Analysis of the effect of locally applied bovine collagen sponge and adipose-derived mesenchymal stem cells on seroma development in rats undergone mastectomy and axillary dissection

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dc.contributor.authorBakır, Hasan
dc.contributor.authorUysal, Erdal
dc.contributor.authorKurt, Akif Hakan
dc.contributor.buuauthorKırdak, Türkay
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.tr_TR
dc.contributor.scopusid8704181100tr_TR
dc.date.accessioned2023-04-03T11:07:20Z
dc.date.available2023-04-03T11:07:20Z
dc.date.issued2016-09-12
dc.description.abstractPurpose: Seroma is the most frequently seen complication after the mastectomy and axillary dissection. The aim of this study was to analyze the effects of locally applied bovine collagen sponge and adipose-derived mesenchymal stem cells on seroma development in rats that undergone mastectomy and axillary dissection. Materials and Methods: Wistar albino rats, were randomly divided into 3 groups (n = 10 per group). For the rats in Group 1, 1 ml 0.09% NaCl was implemented. 2 x 106/kg adipose-derived mesenchymal stem cell was implemented within 1 ml 0.09% NaCl for the rats in Group 2, and 3 cm2 bovine collagen sponge were locally applied for the rats in Group 3. Adhesion scores, histopathological examination, E-cadherin expression and tissue seroma volume were evaluated. Results: The seroma volume of Group 3 were significantly lower than those of Groups 2 and 1 (p < 0.001). General adhesion scores of Group 3 were significantly higher than those of Groups 1 and 2 (p < 0.05). Statistically significant increase was observed in Group 3 compared to Group 1 in terms of fibroblast, neovascularization and collagen density (p < 0.05). Conclusion: Local application of bovine collagen sponge and ADSCs in rats, which have undergone experimental mastectomy and axillary dissection, can be told to decrease the seroma formation and to increase the neovascularization and collagen deposition. This effect is more significant in bovine collagen sponge group.en_US
dc.identifier.citationBakır, H. vd. (2017). ''Analysis of the effect of locally applied bovine collagen sponge and adipose-derived mesenchymal stem cells on seroma development in rats undergone mastectomy and axillary dissection''. Journal of Investigative Surgery, 30(4), 252-259.en_US
dc.identifier.endpage259tr_TR
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue4tr_TR
dc.identifier.pubmed27736251tr_TR
dc.identifier.scopus2-s2.0-84990903043tr_TR
dc.identifier.startpage252tr_TR
dc.identifier.urihttps://doi.org/10.1080/08941939.2016.1236856
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/08941939.2016.1236856
dc.identifier.urihttp://hdl.handle.net/11452/32146
dc.identifier.volume30tr_TR
dc.identifier.wos000402011700006
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSurgeryen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalJournal of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSurgeryen_US
dc.subjectStem cellen_US
dc.subjectBovine collagenen_US
dc.subjectSeromaen_US
dc.subjectMastectomyaxillary dissectionen_US
dc.subjectRaten_US
dc.subjectSurgeryen_US
dc.subjectPreventionen_US
dc.subjectFibroblasten_US
dc.subjectMatrixen_US
dc.subjectModelen_US
dc.subject.emtreeBovine collagen spongeen_US
dc.subject.emtreeCollagen spongeen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeUvomorulinen_US
dc.subject.emtreeCollagenen_US
dc.subject.emtreeAdipose derived stem cellen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAxillary lymph nodeen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFibroblasten_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeImmunohistochemistryen_US
dc.subject.emtreeLymph node dissectionen_US
dc.subject.emtreeMastectomyen_US
dc.subject.emtreeMesenchymal stem cell transplantationen_US
dc.subject.emtreeNeovascularization (pathology)en_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePostoperative complicationen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSeromaen_US
dc.subject.emtreeSurgical techniqueen_US
dc.subject.emtreeTumor growthen_US
dc.subject.emtreeTumor volumeen_US
dc.subject.emtreeWistar raten_US
dc.subject.emtreeWound healingen_US
dc.subject.emtreeAdipose tissueen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeAxillaen_US
dc.subject.emtreeCytologyen_US
dc.subject.emtreeEvaluation studyen_US
dc.subject.emtreeHemostatic techniqueen_US
dc.subject.emtreeMastectomyen_US
dc.subject.emtreeRandomizationen_US
dc.subject.emtreeSeromaen_US
dc.subject.emtreeSurgeryen_US
dc.subject.emtreeSurgical spongeen_US
dc.subject.emtreeTissue adhesionen_US
dc.subject.meshAdipose tissueen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAxillaen_US
dc.subject.meshCollagenen_US
dc.subject.meshFemaleen_US
dc.subject.meshHemostatic techniquesen_US
dc.subject.meshLymph node excisionen_US
dc.subject.meshMastectomyen_US
dc.subject.meshMesenchymal stem cell transplantationen_US
dc.subject.meshRandom allocationen_US
dc.subject.meshRats, wistaren_US
dc.subject.meshSeromaen_US
dc.subject.meshSurgical spongesen_US
dc.subject.meshTissue adhesionsen_US
dc.subject.scopusSeroma; Mastectomy; Breast Neoplasmsen_US
dc.subject.wosSurgeryen_US
dc.titleAnalysis of the effect of locally applied bovine collagen sponge and adipose-derived mesenchymal stem cells on seroma development in rats undergone mastectomy and axillary dissectionen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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