Publication:
Secondary osteosarcomas diagnosed in a single institution: 7 cases in 10 years

dc.contributor.authorYalçınkaya, Ulviye
dc.contributor.authorÇetintaş, Sibel Kahraman
dc.contributor.authorBilgen, Muhammed Sadık
dc.contributor.authorYazıcı, Zeynep
dc.contributor.authorSevinir, Berrin Betül
dc.contributor.authorAydınlı, Ufuk
dc.contributor.buuauthorYALÇINKAYA, ÜLVİYE
dc.contributor.buuauthorÇetintaş, Sibel Kahraman
dc.contributor.buuauthorBilgen, Muhammed Sadık
dc.contributor.buuauthorYAZICI, ZEYNEP
dc.contributor.buuauthorSEVİNİR, BETÜL BERRİN
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Cerrahi Patoloji Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Ortopedi Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Pediatrik Onkoloji Anabilim Dalı.
dc.contributor.orcid0000-0002-3232-7652
dc.contributor.researcheridAAH-1570-2021
dc.contributor.researcheridAAI-2303-2021
dc.contributor.researcheridAAA-7047-2020
dc.contributor.researcheridAAH-8924-2021
dc.contributor.researcheridELH-9133-2022
dc.date.accessioned2024-07-31T06:43:23Z
dc.date.available2024-07-31T06:43:23Z
dc.date.issued2015-05-02
dc.description.abstractAims: Osteosarcoma is the most common, non-hematopoietic primary malignant tumor of bone. Osteosarcomas develop de novo in apparently normal bone. However, some benign bone tumors and non-neoplastic conditions may undergo malignant transformation into osteosarcomas. Such osteosarcomas are called secondary osteosarcoma. The scope of this article is to report on a ten-year experience of secondary osteosarcoma in a single institution.Materials and methods: The archives of Uludag University Medical School Department of Pathology were screened for cases of secondary osteosarcoma between January 2002 and June 2013. Demographics, clinical and pathological data are listed.Results: Of the 62 cases of osteosarcoma diagnosed in the period, 7 were secondary osteosarcomas. There were 5 male and 2 female patients. In 4 cases, the secondary osteosarcomas were due to radiation therapy. The index lesion was Paget's disease of bone, bone infarct and giant cell tumor of bone in the other cases. Index lesions included breast carcinoma, Ewing's sarcoma, rhabdomyosarcoma, and primitive neuroectodermal tumor for postradiation osteosarcomas. Unfortunately all patients passed away except for 3 cases of postradiation osteosarcoma.Conclusion: In cases of benign situations having a tendency of malignant transformation including giant cell tumor of bone, bone infarct, Paget's disease, and areas of former radiation therapy, clinical and radiological findings may be of great help in detecting in earlier stages of malignant transformation, and more promising for a disease free survival.
dc.identifier.endpage881
dc.identifier.issn0393-6384
dc.identifier.issue4
dc.identifier.startpage875
dc.identifier.urihttps://hdl.handle.net/11452/43565
dc.identifier.volume31
dc.identifier.wos000357346000018
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherCarbone Editore
dc.relation.journalActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGiant-cell tumor
dc.subjectMalignant fibrous histiocytoma
dc.subjectPostradiation osteosarcoma
dc.subjectPaget-disease
dc.subjectBone
dc.subjectSarcomas
dc.subjectP53
dc.subjectTransformation
dc.subjectMutation
dc.subjectBenign bone tumors
dc.subjectMalignant transformation
dc.subjectOsteosarcoma
dc.subjectRadiation therapy
dc.subjectGeneral & internal medicine
dc.titleSecondary osteosarcomas diagnosed in a single institution: 7 cases in 10 years
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication88cde6d8-7aff-42a7-8102-4847acdacd8b
relation.isAuthorOfPublication523d917f-26be-4117-90bc-22d8bb2ec1a9
relation.isAuthorOfPublication8d125a37-7601-4609-8cb8-b07ccb1c11a4
relation.isAuthorOfPublication.latestForDiscovery88cde6d8-7aff-42a7-8102-4847acdacd8b

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