU, GÖKHANObjective: In 70% of patients with cervical dystonia (CD), the clinical presentation includes the symptom of pain. In this study, we aimed to define the types and clinical characteristics of the pain and to investigate whether this pain is a result of central sensitization by evaluating pre- and post-botulinum toxin (BoNT) treatment pain threshold values using electrical stimulation.Methods: The study enrolled a total of 35 patients with CD who received BoNT therapy. The patients were evaluated using the pain evaluation scale and Unified Dystonia Rating scale (UDRS) before and after BoNT therapy. The pain threshold values obtained from dystonic muscles, the contiguous or contralateral muscle without dystonic activity and a normal reference muscle with distant localization were recorded through electrical stimulation with EMG guidance, and all values obtained before and after BoNT therapy were compared.Results: No difference was found between the pain threshold values obtained from dystonic muscles before and after treatment. While no difference was observed across genders or VAS groups in terms of pain threshold values, the UDRS (duration and motor severity factor) scores showed significant decreases after treatment with BoNT in patients with painful dystonia and in patients with painless dystonia.Conclusions: The absence of a difference in pre- and post-BoNT treatment pain threshold values in dystonic muscles might be explained by the absence of central sensitization. Pain relief in dystonic patients might occur secondary to decreases in dystonic muscle contractions.Publication Association of brain volume and cognition in the chronic and episodic migraine patients(Sage Publications, 2013-06-01) Zarifoğlu, Mehmet; Şener, D. K.; Karlı, Nejdet; Hakyemez, Bahattin; Taşkapılıoğlu, Özlem; Özbek, Sevda Erer; Bakar, Mustafa; ZARİFOĞLU, MEHMET; Şener, D. K.; KARLI, HAMDİ NECDET; HAKYEMEZ, BAHATTİN; Taşkapılıoğlu, Özlem; ERER ÖZBEK, ÇİĞDEM SEVDA; BAKAR, HACI MUSTAFA; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Bölümü; 0000-0003-4436-3797; AAI-2318-2021; AAK-6623-2020; EHN-5825-2022; IOZ-7564-2023; CXD-7623-2022; DLN-1836-2022; EKN-8251-2022Publication A population-based survey to determine the prevalence of movement disorders in Orhangazi district of Bursa, Turkey(Galenos Yayıncılık, 2009-01-01) Özbek, Sevda Erer; Zarifoğlu, Mehmet; Karlı, Necdet; Özçakir, Alis; Yıldız, Demet; Aslan, Doğa; ERER ÖZBEK, ÇİĞDEM SEVDA; ZARİFOĞLU, MEHMET; KARLI, HAMDİ NECDET; ÖZÇAKIR, ALİS; Yıldız, Demet; Aslan, Doğa; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Aile Hekimliği Anabilim Dalı.; 0000-0001-5588-2037; AAG-8209-2021; JGR-7854-2023; EHN-5825-2022; JDE-9380-2023; CIX-2047-2022; ELJ-9790-2022Objective: In this study we aimed to determine the prevalence of movement disorders among 40 years and older population in Orhangazi district of Bursa, Turkey.Patients and Methods: This population-based study was planned in three phases. In phase I, door-to-door home interviews were performed on 1256 subjects by residents of departments of neurology and family medicine by using a short questionnaire and 404 subjects with suspected symptoms of movement disorders and Parkinsonism were detected. These subjects were examined and videotaped in phase II. Of the suspected subjects in phase I, 131 did not attend to phase II for various reasons. In phase II, subjects were evaluated by movement disorders specialists by using scales specific to tremor, restless leg syndrome, Parkinson disease, and hemi-facial spasm. In phase III, video recording of all identified patients were reviewed and final diagnoses were made with a consensus of all three specialists.Results: In this phase, subjects were diagnosed to have restless leg syndrome n=60, 9.71%, essential tremor n=21, 3.34%, enhanced physhological tremor n=26, 4.14%, Parkinson's disease n= 14, 2.23%, hemifacial spasm n= 4, 0.82%, and dystonia n= 2, 0.41%.Conclusion: Although essential tremor has been reported as the most common movement disorder, in our study restless leg syndrome had higher prevalence than essential tremor.