Publication: Effect of asbestos exposure on the frequency of egfr mutations and alk/ros1 rearrangements in patients with lung adenocarcinoma a multicentric study
dc.contributor.author | Yilmaz, Senay | |
dc.contributor.author | Demirci, Nilgun Yilmaz | |
dc.contributor.author | Metintas, Selma | |
dc.contributor.author | Zamani, Adil | |
dc.contributor.author | Kabalak, Pinar Akin | |
dc.contributor.author | Yilmaz, Ulku | |
dc.contributor.author | Ak, Guntulu | |
dc.contributor.author | Kizilgoz, Derya | |
dc.contributor.author | Ozturk, Akin | |
dc.contributor.author | Yilmaz, Ufuk | |
dc.contributor.author | Batum, Ozgur | |
dc.contributor.author | Kavas, Murat | |
dc.contributor.author | Serifoglu, Irem | |
dc.contributor.author | Unsal, Meftun | |
dc.contributor.author | Komurcuoglu, Berna E. | |
dc.contributor.author | Cengiz, Tuba Inal | |
dc.contributor.author | Ulubay, Gaye | |
dc.contributor.author | Ozdemirel, Tugce S. | |
dc.contributor.author | Ozyurek, Berna A. | |
dc.contributor.author | Kavurgaci, Suna | |
dc.contributor.author | Alizoroglu, Dursun | |
dc.contributor.author | Celik, Pinar | |
dc.contributor.author | Erdogan, Yurdanur | |
dc.contributor.author | In, Erdal | |
dc.contributor.author | Aksoy, Asude | |
dc.contributor.author | Altin, Sedat | |
dc.contributor.author | Gunluoglu, Gulsah | |
dc.contributor.author | Metintas, Muzaffer | |
dc.contributor.buuauthor | Karadag, Mehmet | |
dc.contributor.buuauthor | KARADAĞ, MEHMET | |
dc.contributor.buuauthor | Guclu, Ozge A. | |
dc.contributor.buuauthor | AYDIN GÜÇLÜ, ÖZGE | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.orcid | 0000-0003-0523-7819 | |
dc.contributor.orcid | 0000-0001-6160-3778 | |
dc.contributor.orcid | 0000-0002-9027-1132 | |
dc.contributor.orcid | 0000-0003-1005-3205 | |
dc.contributor.orcid | 0000-0001-8849-193X | |
dc.contributor.orcid | 0000-0002-3445-3804 | |
dc.contributor.orcid | 0000-0002-2806-4781 | |
dc.contributor.orcid | 0000-0002-2877-242X | |
dc.contributor.orcid | 0000-0003-1596-0082 | |
dc.contributor.orcid | 0000-0003-0206-7615 | |
dc.contributor.orcid | 0000-0002-8807-5853 | |
dc.contributor.orcid | 0000-0002-5609-9658 | |
dc.contributor.researcherid | HKN-2974-2023 | |
dc.contributor.researcherid | HNT-0352-2023 | |
dc.contributor.researcherid | AAS-6628-2021 | |
dc.contributor.researcherid | AAG-9930-2019 | |
dc.contributor.researcherid | AFT-6588-2022 | |
dc.contributor.researcherid | AET-7187-2022 | |
dc.contributor.researcherid | D-2127-2014 | |
dc.contributor.researcherid | JWA-4269-2024 | |
dc.contributor.researcherid | AFP-3587-2022 | |
dc.contributor.researcherid | HLH-3244-2023 | |
dc.contributor.researcherid | C-9348-2014 | |
dc.contributor.researcherid | AAG-8744-2021 | |
dc.date.accessioned | 2024-06-28T08:11:57Z | |
dc.date.available | 2024-06-28T08:11:57Z | |
dc.date.issued | 2021-03-01 | |
dc.description.abstract | Objective: The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations. Methods: Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics, asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung adenocarcinoma were recorded. Results: The frequencies of EGFR mutations, ALK, and ROS1 rearrangements were 14.5%, 3.7%, and 0.9%, respectively. The rates of EGFR mutations and ALK rearrangements were more frequent in asbestos exposed non-smokers (48.7% and 9%, respectively). EGFR mutation rate was correlated to female gender and not-smoking, ALK rearrangement rate was correlated to younger age, not-smoking, and a history of asbestos exposure. Conclusions: The higher rate of ALK rearrangements in asbestos-exposed lung adenocarcinoma cases shows that asbestos exposure may most likely cause genetic alterations that drive pulmonary adenocarcinogenesis. | |
dc.identifier.doi | 10.1097/JOM.0000000000002115 | |
dc.identifier.endpage | 243 | |
dc.identifier.issn | 1076-2752 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 238 | |
dc.identifier.uri | https://doi.org/10.1097/JOM.0000000000002115 | |
dc.identifier.uri | https://hdl.handle.net/11452/42566 | |
dc.identifier.volume | 63 | |
dc.identifier.wos | 000663719200021 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Lippincott Williams & Wilkins | |
dc.relation.journal | Journal Of Occupational And Environmental Medicine | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Anaplastic lymphoma kinase | |
dc.subject | Factor receptor-mutations | |
dc.subject | Targeted therapy | |
dc.subject | Cancer | |
dc.subject | Association | |
dc.subject | Smoking | |
dc.subject | Classification | |
dc.subject | Epidemiology | |
dc.subject | Expression | |
dc.subject | Society | |
dc.subject | Alk | |
dc.subject | Asbestos | |
dc.subject | Egfr | |
dc.subject | Genetic alterations | |
dc.subject | Lung adenocarcinoma | |
dc.subject | Ros1 | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Public, environmental & occupational health | |
dc.subject | Public, environmental & occupational health | |
dc.title | Effect of asbestos exposure on the frequency of egfr mutations and alk/ros1 rearrangements in patients with lung adenocarcinoma a multicentric study | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi | |
relation.isAuthorOfPublication | d7720460-3eae-413a-9ffc-16d206d8b896 | |
relation.isAuthorOfPublication | b517ff8d-349f-49cb-b27a-7be17ab074b0 | |
relation.isAuthorOfPublication.latestForDiscovery | d7720460-3eae-413a-9ffc-16d206d8b896 |