Publication:
Evaluation of thyroid hormone levels and somatomedin-C (IGF-1) in patients with chronic obstructive pulmonary disease (COPD) and relation with the severity of the disease

dc.contributor.authorCoşkun, Funda
dc.contributor.authorEge, Ercüment
dc.contributor.authorUzaslan, Esra
dc.contributor.authorEdiger, Dane
dc.contributor.authorKaradağ, Mehmet
dc.contributor.authorGözü, Oktay
dc.contributor.buuauthorCOŞKUN, NECMİYE FUNDA
dc.contributor.buuauthorEge, Ercüment
dc.contributor.buuauthorUZASLAN, AYŞE ESRA
dc.contributor.buuauthorEDİGER, DANE
dc.contributor.buuauthorKARADAĞ, MEHMET
dc.contributor.buuauthorGözü, Oktay
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.
dc.contributor.orcid0000-0003-3604-8826
dc.contributor.orcid0000-0002-2954-4293
dc.contributor.orcid0000-0002-9027-1132
dc.contributor.researcheridAAD-1271-2019
dc.contributor.researcheridCPF-5844-2022
dc.contributor.researcheridAAI-1004-2021
dc.contributor.researcheridAAE-9142-2019
dc.contributor.researcheridAAG-8744-2021
dc.contributor.researcheridEWV-3115-2022
dc.date.accessioned2024-10-03T05:34:10Z
dc.date.available2024-10-03T05:34:10Z
dc.date.issued2009-01-01
dc.description.abstractChronic obstructive pulmonary disease (COPD) has recently become a significant cause of mortality and morbidity. In the present study, we aimed to investigate the relationship between the severity of the disease and levels of serum thyroid hormones and somatomedin-C [Insulin-Like Growth Factor (IGF-1)]. Sixty one COPD cases (group 1) were enrolled. Control group (group 2) consisted of 20 healthy individuals. Blood samples were obtained for the analysis of arterial blood gases and hormone levels and respiratory function tests were performed on the same day. Measured hormone levels were compared between group 1 and group 2. Among thyroid hormone levels, there was no significant difference in thyroid stimulating hormone and free T3 between group 1 and 2 whereas free T4 levels were significantly higher in group 1 (p< 0.01). Additionally, mean IGF-1 levels were significantly lower in group 1 (p< 0.005). When three groups, classified according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria, were compared, significant differences were observed between mild-moderate COPD cases and severe patients with respect to free T3 and IGF-1 levels (p< 0.05). Hormone levels in COPD patients change depending on the severity of the disease. In the future hormone therapies can use for the COPD treatments. Further studies with larger sample sizes are required to confirm our conclusions.
dc.identifier.endpage375
dc.identifier.issn0494-1373
dc.identifier.issue4
dc.identifier.startpage369
dc.identifier.urihttp://www.tuberktoraks.org/managete/fu_folder/2009-04/2009-57-4-369-375.pdf
dc.identifier.urihttps://hdl.handle.net/11452/45729
dc.identifier.volume57
dc.identifier.wos000421268800001
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherTurkish Assoc Tuberculosis & Thorax
dc.relation.journalTüberküloz ve Torak-Tuberculosis and Thorax
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGrowth-hormone
dc.subjectMuscle
dc.subjectBalance
dc.subjectCopd
dc.subjectThyroid hormones
dc.subjectIgf
dc.subjectRespiratory system
dc.titleEvaluation of thyroid hormone levels and somatomedin-C (IGF-1) in patients with chronic obstructive pulmonary disease (COPD) and relation with the severity of the disease
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublicationea25ddfe-3514-411c-8862-e891b0cd651b
relation.isAuthorOfPublicationd7720460-3eae-413a-9ffc-16d206d8b896
relation.isAuthorOfPublication.latestForDiscovery061153e8-bbd9-4c2a-97f6-dc51171a1143

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