Publication: microRNA-21 expression is elevated in esophageal adenocarcinoma after neoadjuvant chemotherapy
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Date
2015-01-01
Authors
Authors
İlhan-Mutlu, Ayşegül
Tezcan, Gülçin
Schoppmann, Sebastian F.
Preusser, Matthias
Spyridoula, Kommata
Karanikas, Georgios
Birner, Peter
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis
Abstract
We investigated whether microRNA-21 and microRNA-148a are predictive for neoadjuvant treatment in esophageal adenocarcinoma. Thirty-six patients with neoadjuvant therapy and surgical resection were included. FFPE tissue from biopsy and esophagectomy were analyzed using RT-qPCR. Results were correlated to histological tumor regression, histopathological variables, FDG-PET-CT and survival. MicroRNA-21 was significantly higher in esophagectomies than in corresponding biopsies (p = .027). No association of microRNA-21 or micro RNA-148a expression in tissue specimens with other clinical parameters was present. Although no influence of microRNA-21 and microRNA-148a on the response to neoadjuvant therapy was seen, upregulation of micro RNA-21 might represent an escape mechanism of tumor cells.
Description
Keywords
Prognostic-significance, Cancer, Invasion, Proliferation, Therapy, Esophageal cancer, Adenocarcinoma, microRNA-21, microRNA-148a, Neoadjuvant therapy, FDG-PET-CT, Oncology