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GÜRBÜZ, TANSU BAHAR

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GÜRBÜZ

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TANSU BAHAR

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    Publication
    Does gonadotropin dose adjustment in inadequate ovarian response during controlled ovarian hyperstimulation improve the live birth rates of patients with diminished ovarian reserve?
    (Oxford Univ Press, 2022-07-01) Mesut, O. C.; MESUT, ÖMER ÇAĞATAY; Gürbüz, T. B.; GÜRBÜZ, TANSU BAHAR; Aslan, K.; ASLAN, MÜNİR KİPER; Uncu, G.; UNCU, GÜRKAN; Kasapoğlu,; KASAPOĞLU, IŞIL; Tıp Fakültesi; Kadın Hastalıkları ve Doğum Ana Bilim Dalı
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    Preliminary results of the DINE study (Dienogest vs. norethindrone acetate in endometriosis treatment)
    (Oxford Univ Press, 2023-06-01) Gürbüz, Tansu Bahar; Uncu, Gürkan; Aslan, K.; Gadirli, Z.; Kasapoğlu, Işıl; GÜRBÜZ, TANSU BAHAR; UNCU, GÜRKAN; Aslan, K.; Gadirli, Z.; KASAPOĞLU, IŞIL; Tıp Fakültesi; Doğum ve Jinekoloji Bilim Dalı; GXB-3440-2022; GER-9626-2022; GLW-2086-2022; JDO-9798-2023; CXJ-7203-2022
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    Long term sexual outcomes of mayer rokitansky küster hauser syndrome patients after uncu-modified davydov procedure
    (Universa Press, 2023-09-01) Aslan, Kiper; ASLAN, MÜNİR KİPER; Gürbüz, T. B.; GÜRBÜZ, TANSU BAHAR; Rhan, A.; Kasapoglu, Işıl; KASAPOĞLU, IŞIL; Zerkan, K.; Uncu, Gürkan; UNCU, GÜRKAN; Tıp Fakültesi; Kadın Hastalıkları ve Doğum Ana Bilim Dalı; 0000-0002-9277-7735; AER-7173-2022
    Background: Mayer-Rokitansky-Kister-Hauser (MRKH) syndrome has an incidence of 1 in 4000. The absence of the vagina and uterus results in sexual dysfunction and infertility. The first-line treatment is vaginal dilatation. There exists a number of second-line surgical options including the Uncu-modified Davydov procedure.Objective: To determine the complication rate, anatomical outcomes, and long-term sexual outcomes of MRKH syndrome patients after Uncu-modified Davydov procedure.Materials and Methods: Patients with MRKH syndrome who underwent paramesonephric remnant-supported laparoscopic double-layer peritoneal pull-down vaginoplasty (aka Uncu-modified Davydov procedure) between January 2008 and December 2021. The procedure involves laparoscopic circular dissection of the pelvic peritoneum followed by pulling down, through the opened vaginal orifice, and suturing the vaginal cuff with the support of uterine remnants. The long-term complication rate, anatomical outcomes, and sexual function outcomes (as measured by Female Sexual Function Index (FSFI)) were ascertained.Main Outcome Measures: The long-term complication rate, anatomical outcomes and FSFI survey results.Results: A total of 50 patients with MRKH syndrome underwent the Uncu-modified Davydov procedure between Jan 2008- Dec 2021. There were four perioperative complications: three bladder injuries (6%) and one rectal serosa injury (2%). Four long-term postoperative complications were identified: one vesicovaginal fistula (2%), one recto-vaginal fistula (2%), and two vaginal stenoses (4%). All patients were physically examined at least one year after surgery. The mean vaginal length was 8.4 + 1.9 cm. The mean FSFI score was 31.5 + 3.9 (minimum score of 24, maximum score of 36).Conclusion: The Uncu-modified Davydov procedure has been demonstrated to be a safe and effective treatment option with high female sexual function index scores for patients with MRKH syndrome. What is new? The long-term complication rate, anatomical and sexual outcomes of Uncu-modified laparoscopic peritoneal pull-down vaginoplasty were reported in this study. The results indicated that the surgical approach could be used in selective MRKH patients who failed first-line self-dilatation therapy.
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    Publication
    The effect of the gonadotropin dose increment during controlled ovarian hyperstimulation on live birth rates of POSEIDON group 3-4 patients
    (Bursa Uludağ Üniversitesi, 2024-06-12) Aslan, Kiper; Kasapoğlu, Işıl; Mesut, Çağatay; Gürbüz, Tansu Bahar; Çakır, Cihan; Avcı, Berrin; Uncu, Gürkan; ASLAN, MÜNİR KİPER; KASAPOĞLU, IŞIL; MESUT, ÖMER ÇAĞATAY; GÜRBÜZ, TANSU BAHAR; ÇAKIR, CİHAN; AVCI, BERRİN; UNCU, GÜRKAN
    This retrospective study seeks to explore whether modifying the gonadotropin dose in cases of poor ovarian response during controlled ovarian hyperstimulation contributes to improved live birth rates in Poseidon Group 3-4 patients. The study took place at a tertiary level university. The electronic database spanning 2012-2021 was scrutinized to identify patients with diminished ovarian reserve (DOR) who underwent intra-cytoplasmic sperm injection – embryo transfer (ICSI-ET). Diminished ovarian reserve was determined using the POSEIDON criteria. Patients were categorized into two groups based on whether dose adjustment was implemented during the initial ultrasound assessment in controlled ovarian hyperstimulation (COH). There were 188 patients in the dose adjustment (DA) group and 310 patients in the fixed-dose (FD) group. The demographic parameters were similar between the groups. The started gonadotropin dose was similar in both groups (300 IU). The median dose adjustment on the first control was +75 IU in the DA group. The follicle output rates, follicle to oocyte indexes, and the embryology parameters were comparable between the groups. The positive pregnancy rate was 19.7% (36/188) in the DA group vs. 19.1% (61/310) in the FD Group (p=0.4). The primary outcome of the study; live birth rates were 12% in the DA group vs. 9% in the FD group, and the results were statistically similar (p=0.3). Our research revealed that adjusting the gonadotropin dose in cases of inadequate ovarian response during COH results in comparable live birth rates to those observed in the fixed-dose group. For patients exhibiting an inadequate response, dose adjustment may be deemed necessary.