Publication: Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder
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Date
2013
Authors
Armaǧan, Erol
Yakut, Tahsin
Köse, Ataman
Karkucak, Mutlu
Köksal, Özlem
Görükmez, Orhan
Authors
Almacıoğlu, M. L.
Journal Title
Journal ISSN
Volume Title
Publisher
Funpec-Editora
Abstract
Alterations in catechol-O-methyltransferase (COMT) activity are involved in various types of neurological disorders. We examined a possible association between the COMT Val158Met polymorphism and conversion disorder in a study of 48 patients with conversion disorder and 48 control patients. In the conversion disorder group, 31 patients were Val/Met heterozygotes, 15 patients were Val/Val homozygotes and 2 patients were Met/Met homozygotes. In the control group, 32 patients were Val/Met heterozygotes and 16 patients were Val/Val homozygotes. There was no significant difference between the groups. We conclude that the COMT Val158Met genotype is quite common in Turkey and that it is not a risk factor for conversion disorder in the Turkish population.
Description
Keywords
Biochemistry & molecular biology, Genetics & heredity, COMT, Val158Met genotype, Conversion disorder, Methyltransferase gene, Bipolar disorder, Conduct disorder, Enzyme-activity, Catechol, Polymorphism, Association, Attention, Adhd
Citation
Armağan, E. (2013). “Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder”. Genetics and Molecular Research, 12(1), 852-858.