Interleukin-2 gene polymorphism in Turkish patients with Behcet's disease and its association with ocular involvement
dc.contributor.author | Özçimen, Ahmet Ata | |
dc.contributor.buuauthor | Yücel, Ali | |
dc.contributor.buuauthor | Dilek, Kamil | |
dc.contributor.buuauthor | Saba, Davit | |
dc.contributor.buuauthor | Yurtkuran, Mustafa Abbas | |
dc.contributor.buuauthor | Oral, Haluk Barbaros | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji ve Romatoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0003-0463-6818 | tr_TR |
dc.contributor.researcherid | K-7285-2012 | tr_TR |
dc.contributor.scopusid | 57225839918 | tr_TR |
dc.contributor.scopusid | 56005080200 | tr_TR |
dc.contributor.scopusid | 55987378200 | tr_TR |
dc.contributor.scopusid | 7003389525 | tr_TR |
dc.contributor.scopusid | 7004498001 | tr_TR |
dc.date.accessioned | 2022-10-20T05:48:53Z | |
dc.date.available | 2022-10-20T05:48:53Z | |
dc.date.issued | 2013-10 | |
dc.description.abstract | Behcet's disease (BD) is a chronic immune-mediated systemic disease, characterized by oral and genital lesions and ocular inflammation. Several cytokine genes may play crucial roles in host susceptibility to BD, because the cytokine production capacity varies among individuals and depends on the cytokine gene polymorphisms. The association of the interleukin (IL)-2 gene polymorphisms with the susceptibility to BD was investigated in this study. DNA samples were obtained from a Turkish population of 97 patients with BD and 76 healthy control subjects. Polymorphisms of IL-2 gene at position -330 and +166 were determined using the polymerase chain reaction with sequence-specific primers. In the patients with BD, there was a significantly increased frequency of IL-2 -330 GT genotype. Interestingly, we demonstrated that the frequencies of IL-2 -330 GT and IL-2+166 GG genotypes were increased in BD patients with ocular involvement, whilst IL-2 -330 TT genotype was significantly decreased. Also, analysis of allele frequency demonstrated that the presence of G allele at position +166 of IL-2 seems to be a risk factor for ocular involvement. These results reveal that IL-2 -330 GT genotype may be a susceptibility factor for BD, whereas IL-2 -330 TT genotype seems to display a protective association with BD. Additionally, IL-2 gene polymorphisms might be associated with ocular involvement in BD. | en_US |
dc.identifier.citation | Yücel, A. vd. (2013). "Interleukin-2 gene polymorphism in Turkish patients with Behcet's disease and its association with ocular involvement". International Journal of Immunogenetics, 40(5), 349-355. | en_US |
dc.identifier.endpage | 355 | tr_TR |
dc.identifier.issn | 1744-3121 | |
dc.identifier.issue | 5 | tr_TR |
dc.identifier.pubmed | 23331481 | tr_TR |
dc.identifier.scopus | 2-s2.0-84883650660 | tr_TR |
dc.identifier.startpage | 349 | tr_TR |
dc.identifier.uri | https://doi.org/10.1111/iji.12039 | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/full/10.1111/iji.12039 | |
dc.identifier.uri | http://hdl.handle.net/11452/29153 | |
dc.identifier.volume | 40 | tr_TR |
dc.identifier.wos | 000324023400001 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.bap | T-2004/59 | tr_TR |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.journal | International Journal of Immunogenetics | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Genetics & heredity | en_US |
dc.subject | Immunology | en_US |
dc.subject | Systemic-lupus-erythematosus | en_US |
dc.subject | Han chinese population | en_US |
dc.subject | Multiple-sclerosis | en_US |
dc.subject | Il-2 gene | en_US |
dc.subject | T-cells | en_US |
dc.subject | Online databases | en_US |
dc.subject | Factor-V | en_US |
dc.subject | Infection | en_US |
dc.subject | Cytokines | en_US |
dc.subject | Turkey | en_US |
dc.subject.emtree | Genomic DNA | en_US |
dc.subject.emtree | Interleukin 2 | en_US |
dc.subject.emtree | Allele | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Behcet disease | en_US |
dc.subject.emtree | Clinical feature | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Cytokine production | en_US |
dc.subject.emtree | DNA polymorphism | en_US |
dc.subject.emtree | Gene frequency | en_US |
dc.subject.emtree | Gene sequence | en_US |
dc.subject.emtree | Genetic association | en_US |
dc.subject.emtree | Genotype | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Major clinical study | en_US |
dc.subject.emtree | Polymerase chain reaction | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Risk factor | en_US |
dc.subject.emtree | Turkey (republic) | en_US |
dc.subject.mesh | Behcet syndrome | en_US |
dc.subject.mesh | DNA | en_US |
dc.subject.mesh | Eye | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gene frequency | en_US |
dc.subject.mesh | Genetic predisposition to disease | en_US |
dc.subject.mesh | Genotype | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Inflammation | en_US |
dc.subject.mesh | Interleukin-2 | en_US |
dc.subject.mesh | Lymphocytes | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Neutrophils | en_US |
dc.subject.mesh | Polymorphism, single nucleotide | en_US |
dc.subject.mesh | Turkey | en_US |
dc.subject.scopus | Fluorescence Lifetime; Esterases; Optical Imaging | en_US |
dc.subject.wos | Genetics & heredity | en_US |
dc.subject.wos | Immunology | en_US |
dc.title | Interleukin-2 gene polymorphism in Turkish patients with Behcet's disease and its association with ocular involvement | en_US |
dc.type | Article | |
dc.wos.quartile | Q4 | en_US |
Files
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: