Publication: Mannose-binding lectin levels in late-onset sepsis in preterm infants: Results from a prospective study in a tertiary care center
dc.contributor.author | Doğan, Pelin | |
dc.contributor.author | Özkan, Hilal | |
dc.contributor.author | Köksal, Nilgün | |
dc.contributor.author | Oral, Haluk Barbaros | |
dc.contributor.author | Çelebi, Solmaz | |
dc.contributor.author | Bağcı, Onur | |
dc.contributor.author | Varal, İpek Güney | |
dc.contributor.buuauthor | Doğan, Pelin | |
dc.contributor.buuauthor | ÖZKAN, HİLAL | |
dc.contributor.buuauthor | Köksal, Nilgün | |
dc.contributor.buuauthor | ORAL, HALUK BARBAROS | |
dc.contributor.buuauthor | ÇELEBİ, SOLMAZ | |
dc.contributor.buuauthor | Bağcı, Onur | |
dc.contributor.buuauthor | Varal, İpek Güney | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Neonatoloji Bilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Enfeksiyon Bilim Dalı. | |
dc.contributor.orcid | 0000-0003-0463-6818 | |
dc.contributor.orcid | 0000-0002-3298-066X | |
dc.contributor.researcherid | AAI-5981-2020 | |
dc.contributor.researcherid | K-7285-2012 | |
dc.contributor.researcherid | AAG-8393-2021 | |
dc.contributor.researcherid | KYP-5736-2024 | |
dc.contributor.researcherid | CNZ-3688-2022 | |
dc.contributor.researcherid | IGT-7005-2023 | |
dc.contributor.researcherid | CZV-1969-2022 | |
dc.contributor.researcherid | ENK-4130-2022 | |
dc.date.accessioned | 2024-09-30T08:25:21Z | |
dc.date.available | 2024-09-30T08:25:21Z | |
dc.date.issued | 2019-08-12 | |
dc.description.abstract | Introduction: This study aimed to determine the association between serum mannose-binding lectin (MBL) levels, gene polymorphisms and late-onset sepsis (LOS) in preterm infants. Methods: Infants with <37 gestational weeks were categorized into two groups according to the presence of LOS during their hospitalization. An MBL level <700 ng/ml was defined as deficiency, MBL2 gene were analyzed. Results: Overall, 153 preterm infants were included. MBL deficiency was found to be more common in the LOS group (p = 0.02). The rate of Gram-negative sepsis was higher in MBL2 variant-type (p = 0.01). In the logistic regression analysis, MBL levels <700 ng/ml were found to have a significant effect on LOS development (odds ratio: 2.692, 95% confidence interval 1.196-5.8, p = 0.02). Conclusions: MBL deficiency is an important risk factor for the development of LOS. Furthermore, there is an association between MBL2 gene polymorphism and Gram-negative sepsis. | |
dc.identifier.doi | 10.1080/15513815.2019.1652374 | |
dc.identifier.endpage | 372 | |
dc.identifier.issn | 1551-3815 | |
dc.identifier.issue | 5 | |
dc.identifier.startpage | 363 | |
dc.identifier.uri | https://doi.org/10.1080/15513815.2019.1652374 | |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/15513815.2019.1652374 | |
dc.identifier.uri | https://hdl.handle.net/11452/45479 | |
dc.identifier.volume | 39 | |
dc.identifier.wos | 000480753900001 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Taylor & Francis Inc | |
dc.relation.bap | KUAP(T)-2013/41 | |
dc.relation.journal | Fetal and Pediatric Pathology | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Neonatal sepsis | |
dc.subject | Gene polymorphism | |
dc.subject | Serum-levels | |
dc.subject | Mbl levels | |
dc.subject | Risk | |
dc.subject | Infection | |
dc.subject | Susceptibility | |
dc.subject | Deficiency | |
dc.subject | Newborns | |
dc.subject | Late-onset sepsis | |
dc.subject | Mannose binding lectin | |
dc.subject | Preterm | |
dc.subject | Pathology | |
dc.subject | Pediatrics | |
dc.title | Mannose-binding lectin levels in late-onset sepsis in preterm infants: Results from a prospective study in a tertiary care center | |
dc.type | Article | |
dspace.entity.type | Publication | |
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relation.isAuthorOfPublication.latestForDiscovery | 67242d15-556e-43b2-a23e-e80ce158b468 |