Publication:
A retrospective multicenter evaluation of cutaneous melanomas in Turkey

dc.contributor.authorGamsızkan, Mehmet
dc.contributor.authorYılmaz, İsmail
dc.contributor.authorBüyükbabanı, Nesimi
dc.contributor.authorDemirkesen, Cüyan
dc.contributor.authorDemiriz, Murat
dc.contributor.authorÇetin, Emel Dikicioǧlu
dc.contributor.authorİnce, Ümit
dc.contributor.authorAkalın, Taner
dc.contributor.authorDemirkan, Neşe Çallı
dc.contributor.authorLebe, Banu Kurtoğlu
dc.contributor.authorErdem, Özlem S.
dc.contributor.authorGököz, Özay Özkaya
dc.contributor.authorSakız, Damlanur
dc.contributor.authorDemireli, Peyker Temiz
dc.contributor.authorAstarcı, Hesna Müzeyyen
dc.contributor.authorZemheri, Ebru Itır
dc.contributor.authorAçıkalın, Arbil Avcı
dc.contributor.authorYaman, Banu
dc.contributor.authorAydın, Övgü
dc.contributor.authorBaşsorgun, Cumhur İbrahim
dc.contributor.buuauthorAdım, Şaduman Balaban
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentPatoloji Ana Bilim Dalı
dc.contributor.scopusid15730076300
dc.date.accessioned2024-02-15T05:21:57Z
dc.date.available2024-02-15T05:21:57Z
dc.date.issued2014
dc.description.abstractBackground: We defined melanoma distribution in a large series of Turkish patients and evaluated the prognostic parameters of melanomas. Materials and Methods: A total of 1574 patients' data was retrospectively collected at 18 centers in Turkey. Demographic characteristics were questioned and noted. Prognostic parametres were evaluated based on sentinel lymph node involvement. Results: Mean age was 56.7 (4-99) years. While 844 (53.6%) cases were male, 730 (46.4%) cases were female. One thousand four hundred forty-seven (92%) cases were invasive melanoma and 127 (8%) cases were in-situ melanoma. The most common histopathological form was the superficial spreading melanoma (SSM) which was found in 549 patients (37.9%). It was followed by nodular melanoma in 379 (26.2%), acral lentiginous melanoma (ALM) in 191 (13.2%) and lentigo maligna melanoma in 132 (9.1%), respectively. On univariate analysis, lymphovascular invasion (p<0.001), tumor thickness (p<0.001), histopathological subtype (p<0.001), Clark level (p=0.001), ulceration (p<0.001), >= 6/mm(2) mitosis (p=0.005), satellite formation (p=0.001) and gender (p=0.03) were found to be associated with sentinel lymph node positivity. Regression was associated with sentinel lymph node negativity (p=0.017). According to multivariate analysis, lymphovascular invasion and tumor thickness were significant independent predictive factors of SLN positivity. Patient age, tumor localization, precursor lesions, lymphocytic infiltration and neurotropism were not related with sentinel lymph node involvement. Conclusions: In this retrospective analysis, it was found that the prevalence of SSM is at a lower rate while the prevalence of ALM is at a higher rate when compared to western countries. According to Breslow index; most of the melanoma lesions' thickness were greater than 2 mm, corresponding Clark IV. Vascular invasion and tumor thickness are the most important factors for sentinel lymph node involvement.
dc.identifier.citationGamsızkan, M. vd. (2014). "A retrospective multicenter evaluation of cutaneous melanomas in Turkey". Asian Pacific Journal of Cancer Prevention, 15(23), 10451-10456.
dc.identifier.doihttps://doi.org/10.7314/APJCP.2014.15.23.10451
dc.identifier.endpage10456
dc.identifier.issn1513-7368
dc.identifier.issue23
dc.identifier.pubmed25556491
dc.identifier.scopus2-s2.0-84921821422
dc.identifier.startpage10451
dc.identifier.urihttp://koreascience.or.kr/article/JAKO201505458144669.page
dc.identifier.urihttps://hdl.handle.net/11452/39717
dc.identifier.volume15
dc.identifier.wos000351058400069
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherAsian Pacific Organization Cancer Prevention
dc.relation.collaborationYurt içi
dc.relation.collaborationSanayi
dc.relation.journalAsian Pacific Journal of Cancer Prevention
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMelanoma
dc.subjectSkin
dc.subjectPrognostic factors
dc.subjectOncology
dc.subjectTumor-infiltrating lymphocytes
dc.subjectBiopsy
dc.subjectLymph-node positivity
dc.subjectRates
dc.subjectMalignant-melanoma
dc.subjectPrognostic-factors
dc.subjectSurvival
dc.subjectRegression
dc.subject.emtreeAdolescent
dc.subject.emtreeAdult
dc.subject.emtreeAged
dc.subject.emtreeCancer staging
dc.subject.emtreeChild
dc.subject.emtreeClinical trial
dc.subject.emtreeFemale
dc.subject.emtreeHuman
dc.subject.emtreeLymph node
dc.subject.emtreeMale
dc.subject.emtreeMelanoma
dc.subject.emtreeMiddle aged
dc.subject.emtreeMulticenter study
dc.subject.emtreeMultivariate analysis
dc.subject.emtreePathology
dc.subject.emtreePreschool child
dc.subject.emtreePrognosis
dc.subject.emtreeRetrospective study
dc.subject.emtreeSentinel lymph node biopsy
dc.subject.emtreeSex difference
dc.subject.emtreeSkin neoplasms
dc.subject.emtreeTumor volume
dc.subject.emtreeTurkey
dc.subject.emtreeVery elderly
dc.subject.emtreeYoung adult
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshChild
dc.subject.meshChild, preschool
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLymph nodes
dc.subject.meshMale
dc.subject.meshMelanoma
dc.subject.meshMiddle aged
dc.subject.meshMultivariate analysis
dc.subject.meshNeoplasm staging
dc.subject.meshPrognosis
dc.subject.meshRetrospective studies
dc.subject.meshSentinel lymph node biopsy
dc.subject.meshSex factors
dc.subject.meshSkin neoplasms
dc.subject.meshTumor burden
dc.subject.meshTurkey
dc.subject.meshYoung adult
dc.subject.scopusSentinel Lymph Node Biopsy; Lymphoscintigraphy; Melanoma
dc.subject.wosOncology
dc.titleA retrospective multicenter evaluation of cutaneous melanomas in Turkey
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Patoloji Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

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