Publication:
Effect of asbestos exposure on the frequency of egfr mutations and alk/ros1 rearrangements in patients with lung adenocarcinoma a multicentric study

dc.contributor.authorYilmaz, Senay
dc.contributor.authorDemirci, Nilgun Yilmaz
dc.contributor.authorMetintas, Selma
dc.contributor.authorZamani, Adil
dc.contributor.authorKabalak, Pinar Akin
dc.contributor.authorYilmaz, Ulku
dc.contributor.authorAk, Guntulu
dc.contributor.authorKizilgoz, Derya
dc.contributor.authorOzturk, Akin
dc.contributor.authorYilmaz, Ufuk
dc.contributor.authorBatum, Ozgur
dc.contributor.authorKavas, Murat
dc.contributor.authorSerifoglu, Irem
dc.contributor.authorUnsal, Meftun
dc.contributor.authorKomurcuoglu, Berna E.
dc.contributor.authorCengiz, Tuba Inal
dc.contributor.authorUlubay, Gaye
dc.contributor.authorOzdemirel, Tugce S.
dc.contributor.authorOzyurek, Berna A.
dc.contributor.authorKavurgaci, Suna
dc.contributor.authorAlizoroglu, Dursun
dc.contributor.authorCelik, Pinar
dc.contributor.authorErdogan, Yurdanur
dc.contributor.authorIn, Erdal
dc.contributor.authorAksoy, Asude
dc.contributor.authorAltin, Sedat
dc.contributor.authorGunluoglu, Gulsah
dc.contributor.authorMetintas, Muzaffer
dc.contributor.buuauthorKaradag, Mehmet
dc.contributor.buuauthorKARADAĞ, MEHMET
dc.contributor.buuauthorGuclu, Ozge A.
dc.contributor.buuauthorAYDIN GÜÇLÜ, ÖZGE
dc.contributor.departmentTıp Fakültesi
dc.contributor.orcid0000-0003-0523-7819
dc.contributor.orcid0000-0001-6160-3778
dc.contributor.orcid0000-0002-9027-1132
dc.contributor.orcid0000-0003-1005-3205
dc.contributor.orcid0000-0001-8849-193X
dc.contributor.orcid0000-0002-3445-3804
dc.contributor.orcid0000-0002-2806-4781
dc.contributor.orcid0000-0002-2877-242X
dc.contributor.orcid0000-0003-1596-0082
dc.contributor.orcid0000-0003-0206-7615
dc.contributor.orcid0000-0002-8807-5853
dc.contributor.orcid0000-0002-5609-9658
dc.contributor.researcheridHKN-2974-2023
dc.contributor.researcheridHNT-0352-2023
dc.contributor.researcheridAAS-6628-2021
dc.contributor.researcheridAAG-9930-2019
dc.contributor.researcheridAFT-6588-2022
dc.contributor.researcheridAET-7187-2022
dc.contributor.researcheridD-2127-2014
dc.contributor.researcheridJWA-4269-2024
dc.contributor.researcheridAFP-3587-2022
dc.contributor.researcheridHLH-3244-2023
dc.contributor.researcheridC-9348-2014
dc.contributor.researcheridAAG-8744-2021
dc.date.accessioned2024-06-28T08:11:57Z
dc.date.available2024-06-28T08:11:57Z
dc.date.issued2021-03-01
dc.description.abstractObjective: The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations. Methods: Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics, asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung adenocarcinoma were recorded. Results: The frequencies of EGFR mutations, ALK, and ROS1 rearrangements were 14.5%, 3.7%, and 0.9%, respectively. The rates of EGFR mutations and ALK rearrangements were more frequent in asbestos exposed non-smokers (48.7% and 9%, respectively). EGFR mutation rate was correlated to female gender and not-smoking, ALK rearrangement rate was correlated to younger age, not-smoking, and a history of asbestos exposure. Conclusions: The higher rate of ALK rearrangements in asbestos-exposed lung adenocarcinoma cases shows that asbestos exposure may most likely cause genetic alterations that drive pulmonary adenocarcinogenesis.
dc.identifier.doi10.1097/JOM.0000000000002115
dc.identifier.endpage243
dc.identifier.issn1076-2752
dc.identifier.issue3
dc.identifier.startpage238
dc.identifier.urihttps://doi.org/10.1097/JOM.0000000000002115
dc.identifier.urihttps://hdl.handle.net/11452/42566
dc.identifier.volume63
dc.identifier.wos000663719200021
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.journalJournal Of Occupational And Environmental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnaplastic lymphoma kinase
dc.subjectFactor receptor-mutations
dc.subjectTargeted therapy
dc.subjectCancer
dc.subjectAssociation
dc.subjectSmoking
dc.subjectClassification
dc.subjectEpidemiology
dc.subjectExpression
dc.subjectSociety
dc.subjectAlk
dc.subjectAsbestos
dc.subjectEgfr
dc.subjectGenetic alterations
dc.subjectLung adenocarcinoma
dc.subjectRos1
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectPublic, environmental & occupational health
dc.subjectPublic, environmental & occupational health
dc.titleEffect of asbestos exposure on the frequency of egfr mutations and alk/ros1 rearrangements in patients with lung adenocarcinoma a multicentric study
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi
relation.isAuthorOfPublicationd7720460-3eae-413a-9ffc-16d206d8b896
relation.isAuthorOfPublicationb517ff8d-349f-49cb-b27a-7be17ab074b0
relation.isAuthorOfPublication.latestForDiscoveryd7720460-3eae-413a-9ffc-16d206d8b896

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