Publication:
Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: Synthesis, characterization and anticancer activity

dc.contributor.authorCoşkun, Demet
dc.contributor.authorUlukaya, Engin
dc.contributor.authorCoşkun, Mehmet Fatih
dc.contributor.buuauthorErkısa, Merve
dc.contributor.buuauthorArı, Ferda
dc.contributor.departmentFen Edebiyet Fakültesi
dc.contributor.departmentBiyoloji Bölümü
dc.contributor.orcid0000-0002-3127-742X
dc.contributor.orcid0000-0002-6729-7908
dc.contributor.researcheridAAM-1001-2020
dc.contributor.researcheridAAG-7012-2021
dc.contributor.scopusid57126208900
dc.contributor.scopusid24376085300
dc.date.accessioned2022-11-02T06:07:35Z
dc.date.available2022-11-02T06:07:35Z
dc.date.issued2017-08-18
dc.description.abstractCancer treatment still requires new compounds to be discovered. Chalcone and its derivatives exhibit anticancer potential in different cancer cells. A new series of benzofuran substituted chalcone derivatives was synthesized by the base-catalyzed Claisen-Schmidt reaction of the 1-(7-ethoxy-1-benzofuran-2-yl) ethanone with different aromatic aldehydes to yield 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives 3a-j. The derivatives were characterized by elemental analysis, FT-IR, H-1 NMR and C-13 NMR spectroscopy techniques. The anti-growth effect of chalcone compounds was tested in breast cancer (MCF-7), non-small cell lung cancer (A549) and prostate cancer (PC-3) cell lines by the SRB and ATP cell viability assays. Apoptosis was detected by mitochondrial membrane potential, Annexin V staining and caspase 3/7 activity. Formation of reactive oxygen species was determined by DCFDA. The results revealed that chalcone derivatives have anticancer activity with especially chalcone derivative 3a showing cytotoxic effects on cancer cells. In addition, chalcone derivative 3a induced apoptosis through caspase dependent pathways in prostate, lung and breast cancer cells.
dc.description.sponsorshipFırat Üniversitesi- FF.16.15
dc.identifier.citationCoşkun, D. vd. (2017). ''Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: Synthesis, characterization and anticancer activity''. European Journal of Medicinal Chemistry, 136, 212-222.
dc.identifier.endpage222
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.pubmed28494257
dc.identifier.scopus2-s2.0-85018440526
dc.identifier.startpage212
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2017.05.017
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0223523417303781
dc.identifier.urihttp://hdl.handle.net/11452/29313
dc.identifier.volume136
dc.identifier.wos000403993500017
dc.indexed.wosSCIE
dc.indexed.wosIC
dc.language.isoen
dc.publisherElsevier
dc.relation.collaborationYurt içi
dc.relation.journalEuropean Journal of Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChemistry, medicinal
dc.subjectBenzofuran
dc.subjectChalcone
dc.subjectCytotoxicity
dc.subjectAnticancer activity
dc.subjectApoptosis
dc.subjectBiological evaluation
dc.subjectAntioxidant
dc.subjectActivities
dc.subjectDependent apoptosis
dc.subjectIn-vitrocells
dc.subjectInhibitors
dc.subjectCaspase-3
dc.subjectPathway
dc.subjectDesign
dc.subjectAgents
dc.subject.emtree1 (7 ethoxy 1 benzofuran 2 yl) 3 (1h pyrrol 2 yl)prop 2 en 1 one
dc.subject.emtree1 (7 ethoxy 1 benzofuran 2 yl) 3 (2 furyl)prop 2 en 1 one
dc.subject.emtree1 (7 ethoxy 1 benzofuran 2 yl) 3 (2 thienyl)prop 2 en 1 one
dc.subject.emtree1 (7 ethoxy 1 benzofuran 2 yl) 3 (2,4 dimethoxyphenyl) prop 2 en 1 one
dc.subject.emtree1 (7 ethoxy 1 benzofuran 2 yl) 3 (2,4,5 trimethoxyphenyl) prop 2 en 1 one
dc.subject.emtree1 (7 ethoxy 1 benzofuran 2 yl) 3 (4 bromophenyl)prop 2 en 1 one
dc.subject.emtree1 (7 ethoxy 1 benzofuran 2 yl) 3 (4 methoxyphenyl)prop 2 en 1 one
dc.subject.emtree1 (7 ethoxy 1 benzofuran 2 yl) 3 (4 methylphenyl)prop 2 en 1 one
dc.subject.emtree1 (7 ethoxy 1 benzofuran 2 yl) 3 phenylprop 2 en 1 one
dc.subject.emtree1 (7 ethoxy 1 benzofuran 2 yl) ethanone
dc.subject.emtree3 [4 (dimethylamino)phenyl] 1 (7 ethoxy 1 benzofuran 2 yl)prop 2 en 1 one
dc.subject.emtreeAntineoplastic agent
dc.subject.emtreeCaspase 3
dc.subject.emtreeCaspase 7
dc.subject.emtreeChalcone derivative
dc.subject.emtreeReactive oxygen metabolite
dc.subject.emtreeUnclassified drug
dc.subject.emtreeAntineoplastic agent
dc.subject.emtreeChalcone
dc.subject.emtreeReactive oxygen metabolite
dc.subject.emtreeA-549 cell line
dc.subject.emtreeAntineoplastic activity
dc.subject.emtreeApoptosis
dc.subject.emtreeArticle
dc.subject.emtreeCancer cell
dc.subject.emtreeCarbon nuclear magnetic resonance
dc.subject.emtreeCell viability
dc.subject.emtreeDrug potency
dc.subject.emtreeDrug synthesis
dc.subject.emtreeEnzyme activity
dc.subject.emtreeHuman
dc.subject.emtreeHuman cell
dc.subject.emtreeInfrared spectroscopy
dc.subject.emtreeMCF-7 cell line
dc.subject.emtreeMitochondrial membrane potential
dc.subject.emtreePC 3 cell line
dc.subject.emtreePhase contrast microscopy
dc.subject.emtreeProstate cancer cell line
dc.subject.emtreeProton nuclear magnetic resonance
dc.subject.emtreeCell proliferation
dc.subject.emtreeCell survival
dc.subject.emtreeChemical structure
dc.subject.emtreeChemistry
dc.subject.emtreeDose response
dc.subject.emtreeDrug effects
dc.subject.emtreeDrug screening
dc.subject.emtreeMetabolism
dc.subject.emtreeStructure activity relation
dc.subject.emtreeSynthesis
dc.subject.emtreeTumor cell line
dc.subject.meshAntineoplastic agents
dc.subject.meshApoptosis
dc.subject.meshCell line
dc.subject.meshTumor
dc.subject.meshCell proliferation
dc.subject.meshCell survival
dc.subject.meshChalcone
dc.subject.meshDose-response relationship, drug
dc.subject.meshDrug screening assays, antitumor
dc.subject.meshHumans
dc.subject.meshMembrane potential, mitochondrial
dc.subject.meshMolecular structure
dc.subject.meshReactive oxygen species
dc.subject.meshStructure-activity relationship
dc.subject.scopusAntineoplastic Activity; Props; Acetophenone Derivative
dc.subject.wosPharmacology & pharmacy
dc.titleNovel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: Synthesis, characterization and anticancer activity
dc.typeArticle
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentFen Edebiyet Fakültesi/Biyoloji Bölümü
local.indexed.atPubMed
local.indexed.atWOS

Files

License bundle

Now showing 1 - 1 of 1
Placeholder
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: