The interrelationship between resistin and amylin plasma concentrations and their relation to the concentrations of selected reproductive and metabolic hormones and biochemical variables in the early lactation stage of Saanen goats

Abstract

Resistin and amylin are metabolic hormones that improve energy homeostasis and insulin resistance in rodents but have not been studied in early lactating goats, which are known to be resistant to insulin. This study sought to determine plasma resistin and amylin concentrations and their interrelationship and correlation with select reproductive and metabolic hormones and biochemical variables in early lactating goats. Blood specimens were collected from thirty lactating goats enrolled in the 3rd, 6th and 9th postpartum weeks. Plasma hormone concentrations were measured by ELISA, and the biochemical variables were determined spectrophotometrically. There were no differences in plasma resistin and amylin concentrations at the 3rd, 6th and 9th postpartum weeks. Plasma resistin and amylin concentrations were interrelated and positively correlated with plasma insulin, cortisol, prolactin and NEFA concentrations (p < 0.001) in the early lactation stage of goats. Amylin and resistin may play a critical role in the decreased insulin sensitivity of peripheral tissues during the early lactation period of goats. Further studies are needed to clarify the causal relationships and secretory mechanisms of resistin and amylin in early lactating goats.