Publication: Effects of intracerebroventricular injected choline on cardiovascular functions and sympathoadrenal activity
dc.contributor.author | Kiran, B. Keerthi | |
dc.contributor.buuauthor | Arslan, Birsen Yiğit | |
dc.contributor.buuauthor | Ulus, İsmail Hakkı | |
dc.contributor.buuauthor | Savcı, Vahide | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Farmakoloji Ana Bilim Dalı | |
dc.contributor.researcherid | D-5340-2015 | tr_TR |
dc.contributor.scopusid | 56698581000 | |
dc.contributor.scopusid | 7004271086 | |
dc.contributor.scopusid | 6603687024 | |
dc.date.accessioned | 2021-06-21T07:16:56Z | |
dc.date.available | 2021-06-21T07:16:56Z | |
dc.date.issued | 1991 | |
dc.description.abstract | Intracerebroventricular (i.c.v.) injection of choline (50-150-mu-g) increased blood pressure (SP) and decreased heart rate (HR) in freely moving rats. Intracerebroventricular pretreatment of rats with mecamylamine (50-mu-g) blocked the reduction in HR and reduced the increase in SP induced by i.c.v. choline (150-mu-g). Central muscarinic blockade with atropine (10-mu-g, i.c.v.) reduced the pressor response to i.c.v. choline (150-mu-g) by about 70%, without influencing the decrease in HR. The decrease in HR induced by i.c.v. choline was prevented by intraarterial (i.a.) treatment of atropine methylnitrate (2 mg/kg). Intracerebroventricular choline (150-mu-g) produced a fivefold increase in catecholamine concentrations in adrenal venous plasma. Bilateral adrenalectomy reduced, but did not block, choline's effect on SP. Intracerebroventricular choline (150-mu-g) showed an ability to increase and restore SP in rats subjected to spinal cord transection or pretreatment with hexamethonium (15 mg/kg, i.a.) or with phentolamine (10 mg/kg, i.a.). Intracerebroventricular choline (150-mu-g) increased plasma vasopressin (VP) levels from 2.2 +/- 0.4 to 25.6 +/- 2.5 pg/ml. Pretreatment of rats with a VP antagonist reduced the pressor response to i.c.v. choline. It is concluded that (a) the reduction in HR results from a central nicotinic receptor-mediated increase in vagal tone, (b) the increase in SP appears to be due to activation of both nicotinic and muscarinic central cholinergic receptors, and that (c) the central activation of the adrenal medulla and the increase in plasma levels of VP are involved in the pressor response to i.c.v. choline. | en_US |
dc.identifier.citation | Arslan, B. Y. vd. (1991). ''Effects of intracerebroventricular injected choline on cardiovascular functions and sympathoadrenal activity''. Journal of Cardiovascular Pharmacology, 17(5), 814-821. | tr_TR |
dc.identifier.endpage | 821 | tr_TR |
dc.identifier.issn | 0160-2446 | |
dc.identifier.issue | 5 | tr_TR |
dc.identifier.pubmed | 1713998 | tr_TR |
dc.identifier.scopus | 2-s2.0-0025797063 | tr_TR |
dc.identifier.startpage | 814 | tr_TR |
dc.identifier.uri | https://doi.org/10.1097/00005344-199105000-00018 | |
dc.identifier.uri | http://hdl.handle.net/11452/20669 | |
dc.identifier.volume | 17 | tr_TR |
dc.identifier.wos | A1991FH07000018 | |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en |
dc.publisher | Lippincott-Raven Publications | tr_TR |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.relation.journal | Journal of Cardiovascular Pharmacology | tr_TR |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Choline | en_US |
dc.subject | Cholinergic | en_US |
dc.subject | Blood pressure | en_US |
dc.subject | Vasopressin | en_US |
dc.subject | Sympathoadrenal activity | en_US |
dc.subject | Tyrosine-hydroxylase | en_US |
dc.subject | Rat-brain | en_US |
dc.subject | Stimulation | en_US |
dc.subject | Acetylcholine | en_US |
dc.subject | Mechanisms | en_US |
dc.subject | Release | en_US |
dc.subject | Neurons | en_US |
dc.subject | Physostigmine | en_US |
dc.subject | Striatum | en_US |
dc.subject.emtree | Atropine | en_US |
dc.subject.emtree | Atropine methyl nitrate | en_US |
dc.subject.emtree | Choline | en_US |
dc.subject.emtree | Examethonium | en_US |
dc.subject.emtree | Mecamylamine | en_US |
dc.subject.emtree | Phentolamine | en_US |
dc.subject.emtree | Vasopressin derivative | en_US |
dc.subject.emtree | Adrenal medulla | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Blood pressure | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Heart rate | en_US |
dc.subject.emtree | Intraarterial drug administration | en_US |
dc.subject.emtree | Intracerebroventricular drug administration | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Sympathetic function | en_US |
dc.subject.emtree | Vasopressin blood level | en_US |
dc.subject.mesh | Adrenal glands | en_US |
dc.subject.mesh | Adrenalectomy | en_US |
dc.subject.mesh | Adrenergic alpha-antagonists | en_US |
dc.subject.mesh | Animal | en_US |
dc.subject.mesh | Atropine | en_US |
dc.subject.mesh | Blood pressure | en_US |
dc.subject.mesh | Cardiovascular system | en_US |
dc.subject.mesh | Choline | en_US |
dc.subject.mesh | Dose-response relationship | en_US |
dc.subject.mesh | Drug | en_US |
dc.subject.mesh | Injections | en_US |
dc.subject.mesh | Intraperitoneal | en_US |
dc.subject.mesh | Injections, Intraventricular | en_US |
dc.subject.mesh | Male; Mecamylamine | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Cholinergic | en_US |
dc.subject.mesh | Receptors | en_US |
dc.subject.mesh | Renin | en_US |
dc.subject.mesh | Spinal cord | en_US |
dc.subject.mesh | Support, Non-U.S. Gov't | en_US |
dc.subject.mesh | Sympathetic nervous system | en_US |
dc.subject.mesh | Vasopressins | en_US |
dc.subject.wos | Cardiac & cardiovascular systems | en_US |
dc.subject.wos | Pharmacology & pharmacy | en_US |
dc.title | Effects of intracerebroventricular injected choline on cardiovascular functions and sympathoadrenal activity | en_US |
dc.type | Article | |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Farmakoloji Ana Bilim Dalı | tr_TR |
local.indexed.at | Scopus |
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