Publication:
Aluminum exposure in premature babies related to total parenteral nutrition and treatments

dc.contributor.authorAsut, Emre
dc.contributor.authorKöksal, Nilgün
dc.contributor.authorDorum, Bayram Ali
dc.contributor.authorÖzkan, Hilal
dc.contributor.buuauthorAsut, Emre
dc.contributor.buuauthorKÖKSAL, FATMA NİRGÜL
dc.contributor.buuauthorDorum, Bayram Ali
dc.contributor.buuauthorÖZKAN, HİLAL
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Yenidoğan Bilim Dalı
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı
dc.contributor.orcid0000-0002-2823-8454
dc.contributor.researcheridA-5375-2017
dc.contributor.researcheridAAG-8393-2021
dc.contributor.researcheridHJH-3690-2023
dc.contributor.researcheridJGS-7600-2023
dc.contributor.researcheridJJY-3921-2023
dc.date.accessioned2024-07-23T09:58:08Z
dc.date.available2024-07-23T09:58:08Z
dc.date.issued2018-07-01
dc.descriptionBu çalışma, 14, Nisan 2017 tarihlerinde Antalya[Türkiye]’de düzenlenen 26. National Neonatology Congress Kongresi‘nde bildiri olarak sunulmuştur.
dc.description.abstractThis study aimed to measure aluminum contamination of parenteral nutrition (PN) solutions and aluminum contents of parenteral products given to newborn infants for nutrition or treatment. In this study, the aluminum content of the first products used to prepare PN solutions for premature neonates, of the final parenteral products prepared therefrom, and of the parenteral drugs frequently used in newborn units was measured using the inductively coupled plasma mass spectrometry. The aluminum contamination of all parenteral nutritional products evaluated, except for one, was detected to be over the recommended doses. Of all the first products analyzed within the scope of the study, trace-element preparation, preparation containing fat-soluble vitamins, 20% dextrose solution, calcium gluconate ampoule and sodium phosphate ampoule indicated high aluminum contamination. The total aluminum content of the prepared final products was identified to be at least 40% higher than the total aluminum content of the ingredients added to the compound. Accordingly, the minimum amount of aluminum content was measured as 233 mu g/kg/day in nutrition solutions prepared for a baby weighing 1,000 g. Contamination was detected in 9 of the 18 drugs evaluated. This study indicated that the rate of aluminum exposure of the premature babies receiving parental nutrition is still much higher than the safe doses recommended as 5 mu g/kg/day by the FDA. Products with lower aluminum content should be preferred in the care of premature infants.
dc.identifier.doi10.24953/turkjped.2018.04.005
dc.identifier.endpage391
dc.identifier.issn0041-4301
dc.identifier.issue4
dc.identifier.startpage385
dc.identifier.urihttps://doi.org/10.24953/turkjped.2018.04.005
dc.identifier.urihttps://turkjpediatr.org/article/view/872
dc.identifier.urihttps://hdl.handle.net/11452/43378
dc.identifier.volume60
dc.indexed.wosWOS.SCI
dc.indexed.wosWOS.ISTP
dc.language.isoen
dc.publisherTürk Pediatri Dergisi
dc.relation.bapKUAP(T)-2016/2
dc.relation.journalTürk Pediatri Dergisi
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNeonatal patients
dc.subjectInfants
dc.subjectAluminum
dc.subjectNeurotoxicity
dc.subjectNewborn
dc.subjectParenteral nutrition
dc.subjectPrematurity
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectPediatrics
dc.titleAluminum exposure in premature babies related to total parenteral nutrition and treatments
dc.typeArticle
dc.typeProceedings Paper
dspace.entity.typePublication
relation.isAuthorOfPublication6b8b9ea5-2e7c-432e-95da-167ec273d5f3
relation.isAuthorOfPublication67242d15-556e-43b2-a23e-e80ce158b468
relation.isAuthorOfPublication.latestForDiscovery6b8b9ea5-2e7c-432e-95da-167ec273d5f3

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