Dosimetric comparison of free-breathing versus respiratory motion-managed radiotherapy via four-dimensional computed tomography-based volumetric-modulated arctherapy for lung cancer

Abstract

Purpose. - The aim of this study is to use respiratory motion-managed radiotherapy (RT) to reduce side effects and to compare dosimetric factors with free-breathing planning in patients with lung cancer.Materials and methods. - Simulation images were obtained in 10 respiratory phases with free breathing using four-dimensional computed tomography (4D-CT) scanner. Planning target volume (PTV) was cre-ated with 5 mm margins in each direction of the internal target volume delineated using the maximum intensity projection. A volumetric arc treatment (VMAT) plan was created so that the prescribed dose would cover 98% of the PTV. Target volumes for the free-breathing VMAT plan were created according to ICRU Reports 62 and the same prescribed dose was used.Results. - Patients were evaluated during January 2020. Median 63 Gy (59.4-64) RT was administered. Median PTV volumes were 173.53 and 494.50 cm3 (P = 0.008) and dose covering 95% of PTV volume was 62.97 and 60.51 Gy (P = 0.13) in 4D-CT based and free-breathing VMAT plans, respectively. The mean and V50 heart dose was 6.03 Gy (vs. 10.36 Gy, P = 0.043) and 8.2% (vs. 33.9%, P = 0.007), and significantly lower in 4D-CT based VMAT plans and there was also found a non-significant reduction for other risky organ doses. Conclusion. - Ten patients treated with respiratory motion-managed RT with 4D-CT based VMAT tech-nique. It was observed that PTV did not increase, the target was covered with 95% accuracy, and with statistical significance in heart doses, all risky organ doses were found to be less.(c) 2023 Societe franc,aise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.